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13 results on '"Wang, Jialiang S."'

6. A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

Author

Yoon, Sung-Hee, Meyer, Mark B., Arevalo, Carlos, Tekguc, Murat, Zhang, Chengcheng, Wang, Jialiang S., Andrade, Christian D. Castro, Strauss, Katelyn, Sato, Tadatoshi, Benkusky, Nancy A., Lee, Seong Min, Berdeaux, Rebecca, Foretz, Marc, Sundberg, Thomas B., Xavier, Ramnik J., Adelmann, Charles H., Brooks, Daniel J., Anselmo, Anthony, Sadreyev, Ruslan I., Rosales, Ivy A., Fisher, David E., Gupta, Navin, Morizane, Ryuji, Greka, Anna, Pike, J. Wesley, Mannstad, Michael, and Wein, Marc N.

Subjects
Care and treatment, Development and progression, Genetic aspects, Health aspects, Cytochrome P-450 -- Health aspects, Parathyroid hormones -- Health aspects, Bone diseases -- Genetic aspects -- Development and progression -- Care and treatment, Cellular signal transduction -- Health aspects, Kidney diseases -- Genetic aspects -- Development and progression -- Care and treatment, Gene expression -- Health aspects, Parathyroid hormone -- Health aspects
Abstract

Introduction Vitamin D plays a critical role in bone and mineral metabolism and also controls other physiologic and pathophysiologic processes, including skeletal muscle function, reproductive health, cancer risk and progression, [...], The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated renal 1,25-vitamin D production downstream of PTH signaling. PTH inhibited SIK cellular activity by cAMP-dependent PKA phosphorylation. Whole-tissue and single-cell transcriptomics demonstrated that both PTH and pharmacologic SIK inhibitors regulated a vitamin D gene module in the proximal tubule. SIK inhibitors increased 1,25-vitamin D production and renal Cyp27b1 mRNA expression in mice and in human embryonic stem cell-derived kidney organoids. Global- and kidney-specific Sik2/Sik3 mutant mice showed Cyp27b1 upregulation, elevated serum 1,25- vitamin D, and PTH-independent hypercalcemia. The SIK substrate CRTC2 showed PTH and SIK inhibitor-inducible binding to key Cyp27b1 regulatory enhancers in the kidney, which were also required for SIK inhibitors to increase Cyp27b1 in vivo. Finally, in a podocyte injury model of chronic kidney disease-mineral bone disorder (CKD-MBD), SIK inhibitor treatment stimulated renal Cyp27b1 expression and 1,25-vitamin D production. Together, these results demonstrated a PTH/SIK/CRTC signaling axis in the kidney that controls Cyp27b1 expression and 1,25-vitamin D synthesis. These findings indicate that SIK inhibitors might be helpful for stimulation of 1,25-vitamin D production in CKD-MBD.

Published
2023
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7. Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Author

Wang, Jialiang S., Kamath, Tushar, Mazur, Courtney M., Mirzamohammadi, Fatemeh, Rotter, Daniel, Hojo, Hironori, Castro, Christian D., Tokavanich, Nicha, Patel, Rushi, Govea, Nicolas, Enishi, Tetsuya, Wu, Yunshu, da Silva Martins, Janaina, Bruce, Michael, Brooks, Daniel J., Bouxsein, Mary L., Tokarz, Danielle, Lin, Charles P., Abdul, Abdul, Macosko, Evan Z., Fiscaletti, Melissa, Munns, Craig F., Ryder, Pearl, Kost-Alimova, Maria, Byrne, Patrick, Cimini, Beth, Fujiwara, Makoto, Kronenberg, Henry M., and Wein, Marc N.

Published
2021
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9. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Author

Sato, Tadatoshi, Verma, Shiv, Andrade, Christian D. Castro, Omeara, Maureen, Campbell, Nia, Wang, Jialiang S., Cetinbas, Murat, Lang, Audrey, Ausk, Brandon J., Brooks, Daniel J., Sadreyev, Ruslan I., Kronenberg, Henry M., Lagares, David, Uda, Yuhei, Pajevic, Paola Divieti, Bouxsein, Mary L., Gross, Ted S., and Wein, Marc N.

Published
2020
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12. Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin

Author

Wang, Jialiang S., primary, Kamath, Tushar, additional, Mirzamohammadi, Fatemeh, additional, Rotter, Daniel, additional, Hojo, Hironori, additional, Castro, Christian D., additional, Patel, Rushi, additional, Govea, Nicolas, additional, Enishi, Tetsuya, additional, Wu, Yunshu, additional, da Silva Martins, Janaina, additional, Bruce, Michael, additional, Brooks, Daniel J., additional, Bouxsein, Mary L., additional, Tokarz, Danielle, additional, Lin, Charles P., additional, Abdul, Abdul, additional, Macosko, Evan Z., additional, Fiscaletti, Melissa, additional, Munns, Craig F., additional, Fujiwara, Makoto, additional, Kronenberg, Henry M., additional, and Wein, Marc N., additional

Published
2021
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