Search

Your search keyword '"Wandl, Ursula"' showing total 87 results
Start Over Author "Wandl, Ursula"
87 results on '"Wandl, Ursula"'

4. Erratum zu: Medizinische Gutachten

Author

Dörfler, Hans, Eisenmenger, Wolfgang, Lippert, Hans-Dieter, Wandl, Ursula, Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

14. Combination therapy with interferon alpha-2b plus low-dose interferon gamma in pretreated patients with Ph-positive chronic myelogenous leukaemia

Author

Wandl, Ursula B., primary, Kloke, Otto, additional, Nagel-Hiemke, Marianne, additional, Moritz, Thomas, additional, Becher, Reinhard, additional, Opalka, Bertram, additional, Holtkamp, Wilhelm, additional, Bartels, Heinrich, additional, Seeber, Siegfried, additional, and Niederle, Norbert, additional

Published
1992
Full Text
View/download PDF

17. Minimal Residual Disease in Patients With Chronic Myelogenous Leukemia Undergoing Long-term Treatment With Recombinant Interferon a-2b Alone or in Combination With Interferon γ

Author

Opalka, Bertram, Wandl, Ursula Brigitte, Becher, Reinhard, Kloke, Otto, Nagel-Hiemke, Marianne, Moritz, Thomas, Beer, Ulrike, Seeber, Siegfried, and Niederle, Norbert

Abstract

Interferon (IFN) therapy has become widely used for the treatment of chronic myelogenous leukemia. Hematologic remissions can be induced in about 60% of patients. Moreover, in a small number of patients loss of the Philadelphia (Ph) chromosome and of the BCR-ABL rearrangement is observed. We have used genomic Southern blotting as well as a two-step polymerase chain reaction (PCR) method to score for BCR-ABL messenger RNA (mRNA) in patients with hematologic remission induced by treatment with IFNα-2b alone or in combination with IFNγ. Concomitantly, cytogenetic analysis was performed. In 11 of 115 patients reported here, a complete loss of rearranged BCR fragments was observed in Southern blots of peripheral blood (PB) and/or bone marrow (BM) cell samples. Malignant marker bands disappeared first in the PB. In six patients, this genotype remained stable, whereas in five patients, low-intensity, rearranged bands reappeared despite continuation of treatment. The reappearance of the malignant marker was not accompanied by a clinical relapse. Ph-negative metaphases were observed in PB cells of four patients and in the PB and BM cells of two of these patients. In the samples of the other patients, residual Ph-positive cells were detected. By two-step PCR, residual BCR-ABL rearranged transcripts were found in samples of 10 patients.

Published
1991
Full Text
View/download PDF

18. Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells

Author

Dempke, Wolfram, Nehls, Peter, Wandl, Ursula, Soll, Detlef, Schmidt, Carl Gottfried, and Osieka, Rainhardt

Abstract

Cells from a resistant (“Gr II”) and a sensitive (“Str”) human melanoma xenograft were incubated in vitro with O6-methylguanine for 2 h, subsequently treated with 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea (MeCCNU) for 1 h and then plated in soft agar. In the resistant cells the O6-methylguanine pretreatment (2 mM) yielded an increase in sensitivity towards MeCCNU by a factor of 7.5. In the sensitive melanoma cells pretreatment with O6-methylguanine did not increase cytotoxicity. Human bone marrow cells from three normal donors were similarly pretreated with O6-methylguanine and MeCCNU. There was a clear increase in MeCCNU-induced cytotoxicity. We conclude, that while O6-methylguanine does potentiate the action of MeCCNU in resistant melanoma cells, the therapeutic usefulness of this treatment strategy may be limited.

Published
1987
Full Text
View/download PDF

19. A PvuII Polymorphism of the bcr Region in Patients With Hematopoietic Disorders and Their Families

Author

Opalka, Bertram, Wandl, Ursula, Kloke, Otto, Oberle, Claudia, Koppe, Jutta, Niederle, Norbert, and Schmidt, Carl Gottfried

Abstract

The BCR gene on chromosome 22 has received increasing attention because of its involvement in the Philadelphia (Ph' ') translocation. For most restriction enzymes, this locus has been found to be nonpolymorphic. Two alleles have only been found when Taql-digested DNA is hybridized to a 5’ bcr-specific probe. We describe another two-allele polymorphism detected by the same probe in Pvull-digested DNA. The polymorphism is characterized by an additional PvuII site in the bcr region: this causes the appearance of an additional band of about 2.3 kb or 2.5 kb besides a 4.8-kb fragment in hybridizations with the 5’ bcr or a 3’ bcr probe. The incidence of the second allele is very low. It has only been found in some patients with hematopoietic malignancies and in a group of volunteers having a leukemia patient in their families.

Published
1989
Full Text
View/download PDF

20. CORRESPONDENCE

Author

OPALKA, BERTRAM, WANDL, URSULA B., STUTENKEMPER, RUTH, KLOKE, OTTO, SEEBER, SIEGFRIED, and NIEDERLE, NORBERT

Published
1992
Full Text
View/download PDF

21. Bewegungsapparat

Author

Nigg, A., Hausdorf, J., Schewe, S., Lamm, P., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

23. Grundbegriffe der Begutachtung

Author

Eisenmenger, W., Lippert, H.-D., Wandl, U., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

24. Respirationstrakt

Author

Baur, X., Huber, R., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

25. Gastrointestinaltrakt

Author

Zoller, W., Heubach, T., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

26. Hypertonie

Author

Bönner, G., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

28. Diabetes mellitus

Author

Dörfler, H., Haslbeck, M., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

30. Psychiatrische Begutachtung

Author

Stadtland, C., Nedopil, N., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

31. Periphere Gefäße

Author

Dohmen, A., Layher, T., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

32. Herz

Author

Schmitz, H., Czernik, A., Lamm, P., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

33. Nierenkrankheiten

Author

Hanel, K.-D., Keller, F., Winkler, U., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

34. Sinnesorgane

Author

Wilhelm, H., Lachenmayr, B., Hamann, K.-F., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

35. Haut und Hautanhangsgebilde

Author

Worm, M., Werner-Busse, A., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

36. Endokrine Organe

Author

Böhm, B., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

37. Nervensystem

Author

Lang, C.J.G., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

40. Rechtliche Grundlagen

Author

Lippert, H.-D., Zahrl, J., Bollag, Y., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2015
Full Text
View/download PDF

42. Bewegungsapparat

Author

Nigg, A., Hausdorf, J., Schewe, S., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

44. Respirationstrakt

Author

Baur, X., Huber, R., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

45. Psychiatrische Begutachtung

Author

Stadtland, C., Nedopil, N., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

46. Hypertonie

Author

Bönner, G., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

48. Diabetes mellitus

Author

Dörfler, H., Haslbeck, M., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

49. Periphere Gefäße

Author

Dohmen, A., Layher, T., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

50. Gastrointestinaltrakt

Author

Zoller, W., Heubach, T., Dörfler, Hans, editor, Eisenmenger, Wolfgang, editor, Lippert, Hans-Dieter, editor, and Wandl, Ursula, editor

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results