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1. Genetic diversity and population structure of Plasmodium falciparum in Nigeria: insights from microsatellite loci analysis

Author

Ajogbasile, Fehintola V., Kayode, Adeyemi T., Oluniyi, Paul E., Akano, Kazeem O., Uwanibe, Jessica N., Adegboyega, Benjamin B., Philip, Courage, John, Oluwagboadurami G., Eromon, Philomena J., Emechebe, George, Finimo, Finimo, Ogbulafor, Nnenna, Jiya, Nma, Okafor, Uche, Ambe, Jose, Wammanda, Robinson D., Oguche, Stephen, Mokuolu, Olugbenga A., Sowunmi, Akintunde, Folarin, Onikepe A., and Happi, Christian T.

Published
2021
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2. Incidence of possible serious bacterial infection in young infants in the three high-burden countries of the Democratic Republic of the Congo, Kenya, and Nigeria: A secondary analysis of a large, multi-country, multi-centre clinical trial

Author

Lokangaka, Adrien, primary, Ramani, Manimaran, additional, Bauserman, Melissa, additional, Patterson, Jackie, additional, Engmann, Cyril, additional, Tshefu, Antoinette, additional, Cousens, Simons, additional, Qazi, Shamim Ahmad, additional, Ayede, Adejumoke Idowu, additional, Adejuyigbe, Ebunoluwa A, additional, Esamai, Fabian, additional, Wammanda, Robinson D, additional, Nisar, Yasir Bin, additional, and Coppieters, Yves, additional

Published
2024
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3. Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE-NI): an extension of the STROBE statement for neonatal infection research

Author

Fitchett, Elizabeth J A, Seale, Anna C, Vergnano, Stefania, Sharland, Michael, Heath, Paul T, Saha, Samir K, Agarwal, Ramesh, Ayede, Adejumoke I, Bhutta, Zulfiqar A, Black, Robert, Bojang, Kalifa, Campbell, Harry, Cousens, Simon, Darmstadt, Gary L, Madhi, Shabir A, Meulen, Ajoke Sobanjo-ter, Modi, Neena, Patterson, Janna, Qazi, Shamim, Schrag, Stephanie J, Stoll, Barbara J, Wall, Stephen N, Wammanda, Robinson D, and Lawn, Joy E

Published
2016
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4. Incidence of possible serious bacterial infection in young infants in the three high-burden countries of the Democratic Republic of the Congo, Kenya, and Nigeria: A secondary analysis of a large, multicountry, multi-centre clinical trial.

Author

Lokangaka, Adrien, Ramani, Manimaran, Bauserman, Melissa, Patterson, Jackie, Engmann, Cyril, Tshefu, Antoinette, Cousens, Simons, Qazi, Shamim Ahmad, Ayede, Adejumoke Idowu, Adejuyigbe, Ebunoluwa A., Esamai, Fabian, Wammanda, Robinson D., Nisar, Yasir Bin, and Coppieters, Yves

Subjects
RISK assessment, RESEARCH funding, SECONDARY analysis, BACTERIAL diseases in children, BACTERIAL diseases, QUALITY assurance
Abstract

Background Neonatal infections are a major public health concern worldwide, particularly in low- and middle-income countries, where most of the infection-related deaths in under-five children occur. Sub-Saharan Africa has the highest mortality rates, but there is a lack of data on the incidence of sepsis from this region, hindering efforts to improve child survival. We aimed to determine the incidence of possible serious bacterial infection (PSBI) in young infants in three high-burden countries in Africa. Methods This is a secondary analysis of data from the African Neonatal Sepsis (AFRINEST) trial, conducted in the Democratic Republic of the Congo (DRC), Kenya, and Nigeria between 15 March 2012 and 15 July 2013. We recorded baseline characteristics, the incidence of PSBI (as defined by the World Health Organization), and the incidence of local infections among infants from 0–59 days after birth. We report descriptive statistics. Results The incidence of PSBI among 0–59-dayold infants across all three countries was 11.2% (95% confidence interval (CI)=11.0–11.4). The DRC had the highest incidence of PSBI (19.0%; 95% CI=18.2–19.8). Likewise, PSBI rates were higher in low birth weight infants (24.5%; 95% CI = 23.1–26.0) and infants born to mothers aged <20 years (14.1%; 95% CI=13.4–14.8). The incidence of PSBI was higher among infants delivered at home (11.7%; 95% CI=11.4–12.0). Conclusions The high burden of PSBI among young infants in DRC, Kenya, and Nigeria demonstrates the importance of addressing PSBI in improving child survival in sub-Saharan Africa to reach the Sustainable Development Goals (SDGs). These data can support government authorities, policymakers, programme implementers, non-governmental organisations, and international partners in reducing preventable under-five deaths. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Oral amoxicillin compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with fast breathing when referral is not possible: a randomised, open-label, equivalence trial

Author

Tshefu, Antoinette, Lokangaka, Adrien, Ngaima, Serge, Engmann, Cyril, Esamai, Fabian, Gisore, Peter, Ayede, Adejumoke Idowu, Falade, Adegoke Gbadegesin, Adejuyigbe, Ebunoluwa A, Anyabolu, Chineme Henry, Wammanda, Robinson D, Ejembi, Clara L, Ogala, William N, Gram, Lu, and Cousens, Simon

Published
2015
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6. Simplified antibiotic regimens compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with clinical signs of possible serious bacterial infection when referral is not possible: a randomised, open-label, equivalence trial

Author

Tshefu, Antoinette, Lokangaka, Adrien, Ngaima, Serge, Engmann, Cyril, Esamai, Fabian, Gisore, Peter, Ayede, Adejumoke Idowu, Falade, Adegoke Gbadegesin, Adejuyigbe, Ebunoluwa A, Anyabolu, Chineme Henry, Wammanda, Robinson D, Ejembi, Clara L, Ogala, William N, Gram, Lu, and Cousens, Simon

Published
2015
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8. Oral amoxicillin plus gentamicin regimens may be superior to the procaine-penicillin plus gentamicin regimens for treatment of young infants with possible serious bacterial infection when referral is not feasible: Pooled analysis from three trials in Africa and Asia

Author

Longombe, Adrien Lokangaka, primary, Ayede, Adejumoke Idowu, additional, Marete, Irene, additional, Mir, Fatima, additional, Ejembi, Clara Ladi, additional, Shahidullah, Mohammod, additional, Adejuyigbe, Ebunoluwa A, additional, Wammanda, Robinson D, additional, Tshefu, Antoinette, additional, Esamai, Fabian, additional, Zaidi, Anita K, additional, Baqui, Abdullah H, additional, and Cousens, Simon, additional

Published
2022
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10. Molecular profiling of the artemisinin resistance Kelch 13 gene in Plasmodium falciparum from Nigeria

Author

Ajogbasile, Fehintola V., primary, Oluniyi, Paul E., additional, Kayode, Adeyemi T., additional, Akano, Kazeem O., additional, Adegboyega, Benjamin B., additional, Philip, Courage, additional, Ogbulafor, Nnenna, additional, Okafor, Henrietta U., additional, Oguche, Stephen, additional, Wammanda, Robinson D., additional, Mokuolu, Olugbenga A., additional, Folarin, Onikepe A., additional, and Happi, Christian T., additional

Published
2022
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11. Clinical signs of possible serious infection and associated mortality among young infants presenting at first-level health facilities

Author

Nisar, Yasir Bin, primary, Tshefu, Antoinette, additional, Longombe, Adrien Lokangaka, additional, Esamai, Fabian, additional, Marete, Irene, additional, Ayede, Adejumoke Idowu, additional, Adejuyigbe, Ebunoluwa A., additional, Wammanda, Robinson D., additional, Qazi, Shamim Ahmad, additional, and Bahl, Rajiv, additional

Published
2021
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12. Costs and cost-effectiveness of management of possible serious bacterial infections in young infants in outpatient settings when referral to a hospital was not possible: Results from randomized trials in Africa

Author

Garg, Charu C., primary, Tshefu, Antoinette, additional, Longombe, Adrien Lokangaka, additional, Kila, Jean-Serge Ngaima, additional, Esamai, Fabian, additional, Gisore, Peter, additional, Ayede, Adejumoke Idowu, additional, Falade, Adegoke Gbadegesin, additional, Adejuyigbe, Ebunoluwa A., additional, Anyabolu, Chineme Henry, additional, Wammanda, Robinson D., additional, Hyellashelni, Joshua Daba, additional, Yoshida, Sachiyo, additional, Gram, Lu, additional, Nisar, Yasir Bin, additional, Qazi, Shamim Ahmad, additional, and Bahl, Rajiv, additional

Published
2021
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13. Prevalence of clinical signs of possible serious bacterial infection and mortality associated with them from population-based surveillance of young infants from birth to 2 months of age

Author

Puri, Dhruv, primary, Nisar, Yasir Bin, additional, Tshefu, Antoinette, additional, Longombe, Adrien Lokangaka, additional, Esamai, Fabian, additional, Marete, Irene, additional, Ayede, Adejumoke Idowu, additional, Adejuyigbe, Ebunoluwa A., additional, Wammanda, Robinson D., additional, Qazi, Shamim Ahmad, additional, and Bahl, Rajiv, additional

Published
2021
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14. Genetic Diversity and Population Structure of Plasmodium Falciparum in Nigeria: Insights From Microsatellites Loci Analysis

Author

Ajogbasile, Fehintola Victoria, primary, Kayode, Adeyemi T., additional, Akano, Kazeem O., additional, Oluniyi, Paul E., additional, Uwanibe, Jessica N., additional, Adegboyega, Benjamin B., additional, Philip, Courage, additional, John, Oluwagboadurami G., additional, Eromon, Philomena J., additional, Emechebe, George, additional, Finimo, Finimo, additional, Ogbulafor, Nnenna, additional, Jiya, Nma, additional, Okafor, Uche, additional, Ambe, Jose, additional, Wammanda, Robinson D., additional, Oguche, Stephen, additional, Mokuolu, Olugbenga A., additional, Sowunmi, Akintunde, additional, Folarin, Onikepe A., additional, and Happi, Christian T., additional

Published
2020
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15. Ensuring Quality in AFRINEST and SATT

Author

Wall, Stephen N., Mazzeo, Corinne I., Adejuyigbe, Ebunoluwa A., Ayede, Adejumoke I., Bahl, Rajiv, Baqui, Abdullah H., Blackwelder, William C., Brandes, Neal, Darmstadt, Gary L., Esamai, Fabian, Hibberd, Patricia L., Jacobs, Marian, Klein, Jerome O., Mwinga, Kasonde, Rollins, Nigel Campbell, Saloojee, Haroon, Tshefu, Antoinette Kitoto, Wammanda, Robinson D., Zaidi, Anita K. M., and Qazi, Shamim Ahmad

Subjects
Community Health Workers, Quality Control, Bangladesh, Biomedical Research, Infant, Newborn, quality assurance, community-based research, Infant, Newborn, Diseases, Anti-Bacterial Agents, Checklist, Epidemiologic Research Design, Sepsis, trial monitoring, Humans, Pakistan, Community Health Services, Africa South of the Sahara, Supplement, Randomized Controlled Trials as Topic
Abstract

Background: Three randomized open-label clinical trials [Simplified Antibiotic Therapy Trial (SATT) Bangladesh, SATT Pakistan and African Neonatal Sepsis Trial (AFRINEST)] were developed to test the equivalence of simplified antibiotic regimens compared with the standard regimen of 7 days of parenteral antibiotics. These trials were originally conceived and designed separately; subsequently, significant efforts were made to develop and implement a common protocol and approach. Previous articles in this supplement briefly describe the specific quality control methods used in the individual trials; this article presents additional information about the systematic approaches used to minimize threats to validity and ensure quality across the trials. Methods: A critical component of quality control for AFRINEST and SATT was striving to eliminate variation in clinical assessments and decisions regarding eligibility, enrollment and treatment outcomes. Ensuring appropriate and consistent clinical judgment was accomplished through standardized approaches applied across the trials, including training, assessment of clinical skills and refresher training. Standardized monitoring procedures were also applied across the trials, including routine (day-to-day) internal monitoring of performance and adherence to protocols, systematic external monitoring by funding agencies and external monitoring by experienced, independent trial monitors. A group of independent experts (Technical Steering Committee/Technical Advisory Group) provided regular monitoring and technical oversight for the trials. Conclusions: Harmonization of AFRINEST and SATT have helped to ensure consistency and quality of implementation, both internally and across the trials as a whole, thereby minimizing potential threats to the validity of the trials’ results.

Published
2013

16. Status of the use and compliance with malaria rapid diagnostic tests in formal private health facilities in Nigeria

Author

Mokuolu, Olugbenga A., primary, Ntadom, Godwin N., additional, Ajumobi, Olufemi O., additional, Alero, Roberts A., additional, Wammanda, Robinson D., additional, Adedoyin, Olanrewaju T., additional, Okafor, Henrietta U., additional, Alabi, Adekunle D., additional, Odey, Friday A., additional, Agomo, Chimere O., additional, Edozieh, Kate U., additional, Fagbemi, Tolulope O., additional, Njidda, Ahmad M., additional, Babatunde, Seye, additional, Agbo, Emmanuel C., additional, Nwaneri, Nnamdi B., additional, Shekarau, Emmanuel D., additional, Obasa, Temitope O., additional, and Ezeigwe, Nnenna M., additional

Published
2016
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18. Pediatric Cerebral Palsy in Africa

Author

Donald, Kirsten A., primary, Kakooza, Angelina M., additional, Wammanda, Robinson D., additional, Mallewa, Macpherson, additional, Samia, Pauline, additional, Babakir, Haydar, additional, Bearden, David, additional, Majnemer, Annette, additional, Fehlings, Darcy, additional, Shevell, Michael, additional, Chugani, Harry, additional, and Wilmshurst, Jo M., additional

Published
2014
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19. Ongoing Trials of Simplified Antibiotic Regimens for the Treatment of Serious Infections in Young Infants in South Asia and Sub-Saharan Africa

Author

Esamai, Fabian, primary, Tshefu, Antoinette Kitoto, additional, Ayede, Adejumoke I., additional, Adejuyigbe, Ebunoluwa A., additional, Wammanda, Robinson D., additional, Baqui, Abdullah H., additional, Zaidi, Anita K. M., additional, Saha, Samir, additional, Rollins, Nigel Campbell, additional, Wall, Stephen, additional, Brandes, Neal, additional, Engmann, Cyril, additional, Darmstadt, Gary, additional, Qazi, Shamim Ahmad, additional, and Bahl, Rajiv, additional

Published
2013
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20. Scientific Rationale for Study Design of Community-based Simplified Antibiotic Therapy Trials in Newborns and Young Infants With Clinically Diagnosed Severe Infections or Fast Breathing in South Asia and sub-Saharan Africa

Author

Zaidi, Anita K. M., primary, Baqui, Abdullah H., additional, Qazi, Shamim Ahmad, additional, Bahl, Rajiv, additional, Saha, Samir, additional, Ayede, Adejumoke I., additional, Adejuyigbe, Ebunoluwa A., additional, Engmann, Cyril, additional, Esamai, Fabian, additional, Tshefu, Antoinette Kitoto, additional, Wammanda, Robinson D., additional, Falade, Adegoke G., additional, Odebiyi, Adetanwa, additional, Gisore, Peter, additional, Longombe, Adrien Lokangaka, additional, Ogala, William N., additional, Tikmani, Shiyam Sundar, additional, Uddin Ahmed, A. S. M. Nawshad, additional, Wall, Steve, additional, Brandes, Neal, additional, Roth, Daniel E., additional, and Darmstadt, Gary L., additional

Published
2013
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21. Children With Epilepsy in Africa

Author

Wilmshurst, Jo M., primary, Cross, J. Helen, additional, Newton, Charles, additional, Kakooza, Angelina M., additional, Wammanda, Robinson D., additional, Mallewa, Macpherson, additional, Samia, Pauline, additional, Venter, Andre, additional, Hirtz, Deborah, additional, and Chugani, Harry, additional

Published
2013
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23. Child Neurology Services in Africa

Author

Wilmshurst, Jo M., primary, Badoe, Eben, additional, Wammanda, Robinson D., additional, Mallewa, Macpherson, additional, Kakooza-Mwesige, Angelina, additional, Venter, Andre, additional, and Newton, Charles R., additional

Published
2011
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24. Pediatric Cerebral Palsy in Africa: Where Are We?

Author

Donald, Kirsten A., Kakooza, Angelina M., Wammanda, Robinson D., Mallewa, Macpherson, Samia, Pauline, Babakir, Haydar, Bearden, David, Majnemer, Annette, Fehlings, Darcy, Shevell, Michael, Chugani, Harry, and Wilmshurst, Jo M.

Subjects
CEREBRAL palsy, CHILDREN with cerebral palsy, DISEASE prevalence, ETIOLOGY of diseases, CHILDREN
Abstract

Cerebral palsy is the most common cause of physical disability in children worldwide. However, little is reported on this condition in the African context. Doctors from 22 countries in Africa, and representatives from a further 5 countries outside Africa, met to discuss the challenges in the evaluation and management of children with cerebral palsy in Africa and to propose service needs and further research. Basic care is limited by the poor availability of diagnostic facilities or medical personnel with experience and expertise in managing cerebral palsy, exacerbated by lack of available interventions such as medications, surgical procedures, or even regular therapy input. Relevant guidelines are lacking. In order to guide services for children with existing disabilities, to effectively target the main etiologies and to develop preventive strategies for the continent, research priorities must include multicenter collaborative studies looking at the prevalence, risk factors, and treatment of cerebral palsy. [ABSTRACT FROM PUBLISHER]

Published
2015
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