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General networks for 3D medical image segmentation have recently undergone extensive exploration. Behind the exceptional performance of these networks lies a significant demand for a large volume of pixel-level annotated data, which is time-consuming and labor-intensive. The emergence of the Segment Anything Model (SAM) has enabled this model to achieve superior performance in 2D medical image segmentation tasks via parameter- and data-efficient feature adaptation. However, the introduction of additional depth channels in 3D medical images not only prevents the sharing of 2D pre-trained features but also results in a quadratic increase in the computational cost for adapting SAM. To overcome these challenges, we present the Tri-Plane Mamba (TP-Mamba) adapters tailored for the SAM, featuring two major innovations: 1) multi-scale 3D convolutional adapters, optimized for efficiently processing local depth-level information, 2) a tri-plane mamba module, engineered to capture long-range depth-level representation without significantly increasing computational costs. This approach achieves state-of-the-art performance in 3D CT organ segmentation tasks. Remarkably, this superior performance is maintained even with scarce training data. Specifically using only three CT training samples from the BTCV dataset, it surpasses conventional 3D segmentation networks, attaining a Dice score that is up to 12% higher.

Federated semi-supervised learning (FedSemi) refers to scenarios where there may be clients with fully labeled data, clients with partially labeled, and even fully unlabeled clients while preserving data privacy. However, challenges arise from client drift due to undefined heterogeneous class distributions and erroneous pseudo-labels. Existing FedSemi methods typically fail to aggregate models from unlabeled clients due to their inherent unreliability, thus overlooking unique information from their heterogeneous data distribution, leading to sub-optimal results. In this paper, we enable unlabeled client aggregation through SemiAnAgg, a novel Semi-supervised Anchor-Based federated Aggregation. SemiAnAgg learns unlabeled client contributions via an anchor model, effectively harnessing their informative value. Our key idea is that by feeding local client data to the same global model and the same consistently initialized anchor model (i.e., random model), we can measure the importance of each unlabeled client accordingly. Extensive experiments demonstrate that SemiAnAgg achieves new state-of-the-art results on four widely used FedSemi benchmarks, leading to substantial performance improvements: a 9% increase in accuracy on CIFAR-100 and a 7.6% improvement in recall on the medical dataset ISIC-18, compared with prior state-of-the-art. Code is available at: https://github.com/xmed-lab/SemiAnAgg., Comment: Accepted by TMLR (10/2024)

Cone-Beam Computed Tomography (CBCT) is an indispensable technique in medical imaging, yet the associated radiation exposure raises concerns in clinical practice. To mitigate these risks, sparse-view reconstruction has emerged as an essential research direction, aiming to reduce the radiation dose by utilizing fewer projections for CT reconstruction. Although implicit neural representations have been introduced for sparse-view CBCT reconstruction, existing methods primarily focus on local 2D features queried from sparse projections, which is insufficient to process the more complicated anatomical structures, such as the chest. To this end, we propose a novel reconstruction framework, namely DIF-Gaussian, which leverages 3D Gaussians to represent the feature distribution in the 3D space, offering additional 3D spatial information to facilitate the estimation of attenuation coefficients. Furthermore, we incorporate test-time optimization during inference to further improve the generalization capability of the model. We evaluate DIF-Gaussian on two public datasets, showing significantly superior reconstruction performance than previous state-of-the-art methods., Comment: Accepted to MICCAI 2024. Project link: https://github.com/xmed-lab/DIF-Gaussian

Cone beam computed tomography (CBCT) is an important imaging technology widely used in medical scenarios, such as diagnosis and preoperative planning. Using fewer projection views to reconstruct CT, also known as sparse-view reconstruction, can reduce ionizing radiation and further benefit interventional radiology. Compared with sparse-view reconstruction for traditional parallel/fan-beam CT, CBCT reconstruction is more challenging due to the increased dimensionality caused by the measurement process based on cone-shaped X-ray beams. As a 2D-to-3D reconstruction problem, although implicit neural representations have been introduced to enable efficient training, only local features are considered and different views are processed equally in previous works, resulting in spatial inconsistency and poor performance on complicated anatomies. To this end, we propose C^2RV by leveraging explicit multi-scale volumetric representations to enable cross-regional learning in the 3D space. Additionally, the scale-view cross-attention module is introduced to adaptively aggregate multi-scale and multi-view features. Extensive experiments demonstrate that our C^2RV achieves consistent and significant improvement over previous state-of-the-art methods on datasets with diverse anatomy., Comment: Accepted to CVPR 2024

Data privacy and long-tailed distribution are the norms rather than the exception in many real-world tasks. This paper investigates a federated long-tailed learning (Fed-LT) task in which each client holds a locally heterogeneous dataset; if the datasets can be globally aggregated, they jointly exhibit a long-tailed distribution. Under such a setting, existing federated optimization and/or centralized long-tailed learning methods hardly apply due to challenges in (a) characterizing the global long-tailed distribution under privacy constraints and (b) adjusting the local learning strategy to cope with the head-tail imbalance. In response, we propose a method termed $\texttt{Fed-GraB}$, comprised of a Self-adjusting Gradient Balancer (SGB) module that re-weights clients' gradients in a closed-loop manner, based on the feedback of global long-tailed distribution evaluated by a Direct Prior Analyzer (DPA) module. Using $\texttt{Fed-GraB}$, clients can effectively alleviate the distribution drift caused by data heterogeneity during the model training process and obtain a global model with better performance on the minority classes while maintaining the performance of the majority classes. Extensive experiments demonstrate that $\texttt{Fed-GraB}$ achieves state-of-the-art performance on representative datasets such as CIFAR-10-LT, CIFAR-100-LT, ImageNet-LT, and iNaturalist., Comment: Accepted by NeurIPS 2023

Quantization has emerged as a promising direction for model compression. Recently, data-free quantization has been widely studied as a promising method to avoid privacy concerns, which synthesizes images as an alternative to real training data. Existing methods use classification loss to ensure the reliability of the synthesized images. Unfortunately, even if these images are well-classified by the pre-trained model, they still suffer from low semantics and homogenization issues. Intuitively, these low-semantic images are sensitive to perturbations, and the pre-trained model tends to have inconsistent output when the generator synthesizes an image with poor semantics. To this end, we propose Robustness-Guided Image Synthesis (RIS), a simple but effective method to enrich the semantics of synthetic images and improve image diversity, further boosting the performance of downstream data-free compression tasks. Concretely, we first introduce perturbations on input and model weight, then define the inconsistency metrics at feature and prediction levels before and after perturbations. On the basis of inconsistency on two levels, we design a robustness optimization objective to enhance the semantics of synthetic images. Moreover, we also make our approach diversity-aware by forcing the generator to synthesize images with small correlations in the label space. With RIS, we achieve state-of-the-art performance for various settings on data-free quantization and can be extended to other data-free compression tasks., Comment: Accepted at AAAI 2024

Data imbalance and open-ended distribution are two intrinsic characteristics of the real visual world. Though encouraging progress has been made in tackling each challenge separately, few works dedicated to combining them towards real-world scenarios. While several previous works have focused on classifying close-set samples and detecting open-set samples during testing, it's still essential to be able to classify unknown subjects as human beings. In this paper, we formally define a more realistic task as distribution-agnostic generalized category discovery (DA-GCD): generating fine-grained predictions for both close- and open-set classes in a long-tailed open-world setting. To tackle the challenging problem, we propose a Self-Balanced Co-Advice contrastive framework (BaCon), which consists of a contrastive-learning branch and a pseudo-labeling branch, working collaboratively to provide interactive supervision to resolve the DA-GCD task. In particular, the contrastive-learning branch provides reliable distribution estimation to regularize the predictions of the pseudo-labeling branch, which in turn guides contrastive learning through self-balanced knowledge transfer and a proposed novel contrastive loss. We compare BaCon with state-of-the-art methods from two closely related fields: imbalanced semi-supervised learning and generalized category discovery. The effectiveness of BaCon is demonstrated with superior performance over all baselines and comprehensive analysis across various datasets. Our code is publicly available., Comment: Accepted at NeurIPS 2023

Recently, large-scale pre-trained vision-language models have presented benefits for alleviating class imbalance in long-tailed recognition. However, the long-tailed data distribution can corrupt the representation space, where the distance between head and tail categories is much larger than the distance between two tail categories. This uneven feature space distribution causes the model to exhibit unclear and inseparable decision boundaries on the uniformly distributed test set, which lowers its performance. To address these challenges, we propose the uniformly category prototype-guided vision-language framework to effectively mitigate feature space bias caused by data imbalance. Especially, we generate a set of category prototypes uniformly distributed on a hypersphere. Category prototype-guided mechanism for image-text matching makes the features of different classes converge to these distinct and uniformly distributed category prototypes, which maintain a uniform distribution in the feature space, and improve class boundaries. Additionally, our proposed irrelevant text filtering and attribute enhancement module allows the model to ignore irrelevant noisy text and focus more on key attribute information, thereby enhancing the robustness of our framework. In the image recognition fine-tuning stage, to address the positive bias problem of the learnable classifier, we design the class feature prototype-guided classifier, which compensates for the performance of tail classes while maintaining the performance of head classes. Our method outperforms previous vision-language methods for long-tailed learning work by a large margin and achieves state-of-the-art performance., Comment: 11pages, 5figures

Out-of-distribution (OOD) detection refers to training the model on an in-distribution (ID) dataset to classify whether the input images come from unknown classes. Considerable effort has been invested in designing various OOD detection methods based on either convolutional neural networks or transformers. However, zero-shot OOD detection methods driven by CLIP, which only require class names for ID, have received less attention. This paper presents a novel method, namely CLIP saying no (CLIPN), which empowers the logic of saying no within CLIP. Our key motivation is to equip CLIP with the capability of distinguishing OOD and ID samples using positive-semantic prompts and negation-semantic prompts. Specifically, we design a novel learnable no prompt and a no text encoder to capture negation semantics within images. Subsequently, we introduce two loss functions: the image-text binary-opposite loss and the text semantic-opposite loss, which we use to teach CLIPN to associate images with no prompts, thereby enabling it to identify unknown samples. Furthermore, we propose two threshold-free inference algorithms to perform OOD detection by utilizing negation semantics from no prompts and the text encoder. Experimental results on 9 benchmark datasets (3 ID datasets and 6 OOD datasets) for the OOD detection task demonstrate that CLIPN, based on ViT-B-16, outperforms 7 well-used algorithms by at least 2.34% and 11.64% in terms of AUROC and FPR95 for zero-shot OOD detection on ImageNet-1K. Our CLIPN can serve as a solid foundation for effectively leveraging CLIP in downstream OOD tasks. The code is available on https://github.com/xmed-lab/CLIPN., Comment: ICCV 2023

In the medical field, federated learning commonly deals with highly imbalanced datasets, including skin lesions and gastrointestinal images. Existing federated methods under highly imbalanced datasets primarily focus on optimizing a global model without incorporating the intra-class variations that can arise in medical imaging due to different populations, findings, and scanners. In this paper, we study the inter-client intra-class variations with publicly available self-supervised auxiliary networks. Specifically, we find that employing a shared auxiliary pre-trained model, like MoCo-V2, locally on every client yields consistent divergence measurements. Based on these findings, we derive a dynamic balanced model aggregation via self-supervised priors (MAS) to guide the global model optimization. Fed-MAS can be utilized with different local learning methods for effective model aggregation toward a highly robust and unbiased global model. Our code is available at \url{https://github.com/xmed-lab/Fed-MAS}.

Though Self-supervised learning (SSL) has been widely studied as a promising technique for representation learning, it doesn't generalize well on long-tailed datasets due to the majority classes dominating the feature space. Recent work shows that the long-tailed learning performance could be boosted by sampling extra in-domain (ID) data for self-supervised training, however, large-scale ID data which can rebalance the minority classes are expensive to collect. In this paper, we propose an alternative but easy-to-use and effective solution, Contrastive with Out-of-distribution (OOD) data for Long-Tail learning (COLT), which can effectively exploit OOD data to dynamically re-balance the feature space. We empirically identify the counter-intuitive usefulness of OOD samples in SSL long-tailed learning and principally design a novel SSL method. Concretely, we first localize the `head' and `tail' samples by assigning a tailness score to each OOD sample based on its neighborhoods in the feature space. Then, we propose an online OOD sampling strategy to dynamically re-balance the feature space. Finally, we enforce the model to be capable of distinguishing ID and OOD samples by a distribution-level supervised contrastive loss. Extensive experiments are conducted on various datasets and several state-of-the-art SSL frameworks to verify the effectiveness of the proposed method. The results show that our method significantly improves the performance of SSL on long-tailed datasets by a large margin, and even outperforms previous work which uses external ID data. Our code is available at https://github.com/JianhongBai/COLT.

Contrastive language-image pre-training (CLIP) is a powerful vision-language model that has shown great benefits for various tasks. However, we have identified some issues with its explainability, which undermine its credibility and limit the capacity for related tasks. Specifically, we find that CLIP tends to focus on background regions rather than foregrounds, with noisy activations at irrelevant positions on the visualization results. These phenomena conflict with conventional explainability methods based on the class attention map (CAM), where the raw model can highlight the local foreground regions using global supervision without alignment. To address these problems, we take a closer look at its architecture and features. Based on thorough analyses, we find the raw self-attentions link to inconsistent semantic regions, resulting in the opposite visualization. Besides, the noisy activations are owing to redundant features among categories. Building on these insights, we propose the CLIP Surgery for reliable CAM, a method that allows surgery-like modifications to the inference architecture and features, without further fine-tuning as classical CAM methods. This approach significantly improves the explainability of CLIP, surpassing existing methods by large margins. Besides, it enables multimodal visualization and extends the capacity of raw CLIP on open-vocabulary tasks without extra alignment. The code is available at https://github.com/xmed-lab/CLIP_Surgery., Comment: 30 pages, 11 figures, under review

Fully supervised semantic segmentation learns from dense masks, which requires heavy annotation cost for closed set. In this paper, we use natural language as supervision without any pixel-level annotation for open world segmentation. We call the proposed framework as FreeSeg, where the mask is freely available from raw feature map of pretraining model. Compared with zero-shot or openset segmentation, FreeSeg doesn't require any annotated masks, and it widely predicts categories beyond class-agnostic unsupervised segmentation. Specifically, FreeSeg obtains free mask from Image-Text Similarity Map (ITSM) of Interpretable Contrastive Language-Image Pretraining (ICLIP). And our core improvements are the smoothed min pooling for dense ICLIP, with the partial label and pixel strategies for segmentation. Furthermore, FreeSeg is very straight forward without complex design like grouping, clustering or retrieval. Besides the simplicity, the performances of FreeSeg surpass previous state-of-the-art at large margins, e.g. 13.4% higher at mIoU on VOC dataset in the same settings., Comment: This paper contains some immature results

Contrastive Language-Image Pre-training (CLIP) learns rich representations via readily available supervision of natural language. It improves the performance of downstream vision tasks, including but not limited to the zero-shot, long tail, segmentation, retrieval, caption, and video. However, the visual explainability of CLIP is rarely studied, especially for the raw feature map. To provide visual explanations of its predictions, we propose the Image-Text Similarity Map (ITSM). Based on it, we surprisingly find that CLIP prefers the background regions than the foregrounds, and shows erroneous visualization results against human understanding. This phenomenon is universal for both vision transformers and convolutional networks, which suggests this problem is unique and not owing to certain network. Experimentally, we find the devil is in the pooling part, where inappropriate pooling methods lead to a phenomenon called semantic shift. For this problem, we propose the Explainable Contrastive Language-Image Pre-training (ECLIP), which corrects the explainability via the Masked Max Pooling. Specifically, to avoid the semantic shift, we replace the original attention pooling by max pooling to focus on the confident foreground, with guidance from free attention during training. Experiments on three datasets suggest that ECLIP greatly improves the explainability of CLIP, and beyond previous explainability methods at large margins. The code will be released later., Comment: 15 pages, 9 figures

Long-tailed learning aims to tackle the crucial challenge that head classes dominate the training procedure under severe class imbalance in real-world scenarios. However, little attention has been given to how to quantify the dominance severity of head classes in the representation space. Motivated by this, we generalize the cosine-based classifiers to a von Mises-Fisher (vMF) mixture model, denoted as vMF classifier, which enables to quantitatively measure representation quality upon the hyper-sphere space via calculating distribution overlap coefficient. To our knowledge, this is the first work to measure representation quality of classifiers and features from the perspective of distribution overlap coefficient. On top of it, we formulate the inter-class discrepancy and class-feature consistency loss terms to alleviate the interference among the classifier weights and align features with classifier weights. Furthermore, a novel post-training calibration algorithm is devised to zero-costly boost the performance via inter-class overlap coefficients. Our method outperforms previous work with a large margin and achieves state-of-the-art performance on long-tailed image classification, semantic segmentation, and instance segmentation tasks (e.g., we achieve 55.0\% overall accuracy with ResNetXt-50 in ImageNet-LT). Our code is available at https://github.com/VipaiLab/vMF\_OP.

Data privacy and class imbalance are the norm rather than the exception in many machine learning tasks. Recent attempts have been launched to, on one side, address the problem of learning from pervasive private data, and on the other side, learn from long-tailed data. However, both assumptions might hold in practical applications, while an effective method to simultaneously alleviate both issues is yet under development. In this paper, we focus on learning with long-tailed (LT) data distributions under the context of the popular privacy-preserved federated learning (FL) framework. We characterize three scenarios with different local or global long-tailed data distributions in the FL framework, and highlight the corresponding challenges. The preliminary results under different scenarios reveal that substantial future work are of high necessity to better resolve the characterized federated long-tailed learning tasks., Comment: Accepted by International Workshop on Trustworthy Federated Learning in Conjunction with IJCAI 2022 (FL-IJCAI'22)