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175 results on '"Wan, Dehui"'

7. Structure-dependent magnetoelectric and magnetothermal effects of MOF-derived zero-valence cobalt and iron oxide nanoparticles on a carbonaceous matrix.

Author

Liang, Jing-Guan, Gao, Wei-Xiang, Chung, Chieh-Wei, Dayao, Loise Ann, Chou, Ho-Hsiu, Lin, Zong-Hong, Wan, Dehui, Huang, Jen-Huang, Chen, Ying-Chieh, and Lu, Tsai-Te

Subjects
MAGNETOCALORIC effects, IRON oxide nanoparticles, MAGNETOELECTRIC effect, METAL nanoparticles, COBALT oxides
Abstract

For the first time, the dominant magnetoelectric activity of ZIF-67-derived carbonaceous microparticles embedded with Co nanoparticles and distinctive magnetothermal effect of MIL-88B-derived Fe3O4 nanocubes decorated on carbonaceous microrods, respectively, were explored to be controlled by the structure of the MOF-derived electrically conductive carbonaceous matrix and metal nanoparticles. [ABSTRACT FROM AUTHOR]

Published
2024
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13. A Chemoimmunotherapy Nanogel Enables Efficient Delivery of Interleukin‐2 and Induction of Immunogenic Cell Death for Effective Cancer Therapy

Author

Mu, Hsuan‐Yu, primary, Ta, Yen‐Nhi Ngoc, additional, Tham, Max Jing Rui, additional, Hsu, Fu‐Fei, additional, Lin, Yu‐Chieh, additional, Huang, Hsi‐Chien, additional, Sung, Yun‐Chieh, additional, Huang, Chih‐I, additional, Wu, Ching‐Ling, additional, Chang, Chao‐Hung, additional, Yang, Sheng, additional, Lee, Tsung‐Ying, additional, Wan, Dehui, additional, Wang, Jane, additional, Duda, Dan G., additional, Boucher, Yves, additional, Huang, Jen‐Huang, additional, Ang, Wee Han, additional, and Chen, Yunching, additional

Published
2023
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15. Eco‐Friendly Transparent Silk Fibroin Radiative Cooling Film for Thermal Management of Optoelectronics (Adv. Funct. Mater. 33/2023)

Author

Chen, Yu‐Hsuan, primary, Hwang, Ching‐Wen, additional, Chang, Sih‐Wei, additional, Tsai, Meng‐Ting, additional, Jayakumaran, Kavya Nair, additional, Yang, Ling‐Chu, additional, Lo, Yu‐Chieh, additional, Ko, Fu‐Hsiang, additional, Wang, Hsueh‐Cheng, additional, Chen, Hsuen‐Li, additional, and Wan, Dehui, additional

Published
2023
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17. A Chemoimmunotherapy Nanogel Enables Efficient Delivery of Interleukin‐2 and Induction of Immunogenic Cell Death for Effective Cancer Therapy.

Author

Mu, Hsuan‐Yu, Ta, Yen‐Nhi Ngoc, Tham, Max Jing Rui, Hsu, Fu‐Fei, Lin, Yu‐Chieh, Huang, Hsi‐Chien, Sung, Yun‐Chieh, Huang, Chih‐I, Wu, Ching‐Ling, Chang, Chao‐Hung, Yang, Sheng, Lee, Tsung‐Ying, Wan, Dehui, Wang, Jane, Duda, Dan G., Boucher, Yves, Huang, Jen‐Huang, Ang, Wee Han, and Chen, Yunching

Subjects
CELL death, T cells, INTERLEUKIN-2, ANGIOTENSIN-receptor blockers, REGULATORY T cells, CANCER treatment, HEPATIC fibrosis, PROGRAMMED cell death 1 receptors
Abstract

Interleukin‐2 (IL‐2) is one of the first FDA‐approved immunotherapeutics, but its use is limited by toxicity and low efficacy. In addition, all immunotherapies are limited by the immunosuppressive and desmoplastic microenvironment of "immunologically cold" tumors, such as pancreatic ductal adenocarcinoma (PDAC) or hepatocellular carcinoma (HCC) with advanced liver fibrosis. Here, a new chemoimmunotherapy nanogel (IL2‐Pt@Nanogel) for dual delivery of IL‐2 and the type II immunogenic cell death inducer Pt‐NHC that reduces the immunosuppressive phenotype of tumor‐associated macrophages and diminishes regulatory T cell infiltration by inducing the production of type I interferon (IFN) by cancer cells is reported. Combining the angiotensin II receptor blocker losartan with IL2‐Pt@Nanogel treatment reduces desmoplasia and reprogrammes the microenvironment of PDAC and HCC toward an immunostimulatory one. These effects result in potent anti‐tumor efficacy in models of primary and metastatic PDAC and HCC with underlying liver fibrosis. This study presents a strategy for IL‐2‐based chemoimmunotherapy with the potential for clinical translation to treat solid tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Solution‐Processable Three‐Dimensional Metamaterials with Ultrahigh Broadband Absorption for Photothermal Electronic Conversion.

Author

Tsao, Shao Hsuan, Sun, Aileen Y., Lee, Yang‐Chun, Hwang, Ching‐Wen, Lin, Keng‐Te, Lai, Yu‐Sheng, Yang, Ling‐Chu, Chen, Hsuen‐Li, and Wan, Dehui

Subjects
PHOTOTHERMAL conversion, SURFACE plasmon resonance, METAMATERIALS, PHOTOTHERMAL effect, SCHOTTKY barrier diodes, METALLIC films
Abstract

Metamaterials are promising candidates for broadband light absorbers, but complex manufacturing procedures with expensive instruments have limited their practical applications. Herein, this work develops an all‐solution‐processed three‐dimensional (3D) metamaterial—based on a gold nanocage (GNC)/silk fibroin (SF) nanocomposite thin film—that achieves near‐unity (>94%) and broadband (350–2000 nm) light absorption. At a low particle density, the film exhibits a typical signal for localized surface plasmon resonance (LSPR) absorption at 856 nm, originating from its hollow geometrical shape of GNCs. In contrast, at high particle densities the films display ultrahigh broadband absorption, even in the non‐LSPR regions. This work attributes this behavior to the highly dense GNCs dispersed uniformly in the SF matrix acting optically as extremely fragmented metallic films, thereby retaining the highly absorptive nature of the metal while strongly suppressing its highly reflective properties. Moreover, the metamaterial absorber displays a desirable broadband‐light‐induced photothermal effect when illuminated with a halogen lamp. Finally, investigations into the photothermal electronic properties of this metamaterial combined with an Al/Si Schottky diode reveal an excellent photoresponse and photostability. The as‐designed systems can function at telecommunication wavelengths longer than the typical operation wavelengths of Si‐based devices. Such 3D metamaterial absorbers can be efficient platforms for various photothermal applications. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours

Author

Huang, Hsi-Chien, primary, Sung, Yun-Chieh, additional, Li, Chung-Pin, additional, Wan, Dehui, additional, Chao, Po-Han, additional, Tseng, Yu-Ting, additional, Liao, Bo-Wen, additional, Cheng, Hui-Teng, additional, Hsu, Fu-Fei, additional, Huang, Chieh-Cheng, additional, Chen, Yi-Ting, additional, Liao, Yu-Hui, additional, Hsieh, Hsin Tzu, additional, Shih, Yu-Chuan, additional, Liu, I-Ju, additional, Wu, Han-Chung, additional, Lu, Tsai-Te, additional, Wang, Jane, additional, and Chen, Yunching, additional

Published
2021
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31. Nanoparticle Delivery of MnO2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma

Author

Chang, Chih-Chun, primary, Dinh, Trinh Kieu, additional, Lee, Yi-An, additional, Wang, Fu-Nien, additional, Sung, Yun-Chieh, additional, Yu, Pei-Lun, additional, Chiu, Shao-Chieh, additional, Shih, Yu-Chuan, additional, Wu, Cheng-Yun, additional, Huang, Yi-Da, additional, Wang, Jane, additional, Lu, Tsai-Te, additional, Wan, Dehui, additional, and Chen, Yunching, additional

Published
2020
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35. Reversal of pancreatic desmoplasia by a tumour stroma-targeted nitric oxide nanogel overcomes TRAIL resistance in pancreatic tumours

Author

Huang, Hsi-Chien, Sung, Yun-Chieh, Li, Chung-Pin, Wan, Dehui, Chao, Po-Han, Tseng, Yu-Ting, Liao, Bo-Wen, Cheng, Hui-Teng, Hsu, Fu-Fei, Huang, Chieh-Cheng, Chen, Yi-Ting, Liao, Yu-Hui, Hsieh, Hsin Tzu, Shih, Yu-Chuan, Liu, I-Ju, Wu, Han-Chung, Lu, Tsai-Te, Wang, Jane, and Chen, Yunching

Abstract

ObjectiveStromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), which can selectively induce cancer cell apoptosis. This study aimed to develop a TRAIL-based nanotherapy that not only eliminated the extracellular matrix barrier to increase TRAIL delivery into tumours but also blocked antiapoptotic mechanisms to overcome TRAIL resistance in PDAC.DesignNitric oxide (NO) plays a role in preventing tissue desmoplasia and could thus be delivered to disrupt the stromal barrier and improve TRAIL delivery in PDAC. We applied an in vitro–in vivocombinatorial phage display technique to identify novel peptide ligands to target the desmoplastic stroma in both murine and human orthotopic PDAC. We then constructed a stroma-targeted nanogel modified with phage display-identified tumour stroma-targeting peptides to co-deliver NO and TRAIL to PDAC and examined the anticancer effect in three-dimensional spheroid cultures in vitroand in orthotopic PDAC models in vivo.ResultsThe delivery of NO to the PDAC tumour stroma resulted in reprogramming of activated pancreatic stellate cells, alleviation of tumour desmoplasia and downregulation of antiapoptotic BCL-2 protein expression, thereby facilitating tumour penetration by TRAIL and substantially enhancing the antitumour efficacy of TRAIL therapy.ConclusionThe co-delivery of TRAIL and NO by a stroma-targeted nanogel that remodels the fibrotic tumour microenvironment and suppresses tumour growth has the potential to be translated into a safe and promising treatment for PDAC.

Published
2022
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36. Robust O2Supplementation from a Trimetallic Nanozyme-Based Self-Sufficient Complementary System Synergistically Enhances the Starvation/Photothermal Therapy against Hypoxic Tumors

Author

Wu, Cheng-Yun, Hsu, Yu-Hsuan, Chen, Yunching, Yang, Ling-Chu, Tseng, Shao-Chin, Chen, Wan-Ru, Huang, Chieh-Cheng, and Wan, Dehui

Abstract

Much effort has been focused on novel nanomedicine for cancer therapy. However, tumor hypoxia limits the efficacy of various cancer therapeutics. Herein, we constructed a self-sufficient hybrid enzyme-based silk fibroin hydrogel system, consisting of Pt-decorated hollow Ag–Au trimetallic nanocages (HGN@Pt) and glucose oxidase (GOx), to supply O2continuously and consume glucose concurrently and, thereby, synergistically enhance the anti-cancer efficacy of a combined starvation and photothermal therapy operating in a hypoxic tumor microenvironment. Thanks to the cooperative effects of the active surface atoms (resulting from the island-like features of the Pt coating), the intrinsically hollow structure, and the strain effect induced by the trimetallic composition, HGN@Pt displayed efficient catalase-like activity. The enhancement in the generation of O2through the decomposition of H2O2mediated by the as-designed nanozyme was greater than 400% when compared with that of hollow Ag–Pt bimetallic nanospheres or tiny Pt nanoparticles. Moreover, in the presence of HGN@Pt, significant amounts of O2could be generated within a few minutes, even in an acidic buffer solution (pH 5.8–6.5) containing a low concentration of H2O2(100–500 μM). Because HGN@Pt exhibited a strong surface plasmon resonance peak in the near-infrared wavelength range, it could be used as a photothermal agent for hyperthermia therapy. Furthermore, GOx was released gradually from the SF hydrogel into the tumor microenvironment to mediate the depletion of glucose, leading to glucose starvation-induced cancer cell death. Finally, the O2supplied by HGN@Pt overcame the hypoxia of the microenvironment and, thereby, promoted the starvation therapeutic effect of the GOx-mediated glucose consumption. Meanwhile, the GOx-produced H2O2from the oxidation of glucose could be used to regenerate O2and, thereby, construct a complementary circulatory system. Accordingly, this study presents a self-sufficient hybrid enzyme-based system that synergistically alleviates tumor hypoxia and induces an anti-cancer effect when combined with irradiation of light from a near-infrared laser.

Published
2021
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41. Nanoparticle Delivery of MnO2and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma

Author

Chang, Chih-Chun, Dinh, Trinh Kieu, Lee, Yi-An, Wang, Fu-Nien, Sung, Yun-Chieh, Yu, Pei-Lun, Chiu, Shao-Chieh, Shih, Yu-Chuan, Wu, Cheng-Yun, Huang, Yi-Da, Wang, Jane, Lu, Tsai-Te, Wan, Dehui, and Chen, Yunching

Abstract

Antiangiogenic therapy is widely administered in many cancers, and the antiangiogenic drug sorafenib offers moderate benefits in advanced hepatocellular carcinoma (HCC). However, antiangiogenic therapy can also lead to hypoxia-driven angiogenesis and immunosuppression in the tumor microenvironment (TME) and metastasis. Here, we report the synthesis and evaluation of NanoMnSor, a tumor-targeted, nanoparticle drug carrier that efficiently codelivers oxygen-generating MnO2and sorafenib into HCC. We found that MnO2not only alleviates hypoxia by catalyzing the decomposition of H2O2to oxygen but also enhances pH/redox-responsive T1-weighted magnetic resonance imaging and drug-release properties upon decomposition into Mn2+ions in the TME. Moreover, macrophages exposed to MnO2displayed increased mRNA associated with the immunostimulatory M1 phenotype. We further show that NanoMnSor treatment leads to sorafenib-induced decrease in tumor vascularization and significantly suppresses primary tumor growth and distal metastasis, resulting in improved overall survival in a mouse orthotopic HCC model. Furthermore, NanoMnSor reprograms the immunosuppressive TME by reducing the hypoxia-induced tumor infiltration of tumor-associated macrophages, promoting macrophage polarization toward the immunostimulatory M1 phenotype, and increasing the number of CD8+cytotoxic T cells in tumors, thereby augmenting the efficacy of anti-PD-1 antibody and whole-cell cancer vaccine immunotherapies. Our study demonstrates the potential of oxygen-generating nanoparticles to deliver antiangiogenic agents, efficiently modulate the hypoxic TME, and overcome hypoxia-driven drug resistance, thereby providing therapeutic benefit in cancer.

Published
2020
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