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14 results on '"Wang, Eun Kyung"'

10. Serum glucose excretion after Roux-en-Y gastric bypass: a potential target for diabetes treatment

Author

Kwon, In Gyu, primary, Kang, Chan Woo, additional, Park, Jong-Pil, additional, Oh, Ju Hun, additional, Wang, Eun Kyung, additional, Kim, Tae Young, additional, Sung, Jin Sol, additional, Park, Namhee, additional, Lee, Yang Jong, additional, Sung, Hak-Joon, additional, Lee, Eun Jig, additional, Hyung, Woo Jin, additional, Shin, Su-Jin, additional, Noh, Sung Hoon, additional, Yun, Mijin, additional, Kang, Won Jun, additional, Cho, Arthur, additional, and Ku, Cheol Ryong, additional

Published
2020
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11. Serum glucose excretion after Roux-en-Y gastric bypass: a potential target for diabetes treatment

Author

Kwon, In Gyu, Kang, Chan Woo, Park, Jong-Pil, Oh, Ju Hun, Wang, Eun Kyung, Kim, Tae Young, Sung, Jin Sol, Park, Namhee, Lee, Yang Jong, Sung, Hak-Joon, Lee, Eun Jig, Hyung, Woo Jin, Shin, Su-Jin, Noh, Sung Hoon, Yun, Mijin, Kang, Won Jun, Cho, Arthur, and Ku, Cheol Ryong

Abstract

ObjectiveThe mechanisms underlying type 2 diabetes resolution after Roux-en-Y gastric bypass (RYGB) are unclear. We suspected that glucose excretion may occur in the small bowel based on observations in humans. The aim of this study was to evaluate the mechanisms underlying serum glucose excretion in the small intestine and its contribution to glucose homeostasis after bariatric surgery.Design2-Deoxy-2-[18F]-fluoro-D-glucose (FDG) was measured in RYGB-operated or sham-operated obese diabetic rats. Altered glucose metabolism was targeted and RNA sequencing was performed in areas of high or low FDG uptake in the ileum or common limb. Intestinal glucose metabolism and excretion were confirmed using 14C-glucose and FDG. Increased glucose metabolism was evaluated in IEC-18 cells and mouse intestinal organoids. Obese or ob/obmice were treated with amphiregulin (AREG) to correlate intestinal glycolysis changes with changes in serum glucose homeostasis.ResultsThe AREG/EGFR/mTOR/AKT/GLUT1 signal transduction pathway was activated in areas of increased glycolysis and intestinal glucose excretion in RYGB-operated rats. Intraluminal GLUT1 inhibitor administration offset improved glucose homeostasis in RYGB-operated rats. AREG-induced signal transduction pathway was confirmed using IEC-18 cells and mouse organoids, resulting in a greater capacity for glucose uptake via GLUT1 overexpression and sequestration in apical and basolateral membranes. Systemic and local AREG administration increased GLUT1 expression and small intestinal membrane translocation and prevented hyperglycaemic exacerbation.ConclusionBariatric surgery or AREG administration induces apical and basolateral membrane GLUT1 expression in the small intestinal enterocytes, resulting in increased serum glucose excretion in the gut lumen. Our findings suggest a novel, potentially targetable glucose homeostatic mechanism in the small intestine.

Published
2021
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12. Abstract 2067: Hyperpolarized 13C-pyruvate MRS quantitatively monitor the therapeutic efficacy of adjuvant metformin combined RT in brain metastasis from triple negative breast cancer

Author

Choi, Young-suk, primary, Lee, Han-Sol, additional, Lee, Jung-Sung, additional, Park, Hyun-Jin, additional, Lee, Ju-Hyun, additional, Wang, Eun-Kyung, additional, Yang, Seung-Wook, additional, Joe, Eunhae, additional, Lee, Soo Hyeon, additional, Kim, Dong-Hyun, additional, and Song, Ho-Taek, additional

Published
2014
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13. pH-Responsive Assembly of Gold Nanoparticles and “Spatiotemporally Concerted” Drug Release for Synergistic Cancer Therapy

Author

Nam, Jutaek, primary, La, Wan-Geun, additional, Hwang, Sekyu, additional, Ha, Yeong Su, additional, Park, Nokyoung, additional, Won, Nayoun, additional, Jung, Sungwook, additional, Bhang, Suk Ho, additional, Ma, Yoon-Ji, additional, Cho, Yong-Min, additional, Jin, Min, additional, Han, Jin, additional, Shin, Jung-Youn, additional, Wang, Eun Kyung, additional, Kim, Sang Geol, additional, Cho, So-Hye, additional, Yoo, Jeongsoo, additional, Kim, Byung-Soo, additional, and Kim, Sungjee, additional

Published
2013
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14. Facile Preparation of a Hybrid Nanoprobe for Triple‐Modality Optical/PET/MR Imaging

Author

Park, Jeong Chan, primary, Yu, Mi Kyung, additional, An, Gwang Il, additional, Park, Se‐Il, additional, Oh, Jungmin, additional, Kim, Hong Joo, additional, Kim, Joo‐Hyun, additional, Wang, Eun Kyung, additional, Hong, Il‐Hwa, additional, Ha, Yeong Su, additional, Choi, Tae Hyun, additional, Jeong, Kyu‐Shik, additional, Chang, Yongmin, additional, Welch, Michael J., additional, Jon, Sangyong, additional, and Yoo, Jeongsoo, additional

Published
2010
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