Search

With the new media and other elements deeply rooted in people’s hearts, the innovation-related undertakings related to library management and service are developing vigorously, and the ambitious goals and ideals of “reading for all” and “building a cultural society” are also achieved at an early date. This paper makes innovations from three creative points, namely, “developing library business propaganda from the perspective of brand building to carry out reading promotion practice”, “innovating library work from the perspective of cultural inheritance to carry out reading promotion practice” and “expanding library management and service field from the direction of intelligent environment to carry out reading promotion practice”, and uses literature research, investigation and induction to carry out innovative development research.

Objective: Transcranial sonography (TCS) is a noninvasive neuroimaging technique, visualizing deep brain structures and the ventricular system. Although widely employed in diagnosing various movement disorders, such as Parkinson's disease and dystonia, by detecting disease‐specific abnormalities, the specific characteristics of the TCS in cerebellar ataxia remain inconclusive. We aimed to assess the potential value of TCS in patients with cerebellar ataxias for disease diagnosis and severity assessment. Methods: TCS on patients with genetic and acquired cerebellar ataxia, including 94 with spinocerebellar ataxias (SCAs) containing 10 asymptomatic carriers, 95 with cerebellar subtype of multiple system atrophy (MSA‐C), and 100 healthy controls (HC), was conducted. Assessments included third ventricle width, substantia nigra (SN) and lentiform nucleus (LN) echogenicity, along with comprehensive clinical evaluations and genetic testing. Results: The study revealed significant TCS abnormalities in patients with cerebellar ataxia, such as enlarged third ventricle widths and elevated rates of hyperechogenic SN and LN. TCS showed high accuracy in distinguishing patients with SCA or MSA‐C from HC, with an AUC of 0.870 and 0.931, respectively. TCS abnormalities aided in identifying asymptomatic SCA carriers, effectively differentiating them from HC, with an AUC of 0.725. Furthermore, third ventricle width was significantly correlated with SARA and ICARS scores in patients with SCA3 and SCOPA‐AUT scores in patients with MSA‐C. The SN area and SARA or ICARS scores in patients with SCA3 were also positively correlated. Interpretation: Our findings illustrate remarkable TCS abnormalities in patients with cerebellar ataxia, serving as potential biomarkers for clinical diagnosis and progression assessment. [ABSTRACT FROM AUTHOR]

Background: Neuroinflammation might contribute to the pathogenesis of multiple systemic atrophy (MSA). However, specific alterations in the peripheral inflammatory and immune profiles of patients with MSA remain unclear. Objectives: To determine the peripheral inflammatory and immune profiles of patients with MSA and their potential value as biomarkers for facilitating clinical diagnosis and monitoring disease severity. Methods: This cross‐sectional study included 235, 240, and 235 patients with MSA, patients with Parkinson's disease (PD), and healthy controls (HCs), respectively. Inflammatory and immune parameters were measured in peripheral blood, differences between groups were assessed, and clusters were analyzed. Associations between the parameters and clinical characteristics of MSA were assessed using Spearman and partial correlation analyses. Results: Significant differences were observed especially in monocytes, neutrophils‐to‐lymphocyte ratio (NLR) and neutrophils‐to‐lymphocyte ratio (MPV) between MSA patients and HCs (P < 0.01). Monocytes and uric acid (UA) levels were also significantly different between the MSA and PD patients (P < 0.05). The combination of NLR and MPV distinguished MSA‐P patients from HCs (areas under the curve = 0.824). In addition, complement components C4 and C3 were significantly correlated with the Scale Outcomes in PD for Autonomic Symptoms and Wexner scale, whereas immunoglobulin G (IgG) was significantly correlated with scores of Unified Multiple System Atrophy Rating Scale (P < 0.05). Conclusions: In MSA patients, monocytes, NLR and MPV might serve as potential diagnostic biomarkers, whereas MLR, C3, C4, and IgG significantly correlate with disease severity. © 2023 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Reducing the energy consumption of machine tool processing has been a consistent concern and research issue in the international manufacturing industry. To achieve energy conservation and emissions reduction in machine tools, an energy consumption model of the machining process must first be established. However, considering the differences in machining equipment, complex energy flow conditions and time-varying load forces, accurate energy consumption of machining process can be difficult to obtain. Against this backdrop, our research proposes a modelling method for processing energy consumption with an integration mechanism and data, that considers the advantages of mechanism analysis modelling and data modelling. Among them, the mechanism analytical model for characterising energy consumption is determined by the dynamic mechanism of the multi-energy source of the machine tool. The data model is built using a support vector machine (SVM) algorithm based on the deviation between the actual results and the theoretical model. Then, a case study is performed to verify the feasibility and practicability of the proposed method. The results demonstrate accurate prediction and quantitative analysis of energy consumption. [ABSTRACT FROM AUTHOR]

At present, the evaluation index for low carbon manufacturing was mainly focused on the relationship between carbon emission and economic benefits or removal volume. But there was rarely comprehensive evaluation index to evaluate the carbon utilisation level of processing. Based on this, this paper presented the carbon utilisation efficiency as the comprehensive evaluation index in low carbon manufacturing. The carbon utilisation efficiency was defined as the ratio of the carbon emission of materials removal to the whole carbon emission in manufacturing process. A carbon utilisation efficiency model was established in milling process, based on flow characteristics and removal mechanism of carbon emission during milling. Then a multi-objective optimisation model was established based on Particle Swarm Optimisation, and the minimum processing time and high carbon utilisation efficiency were set as the optimisation objectives. And the experiment was performed to confirm the undetermined constant in the optimisation model and verify the effectiveness of the optimisation model. The optimised milling parameters were verified to reduce the processing time and improve the carbon utilisation efficiency. [ABSTRACT FROM AUTHOR]

Background: Glycoprotein nonmetastatic melanoma protein B (GPNMB) has been demonstrated to mediate pathogenicity in Parkinson's disease (PD) through interactions with α‐synuclein, and plasma GPNMB tended to be a novel biomarker for PD. Objective: The goal of this study was to investigate whether plasma GPNMB could act as a potential biomarker for the clinical diagnosis and severity monitoring of multiple system atrophy (MSA), another typical synucleinopathy. Methods: Plasma GPNMB levels in patients with MSA, patients with PD, and healthy control subjects (HCs) were quantified using enzyme‐linked immunosorbent assays. Results: A total of 204 patients with MSA, 65 patients with PD, and 207 HCs were enrolled. The plasma GPNMB levels in patients with MSA were similar to those in HCs (P = 0.251) but were significantly lower than those in patients with PD (P = 0.003). Moreover, there was no significant correlation detected between the plasma GPNMB levels and disease severity scores of patients with MSA. Conclusions: No evidence was detected for the biomarker potential of plasma GPNMB in MSA. © 2023 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]