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9 results on '"Wang, Gaojianyong"'

2. PATH-45. INTRAEPIGLIOM - RAPID SEQUENCING-BASED DIAGNOSIS OF BRAIN TUMORS

Author

Kubelt, Carolin, primary, Brändl, Björn, additional, van Bömmel, Alena, additional, Rohrandt, Christian, additional, Wang, Gaojianyong, additional, Evers, Maximilian, additional, Kolkenbrock, Stephan, additional, Wong, Derek, additional, Danso, Dominik, additional, Maicher, Andre, additional, Friedrichsen, Sönke, additional, Proescholdt, Martin, additional, Riemenschneider, Markus, additional, Jetzek, Ulrich, additional, Meissner, Alexander, additional, Yip, Stephen, additional, Kretzmer, Helene, additional, Synowitz, Michael, additional, and Müller, Franz-Josef, additional

Published
2022
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4. A Chromosome-Length Reference Genome for the Endangered Pacific Pocket Mouse Reveals Recent Inbreeding in a Historically Large Population

Author

Wilder, Aryn P, primary, Dudchenko, Olga, additional, Curry, Caitlin, additional, Korody, Marisa, additional, Turbek, Sheela P, additional, Daly, Mark, additional, Misuraca, Ann, additional, Wang, Gaojianyong, additional, Khan, Ruqayya, additional, Weisz, David, additional, Fronczek, Julie, additional, Aiden, Erez Lieberman, additional, Houck, Marlys L, additional, Shier, Debra M, additional, Ryder, Oliver A, additional, and Steiner, Cynthia C, additional

Published
2022
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5. The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms

Author

Walker, Kimberly, primary, Kalra, Divya, additional, Lowdon, Rebecca, additional, Chen, Guangyi, additional, Molik, David, additional, Soto, Daniela C., additional, Dabbaghie, Fawaz, additional, Khleifat, Ahmad Al, additional, Mahmoud, Medhat, additional, Paulin, Luis F, additional, Raza, Muhammad Sohail, additional, Pfeifer, Susanne P., additional, Agustinho, Daniel Paiva, additional, Aliyev, Elbay, additional, Avdeyev, Pavel, additional, Barrozo, Enrico R., additional, Behera, Sairam, additional, Billingsley, Kimberley, additional, Chong, Li Chuin, additional, Choubey, Deepak, additional, De Coster, Wouter, additional, Fu, Yilei, additional, Gener, Alejandro R., additional, Hefferon, Timothy, additional, Henke, David Morgan, additional, Höps, Wolfram, additional, Illarionova, Anastasia, additional, Jochum, Michael D., additional, Jose, Maria, additional, Kesharwani, Rupesh K., additional, Kolora, Sree Rohit Raj, additional, Kubica, Jędrzej, additional, Lakra, Priya, additional, Lattimer, Damaris, additional, Liew, Chia-Sin, additional, Lo, Bai-Wei, additional, Lo, Chunhsuan, additional, Lötter, Anneri, additional, Majidian, Sina, additional, Mendem, Suresh Kumar, additional, Mondal, Rajarshi, additional, Ohmiya, Hiroko, additional, Parvin, Nasrin, additional, Peralta, Carolina, additional, Poon, Chi-Lam, additional, Prabhakaran, Ramanandan, additional, Saitou, Marie, additional, Sammi, Aditi, additional, Sanio, Philippe, additional, Sapoval, Nicolae, additional, Syed, Najeeb, additional, Treangen, Todd, additional, Wang, Gaojianyong, additional, Xu, Tiancheng, additional, Yang, Jianzhi, additional, Zhang, Shangzhe, additional, Zhou, Weiyu, additional, Sedlazeck, Fritz J, additional, and Busby, Ben, additional

Published
2022
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6. Chromosome-level genome assembly of the functionally extinct northern white rhinoceros (Ceratotherium simum cottoni)

Author

Wang, Gaojianyong, primary, Brändl, Björn, additional, Rohrandt, Christian, additional, Hong, Karl, additional, Pang, Andy, additional, Lee, Joyce, additional, Lewin, Harris A., additional, Migliorelli, Giovanna, additional, Stanke, Mario, additional, Schwab, Remy, additional, Ford, Sarah, additional, Pollmann, Iris, additional, Schuldt, Bernhard M., additional, Houck, Marlys, additional, Ryder, Oliver A., additional, Meissner, Alexander, additional, Loring, Jeanne F., additional, Müller, Franz-Josef, additional, and Korody, Marisa L., additional

Published
2021
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7. An international virtual hackathon to build tools for the analysis of structural variants within species ranging from coronaviruses to vertebrates

Author

Mc Cartney, Ann M., primary, Mahmoud, Medhat, additional, Jochum, Michael, additional, Agustinho, Daniel Paiva, additional, Zorman, Barry, additional, Al Khleifat, Ahmad, additional, Dabbaghie, Fawaz, additional, K Kesharwani, Rupesh, additional, Smolka, Moritz, additional, Dawood, Moez, additional, Albin, Dreycey, additional, Aliyev, Elbay, additional, Almabrazi, Hakeem, additional, Arslan, Ahmed, additional, Balaji, Advait, additional, Behera, Sairam, additional, Billingsley, Kimberley, additional, L Cameron, Daniel, additional, Daw, Joyjit, additional, T. Dawson, Eric, additional, De Coster, Wouter, additional, Du, Haowei, additional, Dunn, Christopher, additional, Esteban, Rocio, additional, Jolly, Angad, additional, Kalra, Divya, additional, Liao, Chunxiao, additional, Liu, Yunxi, additional, Lu, Tsung-Yu, additional, M Havrilla, James, additional, M Khayat, Michael, additional, Marin, Maximillian, additional, Monlong, Jean, additional, Price, Stephen, additional, Rafael Gener, Alejandro, additional, Ren, Jingwen, additional, Sagayaradj, Sagayamary, additional, Sapoval, Nicolae, additional, Sinner, Claude, additional, C. Soto, Daniela, additional, Soylev, Arda, additional, Subramaniyan, Arun, additional, Syed, Najeeb, additional, Tadimeti, Neha, additional, Tater, Pamella, additional, Vats, Pankaj, additional, Vaughn, Justin, additional, Walker, Kimberly, additional, Wang, Gaojianyong, additional, Zeng, Qiandong, additional, Zhang, Shangzhe, additional, Zhao, Tingting, additional, Kille, Bryce, additional, Biederstedt, Evan, additional, Chaisson, Mark, additional, English, Adam, additional, Kronenberg, Zev, additional, J. Treangen, Todd, additional, Hefferon, Timothy, additional, Chin, Chen-Shan, additional, Busby, Ben, additional, and J Sedlazeck, Fritz, additional

Published
2021
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8. Chromosome-Length Reference Genome for the Endangered Pacific Pocket Mouse Reveals Recent Inbreeding in a Historically Large Population.

Author

Wilder, Aryn P, Dudchenko, Olga, Curry, Caitlin, Korody, Marisa, Turbek, Sheela P, Daly, Mark, Misuraca, Ann, Wang, Gaojianyong, Khan, Ruqayya, Weisz, David, Fronczek, Julie, Aiden, Erez Lieberman, Houck, Marlys L, Shier, Debra M, Ryder, Oliver A, and Steiner, Cynthia C

Subjects
GENETIC load, MITOCHONDRIAL DNA, INBREEDING, GENOMES, GENETIC variation, BIODIVERSITY conservation
Abstract

High-quality reference genomes are fundamental tools for understanding population history, and can provide estimates of genetic and demographic parameters relevant to the conservation of biodiversity. The federally endangered Pacific pocket mouse (PPM), which persists in three small, isolated populations in southern California, is a promising model for studying how demographic history shapes genetic diversity, and how diversity in turn may influence extinction risk. To facilitate these studies in PPM, we combined PacBio HiFi long reads with Omni-C and Hi-C data to generate a de novo genome assembly, and annotated the genome using RNAseq. The assembly comprised 28 chromosome-length scaffolds (N50 = 72.6 MB) and the complete mitochondrial genome, and included a long heterochromatic region on chromosome 18 not represented in the previously available short-read assembly. Heterozygosity was highly variable across the genome of the reference individual, with 18% of windows falling in runs of homozygosity (ROH) >1 MB, and nearly 9% in tracts spanning >5 MB. Yet outside of ROH, heterozygosity was relatively high (0.0027), and historical Ne estimates were large. These patterns of genetic variation suggest recent inbreeding in a formerly large population. Currently the most contiguous assembly for a heteromyid rodent, this reference genome provides insight into the past and recent demographic history of the population, and will be a critical tool for management and future studies of outbreeding depression, inbreeding depression, and genetic load. [ABSTRACT FROM AUTHOR]

Published
2022
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