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This work proposes an intelligent grey-wolf-optimizer-improved Apriori algorithm (GWO-Apriori) to mine the association rules of hidden dangers in hydrogen pipeline transmission stations. The optimal minimum support and minimum confidence are determined by GWO instead of the time-consuming trial approach. Experiments show that the average support and average confidence of association rules using GWO-Apriori increase by 29.8% and 21.3%, respectively, when compared with traditional Apriori. Overall, 59 ineffective association rules out of the total 105 rules are filtered by GWO, which dramatically improves data mining effectiveness. Moreover, 23 illogical association rules are excluded, and 12 new strong association rules ignored by the traditional Apriori are successfully mined. Compared with the inefficient and labor-intensive manual investigation, the intelligent GWO-Apriori algorithm dramatically improves pertinency and efficiency of hidden danger identification in hydrogen pipeline transmission stations. [ABSTRACT FROM AUTHOR]

A series of polyethylene glycol (PEG)/epoxy (EP) resin composites with various mass loadings of PEG (50%-80%), in which PEG acted as phase change materials (PCMs) and EP served as the supporting matrix to afford structural strength and avoided the leakage of melt PEG, was made via casting mold technique. The effect of PEG mass content on the form-stability, thermal property, morphology, and mechanical property of the composite phase change materials (CPCMs) were characterized by Fourier transformation infrared spectroscope (FTIR), differential scanning calorimeter (DSC), thermogravimetric analyzer (TGA), and atomic force microscopy (AFM), respectively. The results displayed that the EP was compatible well with the PEG, and the CPCMs showed excellent form-stability, good thermal reliability and stability even with 80 wt% PEG loading and under high temperature. In addition, the average adhesion force of the PEG/EP CPCMs increased as the PEG mass loading increased. In summary, the as-prepared form-stable PEG/EP CPCMs had promising potential for practical latent heat thermal energy storage (LHTES) applications. KEYWORDS adhesion force, epoxy resin, form-stable, phase change material, polyethylene glycol, 1 | INTRODUCTION Due to the increasing energy crisis, environmental pollution, and global warming, exploring and developing renewable and cleanable energy such as thermal energy have attracted extensive attention. As [...]

The mechanism by which inflammasome activation is modulated remains unclear. In this study, we identified an AIM2-interacting protein, the E3 ubiquitin ligase HUWE1, which was also found to interact with NLRP3 and NLRC4 through the HIN domain of AIM2 and the NACHT domains of NLRP3 and NLRC4. The BH3 domain of HUWE1 was important for its interaction with NLRP3, AIM2, and NLRC4. Caspase-1 maturation, IL-1[beta] release, and pyroptosis were reduced in Huwe1-deficient bone marrow-derived macrophages (BMDMs) compared with WT BMDMs in response to stimuli to induce NLRP3, NLRC4, and AIM2 inflammasome activation. Furthermore, the activation of NLRP3, NLRC4, and AIM2 inflammasomes in both mouse and human cells was remarkably reduced by treatment with the HUWE1 inhibitor BI8622. HUWE1 mediated the K27-linked polyubiquitination of AIM2, NLRP3, and NLRC4, which led to inflammasome assembly, ASC speck formation, and sustained caspase-1 activation. Huwe1-deficient mice had an increased bacterial burden and decreased caspase-1 activation and IL-1[beta] production upon Salmonella, Francisella, or Acinetobacter baumannii infection. Our study provides insights into the mechanisms of inflammasome activation as well as a potential therapeutic target against bacterial infection., Introduction Inflammasomes are multiprotein complexes activated by infection and sterile stress that contribute to the initiation of pyroptotic cell death and release of the proinflammatory cytokines IL-1[beta] and IL-18 (1, [...]

The development of thermal energy storage materials applied in various fields has been attracting considerable attention in recent years. In this paper, a series of 1,6-hexanediol (HDL)/silicon dioxide (SiO2) form-stable composite phase change materials (fs-CPCMs) with various mass percentage of HDL loadings were made through sol–gel technique. For HDL/SiO2 fs-CPCMs, HDL was served as PCM, and silica gel was acted as the supporting matrix to keep a stable state without leakage of the composites even the temperature was over 85 °C. The results from form-stability test and DSC measurements showed that the as-prepared fs-CPCM with the mass fraction of HDL at 70 wt% presented good form-stability, suitable melting point (43.5 °C), and reasonable fusion enthalpy of 130.9 J/g. Fourier transform infrared (FT-IR) spectroscopy indicated that only physical adsorption existed between the HDL and silica gel. Moreover, the thermal performance tests showed that the thermal energy storage and release rates of the as-prepared HDL/SiO2 fs-CPCM was enhanced compared to pure HDL. In summary, the as-prepared fs-CPCMs exhibit reasonable latent heats, good thermal stabilities, and reliability, which are promising candidates for energy-saving construction materials. [ABSTRACT FROM AUTHOR]