Search

Your search keyword '"Wang, B. D."' showing total 33 results
Start Over Author "Wang, B. D."
33 results on '"Wang, B. D."'

1. Flux Variations of Cosmic Ray Air Showers Detected by LHAASO-KM2A During a Thunderstorm on 10 June 2021

Author

LHAASO Collaboration, Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Zhe, Cao, Zhen, Chang, J., Chang, J. F., Chen, E. S., Chen, Liang, Chen, Long, Chen, M. J., Chen, M. L., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. J., Chen, Y., Cheng, H. L., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Duan, K. K., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Gu, F. L., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, W. H., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Li, B. B., Li, Cheng, Li, Cong, Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Long, W. J., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Min, Z., Mitthumsiri, W., Nan, Y. C., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. Y., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R., Wang, R. N., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z. H. Wang. Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., W, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yan, J. Z., Yang, C. W., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, Lu, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Y. L., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The Large High Altitude Air Shower Observatory (LHAASO) has three sub-arrays, KM2A, WCDA and WFCTA. The flux variations of cosmic ray air showers were studied by analyzing the KM2A data during the thunderstorm on 10 June 2021. The number of shower events that meet the trigger conditions increases significantly in atmospheric electric fields, with maximum fractional increase of 20%. The variations of trigger rates (increases or decreases) are found to be strongly dependent on the primary zenith angle. The flux of secondary particles increases significantly, following a similar trend with that of the shower events. To better understand the observed behavior, Monte Carlo simulations are performed with CORSIKA and G4KM2A (a code based on GEANT4). We find that the experimental data (in saturated negative fields) are in good agreement with simulations, assuming the presence of a uniform upward electric field of 700 V/cm with a thickness of 1500 m in the atmosphere above the observation level. Due to the acceleration/deceleration and deflection by the atmospheric electric field, the number of secondary particles with energy above the detector threshold is modified, resulting in the changes in shower detection rate., Comment: 18 pages, 11 figures

Published
2022
Full Text
View/download PDF

2. Peta-electron volt gamma-ray emission from the Crab Nebula

Author

The LHAASO Collaboration, Cao, Zhen, Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Zhe, Chang, J., Chang, J. F., Chen, B. M., Chen, E. S., Chen, J., Chen, Liang, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Piazzoli, B. D'Ettorre, Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Dong, X. J., Duan, K. K., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, X. Y., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Ke, T., Kuleshov, D., Levochkin, K., Li, B. B., Li, Cheng, Li, Cong, Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, Jie, Li, Jian, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Y., Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Min, Z., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. Y., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, Wei, Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yan, J. Z., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L. X., Zhang, Li, Zhang, Lu, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Y. L., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Crab pulsar and the surrounding nebula powered by the pulsar's rotational energy through the formation and termination of a relativistic electron-positron wind is a bright source of gamma-rays carrying crucial information about this complex conglomerate. We report the detection of $\gamma$-rays with a spectrum showing gradual steepening over three energy decades, from $5\times 10^{-4}$ to $1.1$ petaelectronvolt (PeV). The ultra-high-energy photons exhibit the presence of a PeV electron accelerator (a pevatron) with an acceleration rate exceeding 15% of the absolute theoretical limit. Assuming that unpulsed $\gamma$-rays are produced at the termination of the pulsar's wind, we constrain the pevatron's size, between $0.025$ and $0.1$ pc, and the magnetic field $\approx 110 \mu$G. The production rate of PeV electrons, $2.5 \times 10^{36}$ erg $\rm s^{-1}$, constitutes 0.5% of the pulsar's spin-down luminosity, although we do not exclude a non-negligible contribution of PeV protons to the production of the highest energy $\gamma$-rays., Comment: 43 pages, 13 figures, 2 tables; Published in Science

Published
2021
Full Text
View/download PDF

3. Calibration of the Air Shower Energy Scale of the Water and Air Cherenkov Techniques in the LHAASO experiment

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Z. Cao Z., Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Piazzoli, B. DEttorre, Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, C., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, X. R., Li, Y., Li, Y. Z., Li, Z., Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Saiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z., Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y., Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Wide Field-of-View Cherenkov Telescope Array (WFCTA) and the Water Cherenkov Detector Arrays (WCDA) of LHAASO are designed to work in combination for measuring the energy spectra of various cosmic ray species over a very wide energy range from a few TeV to 10 PeV. The energy calibration of WCDA can be achieved with a proven technique of measuring the westward shift of the Moon shadow of galactic cosmic rays due to the geomagnetic field. This deflection angle $\Delta$ is inversely proportional to the energy of the cosmic rays. The precise measurements of the shifts by WCDA allows us to calibrate its energy scale for energies as high as 35 TeV. The energy scale measured by WCDA can be used to cross calibrate the energy reconstructed by WFCTA, which spans the whole energy range up to 10 PeV. In this work, we will demonstrate the feasibility of the method using the data collected from April 2019 to January 2020 by the WFCTA array and WCDA-1 detector, the first of the three water Cherenkov ponds, already commissioned at LHAASO site.

Published
2021
Full Text
View/download PDF

4. Construction and On-site Performance of the LHAASO WFCTA Camera

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Z., Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Piazzoli, B. D'Ettorre, Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, C., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, X. R., Li, Y., Li, Y. Z., Li, Z., Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z., Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y., Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The focal plane camera is the core component of the Wide Field-of-view Cherenkov/fluorescence Telescope Array (WFCTA) of the Large High-Altitude Air Shower Observatory (LHAASO). Because of the capability of working under moonlight without aging, silicon photomultipliers (SiPM) have been proven to be not only an alternative but also an improvement to conventional photomultiplier tubes (PMT) in this application. Eighteen SiPM-based cameras with square light funnels have been built for WFCTA. The telescopes have collected more than 100 million cosmic ray events and preliminary results indicate that these cameras are capable of working under moonlight. The characteristics of the light funnels and SiPMs pose challenges (e.g. dynamic range, dark count rate, assembly techniques). In this paper, we present the design features, manufacturing techniques and performances of these cameras. Finally, the test facilities, the test methods and results of SiPMs in the cameras are reported here., Comment: 45 pages, 21 figures, article

Published
2020
Full Text
View/download PDF

5. The observation of the Crab Nebula with LHAASO-KM2A for the performance study

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Z., Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Piazzoli, B. D'Ettorre, Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, C., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, X. R., Li, Y., Li, Y. Z., Li, Z., Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z., Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y., Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

As a sub-array of the Large High Altitude Air Shower Observatory (LHAASO), KM2A is mainly designed to cover a large fraction of the northern sky to hunt for gamma-ray sources at energies above 10 TeV. Even though the detector construction is still underway, a half of the KM2A array has been operating stably since the end of 2019. In this paper, we present the pipeline of KM2A data analysis and the first observation on the Crab Nebula, a standard candle in very high energy gamma-ray astronomy. We detect gamma-ray signals from the Crab Nebula in both energy ranges of 10$-$100 TeV and $>$100 TeV with high significance, by analyzing the KM2A data of 136 live days between December 2019 and May 2020. With the observations, we test the detector performance including angular resolution, pointing accuracy and cosmic ray background rejection power. The energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE =(1.13$\pm$0.05$_{stat}$$\pm$0.08$_{sys}$)$\times$10$^{-14}$$\cdot$(E/20TeV)$^{-3.09\pm0.06_{stat}\pm0.02_{sys}}$ cm$^{-2}$ s$^{-1}$ TeV$^{-1}$. It is consistent with previous measurements by other experiments. This opens a new window of gamma-ray astronomy above 0.1 PeV through which ultrahigh-energy gamma-ray new phenomena, such as cosmic PeVatrons, might be discovered., Comment: 13 pages, 15 figures,submitted to CPC

Published
2020
Full Text
View/download PDF

6. Reconstruction of Cherenkov image by multiple telescopes of LHAASO-WFCTA

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, J. T., Cao, Zhe, Cao, Zhen, Chang, J., Chang, J. F., Chen, E. S., Chen, Liang, Chen, Liang, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, Y., Cheng, H. L., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., D’Ettorre Piazzoli, B., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., Duan, K. K., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, X. T., Feng, Y. L., Gao, B., Gao, C. D., Gao, L. Q., Gao, Q., Gao, W., Gao, W. K., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, F. L., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, Q., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, W. H., Huang, X. T., Huang, X. Y., Huang, Y., Huang, Z. C., Ji, X. L., Jia, H. Y., Jia, K., Jiang, K., Jiang, Z. J., Jin, M., Kang, M. M., Ke, T., Kuleshov, D., Levochkin, K., Li, B. B., Li, Cheng, Li, Cong, Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, Jian, Li, Jie, Li, K., Li, W. L., Li, X. R., Li, Xin, Li, Xin, Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y., Liu, Y. N., Long, W. J., Lu, R., Luo, Q., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Min, Z., Mitthumsiri, W., Nan, Y. C., Ou, Z. W., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Qi, Y. Q., Qiao, B. Q., Qin, J. J., Ruffolo, D., Sáiz, A., Shao, C. Y., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. Y., Song, H. C., Stenkin, Yu. V., Stepanov, V., Su, Y., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R., Wang, R. N., Wang, W., Wang, X. G., Wang, X. Y., Wang, Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z. H., Wang, Z. X., Wang, Zhen, Wang, Zheng, Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, X. F., Wu, Y. S., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, D. X., Xiao, G., Xin, G. G., Xin, Y. L., Xing, Y., Xiong, Z., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yan, J. Z., Yang, C. W., Yang, F. F., Yang, H. W., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Yue, H., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, F., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, L. X., Zhang, Li, Zhang, Lu, Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. B., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y. F., Zhang, Y. L., Zhang, Yi, Zhang, Yong, Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Published
2022
Full Text
View/download PDF

7. Line-of-shower trigger method to lower energy threshold for GRB detection using LHAASO-WCDA

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Z., Cao, Z., Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, L., Chen, L., Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Volpe, D. della, Piazzoli, B. D’Ettorre, Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, C., Li, C., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, X., Li, X. R., Li, Y., Li, Y. Z., Li, Z., Li, Z., Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z., Wang, Z., Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, L., Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y., Zhang, Y., Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Published
2021
Full Text
View/download PDF

8. A dynamic range extension system for LHAASO WCDA-1

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Z., Cao, Z., Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, L., Chen, L., Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Volpe, D. della, Piazzoli, B. D’Ettorre, Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Y., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, C., Li, C., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, X., Li, X. R., Li, Y., Li, Y. Z., Li, Z., Li, Z., Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z., Wang, Z., Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, L., Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Y., Zhang, Y., Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Published
2021
Full Text
View/download PDF

9. Ultrahigh-energy photons up to 1.4 petaelectronvolts from 12 γ-ray Galactic sources

Author

Cao, Zhen, Aharonian, F. A., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Zhe, Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, Liang, Chen, Long, Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, della Volpe, D., D′Ettorre Piazzoli, B., Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, Cong, Li, Cheng, Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, Xin, Li, X. R., Li, Y., Li, Y. Z., Li, Zhe, Li, Zhuo, Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Zheng, Wang, Zhen, Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, Li, Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S. S., Zhang, X., Zhang, X. P., Zhang, Yong, Zhang, Yi, Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Published
2021
Full Text
View/download PDF

10. Construction and on-site performance of the LHAASO WFCTA camera

Author

Aharonian, F., An, Q., Axikegu, Bai, L. X., Bai, Y. X., Bao, Y. W., Bastieri, D., Bi, X. J., Bi, Y. J., Cai, H., Cai, J. T., Cao, Z., Cao, Z., Chang, J., Chang, J. F., Chang, X. C., Chen, B. M., Chen, J., Chen, L., Chen, L., Chen, L., Chen, M. J., Chen, M. L., Chen, Q. H., Chen, S. H., Chen, S. Z., Chen, T. L., Chen, X. L., Chen, Y., Cheng, N., Cheng, Y. D., Cui, S. W., Cui, X. H., Cui, Y. D., Dai, B. Z., Dai, H. L., Dai, Z. G., Danzengluobu, Volpe, D. della, Piazzoli, B. D’Ettorre, Dong, X. J., Fan, J. H., Fan, Y. Z., Fan, Z. X., Fang, J., Fang, K., Feng, C. F., Feng, L., Feng, S. H., Feng, Y. L., Gao, B., Gao, C. D., Gao, Q., Gao, W., Ge, M. M., Geng, L. S., Gong, G. H., Gou, Q. B., Gu, M. H., Guo, J. G., Guo, X. L., Guo, Y. Q., Guo, Y. Y., Han, Y. A., He, H. H., He, H. N., He, J. C., He, S. L., He, X. B., He, Y., Heller, M., Hor, Y. K., Hou, C., Hou, X., Hu, H. B., Hu, S., Hu, S. C., Hu, X. J., Huang, D. H., Huang, Q. L., Huang, W. H., Huang, X. T., Huang, Z. C., Ji, F., Ji, X. L., Jia, H. Y., Jiang, K., Jiang, Z. J., Jin, C., Kuleshov, D., Levochkin, K., Li, B. B., Li, C., Li, C., Li, F., Li, H. B., Li, H. C., Li, H. Y., Li, J., Li, K., Li, W. L., Li, X., Li, X., Li, X. R., Li, Y., Li, Y. Z., Li, Z., Li, Z., Liang, E. W., Liang, Y. F., Lin, S. J., Liu, B., Liu, C., Liu, D., Liu, H., Liu, H. D., Liu, J., Liu, J. L., Liu, J. S., Liu, J. Y., Liu, M. Y., Liu, R. Y., Liu, S. M., Liu, W., Liu, Y. N., Liu, Z. X., Long, W. J., Lu, R., Lv, H. K., Ma, B. Q., Ma, L. L., Ma, X. H., Mao, J. R., Masood, A., Mitthumsiri, W., Montaruli, T., Nan, Y. C., Pang, B. Y., Pattarakijwanich, P., Pei, Z. Y., Qi, M. Y., Ruffolo, D., Rulev, V., Sáiz, A., Shao, L., Shchegolev, O., Sheng, X. D., Shi, J. R., Song, H. C., Stenkin, Yu. V., Stepanov, V., Sun, Q. N., Sun, X. N., Sun, Z. B., Tam, P. H. T., Tang, Z. B., Tian, W. W., Wang, B. D., Wang, C., Wang, H., Wang, H. G., Wang, J. C., Wang, J. S., Wang, L. P., Wang, L. Y., Wang, R. N., Wang, W., Wang, W., Wang, X. G., Wang, X. J., Wang, X. Y., Wang, Y. D., Wang, Y. J., Wang, Y. P., Wang, Z., Wang, Z., Wang, Z. H., Wang, Z. X., Wei, D. M., Wei, J. J., Wei, Y. J., Wen, T., Wu, C. Y., Wu, H. R., Wu, S., Wu, W. X., Wu, X. F., Xi, S. Q., Xia, J., Xia, J. J., Xiang, G. M., Xiao, G., Xiao, H. B., Xin, G. G., Xin, Y. L., Xing, Y., Xu, D. L., Xu, R. X., Xue, L., Yan, D. H., Yang, C. W., Yang, F. F., Yang, J. Y., Yang, L. L., Yang, M. J., Yang, R. Z., Yang, S. B., Yao, Y. H., Yao, Z. G., Ye, Y. M., Yin, L. Q., Yin, N., You, X. H., You, Z. Y., Yu, Y. H., Yuan, Q., Zeng, H. D., Zeng, T. X., Zeng, W., Zeng, Z. K., Zha, M., Zhai, X. X., Zhang, B. B., Zhang, H. M., Zhang, H. Y., Zhang, J. L., Zhang, J. W., Zhang, L., Zhang, L., Zhang, L. X., Zhang, P. F., Zhang, P. P., Zhang, R., Zhang, S. R., Zhang, S S., Zhang, X., Zhang, X. P., Zhang, Y., Zhang, Y., Zhang, Y. F., Zhang, Y. L., Zhao, B., Zhao, J., Zhao, L., Zhao, L. Z., Zhao, S. P., Zheng, F., Zheng, Y., Zhou, B., Zhou, H., Zhou, J. N., Zhou, P., Zhou, R., Zhou, X. X., Zhu, C. G., Zhu, F. R., Zhu, H., Zhu, K. J., and Zuo, X.

Published
2021
Full Text
View/download PDF

12. DNA binding properties and cell viabilities of metal complexes derived from (E)-2-hydroxy-N’-((thiophen-2-yl)methylene)benzohydrazone and (E)-N’-((thiophen-2-yl)methylene) isonicotinylhydrazone.

Author

LIU, Y.-C., LUO, J., WANG, S.-Y., LIANG, Z.-X., ZHANG, X., WANG, B.-D., LI, Y.-Y., LEI, R.-X., WANG, J.-Y., ZHAO, G.-P., BAI, C.-X., and CHEN, H.

Abstract

OBJECTIVE: This study aims to investigate the CT-DNA (Calf thymus DNA) binding properties and HeLa cell viabilities of metal complexes derived from (E)-2-hydroxy-N’-((thiophen-2-yl)methylene)benzohydrazone (H2L¹ ) and (E)-N’-((thiophen-2-yl)methylene)isonicotinylhydrazone (HL² ). MATERIALS AND METHODS: A series of metal complexes derived from (E)-2-hydroxyN’-((thiophen-2-yl)methylene)benzohydrazone (H2L¹ ) and (E)-N’-((thiophen-2-yl)methylene)isonicotinylhydrazonewere (HL² ) were synthesized, and their structures were characterized through FT-IR, ESI-MS, elemental analysis, molar conductivities and X-ray diffraction. DNA binding properties between CT-DNA and metal complexes were investigated by UV-Vis spectrophotometry and viscosity titration. The toxicological properties of compounds on HeLa cell were measured in vitro. RESULTS: Ligand H2L¹ or HL2 exhibits a tridentate and anion ligand and uses oxygen anion, nitrogen atom and sulfur atom to coordinate with metal ions. When coordinated with metal ions, the unit O=C–NH– of each ligand has been enolized and deprotonated into –O–C=N–. The suggested chemical formulas of metal complexes are: [Co(HL¹ ) 2 ], [Ni(HL¹ ) 2 ], [Cu(HL¹ ) 2 ], [Co(L² ) 2 ], [Cu(L² ) 2 ], [Zn(L² ) 2 ], [ScL²(NO3 ) 2(H2 O)2 ], [Pr(L² ) 2(- NO3 )] and [Dy(L² ) 2(NO3 )]. Both ligands and their metal complexes can bind strongly to CT-DNA through hydrogen bond and intercalation with Kb of 104~105 L mol−1 compared to ethidium bromide [classical DNA intercalator, Kb(EB–DNA) = 3.068 × 104 L mol–1]; however, the groove pattern cannot be excluded. The coexistence of multiple binding modes may be a common form of drug binding to DNA. HeLa cell shows lower viabilities in the presence of [Ni(HL¹ ) 2 ] and [Cu(HL¹ ) 2 ] (*p < 0.05) compared to the other compounds, with the LC50 of 2.6 μmol L–1 and 2.2 μmol L–1, respectively. CONCLUSIONS: These compounds, especially [Ni(HL¹ )2] and [Cu(HL¹ )2], will be promising for anti-tumor drugs, which should be further studied. [ABSTRACT FROM AUTHOR]

Published
2023

13. Observation of the Crab Nebula with LHAASO-KM2A − a performance study *

Author

Aharonian, F., primary, An, Q., additional, Axikegu, 克古, additional, Bai, L. X., additional, Bai, Y. X., additional, Bao, Y. W., additional, Bastieri, D., additional, Bi, X. J., additional, Bi, Y. J., additional, Cai, H., additional, Cai, J. T., additional, Cao, Z., additional, Chang, J., additional, Chang, J. F., additional, Chang, X. C., additional, Chen, B. M., additional, Chen, J., additional, Chen, L., additional, Chen, M. J., additional, Chen, M. L., additional, Chen, Q. H., additional, Chen, S. H., additional, Chen, S. Z., additional, Chen, T. L., additional, Chen, X. L., additional, Chen, Y., additional, Cheng, N., additional, Cheng, Y. D., additional, Cui, S. W., additional, Cui, X. H., additional, Cui, Y. D., additional, Dai, B. Z., additional, Dai, H. L., additional, Dai, Z. G., additional, Danzengluobu, 罗布, additional, Volpe, D. della, additional, Piazzoli, B. D'Ettorre, additional, Dong, X. J., additional, Fan, J. H., additional, Fan, Y. Z., additional, Fan, Z. X., additional, Fang, J., additional, Fang, K., additional, Feng, C. F., additional, Feng, L., additional, Feng, S. H., additional, Feng, Y. L., additional, Gao, B., additional, Gao, C. D., additional, Gao, Q., additional, Gao, W., additional, Ge, M. M., additional, Geng, L. S., additional, Gong, G. H., additional, Gou, Q. B., additional, Gu, M. H., additional, Guo, J. G., additional, Guo, X. L., additional, Guo, Y. Q., additional, Guo, Y. Y., additional, Han, Y. A., additional, He, H. H., additional, He, H. N., additional, He, J. C., additional, He, S. L., additional, He, X. B., additional, He, Y., additional, Heller, M., additional, Hor, Y. K., additional, Hou, C., additional, Hou, X., additional, Hu, H. B., additional, Hu, S., additional, Hu, S. C., additional, Hu, X. J., additional, Huang, D. H., additional, Huang, Q. L., additional, Huang, W. H., additional, Huang, X. T., additional, Huang, Z. C., additional, Ji, F., additional, Ji, X. L., additional, Jia, H. Y., additional, Jiang, K., additional, Jiang, Z. J., additional, Jin, C., additional, Kuleshov, D., additional, Levochkin, K., additional, Li, B. B., additional, Li, C., additional, Li, F., additional, Li, H. B., additional, Li, H. C., additional, Li, H. Y., additional, Li, J., additional, Li, K., additional, Li, W. L., additional, Li, X., additional, Li, X. R., additional, Li, Y., additional, Li, Y. Z., additional, Li, Z., additional, Liang, E. W., additional, Liang, Y. F., additional, Lin, S. J., additional, Liu, B., additional, Liu, C., additional, Liu, D., additional, Liu, H., additional, Liu, H. D., additional, Liu, J., additional, Liu, J. L., additional, Liu, J. S., additional, Liu, J. Y., additional, Liu, M. Y., additional, Liu, R. Y., additional, Liu, S. M., additional, Liu, W., additional, Liu, Y. N., additional, Liu, Z. X., additional, Long, W. J., additional, Lu, R., additional, Lv, H. K., additional, Ma, B. Q., additional, Ma, L. L., additional, Ma, X. H., additional, Mao, J. R., additional, Masood, A., additional, Mitthumsiri, W., additional, Montaruli, T., additional, Nan, Y. C., additional, Pang, B. Y., additional, Pattarakijwanich, P., additional, Pei, Z. Y., additional, Qi, M. Y., additional, Ruffolo, D., additional, Rulev, V., additional, Sáiz, A., additional, Shao, L., additional, Shchegolev, O., additional, Sheng, X. D., additional, Shi, J. R., additional, Song, H. C., additional, Stenkin, Yu. V., additional, Stepanov, V., additional, Sun, Q. N., additional, Sun, X. N., additional, Sun, Z. B., additional, Tam, P. H. T., additional, Tang, Z. B., additional, Tian, W. W., additional, Wang, B. D., additional, Wang, C., additional, Wang, H., additional, Wang, H. G., additional, Wang, J. C., additional, Wang, J. S., additional, Wang, L. P., additional, Wang, L. Y., additional, Wang, R. N., additional, Wang, W., additional, Wang, X. G., additional, Wang, X. J., additional, Wang, X. Y., additional, Wang, Y. D., additional, Wang, Y. J., additional, Wang, Y. P., additional, Wang, Z., additional, Wang, Z. H., additional, Wang, Z. X., additional, Wei, D. M., additional, Wei, J. J., additional, Wei, Y. J., additional, Wen, T., additional, Wu, C. Y., additional, Wu, H. R., additional, Wu, S., additional, Wu, W. X., additional, Wu, X. F., additional, Xi, S. Q., additional, Xia, J., additional, Xia, J. J., additional, Xiang, G. M., additional, Xiao, G., additional, Xiao, H. B., additional, Xin, G. G., additional, Xin, Y. L., additional, Xing, Y., additional, Xu, D. L., additional, Xu, R. X., additional, Xue, L., additional, Yan, D. H., additional, Yang, C. W., additional, Yang, F. F., additional, Yang, J. Y., additional, Yang, L. L., additional, Yang, M. J., additional, Yang, R. Z., additional, Yang, S. B., additional, Yao, Y. H., additional, Yao, Z. G., additional, Ye, Y. M., additional, Yin, L. Q., additional, Yin, N., additional, You, X. H., additional, You, Z. Y., additional, Yu, Y. H., additional, Yuan, Q., additional, Zeng, H. D., additional, Zeng, T. X., additional, Zeng, W., additional, Zeng, Z. K., additional, Zha, M., additional, Zhai, X. X., additional, Zhang, B. B., additional, Zhang, H. M., additional, Zhang, H. Y., additional, Zhang, J. L., additional, Zhang, J. W., additional, Zhang, L., additional, Zhang, L. X., additional, Zhang, P. F., additional, Zhang, P. P., additional, Zhang, R., additional, Zhang, S. R., additional, Zhang, S. S., additional, Zhang, X., additional, Zhang, X. P., additional, Zhang, Y., additional, Zhang, Y. F., additional, Zhang, Y. L., additional, Zhao, B., additional, Zhao, J., additional, Zhao, L., additional, Zhao, L. Z., additional, Zhao, S. P., additional, Zheng, F., additional, Zheng, Y., additional, Zhou, B., additional, Zhou, H., additional, Zhou, J. N., additional, Zhou, P., additional, Zhou, R., additional, Zhou, X. X., additional, Zhu, C. G., additional, Zhu, F. R., additional, Zhu, H., additional, Zhu, K. J., additional, and Zuo, X., additional

Published
2021
Full Text
View/download PDF

22. [Predictive value of ultrasound-guided anesthesia injection in arthroscopy for borderline developmental dysplasia of the hip].

Author

Yu KK, Wu YD, Shuang YJ, An MY, Zhang J, Wang BD, Zhang MB, and Li CB

Subjects
Male, Female, Humans, Adult, Middle Aged, Hip Joint surgery, Follow-Up Studies, Arthroscopy methods, Treatment Outcome, Retrospective Studies, Pain, Ultrasonography, Interventional, Developmental Dysplasia of the Hip, Anesthesia
Abstract

Objective: To evaluate the value of ultrasound-guided intra-articular anesthetic injection in predicting postoperative outcomes for borderline developmental hip dysplasia (BDDH). Methods: A follow-up study. The clinical data of 37 BDDH patients who received ultrasound-guided intra-articular anesthetic injection and arthroscopic examination in the Department of Sports Medicine, Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital from May 2018 to February 2021 were retrospectively analyzed. Among them, there were 17 males and 20 females with a mean age of (37.9±12.8) years. All patients underwent ultrasound-guided intra-articular anesthetic injection prior to arthroscopy, and were evaluated with hip physical examination before and after injection, as well as before and after arthroscopy, in order to obtain the visual analog score (VAS) of pain for seven assessments. The total VAS score was calculated based on these evaluations. Follow-up was conducted for at least 12 months. The effective rate of injection referred to the ratio of the improvement of VAS score after anesthetic injection to the total VAS score before injection. Pearson correlation analysis and Bland-Altman analysis were used to test the correlation between modified Harris hip score (mHHS) after ultrasound-guided intra-articular anesthetic injection and mHHS score after arthroscopic surgery. A binary logistic regression model was established to analyze the substantial clinical benefit (SCB) for patients. Following the logistic regression analysis, a receiver operating characteristic (ROC) curve was constructed to evaluate the predictive power of ultrasound-guided intra-articular anesthetic injection in achieving SCB in those patients. The optimal cut-off value for injection efficacy was determined based on the ROC curve when SCB was achieved. Results: The follow-up time for all patients was (26.3±7.6) months. After anesthetic injection for 20 minutes, the total VAS score of pain [ M ( Q 1 , Q 3 )] decreased from 13(8,23) points before injection to 1(0,4) points; and the mHHS score [ M ( Q 1 , Q 3 )] increased from 60(46,70) points before arthroscopy to 90(84,96) points after, with statistically significant differences before and after injection and before and after arthroscopy (both P <0.001). Pearson correlation analysis showed that the mHHS score after intra-articular anesthetic injection was positively correlated with the mHHS score after surgery ( r =0.961, P <0.001). The area under the ROC curve for predicting SCB after arthroscopy with ultrasound-guided intra-articular anesthetic injection was 0.769 (95% CI : 0.561-0.976), the Youden index was 0.663, the cut-off value was 0.569 2, the sensitivity was 96.3%, and the specificity was 70.0%. Conclusions: The results of ultrasound-guided intra-articular anesthetic injection before arthroscopy can indicate the presence of intra-articular lesions, and the degree of pain relief after injection is proportional to the functional recovery after arthroscopy. Patients with intra-articular anesthetic injection efficacy>56.92% have better results in hip arthroscopy.

Published
2023
Full Text
View/download PDF

23. [Clinical efficacy of the treatment of bilateral gluteal muscle contracture by inside-out iliotibial band release under arthroscopy in the supine position].

Author

Wu YD, Yu KK, An MY, Li ZY, Wang BD, Li YB, Wang L, Wang MX, and Li CB

Subjects
Male, Female, Humans, Young Adult, Adult, Prospective Studies, Supine Position, Muscle, Skeletal surgery, Treatment Outcome, Buttocks surgery, Arthroscopy methods, Contracture surgery
Abstract

Objective: To investigate the clinical efficacy of bilateral gluteal muscle contracture treated with inside-out iliotibial band release under arthroscopy in the supine position. Methods: A prospective non-randomized controlled trial. Forty-six patients admitted to the Department of Sports Medicine, Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital from April 2021 to August 2022 for bilateral gluteal muscle contracture and proposed surgical treatment were enrolled. The subjects were divided into two groups according to the preferred surgical protocols of the patients: the supine position group was treated with inside-out iliotibial band release under arthroscopy in the supine position, and the operation in lateral position group was carried out with outside-in iliotibial band release under arthroscopy in the lateral position. The total duration of non-surgical operations and the total duration of surgical operations were recorded for all patients. The gluteal muscle contracture disability scale within 3 days before surgery and at least 2 months after surgery were compared between the two groups, and the occurrence of complications between the two groups was compared too. Results: There were 26 cases in the supine position group, 11 males and 15 females with a mean age of (31.8±7.3) years; and there were 20 cases in the lateral position group, 7 males and 13 females with a mean age of (30.6±6.3) years. The differences in gender, age, body mass index (BMI) and postoperative follow-up time between the two groups were not statistically significant (all P >0.05). The total duration of non-surgical operations was shorter in the supine position group than in the lateral position group [(47.9±10.4) min vs (63.9±7.5) min, P <0.001]. There was no statistically significant difference in the total duration of surgical operations between the supine position group and the lateral position group [31.0(27.0, 43.5) min vs 33.0(24.8, 38.0) min, P >0.05]. The postoperative gluteal muscle contracture disability scales were significantly improved in both the supine position and lateral position groups when compared with those before the operation [93.0 (85.0, 98.0) vs 61.0 (50.5, 66.8), P <0.001 and 88.5±6.9 vs 63.6±9.6, P <0.001, respectively]. There was no statistically significant difference in the gluteal muscle contracture disability scale between the supine position and lateral position groups before and 2 months after surgery [59.3±11.9 vs 63.6±9.6 and 93.0 (85.0, 98.0) vs 89.5(84.0, 94.8), both P >0.05, respectively]. Two patients in each group developed subcutaneous hematoma after surgery, and all of them resolved within 2 weeks after surgery, the difference in complication incidence rate was not statistically significant ( P >0.05). No postoperative complications such as fat liquefaction in the operated area, infection, decreased hip abductor muscle strength or nerve injury in the lower extremity were observed in both groups. Conclusion: The treatment of bilateral gluteal muscle contracture by inside-out iliotibial band release under arthroscopy in the supine position can effectively improve clinical efficiency, with definite efficacy, and it is an operative program worth promoting.

Published
2023
Full Text
View/download PDF

25. Constraints on Heavy Decaying Dark Matter from 570 Days of LHAASO Observations.

Author

Cao Z, Aharonian F, An Q, Axikegu, Bai LX, Bai YX, Bao YW, Bastieri D, Bi XJ, Bi YJ, Cai JT, Cao Z, Chang J, Chang JF, Chen ES, Chen L, Chen L, Chen L, Chen MJ, Chen ML, Chen QH, Chen SH, Chen SZ, Chen TL, Chen Y, Cheng HL, Cheng N, Cheng YD, Cui SW, Cui XH, Cui YD, D'Ettorre Piazzoli B, Dai BZ, Dai HL, Dai ZG, Danzengluobu, Della Volpe D, Duan KK, Fan JH, Fan YZ, Fan ZX, Fang J, Fang K, Feng CF, Feng L, Feng SH, Feng XT, Feng YL, Gao B, Gao CD, Gao LQ, Gao Q, Gao W, Gao WK, Ge MM, Geng LS, Gong GH, Gou QB, Gu MH, Guo FL, Guo JG, Guo XL, Guo YQ, Guo YY, Han YA, He HH, He HN, He SL, He XB, He Y, Heller M, Hor YK, Hou C, Hou X, Hu HB, Hu Q, Hu S, Hu SC, Hu XJ, Huang DH, Huang WH, Huang XT, Huang XY, Huang Y, Huang ZC, Ji XL, Jia HY, Jia K, Jiang K, Jiang ZJ, Jin M, Kang MM, Ke T, Kuleshov D, Levochkin K, Li BB, Li C, Li C, Li F, Li HB, Li HC, Li HY, Li J, Li J, Li J, Li K, Li WL, Li XR, Li X, Li X, Li YZ, Li Z, Li Z, Liang EW, Liang YF, Lin SJ, Liu B, Liu C, Liu D, Liu H, Liu HD, Liu J, Liu JL, Liu JS, Liu JY, Liu MY, Liu RY, Liu SM, Liu W, Liu Y, Liu YN, Long WJ, Lu R, Luo Q, Lv HK, Ma BQ, Ma LL, Ma XH, Mao JR, Masood A, Min Z, Mitthumsiri W, Nan YC, Ou ZW, Pang BY, Pattarakijwanich P, Pei ZY, Qi MY, Qi YQ, Qiao BQ, Qin JJ, Ruffolo D, Sáiz A, Shao CY, Shao L, Shchegolev O, Sheng XD, Shi JY, Song HC, Stenkin YV, Stepanov V, Su Y, Sun QN, Sun XN, Sun ZB, Tam PHT, Tang ZB, Tian WW, Wang BD, Wang C, Wang H, Wang HG, Wang JC, Wang JS, Wang LP, Wang LY, Wang R, Wang RN, Wang W, Wang XG, Wang XY, Wang Y, Wang YD, Wang YJ, Wang YP, Wang ZH, Wang ZX, Wang Z, Wang Z, Wei DM, Wei JJ, Wei YJ, Wen T, Wu CY, Wu HR, Wu S, Wu XF, Wu YS, Xi SQ, Xia J, Xia JJ, Xiang GM, Xiao DX, Xiao G, Xin GG, Xin YL, Xing Y, Xiong Z, Xu DL, Xu RX, Xue L, Yan DH, Yan JZ, Yang CW, Yang FF, Yang HW, Yang JY, Yang LL, Yang MJ, Yang RZ, Yang SB, Yao YH, Yao ZG, Ye YM, Yin LQ, Yin N, You XH, You ZY, Yu YH, Yuan Q, Yue H, Zeng HD, Zeng TX, Zeng W, Zeng ZK, Zha M, Zhai XX, Zhang BB, Zhang F, Zhang HM, Zhang HY, Zhang JL, Zhang LX, Zhang L, Zhang L, Zhang PF, Zhang PP, Zhang R, Zhang SB, Zhang SR, Zhang SS, Zhang X, Zhang XP, Zhang YF, Zhang YL, Zhang Y, Zhang Y, Zhao B, Zhao J, Zhao L, Zhao LZ, Zhao SP, Zheng F, Zheng Y, Zhou B, Zhou H, Zhou JN, Zhou P, Zhou R, Zhou XX, Zhu CG, Zhu FR, Zhu H, Zhu KJ, Zuo X, Ando S, Chianese M, Fiorillo DFG, Miele G, and Ng KCY

Abstract

The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying the northern γ-ray sky at energies above 10 TeV with unprecedented sensitivity. γ-ray observations have long been one of the most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by the decays of heavy dark matter particles. In this Letter, we present the first dark matter analysis with LHAASO-KM2A, using the first 340 days of data from 1/2-KM2A and 230 days of data from 3/4-KM2A. Several regions of interest are used to search for a signal and account for the residual cosmic-ray background after γ/hadron separation. We find no excess of dark matter signals, and thus place some of the strongest γ-ray constraints on the lifetime of heavy dark matter particles with mass between 10^{5} and 10^{9}  GeV. Our results with LHAASO are robust, and have important implications for dark matter interpretations of the diffuse astrophysical high-energy neutrino emission.

Published
2022
Full Text
View/download PDF

26. Exploring Lorentz Invariance Violation from Ultrahigh-Energy γ Rays Observed by LHAASO.

Author

Cao Z, Aharonian F, An Q, Axikegu, Bai LX, Bai YX, Bao YW, Bastieri D, Bi XJ, Bi YJ, Cai H, Cai JT, Cao Z, Chang J, Chang JF, Chen BM, Chen ES, Chen J, Chen L, Chen L, Chen L, Chen MJ, Chen ML, Chen QH, Chen SH, Chen SZ, Chen TL, Chen XL, Chen Y, Cheng N, Cheng YD, Cui SW, Cui XH, Cui YD, Piazzoli BD, Dai BZ, Dai HL, Dai ZG, Danzengluobu, Della Volpe D, Dong XJ, Duan KK, Fan JH, Fan YZ, Fan ZX, Fang J, Fang K, Feng CF, Feng L, Feng SH, Feng YL, Gao B, Gao CD, Gao LQ, Gao Q, Gao W, Ge MM, Geng LS, Gong GH, Gou QB, Gu MH, Guo FL, Guo JG, Guo XL, Guo YQ, Guo YY, Han YA, He HH, He HN, He JC, He SL, He XB, He Y, Heller M, Hor YK, Hou C, Hou X, Hu HB, Hu S, Hu SC, Hu XJ, Huang DH, Huang QL, Huang WH, Huang XT, Huang XY, Huang ZC, Ji F, Ji XL, Jia HY, Jiang K, Jiang ZJ, Jin C, Ke T, Kuleshov D, Levochkin K, Li BB, Li C, Li C, Li F, Li HB, Li HC, Li HY, Li J, Li J, Li K, Li WL, Li XR, Li X, Li X, Li Y, Li YZ, Li Z, Li Z, Liang EW, Liang YF, Lin SJ, Liu B, Liu C, Liu D, Liu H, Liu HD, Liu J, Liu JL, Liu JS, Liu JY, Liu MY, Liu RY, Liu SM, Liu W, Liu Y, Liu YN, Liu ZX, Long WJ, Lu R, Lv HK, Ma BQ, Ma LL, Ma XH, Mao JR, Masood A, Min Z, Mitthumsiri W, Montaruli T, Nan YC, Pang BY, Pattarakijwanich P, Pei ZY, Qi MY, Qi YQ, Qiao BQ, Qin JJ, Ruffolo D, Rulev V, Sáiz A, Shao L, Shchegolev O, Sheng XD, Shi JR, Song HC, Stenkin YV, Stepanov V, Su Y, Sun QN, Sun XN, Sun ZB, Tam PHT, Tang ZB, Tian WW, Wang BD, Wang C, Wang H, Wang HG, Wang JC, Wang JS, Wang LP, Wang LY, Wang RN, Wang W, Wang W, Wang XG, Wang XJ, Wang XY, Wang Y, Wang YD, Wang YJ, Wang YP, Wang ZH, Wang ZX, Wang Z, Wang Z, Wei DM, Wei JJ, Wei YJ, Wen T, Wu CY, Wu HR, Wu S, Wu WX, Wu XF, Xi SQ, Xia J, Xia JJ, Xiang GM, Xiao DX, Xiao G, Xiao HB, Xin GG, Xin YL, Xing Y, Xu DL, Xu RX, Xue L, Yan DH, Yan JZ, Yang CW, Yang FF, Yang JY, Yang LL, Yang MJ, Yang RZ, Yang SB, Yao YH, Yao ZG, Ye YM, Yin LQ, Yin N, You XH, You ZY, Yu YH, Yuan Q, Zeng HD, Zeng TX, Zeng W, Zeng ZK, Zha M, Zhai XX, Zhang BB, Zhang HM, Zhang HY, Zhang JL, Zhang JW, Zhang LX, Zhang L, Zhang L, Zhang PF, Zhang PP, Zhang R, Zhang SR, Zhang SS, Zhang X, Zhang XP, Zhang YF, Zhang YL, Zhang Y, Zhang Y, Zhao B, Zhao J, Zhao L, Zhao LZ, Zhao SP, Zheng F, Zheng Y, Zhou B, Zhou H, Zhou JN, Zhou P, Zhou R, Zhou XX, Zhu CG, Zhu FR, Zhu H, Zhu KJ, and Zuo X

Abstract

Recently, the LHAASO Collaboration published the detection of 12 ultrahigh-energy γ-ray sources above 100 TeV, with the highest energy photon reaching 1.4 PeV. The first detection of PeV γ rays from astrophysical sources may provide a very sensitive probe of the effect of the Lorentz invariance violation (LIV), which results in decay of high-energy γ rays in the superluminal scenario and hence a sharp cutoff of the energy spectrum. Two highest energy sources are studied in this work. No signature of the existence of the LIV is found in their energy spectra, and the lower limits on the LIV energy scale are derived. Our results show that the first-order LIV energy scale should be higher than about 10^{5} times the Planck scale M&#95;{Pl} and that the second-order LIV scale is >10^{-3}M&#95;{Pl}. Both limits improve by at least one order of magnitude the previous results.

Published
2022
Full Text
View/download PDF

27. Peta-electron volt gamma-ray emission from the Crab Nebula.

Author

Cao Z, Aharonian F, An Q, Axikegu, Bai LX, Bai YX, Bao YW, Bastieri D, Bi XJ, Bi YJ, Cai H, Cai JT, Cao Z, Chang J, Chang JF, Chen BM, Chen ES, Chen J, Chen L, Chen L, Chen L, Chen MJ, Chen ML, Chen QH, Chen SH, Chen SZ, Chen TL, Chen XL, Chen Y, Cheng N, Cheng YD, Cui SW, Cui XH, Cui YD, D'Ettorre Piazzoli B, Dai BZ, Dai HL, Dai ZG, Danzengluobu, Della Volpe D, Dong XJ, Duan KK, Fan JH, Fan YZ, Fan ZX, Fang J, Fang K, Feng CF, Feng L, Feng SH, Feng YL, Gao B, Gao CD, Gao LQ, Gao Q, Gao W, Ge MM, Geng LS, Gong GH, Gou QB, Gu MH, Guo FL, Guo JG, Guo XL, Guo YQ, Guo YY, Han YA, He HH, He HN, He JC, He SL, He XB, He Y, Heller M, Hor YK, Hou C, Hou X, Hu HB, Hu S, Hu SC, Hu XJ, Huang DH, Huang QL, Huang WH, Huang XT, Huang XY, Huang ZC, Ji F, Ji XL, Jia HY, Jiang K, Jiang ZJ, Jin C, Ke T, Kuleshov D, Levochkin K, Li BB, Li C, Li C, Li F, Li HB, Li HC, Li HY, Li J, Li J, Li K, Li WL, Li XR, Li X, Li X, Li Y, Li YZ, Li Z, Li Z, Liang EW, Liang YF, Lin SJ, Liu B, Liu C, Liu D, Liu H, Liu HD, Liu J, Liu JL, Liu JS, Liu JY, Liu MY, Liu RY, Liu SM, Liu W, Liu Y, Liu YN, Liu ZX, Long WJ, Lu R, Lv HK, Ma BQ, Ma LL, Ma XH, Mao JR, Masood A, Min Z, Mitthumsiri W, Montaruli T, Nan YC, Pang BY, Pattarakijwanich P, Pei ZY, Qi MY, Qi YQ, Qiao BQ, Qin JJ, Ruffolo D, Rulev V, Saiz A, Shao L, Shchegolev O, Sheng XD, Shi JY, Song HC, Stenkin YV, Stepanov V, Su Y, Sun QN, Sun XN, Sun ZB, Tam PHT, Tang ZB, Tian WW, Wang BD, Wang C, Wang H, Wang HG, Wang JC, Wang JS, Wang LP, Wang LY, Wang RN, Wang W, Wang W, Wang XG, Wang XJ, Wang XY, Wang Y, Wang YD, Wang YJ, Wang YP, Wang ZH, Wang ZX, Wang Z, Wang Z, Wei DM, Wei JJ, Wei YJ, Wen T, Wu CY, Wu HR, Wu S, Wu WX, Wu XF, Xi SQ, Xia J, Xia JJ, Xiang GM, Xiao DX, Xiao G, Xiao HB, Xin GG, Xin YL, Xing Y, Xu DL, Xu RX, Xue L, Yan DH, Yan JZ, Yang CW, Yang FF, Yang JY, Yang LL, Yang MJ, Yang RZ, Yang SB, Yao YH, Yao ZG, Ye YM, Yin LQ, Yin N, You XH, You ZY, Yu YH, Yuan Q, Zeng HD, Zeng TX, Zeng W, Zeng ZK, Zha M, Zhai XX, Zhang BB, Zhang HM, Zhang HY, Zhang JL, Zhang JW, Zhang LX, Zhang L, Zhang L, Zhang PF, Zhang PP, Zhang R, Zhang SR, Zhang SS, Zhang X, Zhang XP, Zhang YF, Zhang YL, Zhang Y, Zhang Y, Zhao B, Zhao J, Zhao L, Zhao LZ, Zhao SP, Zheng F, Zheng Y, Zhou B, Zhou H, Zhou JN, Zhou P, Zhou R, Zhou XX, Zhu CG, Zhu FR, Zhu H, Zhu KJ, and Zuo X

Abstract

The Crab Nebula is a bright source of gamma rays powered by the Crab Pulsar's rotational energy through the formation and termination of a relativistic electron-positron wind. We report the detection of gamma rays from this source with energies from 5 × 10 -4 to 1.1 peta-electron volts with a spectrum showing gradual steepening over three energy decades. The ultrahigh-energy photons imply the presence of a peta-electron volt electron accelerator (a pevatron) in the nebula, with an acceleration rate exceeding 15% of the theoretical limit. We constrain the pevatron's size between 0.025 and 0.1 parsecs and the magnetic field to ≈110 microgauss. The production rate of peta-electron volt electrons, 2.5 × 10 36 ergs per second, constitutes 0.5% of the pulsar spin-down luminosity, although we cannot exclude a contribution of peta-electron volt protons to the production of the highest-energy gamma rays., (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)

Published
2021
Full Text
View/download PDF

28. Extended Very-High-Energy Gamma-Ray Emission Surrounding PSR J0622+3749 Observed by LHAASO-KM2A.

Author

Aharonian F, An Q, Axikegu, Bai LX, Bai YX, Bao YW, Bastieri D, Bi XJ, Bi YJ, Cai H, Cai JT, Cao Z, Cao Z, Chang J, Chang JF, Chang XC, Chen BM, Chen J, Chen L, Chen L, Chen L, Chen MJ, Chen ML, Chen QH, Chen SH, Chen SZ, Chen TL, Chen XL, Chen Y, Cheng N, Cheng YD, Cui SW, Cui XH, Cui YD, Dai BZ, Dai HL, Dai ZG, Danzengluobu, Della Volpe D, D'Ettorre Piazzoli B, Dong XJ, Fan JH, Fan YZ, Fan ZX, Fang J, Fang K, Feng CF, Feng L, Feng SH, Feng YL, Gao B, Gao CD, Gao Q, Gao W, Ge MM, Geng LS, Gong GH, Gou QB, Gu MH, Guo JG, Guo XL, Guo YQ, Guo YY, Han YA, He HH, He HN, He JC, He SL, He XB, He Y, Heller M, Hor YK, Hou C, Hou X, Hu HB, Hu S, Hu SC, Hu XJ, Huang DH, Huang QL, Huang WH, Huang XT, Huang ZC, Ji F, Ji XL, Jia HY, Jiang K, Jiang ZJ, Jin C, Kuleshov D, Levochkin K, Li BB, Li C, Li C, Li F, Li HB, Li HC, Li HY, Li J, Li K, Li WL, Li X, Li X, Li XR, Li Y, Li YZ, Li Z, Li Z, Liang EW, Liang YF, Lin SJ, Liu B, Liu C, Liu D, Liu H, Liu HD, Liu J, Liu JL, Liu JS, Liu JY, Liu MY, Liu RY, Liu SM, Liu W, Liu YN, Liu ZX, Long WJ, Lu R, Lv HK, Ma BQ, Ma LL, Ma XH, Mao JR, Masood A, Mitthumsiri W, Montaruli T, Nan YC, Pang BY, Pattarakijwanich P, Pei ZY, Qi MY, Ruffolo D, Rulev V, Sáiz A, Shao L, Shchegolev O, Sheng XD, Shi JR, Song HC, Stenkin YV, Stepanov V, Sun QN, Sun XN, Sun ZB, Tam PHT, Tang ZB, Tian WW, Wang BD, Wang C, Wang H, Wang HG, Wang JC, Wang JS, Wang LP, Wang LY, Wang RN, Wang W, Wang W, Wang XG, Wang XJ, Wang XY, Wang YD, Wang YJ, Wang YP, Wang Z, Wang Z, Wang ZH, Wang ZX, Wei DM, Wei JJ, Wei YJ, Wen T, Wu CY, Wu HR, Wu S, Wu WX, Wu XF, Xi SQ, Xia J, Xia JJ, Xiang GM, Xiao G, Xiao HB, Xin GG, Xin YL, Xing Y, Xu DL, Xu RX, Xue L, Yan DH, Yang CW, Yang FF, Yang JY, Yang LL, Yang MJ, Yang RZ, Yang SB, Yao YH, Yao ZG, Ye YM, Yin LQ, Yin N, You XH, You ZY, Yu YH, Yuan Q, Zeng HD, Zeng TX, Zeng W, Zeng ZK, Zha M, Zhai XX, Zhang BB, Zhang HM, Zhang HY, Zhang JL, Zhang JW, Zhang L, Zhang L, Zhang LX, Zhang PF, Zhang PP, Zhang R, Zhang SR, Zhang SS, Zhang X, Zhang XP, Zhang Y, Zhang Y, Zhang YF, Zhang YL, Zhao B, Zhao J, Zhao L, Zhao LZ, Zhao SP, Zheng F, Zheng Y, Zhou B, Zhou H, Zhou JN, Zhou P, Zhou R, Zhou XX, Zhu CG, Zhu FR, Zhu H, Zhu KJ, Zuo X, and Huang XY

Abstract

We report the discovery of an extended very-high-energy (VHE) gamma-ray source around the location of the middle-aged (207.8 kyr) pulsar PSR J0622+3749 with the Large High-Altitude Air Shower Observatory (LHAASO). The source is detected with a significance of 8.2σ for E>25  TeV assuming a Gaussian template. The best-fit location is (right ascension, declination) =(95.47°±0.11°,37.92°±0.09°), and the extension is 0.40°±0.07°. The energy spectrum can be described by a power-law spectrum with an index of -2.92±0.17&#95;{stat}±0.02&#95;{sys}. No clear extended multiwavelength counterpart of the LHAASO source has been found from the radio to sub-TeV bands. The LHAASO observations are consistent with the scenario that VHE electrons escaped from the pulsar, diffused in the interstellar medium, and scattered the interstellar radiation field. If interpreted as the pulsar halo scenario, the diffusion coefficient, inferred for electrons with median energies of ∼160  TeV, is consistent with those obtained from the extended halos around Geminga and Monogem and much smaller than that derived from cosmic ray secondaries. The LHAASO discovery of this source thus likely enriches the class of so-called pulsar halos and confirms that high-energy particles generally diffuse very slowly in the disturbed medium around pulsars.

Published
2021
Full Text
View/download PDF

29. [Schistosomiasis control effect in Mianyang City in ten years after Wenchuan earthquake].

Author

Shi YH and Wang BD

Subjects
Animals, China epidemiology, Cities epidemiology, Humans, Snails, Earthquakes, Schistosomiasis epidemiology, Schistosomiasis prevention & control
Abstract

Objective: To evaluate the effect of schistosomiasis control in Mianyang City in ten years after Wenchuan earth-quake, so as to provide the experiences for schistosomiasis control post-disaster., Methods: The data of implementation of schistosomiasis control work in ten years after the Wenchuan earthquake were collected and analyzed for the epidemic situation of schistosomiasis in Mianyang City. Meanwhile, the awareness situation on schistosomiasis control of villagers and students was investigated by questionnaires in 2008 and 2015., Results: All of the 6 counties (cities, districts) with schistosomiasis endemic in Mianyang City were hit by the earthquake disaster. After the disaster, the measurements including the conventional schistosomiasis control measures, the control of exogenous infection sources, the control of Oncomelania hupensis snails, and health education were carried out. The relevant departments of schistosomiasis control were cooperated to implement the prevention and control measures. The schistosomiasis prevalence of population and the snail condition rose in the year of the earthquake, but then declined year by year. In 2015, the awareness rates of schistosomiasis control of both villagers and the students were significantly improved compared with those in 2008., Conclusions: The measures of schistosomiasis control after the earthquake disaster are effective in Mianyang City, and the goal to prevent major plague after the earthquake is achieved.

Published
2018
Full Text
View/download PDF

31. Induction of a mitosis delay and cell lysis by high-level secretion of mouse alpha-amylase from Saccharomyces cerevisiae.

Author

Wang BD and Kuo TT

Subjects
Animals, CDC28 Protein Kinase, S cerevisiae genetics, CDC28 Protein Kinase, S cerevisiae metabolism, Cell Cycle Proteins metabolism, Culture Media, DNA, Fungal analysis, Maturation-Promoting Factor metabolism, Mesothelin, Mice, Phosphoprotein Phosphatases metabolism, Protein Phosphatase 2, Recombinant Proteins metabolism, Saccharomyces cerevisiae ultrastructure, alpha-Amylases genetics, Gene Expression Regulation, Fungal, Mitosis physiology, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae physiology, Saccharomyces cerevisiae Proteins, alpha-Amylases metabolism
Abstract

Some foreign proteins are produced in yeast in a cell cycle-dependent manner, but the cause of the cell cycle dependency is unknown. In this study, we found that Saccharomyces cerevisiae cells secreting high levels of mouse alpha-amylase have elongated buds and are delayed in cell cycle completion in mitosis. The delayed cell mitosis suggests that critical events during exit from mitosis might be disturbed. We found that the activities of PP2A (protein phosphatase 2A) and MPF (maturation-promoting factor) were reduced in alpha-amylase-oversecreting cells and that these cells showed a reduced level of assembly checkpoint protein Cdc55, compared to the accumulation in wild-type cells. MPF inactivation is due to inhibitory phosphorylation on Cdc28, as a cdc28 mutant which lacks an inhibitory phosphorylation site on Cdc28 prevents MPF inactivation and prevents the defective bud morphology induced by overproduction of alpha-amylase. Our data also suggest that high levels of alpha-amylase may downregulate PPH22, leading to cell lysis. In conclusion, overproduction of heterologous alpha-amylase in S. cerevisiae results in a negative regulation of PP2A, which causes mitotic delay and leads to cell lysis.

Published
2001
Full Text
View/download PDF

32. Asparagine as a nitrogen source for improving the secretion of mouse alpha-amylase in Saccharomyces cerevisiae protease A-deficient strains.

Author

Chen DC, Wang BD, Chou PY, and Kuo TT

Subjects
Amino Acids metabolism, Ammonium Sulfate metabolism, Animals, Aspartic Acid Endopeptidases genetics, Culture Media chemistry, DNA, Recombinant, Humans, Immunoblotting, Mice, Nitrogen metabolism, Plasmids genetics, Saccharomyces cerevisiae genetics, Saccharomyces cerevisiae growth & development, Saccharomyces cerevisiae Proteins, alpha-Amylases genetics, Asparagine metabolism, Aspartic Acid Endopeptidases metabolism, Saccharomyces cerevisiae enzymology, alpha-Amylases metabolism
Abstract

A modified chemically defined medium was achieved by using asparagine as a nitrogen source to increase the production of secreted mouse alpha-amylase in several Saccharomyces cerevisiae protease A-deficient (pep4) strains. The specific productivity (quantity) and the 53 kDa non-glycosylated active form (quality) of mouse salivary alpha-amylase in liquid medium containing asparagine was remarkably improved compared to media containing other nitrogen sources, including ammonium sulphate, glutamic acid, arginine, casamino acids, yeast extract and peptone. Similar improvement was also observed on starch solid agar regarding the clarity and size of the halo zone formed by alpha-amylase activity. Compared with ammonium sulphate, advantages of using asparagine as the nitrogen source in liquid or solid medium included increasing the cell mass of test strains, recovering the viability of protease-deficient strains to levels similar to the wild-type strain, and increasing the copy number of the mouse alpha-amylase expression vector in test strains. In turn, these advantages apparently contributed to the increase of secretion of mouse alpha-amylase in several test strains and especially in the protease A-deficient strains. In addition to demonstrating the use of modified chemically defined medium to improve the quality and quantity of secreted mouse alpha-amylase, this study also provides a new strategy to improve the secretion of heterologous proteins in protease A deficient strains., (Copyright 2000 John Wiley & Sons, Ltd.)

Published
2000
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results