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9. Risk of Estrogen Receptor–Positive and –Negative Breast Cancer and Single–Nucleotide Polymorphism 2q35-rs13387042

Author

Milne, Roger L, Benítez, Javier, Nevanlinna, Heli, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Arias, José Ignacio, Zamora, M Pilar, Burwinkel, Barbara, Bartram, Claus R, Meindl, Alfons, Schmutzler, Rita K, Cox, Angela, Brock, Ian, Elliott, Graeme, Reed, Malcolm WR, Southey, Melissa C, Smith, Letitia, Spurdle, Amanda B, Hopper, John L, Couch, Fergus J, Olson, Janet E, Wang, Xianshu, Fredericksen, Zachary, Schürmann, Peter, Bremer, Michael, Hillemanns, Peter, Dörk, Thilo, Devilee, Peter, van Asperen, Christie J, Tollenaar, Rob AEM, Seynaeve, Caroline, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Yuqing, Ahmed, Shahana, Dunning, Alison M, Maranian, Melanie, Pharoah, Paul DP, Chenevix-Trench, Georgia, Beesley, Jonathan, Investigators, kConFab, Group, AOCS, Bogdanova, Natalia V, Antonenkova, Natalia N, Zalutsky, Iosif V, Anton-Culver, Hoda, Ziogas, Argyrios, Brauch, Hiltrud, Justenhoven, Christina, Ko, Yon-Dschun, Haas, Susanne, Fasching, Peter A, Strick, Reiner, Ekici, Arif B, Beckmann, Matthias W, Giles, Graham G, Severi, Gianluca, Baglietto, Laura, English, Dallas R, Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Peto, Julian, Turnbull, Clare, Hines, Sarah, Renwick, Anthony, Rahman, Nazneen, Nordestgaard, Børge G, Bojesen, Stig E, Flyger, Henrik, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, García-Closas, Montserrat, Chanock, Stephen, Lissowska, Jolanta, Brinton, Louise A, Chang-Claude, Jenny, Wang-Gohrke, Shan, Shen, Chen-Yang, Wang, Hui-Chun, Yu, Jyh-Cherng, Chen, Sou-Tong, Bermisheva, Marina, Nikolaeva, Tatjana, Khusnutdinova, Elza, Humphreys, Manjeet K, Morrison, Jonathan, Platte, Radka, Easton, Douglas F, and Consortium, on behalf of the Breast Cancer Association

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetics, Breast Cancer, Clinical Research, Cancer, Human Genome, Estrogen, Adult, Aged, Asian People, Biomarkers, Tumor, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Intraductal, Noninfiltrating, Case-Control Studies, Confidence Intervals, Confounding Factors, Epidemiologic, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Linkage Disequilibrium, Middle Aged, Neoplasms, Hormone-Dependent, Odds Ratio, Polymorphism, Single Nucleotide, Receptors, Estrogen, Receptors, Progesterone, White People, kConFab Investigators, AOCS Group, Breast Cancer Association Consortium, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundA recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)-positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium.Methods2q35-rs13387042 SNP was genotyped for 31 510 women with invasive breast cancer, 1101 women with ductal carcinoma in situ, and 35 969 female control subjects from 25 studies. Odds ratios (ORs) were estimated by logistic regression, adjusted for study. Heterogeneity in odds ratios by each of age, ethnicity, and study was assessed by fitting interaction terms. Heterogeneity by each of invasiveness, family history, bilaterality, and hormone receptor status was assessed by subclassifying case patients and applying polytomous logistic regression. All statistical tests were two-sided.ResultsWe found strong evidence of association between rs13387042 and breast cancer in white women of European origin (per-allele OR = 1.12, 95% confidence interval [CI] = 1.09 to 1.15; P(trend) = 1.0 x 10(-19)). The odds ratio was lower than that previously reported (P = .02) and did not vary by age or ethnicity (all P > or = .2). However, it was higher when the analysis was restricted to case patients who were selected for a strong family history (P = .02). An association was observed for both ER-positive (OR = 1.14, 95% CI = 1.10 to 1.17; P = 10(-15)) and ER-negative disease (OR = 1.10, 95% CI = 1.04 to 1.15; P = .0003) and both progesterone receptor (PR)-positive (OR = 1.15, 95% CI = 1.11 to 1.19; P = 5 x 10(-14)) and PR-negative disease (OR = 1.10, 95% CI = 1.06 to 1.15; P = .00002).ConclusionThe rs13387042 is associated with both ER-positive and ER-negative breast cancer in European women.

Published
2009

10. Study on extraction process and purification of polysaccharide from red beet.

Author

PENG Mao-de-ji, WANG Hui-chun, LI Jia-yu, HU Ying, JIA Hui-ping, LIU Yang-yang, and ZHU Tian-tian

Subjects
*BEETS, *PRECIPITATION (Chemistry), *SOLVENT extraction, *ACTIVATED carbon, *RAW materials, *CHEMICAL purification, *LOW temperatures, *POLYSACCHARIDES
Abstract

The experiment was conducted to explore the extraction effect of different extraction methods on red beet polysaccharide. In the experiment, red beet was used as raw material, water extraction and alcohol precipitation method and ultrasonic assisted water extraction method were used respectively. Orthogonal design was carried out to optimize the extraction process on the basis of single factor experiment, and the effect of liquid to solid ratio, extraction temperature and extraction time on the extraction rate of red beet polysaccharide were investigated. The crude polysaccharides were purified by Sevag reagent, activated carbon and petroleum ether. The results showed that the optimal extraction conditions of red beet polysaccharide by water extraction and alcohol precipitation were as follows: Liquid to solid ratio of 90 mL/g, extraction temperature of 70 °C, and an extraction time of 1.5 h. Under the conditions, the extraction yield of red beet polysaccharide was the highest, reaching 2.33%. The optimal extraction process of ultrasonic assisted water extraction was as follows: Liquid to solid ratio 40 mL/g, extraction temperature of 40 °C, extraction time of 30 min. Under the conditions, the extraction rate was 6.85%. The removal rates of protein, pigment and fat were 29.73%, 3.88% and 2.76%, respectively. The study indicates that ultrasonic assisted water extraction method is more suitable for the extraction of red beet polysaccharide with less solvent, shorter time, lower temperature and higher extraction rate. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Supplementary Methods from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo

Author

Wang, Hui-Chun, primary, Lee, Alan Yueh-Luen, primary, Chou, Wen-Cheng, primary, Wu, Chin-Chung, primary, Tseng, Chao-Neng, primary, Liu, Kevin Yen-Ting, primary, Lin, Wen-Lien, primary, Chang, Fang-Rong, primary, Chuang, Da-Wei, primary, Hunyadi, Attila, primary, and Wu, Yang-Chang, primary

Published
2023
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12. Data from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo

Author

Wang, Hui-Chun, primary, Lee, Alan Yueh-Luen, primary, Chou, Wen-Cheng, primary, Wu, Chin-Chung, primary, Tseng, Chao-Neng, primary, Liu, Kevin Yen-Ting, primary, Lin, Wen-Lien, primary, Chang, Fang-Rong, primary, Chuang, Da-Wei, primary, Hunyadi, Attila, primary, and Wu, Yang-Chang, primary

Published
2023
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13. Supplementary Figures 1 - 8 from Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo

Author

Wang, Hui-Chun, primary, Lee, Alan Yueh-Luen, primary, Chou, Wen-Cheng, primary, Wu, Chin-Chung, primary, Tseng, Chao-Neng, primary, Liu, Kevin Yen-Ting, primary, Lin, Wen-Lien, primary, Chang, Fang-Rong, primary, Chuang, Da-Wei, primary, Hunyadi, Attila, primary, and Wu, Yang-Chang, primary

Published
2023
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20. Using HMMs and Depth Information for Signer-Independent Sign Language Recognition

Author

Wu, Yeh-Kuang, Wang, Hui-Chun, Chang, Liung-Chun, Li, Ke-Chun, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Ramanna, Sheela, editor, Lingras, Pawan, editor, Sombattheera, Chattrakul, editor, and Krishna, Aneesh, editor

Published
2013
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39. Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cellsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00251a

Author

Girst, Gábor, Lopes, Elizabeth A., Gonçalves, Lídia M., Espadinha, Margarida, Kúsz, Norbert, Wang, Hui-Chun, Santos, Maria M. M., and Hunyadi, Attila

Abstract

The combination of compounds with complementary bioactivities into hybrid molecules is an emerging concept in drug discovery. In this study, we aimed to synthesize new hybrid compounds based on p53-MDM2/X protein–protein interaction spiropyrazoline oxindole-based inhibitors and ataxia telangiectasia and Rad3-related (ATR) protoflavone-based inhibitors through copper(i) catalysed azide–alkyne cycloaddition. Five new hybrids were prepared along with three representative reference fragments. The compounds were tested against human breast cancer cell lines MCF-7 (hormone-dependent, wild-type p53) and MDA-MB-231 (triple-negative, mutant p53). Most of the new hybrids were more cytotoxic than their reference fragments and several showed 2–4 times selective toxicity against MDA-MB-231 cells. Relevant pharmacological benefit gained from the hybrid coupling was further confirmed by virtual combination index calculations using the Chou method. Compound 13modulated doxorubicin-induced DNA damage response through inhibiting the ATR-dependent activation of Chk-1, while increasing the activation of Chk-2. Our results suggest that the new hybrids may serve as new leads against triple negative breast cancer.

Published
2023
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43. Genome-wide association study identifies novel breast cancer susceptibility loci

Author

Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D. P., Thompson, Deborah, Ballinger, Dennis G., Struewing, Jeffery P., Morrison, Jonathan, Field, Helen, Luben, Robert, Wareham, Nicholas, Ahmed, Shahana, Healey, Catherine S., Bowman, Richard, Meyer, Kerstin B., Haiman, Christopher A., Kolonel, Laurence K., Henderson, Brian E., Le Marchand, Loic, Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Eccles, Diana, Evans, D. Gareth, Peto, Julian, Fletcher, Olivia, Johnson, Nichola, Seal, Sheila, Stratton, Michael R., Rahman, Nazneen, Chenevix-Trench, Georgia, Bojesen, Stig E., Nordestgaard, Børge G., Axelsson, Christen K., Garcia-Closas, Montserrat, Brinton, Louise, Chanock, Stephen, Lissowska, Jolanta, Peplonska, Beata, Nevanlinna, Heli, Fagerholm, Rainer, Eerola, Hannaleena, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Hunter, David J., Hankinson, Susan E., Cox, David G., Hall, Per, Wedren, Sara, Liu, Jianjun, Low, Yen-Ling, Bogdanova, Natalia, Schürmann, Peter, Dörk, Thilo, Tollenaar, Rob A. E. M., Jacobi, Catharina E., Devilee, Peter, Klijn, Jan G. M., Sigurdson, Alice J., Doody, Michele M., Alexander, Bruce H., Zhang, Jinghui, Cox, Angela, Brock, Ian W., MacPherson, Gordon, Reed, Malcolm W. R., Couch, Fergus J., Goode, Ellen L., Olson, Janet E., Meijers-Heijboer, Hanne, van den Ouweland, Ans, Uitterlinden, André, Rivadeneira, Fernando, Milne, Roger L., Ribas, Gloria, Gonzalez-Neira, Anna, Benitez, Javier, Hopper, John L., McCredie, Margaret, Southey, Melissa, Giles, Graham G., Schroen, Chris, Justenhoven, Christina, Brauch, Hiltrud, Hamann, Ute, Ko, Yon-Dschun, Spurdle, Amanda B., Beesley, Jonathan, Chen, Xiaoqing, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Hartikainen, Jaana, Day, Nicholas E., Cox, David R., and Ponder, Bruce A. J.

Published
2007
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45. The Impact of Urate‐Lowering Therapy in Post‐Myocardial Infarction Patients: Insights From a Population‐Based, Propensity Score‐Matched Analysis.

Author

Tai, Chi‐Jung, Wu, Chin‐Chung, Lee, Kun‐Tai, Tseng, Tzyy‐Guey, Wang, Hui‐Chun, Chang, Fang‐Rong, and Yang, Yi‐Hsin

Subjects
MYOCARDIAL infarction, CORONARY artery bypass, MOTIVATIONAL interviewing, PERCUTANEOUS coronary intervention, XANTHINE oxidase, NATIONAL health insurance, ARRHYTHMIA
Abstract

The role of urate‐lowering therapy (ULT) for the primary prevention of cardiovascular (CV) events has been widely discussed, but its evidence for the secondary prevention of myocardial infarction (MI) is limited. Therefore, we conduct a population‐based, propensity score‐matched cohort study to investigate the CV outcomes among patients with post‐MI with and without ULT. A total of 19,042 newly diagnosed in‐hospital patients with MI were selected using the Taiwan National Health Insurance Database between January 1, 2005, and December 31, 2016. After 1:1 propensity score matching with covariates, patients with MI with (n = 963) and without (n = 963) ULT were selected for further analysis. The primary outcome was the all‐cause mortality and the secondary outcomes were composite CV outcomes, including hospitalization for recurrent MI, stroke, heart failure, and cardiac arrhythmias. ULT users were associated with lower all‐cause mortality (adjusted hazard ratio (adjHR), 0.67; 95% confidence interval (CI), 0.51–0.87) compared to the ULT nonusers. In addition, ULT users had a significantly lower risk of recurrent MI, which needed revascularization by percutaneous coronary intervention or coronary artery bypass grafting (adjHR, 0.67; 95% CI, 0.53–0.86) than the ULT nonusers. The primary and secondary outcomes were not different between patients with post‐MI who received uricosuric agents and xanthine oxidase inhibitors. The anti‐inflammatory effect of ULT plays an essential role in MI management. From a real‐world setting, this study shows that ULT is associated with the lower risk of all‐cause mortality in patients with post‐MI. In addition, the result shows the possible lower incidence of repeat revascularization procedures in the ULT users. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling

Author

Latif, Ahmed Dhahir, primary, Jernei, Tamás, additional, Podolski-Renić, Ana, additional, Kuo, Ching-Ying, additional, Vágvölgyi, Máté, additional, Girst, Gábor, additional, Zupkó, István, additional, Develi, Sedef, additional, Ulukaya, Engin, additional, Wang, Hui-Chun, additional, Pešić, Milica, additional, Csámpai, Antal, additional, and Hunyadi, Attila, additional

Published
2020
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48. FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation

Author

Udler, Miriam S., Meyer, Kerstin B., Pooley, Karen A., Karlins, Eric, Struewing, Jeffery P., Zhang, Jinghui, Doody, David R., MacArthur, Stewart, Tyrer, Jonathan, Pharoah, Paul D., Luben, Robert, Bernstein, Leslie, Kolonel, Laurence N., Henderson, Brian E., Le Marchand, Loic, Ursin, Giske, Press, Michael F., Brennan, Paul, Sangrajrang, Suleeporn, Gaborieau, Valerie, Odefrey, Fabrice, Shen, Chen-Yang, Wu, Pei-Ei, Wang, Hui-Chun, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Ahn, Sei-Hyun, Ponder, Bruce A.J., Haiman, Christopher A., Malone, Kathleen E., Dunning, Alison M., Ostrander, Elaine A., and Easton, Douglas F.

Published
2009

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