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610 results on '"Wang, I-Jong"'

16. Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice

Author

Liu, Hongshan, Zhang, Jianhua, Liu, Chia-Yang, Wang, I-Jong, Sieber, Martin, Chang, John, Jester, James V., and Kao, Winston Y.

Subjects
marrow stromal cells, bone-marrow, confocal microscopy, skeletal-muscle, spinal-cord, transplantation, tissue, expression, keratocan, repair
Abstract

BackgroundKeratoplasty is the most effective treatment for corneal blindness, but suboptimal medical conditions and lack of qualified medical personnel and donated cornea often prevent the performance of corneal transplantation in developing countries. Our study aims to develop alternative treatment regimens for congenital corneal diseases of genetic mutation.Methodology/Principal FindingsHuman mesenchymal stem cells isolated from neonatal umbilical cords were transplanted to treat thin and cloudy corneas of lumican null mice. Transplantation of umbilical mesenchymal stem cells significantly improved corneal transparency and increased stromal thickness of lumican null mice, but human umbilical hematopoietic stem cells failed to do the same. Further studies revealed that collagen lamellae were re-organized in corneal stroma of lumican null mice after mesenchymal stem cell transplantation. Transplanted umbilical mesenchymal stem cells survived in the mouse corneal stroma for more than 3 months with little or no graft rejection. In addition, these cells assumed a keratocyte phenotype, e.g., dendritic morphology, quiescence, expression of keratocyte unique keratan sulfated keratocan and lumican, and CD34. Moreover, umbilical mesenchymal stem cell transplantation improved host keratocyte functions, which was verified by enhanced expression of keratocan and aldehyde dehydrogenase class 3A1 in lumican null mice.Conclusions/SignificanceUmbilical mesenchymal stem cell transplantation is a promising treatment for congenital corneal diseases involving keratocyte dysfunction. Unlike donated corneas, umbilical mesenchymal stem cells are easily isolated, expanded, stored, and can be quickly recovered from liquid nitrogen when a patient is in urgent need.

Published
2010

18. A Method of Measuring Corneal Young’s Modulus

Author

Cao, Huei-Jyun, Huang, Chun-Ju, Shih, Po-Jen, Wang, I-Jong, Yen, Jia-Yush, MAGJAREVIC, Ratko, Editor-in-chief, Ładyzynsk, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Goh, James, editor, and Lim, Chwee Teck, editor

Published
2015
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37. Use of white light in vivo confocal microscopy for the detection of spatial changes in the corneal nerves in cases of early-stage Acanthamoeba keratitis with radial keratoneuritis

Author

Hung, Kuo-Chi, Lu, Chia-Ju, Liu, Hsin-Yu, Hou, Yu-Chih, Wang, I-Jong, Hu, Fung-Rong, and Chen, Wei-Li

Subjects
Acanthamoeba keratitis -- Diagnosis -- Care and treatment -- Methods, Radial keratotomy -- Methods, Confocal microscopy -- Methods, Time, Corneal diseases, Microscopy, Keratitis, Diseases, Health
Abstract

Byline: Kuo-Chi. Hung, Chia-Ju. Lu, Hsin-Yu. Liu, Yu-Chih. Hou, I-Jong. Wang, Fung-Rong. Hu, Wei-Li. Chen Purpose: Radial keratoneuritis (RK) is a common feature of Acanthamoeba keratitis (AK). In vivo confocal [...]

Published
2020

48. sj-pdf-1-imr-10.1177_03000605221108100 - Supplemental material for Correlation between corneal dynamic responses and keratoconus topographic parameters

Author

Tai, Hsi-Yun, Lin, Jun-Ji, Huang, Yi-Hung, Shih, Po-Jen, Wang, I-Jong, and Yen, Jia-Yush

Subjects
111199 Nutrition and Dietetics not elsewhere classified, Cardiology, 170199 Psychology not elsewhere classified, 111799 Public Health and Health Services not elsewhere classified, 110604 Sports Medicine, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 111099 Nursing not elsewhere classified, 111708 Health and Community Services, 160807 Sociological Methodology and Research Methods, 111702 Aged Health Care, 111403 Paediatrics, 110904 Neurology and Neuromuscular Diseases, 110203 Respiratory Diseases, 110315 Otorhinolaryngology, FOS: Clinical medicine, 110319 Psychiatry (incl. Psychotherapy), FOS: Sociology, FOS: Psychology, 110599 Dentistry not elsewhere classified, 110323 Surgery, 110305 Emergency Medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-pdf-1-imr-10.1177_03000605221108100 for Correlation between corneal dynamic responses and keratoconus topographic parameters by Hsi-Yun Tai, Jun-Ji Lin, Yi-Hung Huang, Po-Jen Shih, I-Jong Wang and Jia-Yush Yen in Journal of International Medical Research

Published
2022
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