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162 results on '"Wang, Fangying"'

10. Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

Author

Nasu, Yusuke, Aggarwal, Abhi, Le, Giang N. T., Vo, Camilla Trang, Kambe, Yuki, Wang, Xinxing, Beinlich, Felix R. M., Lee, Ashley Bomin, Ram, Tina R., Wang, Fangying, Gorzo, Kelsea A., Kamijo, Yuki, Boisvert, Marc, Nishinami, Suguru, Kawamura, Genki, Ozawa, Takeaki, Toda, Hirofumi, Gordon, Grant R., Ge, Shaoyu, Hirase, Hajime, Nedergaard, Maiken, Paquet, Marie-Eve, Drobizhev, Mikhail, Podgorski, Kaspar, and Campbell, Robert E.

Published
2023
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42. Flexural and cracking behavior of corroded RC continuous beams strengthened with energized C‐FRCM system.

Author

Feng, Ran, Tang, Jing‐Pu, Liu, Panpan, Wang, Fangying, Zeng, Jun‐Jie, and Zhu, Ji‐Hua

Subjects
CONCRETE beams, REINFORCED concrete corrosion, CARBON fiber-reinforced plastics, DIGITAL image correlation, DIGITAL images, CARBON nanofibers, FAILURE mode & effects analysis
Abstract

This paper presents an experimental investigation into the flexural and cracking behavior of corroded reinforced concrete continuous beams with 11‐month wet–dry cycles strengthened by anodic polarized carbon‐fabric‐reinforced cementitious matrix (C‐FRCM) plates. The failure modes and flexural bearing capacities were discussed. The influences of the layer of carbon fabric mesh and complete carbon fiber‐reinforced polymer (CFRP) wrapping as end anchorage on the strengthening effectiveness were explored. The complete crack development patterns were captured by a digital image correlation system, and the results showed that the C‐FRCM system can provide satisfactory crack width control, as proved by the reduced crack spacing and the maximum crack width. The flexural capacities of the strengthened beams were effectively enhanced and the debonding failure can be eliminated through complete CFRP wrappings. Moreover, the design recommendations were proposed based on the estimation of the crack development as per related design guidelines. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Age‐related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis.

Author

Cheng, Qi, Chen, Mo, Liu, Mengdan, Wang, Fangying, Chen, Xin, Sun, Wenjia, Du, Yan, and Wu, Huaxiang

Abstract

Background: There are large differences in clinical manifestations and biological markers between elderly patients with rheumatoid arthritis (EPRA, age >60) and younger patients with RA (YPRA, age ≤60), partly owing to variations in the immune system of different age groups. Here, we focused on the changes of immune cell infiltration in YPRA and EPRA. Methods: The R packages "ssGSEA" and "GSEA" were used to identify the changes in immune cell infiltration and immune‐related pathways between the two groups. The R packages "WGCNA" and "DEseq2" were used to screen and verify age‐related differentially expressed genes (DEGs). Hub genes were identified using Cytoscape and cytoHubba. Spearman correlation coefficient was conducted to evaluate correlations between hub age‐related genes and immune cells. Results: Compared with 54 established YPRA, several immune cells and immune‐related pathways were markedly decreased in 29 EPRA synovial tissues. Moreover, 78 age‐related DEGs related to amino acid and glycosphingolipid synthesis and metabolism were identified. USP2 and ARG2 were verified to be upregulated in EPRA, signifying that these two genes could effectively distinguish YPRA and EPRA and have potential as biomarkers. In addition, we found that USP2 was significantly negatively correlated with B cells and monocytes, while there was a significant negative association between ARG2 and T cells. Conclusions: In conclusion, this study is the first to systematically analyze changes in immune cell infiltration between YPRA and EPRA patients and obtain hub age‐related genes, which may provide the basis for illuminating the pathogenesis of EPRA and informing treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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