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662 results on '"Wang, Haisong"'

27. RNA m5C methylation: a potential modulator of innate immune pathways in hepatocellular carcinoma

Author

Sun Meng, Bai Jiangtao, Wang Haisong, Li Mei, Zhou Long, and Li Shanfeng

Subjects
RNA m5C methylation, TLR, cGAS-STING, RIG-I, hepatocellular carcinoma, Immunologic diseases. Allergy, RC581-607
Abstract

RNA 5-methylcytosine (m5C) methylation plays a crucial role in hepatocellular carcinoma (HCC). As reported, aberrant m5C methylation is closely associated with the progression, therapeutic efficacy, and prognosis of HCC. The innate immune system functions as the primary defense mechanism in the body against pathogenic infections and tumors since it can activate innate immune pathways through pattern recognition receptors to exert anti-infection and anti-tumor effects. Recently, m5C methylation has been demonstrated to affect the activation of innate immune pathways including TLR, cGAS-STING, and RIG-I pathways by modulating RNA function, unveiling new mechanisms underlying the regulation of innate immune responses by tumor cells. However, research on m5C methylation and its interplay with innate immune pathways is still in its infancy. Therefore, this review details the biological significance of RNA m5C methylation in HCC and discusses its potential regulatory relationship with TLR, cGAS-STING, and RIG-I pathways, thereby providing fresh insights into the role of RNA methylation in the innate immune mechanisms and treatment of HCC.

Published
2024
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28. Effect of citric acid on properties of (3-mercaptopropyl)trimethoxysilane modified xylan/polyvinyl alcohol composite film

Author

LI Jinhui, WANG Yining, YANG Sixia, WANG Haisong, and LYU Yanna

Subjects
citric acid, xylan, polyvinyl alcohol, crosslinking agent, composite film, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

In order to improved the defects of xylan-based films such as strong hygroscopicity and low mechanical strength, a collaborative modification protocol of citric acid (CA) and MPTMS-modified xylan (MSMX) was proposed. Xylan from sugarcane bagasse was firstly modified by (3-mercaptopropyl)trimethoxysilane (MPTMS), and then citric acid was used as crosslinking agent or plasticizer. The MSMX/PVA/CA films were prepared by casting method and the effects of citric acid content on the structure and packaging performance of the composite film were studied. The results show that with the increase of CA content, the cross-linking degree of MSMX/PVA/CA films increases and the internal structure becomes more dense, which lead to the significant enhancement of mechanical properties and water vapor barrier performance. Meanwhile, the hydrophobicity of the MSMX/PVA/CA films is improved with the decrease of hydrophilice groups. When CA content is 20% (mass fraction), the tensile strength of MSMX/PVA/CA film is 41.8 MPa, water contact angle is 82°, and the water vapor transmittance reaches 2.79×10-13 g·cm·cm-2·s-1·Pa-1, which is 37.79% lower than that of film without CA. The addition of CA improves the moisture barrier properties and mechanical strength of xylan composite films, which makes it have a potential application in the field of food and drug packaging.

Published
2023
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36. Commoning and Territoriality in the Public Space 'Plasma' of Historical Cities: Investigating Emplaced Network Dynamics in Bhaktapur, Kathmandu Valley, Nepal

Author

Kawan, Shyam Sunder, Manfredini, Manfredo, Wang, Haisong, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Swasto, Deva Fosterharoldas, editor, Rahmi, Dwita Hadi, editor, Rahmawati, Yani, editor, Hidayati, Isti, editor, Al-Faraby, Jimly, editor, and Widita, Alyas, editor

Published
2023
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