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Little is known about the association between whole-blood nicotinamide adenine dinucleotide (NAD+) levels and nabothian cysts. This study aimed to assess the association between NAD+ levels and nabothian cysts in healthy Chinese women. Multivariate logistic regression analysis was performed to analyze the association between NAD+ levels and nabothian cysts. The mean age was 43.0 ± 11.5 years, and the mean level of NAD+ was 31.3 ± 5.3 μmol/L. Nabothian cysts occurred in 184 (27.7%) participants, with single and multiple cysts in 100 (15.0%) and 84 (12.6%) participants, respectively. The total nabothian cyst prevalence gradually decreased from 37.4% to 21.6% from Q1 to Q4 of NAD+ and the prevalence of single and multiple nabothian cysts also decreased across the NAD+ quartiles. As compared with the highest NAD+ quartile (≥ 34.4 μmol/L), the adjusted odds ratios with 95% confidence interval of the NAD+ Q1 was 1.89 (1.14–3.14) for total nabothian cysts. The risk of total and single nabothian cysts linearly decreased with increasing NAD+ levels, while the risk of multiple nabothian cysts decreased more rapidly at NAD+ levels of 28.0 to 35.0 μmol/L. Low NAD+ levels were associated with an increased risk of total and multiple nabothian cysts. [ABSTRACT FROM AUTHOR]

As a leading cause of death, second only to heart disease, cancer has always been one of the burning topics in medical research. When targeting multiple signal pathways in tumorigenesis chemoprevention, using natural or synthetic anti-cancer drugs is a vital strategy to reduce cancer damage. However, toxic effects, multidrug resistance (MDR) as well as cancer stem cells (CSCs) all prominently limited the clinical application of conventional anticancer drugs. With low side effects, strong biological activity, unique mechanism, and wide range of targets, natural products derived from plants are considered significant sources for new drug development. Nobiletin is one of the most attractive compounds, a unique flavonoid primarily isolated from the peel of citrus fruits. Numerous studies in vitro and in vivo have suggested that nobiletin and its derivatives possess the eminent potential to become effective cancer chemoprevention agents through various cellular and molecular levels. This article aims to comprehensively review the anticancer efficacy and specific mechanisms of nobiletin, enhancing our understanding of its chemoprevention properties and providing the latest research findings. At the end of this review, we also give some discussion and future perspectives regarding the challenges and opportunities in nobiletin efficient exploitation. [ABSTRACT FROM AUTHOR]

Objective: Little is known about the association between whole-blood nicotinamide adenine dinucleotide (NAD + ) levels and nabothian cysts. This study aimed to assess the association between NAD + levels and nabothian cysts in healthy Chinese women., Methods: Multivariate logistic regression analysis was performed to analyze the association between NAD + levels and nabothian cysts., Results: The mean age was 43.0 ± 11.5 years, and the mean level of NAD + was 31.3 ± 5.3 μmol/L. Nabothian cysts occurred in 184 (27.7%) participants, with single and multiple cysts in 100 (15.0%) and 84 (12.6%) participants, respectively. The total nabothian cyst prevalence gradually decreased from 37.4% to 21.6% from Q1 to Q4 of NAD + and the prevalence of single and multiple nabothian cysts also decreased across the NAD + quartiles. As compared with the highest NAD + quartile (≥ 34.4 μmol/L), the adjusted odds ratios with 95% confidence interval of the NAD + Q1 was 1.89 (1.14-3.14) for total nabothian cysts. The risk of total and single nabothian cysts linearly decreased with increasing NAD + levels, while the risk of multiple nabothian cysts decreased more rapidly at NAD + levels of 28.0 to 35.0 μmol/L., Conclusion: Low NAD + levels were associated with an increased risk of total and multiple nabothian cysts., (Copyright © 2024 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)