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Neural progenitor cells within the cerebral cortex undergo a characteristic switch between symmetric self-renewing cell divisions early in development and asymmetric neurogenic divisions later. Yet, the mechanisms controlling this transition remain unclear. Previous work has shown that early but not late neural progenitor cells (NPCs) endogenously express the autism-linked transcription factor Foxp1, and both loss and gain of Foxp1 function can alter NPC activity and fate choices. Here, we show that premature loss of Foxp1 upregulates transcriptional programs regulating angiogenesis, glycolysis, and cellular responses to hypoxia. These changes coincide with a premature destabilization of HIF-1α, an elevation in HIF-1α target genes, including Vegfa in NPCs, and precocious vascular network development. In vitro experiments demonstrate that stabilization of HIF-1α in Foxp1-deficient NPCs rescues the premature differentiation phenotype and restores NPC maintenance. Our data indicate that the endogenous decline in Foxp1 expression activates the HIF-1α transcriptional program leading to changes in the tissue environment adjacent to NPCs, which, in turn, might alter their self-renewal and neurogenic capacities.

Moral education is a core component of ideological and political courses in primary and secondary schools and universities in China, and also an important part of contemporary Chinese Marxist educational theory and practice. In Chinese senior high schools, the main curriculum and platform for moral education is ideological and political courses. The "Ideological and Political Curriculum Standards for General Senior High Schools (2017 Edition, 2020 Revised)" issued by the Ministry of Education of the People's Republic of China explicitly includes a course on logical thinking in the ideological and political curriculum in general senior high schools, strengthening the importance of logic in moral education there. In this paper, the authors explain the necessity of intensifying logic training for contemporary Chinese teenagers, introduce and interpret the relevant contents in the "Ideological and Political Curriculum Standards for General Senior High Schools (2017 Edition, 2020 Revised)," and put forward some theoretical suggestions on how to conduct teaching on the subject of logic.

The study of dialectical logic has a history of nearly one hundred years in China. It is significant for understanding both the growth of Chinese logic and the Sinicization of Marxism to review dialectical logic in the context of introducing the study of Marxism in China. Debates about dialectical logic in Chinese academic circles involve not only the problems of logic itself, but more importantly the understanding of Marxist philosophy. In the 1920s and 1930s, some Marxist researchers in China were influenced by the philosophers and logicians of the former Soviet Union, and they came very close to equating dialectical logic with Marxist dialectics. They also identified the formal logic originating from ancient Greece as metaphysics, praising the former and criticizing the latter. In the upsurge of Marxist philosophy in the 1950s and 1960s, Chinese logicians carried out normal and formal academic research on dialectical logic. During the period from the end of 1970s to the end of 1990s, the research and teaching of dialectical logic in China reached its heyday, and logicians performed comprehensive and detailed research on some critical issues, including the basic laws of dialectical logic, which they tried to formalize. Since the beginning of the 21st century, dialectical logic has ceased to prosper and has faded from the core field of the discipline of logic, although some honorable scholars still persist in studying it.

In recent years, with the development of solar seawater desalination technology, many solar evaporators are affected by precipitated salts during the evaporation process, which can reduce efficiency. In this work, flexible fabrics made of polypyrrole (PPy)/MXene are obtained by impregnating the prepared PPy ink onto waffle like fabrics. The combination of PPy and fabric greatly improves the water absorption and evaporation performance of the fabric. The average evaporation rate of this structure is 1.43 kg m−2 h−1, and the average evaporation efficiency under a single light source is 85.13%. After a 15‐h testing cycle and a total of 8 cycles, lasting nearly 120 h, the performance of the device remained stable. The structural characteristics of waffle fabric, based on the Marangoni thermal effect, make it possible to suppress salt precipitation during evaporation, avoiding large salt particles covering the evaporation surface and reducing efficiency. This experiment successfully demonstrated long‐term stable water evaporation, providing new ideas for the development of fabric evaporators. [ABSTRACT FROM AUTHOR]

A 7‐month‐old boy presented to our clinic with developmental delay, Magnetic Resonance Imaging (MRI) features of delayed myelination and diffusion restriction, and a homozygous variant of uncertain significance (c.4T>G, p.Phe2Val) in HIKESHI, a gene associated with autosomal‐recessive hypomyelinating leukodystrophy 13. We hypothesized that the variant is disease‐causing and aimed to rescue the cellular phenotype with vector‐mediated gene replacement. HIKESHI mediates heat‐induced nuclear accumulation of heat‐shock proteins, including HSP70, to protect cells from stress. We generated skin fibroblasts from the proband and proband's mother (heterozygous) to compare protein expression and subcellular localization of HSP70 under heat stress conditions, and the effect of vector‐mediated overexpression of HIKESHI in the proband's cells under the same heat stress conditions. Western blot analysis revealed absent HIKESHI protein from proband fibroblasts, contrasted with ample expression in parental cells. Under heat stress conditions, while the mother's cells displayed appropriate nuclear localization of HSP70, the proband's cells displayed impaired nuclear translocalization. When patient fibroblasts were provided exogenous HIKESHI, the transfected proband's cells showed restored heat‐induced nuclear translocalization of HSP70 under conditions of heat stress. These functional data establish that the patient's variant is a pathogenic loss‐of‐function mutation, thus confirming a diagnosis of hypomyelinating leukodystrophy 13 and that vector‐mediated gene replacement may be an effective treatment approach for patients with this disorder. [ABSTRACT FROM AUTHOR]