150 results on '"Wambre, Erik"'
Search Results
2. Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy
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Kim, Edwin H., Nadeau, Kari C., Nowak-Wegrzyn, Anna, Wood, Robert A., Sampson, Hugh A., Scurlock, Amy M., Chinthrajah, Sharon, Wang, Julie, Pesek, Robert D., Sindher, Sayantani B., Kulis, Mike, Johnson, Jacqueline, Spain, Katharine, Babineau, Denise C., Chin, Hyunsook, Laurienzo-Panza, Joy, Rachel Yan, Larson, David, Tielin Qin, Whitehouse, Don, Sever, Michelle L., Sanda, Srinath, Plaut, Marshall, Wheatley, Lisa M., Wesley Burks, A., Marchesini, Gina, Gilroy, Kavitha, Posso, Sylvia, Skiba, Sabrina, Nguyen, Thien-Son, Wojno, Adam, Nguyen, Tuan, Gersuk, Vivian, Nguyen, Quynh-Anh, Garber, Jessica, O’Brien, Kimberly, Larson, Brandon, Cousens-Jacobs, C., Hu, Alex, Calise, Justine, DeBerg, Hannah, Garabatos, Nahir, Khosa, Sugandhika, Bajzik, Veronique, Calderon, Lorena Botero, Aldridge, Kelly, Rosasco, Mario, Ferslew, Brian C., Zhu, Tong, Smulders, Ronald, Laidlaw, Tanya M., Qin, Tielin, Chichili, Gurunadh R., Adelman, Daniel C., Farrington, Mary, Robinson, David, Jeong, David, Jones, Stacie M., Kwok, William W., Baloh, Carolyn, Nepom, Gerald T., and Wambre, Erik
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- 2023
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3. Safety and immunopharmacology of ASP0892 in adults or adolescents with peanut allergy: two randomized trials
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Ferslew, Brian C., primary, Smulders, Ronald, additional, Zhu, Tong, additional, Blauwet, Mary B., additional, Kusawake, Tomohiro, additional, Spence, Anna, additional, Aldridge, Kelly, additional, DeBerg, Hannah A., additional, Khosa, Sugandhika, additional, Wambre, Erik, additional, and Chichili, Gurunadh R., additional
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- 2023
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4. T cells specific to multiple Bet v 1 peptides are highly cross-reactive toward the corresponding peptides from the homologous group of tree pollens
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Lund, Gitte, primary, Christensen, Lars Harder, additional, Ihlemann, Jacob, additional, Andersen, Peter Sejer, additional, Wambre, Erik, additional, Würtzen, Peter Adler, additional, and Gupta, Shashank, additional
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- 2023
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5. Mechanisms and predictive biomarkers of allergen immunotherapy in the clinic
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Layhadi, Janice A., primary, Lalioti, Anastasia, additional, Palmer, Elizabeth, additional, van Zelm, Menno C., additional, Wambre, Erik, additional, and Shamji, Mohamed H., additional
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- 2023
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6. Oral Tolerance Development and Maintenance
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Wambre, Erik and Jeong, David
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- 2018
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7. Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy.
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Voskamp, Astrid L., Khosa, Sugandhika, Phan, Tracy, DeBerg, Hannah A., Bingham, Judy, Hew, Mark, Smith, William, Abramovitch, Jodie, Rolland, Jennifer M., Moyle, Matthew, Nadeau, Kari C., Lack, Gideon, Larché, Mark, Wambre, Erik, O'Hehir, Robyn E., Hickey, Pascal, and Prickett, Sara R.
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PEANUT allergy ,PEPTIDES ,FOOD allergy ,ALLERGIES ,IMMUNOTHERAPY ,ALLERGENS ,IMMUNOGLOBULIN E - Abstract
Background: Food allergy is a leading cause of anaphylaxis worldwide. Allergen‐specific immunotherapy is the only treatment shown to modify the natural history of allergic disease, but application to food allergy has been hindered by risk of severe allergic reactions and short‐lived efficacy. Allergen‐derived peptides could provide a solution. PVX108 comprises seven short peptides representing immunodominant T‐cell epitopes of major peanut allergens for treatment of peanut allergy. Methods: Pre‐clinical safety of PVX108 was assessed using ex vivo basophil activation tests (n = 185). Clinical safety and tolerability of single and repeat PVX108 doses were evaluated in a first‐in‐human, randomized, double‐blind, placebo‐controlled trial in peanut‐allergic adults (46 active, 21 placebo). The repeat‐dose cohort received six doses over 16 weeks with safety monitored to 21 weeks. Exploratory immunological analyses were performed at pre‐dose, Week 21 and Month 18 after treatment. Results: PVX108 induced negligible activation of peanut‐sensitised basophils. PVX108 was safe and well tolerated in peanut‐allergic adults. There were no treatment‐related hypersensitivity events or AEs of clinical concern. The only events occurring more frequently in active than placebo were mild injection site reactions. Exploratory immunological analyses revealed a decrease in the ratio of ST2+ Th2A:CCR6+ Th17‐like cells within the peanut‐reactive Th pool which strengthened following treatment. Conclusion: This study supports the concept that PVX108 could provide a safe alternative to whole peanut immunotherapies and provides evidence of durable peanut‐specific T‐cell modulation. Translation of these findings to clinical efficacy in ongoing Phase 2 trials would provide important proof‐of‐concept for using peptides to treat food allergy. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Safety and immunopharmacology of ASP0892 in adults or adolescents with peanut allergy: two randomized trials.
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Ferslew, Brian C., Smulders, Ronald, Zhu, Tong, Blauwet, Mary B., Kusawake, Tomohiro, Spence, Anna, Aldridge, Kelly, DeBerg, Hannah A., Khosa, Sugandhika, Wambre, Erik, and Chichili, Gurunadh R.
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TERMINATION of treatment ,PEANUT allergy ,ADULTS ,TEENAGERS ,IMMUNOPHARMACOLOGY ,DNA vaccines - Abstract
Background: New treatment options with improved safety and novel mechanisms of actions are needed for patients with peanut allergy. Objectives: To evaluate the safety, tolerability, and immunogenicity of ASP0892, a peanut DNA vaccine, after intradermal (id) or intramuscular (im) administration in adult or adolescent patients with peanut allergy in two phase 1 studies. Methods: ASP0892 or placebo was administered every 2 weeks for a total of 4 doses. The doses were 1 mg or 4 mg id or 4 mg im for adults, and 1 mg or 4 mg id for adolescents. Immunologic parameters were assessed longitudinally. Results: Thirty‐one adults (mean age 24.3 years, 17 males) received ASP0892 (9, 8, 8 patients for 1 mg id, 4 mg id or 4 mg im, respectively) or placebo (2 patients/group). Twenty adolescents (mean age 14.2 years, 11 males) received ASP0892 (8 patients/group) or placebo (2 patients/group). In both studies, the most common treatment‐emergent adverse event (TEAE) was injection site pruritus. No deaths or treatment withdrawal were related to TEAEs. No serious TEAEs related to treatment were observed in adult or adolescent patients. ASP0892 treatment led to modest increases in allergen‐specific IgG and/or IgG4 in adults (1 mg id, 4 mg im) and adolescents (1 mg id, 4 mg id). No improvements in clinical outcomes, including double‐blind placebo‐controlled food challenge, were found after ASP0892 treatment. Conclusions: In two phase 1 studies, ASP0892 was well tolerated with modest but not clinically relevant changes in immune responses. ClinicalTrials.gov Identifiers NCT02851277, NCT03755713. [ABSTRACT FROM AUTHOR]
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- 2024
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9. The Use of pMHCII Tetramer Technology for the Identification and Characterization of CD4+ T Cells
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Wambre, Erik, primary
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- 2019
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10. Chronic cat allergen exposure induces a TH2 cell–dependent IgG4 response related to low sensitization
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Renand, Amedee, Archila, Luis D., McGinty, John, Wambre, Erik, Robinson, David, Hales, Belinda J., Thomas, Wayne R., and Kwok, William W.
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- 2015
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11. Biomarkers for antigen immunotherapy in allergy and type 1 diabetes
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Odegard, Jared M., Nepom, Gerald T., and Wambre, Erik
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- 2015
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12. Human Immune Monitoring Techniques during Food Allergen Immunotherapy
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Rust, Blake and Wambre, Erik
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- 2017
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13. Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner
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Wambre, Erik, DeLong, Jonathan H., James, Eddie A., Torres-Chinn, Nadia, Pfützner, Wolfgang, Möbs, Christian, Durham, Stephen R., Till, Stephen J., Robinson, David, and Kwok, William W.
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- 2014
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14. Immune mechanisms of oral immunotherapy
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Kulis, Michael D., Patil, Sarita U., Wambre, Erik, and Vickery, Brian P.
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- 2018
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15. Oral desensitization therapy for peanut allergy induces dynamic changes in peanut‐specific immune responses
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Bajzik, Veronique, primary, DeBerg, Hannah A., additional, Garabatos, Nahir, additional, Rust, Blake J., additional, Obrien, Kimberly K., additional, Nguyen, Quynh‐Anh, additional, O’Rourke, Colin, additional, Smith, Alex, additional, Walker, Alex H., additional, Quinn, Charlie, additional, Gersuk, Vivian H., additional, Farrington, Mary, additional, Jeong, David, additional, Vickery, Brian P., additional, Adelman, Daniel C., additional, and Wambre, Erik, additional
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- 2022
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16. Ara h 1–reactive T cells in individuals with peanut allergy
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DeLong, Jonathan H., Simpson, Kelly Hetherington, Wambre, Erik, James, Eddie A., Robinson, David, and Kwok, William W.
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- 2011
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17. Clinical and immunological evaluation of cat‐allergic asthmatics living with or without a cat
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Wambre, Erik R., primary, Farrington, Mary, additional, Bajzik, Veronique, additional, DeBerg, Hannah A., additional, Ruddy, Marcella, additional, DeVeaux, Michelle, additional, Meier, Pretty, additional, Robinson, David, additional, Cantor, Matt, additional, Huang, Chengrui, additional, Orengo, Jamie M., additional, Wang, Claire Q., additional, and Radin, Allen, additional
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- 2021
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18. Optimal human pathogenic TH2 cell effector function requires local epithelial cytokine signaling
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Calise, Justine, primary, Garabatos, Nahir, additional, Bajzik, Veronique, additional, Farrington, Mary, additional, Robinson, David, additional, Jeong, David, additional, Londei, Marco, additional, and Wambre, Erik, additional
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- 2021
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19. Activation of natural regulatory T cells by IgG Fc–derived peptide “Tregitopes”
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De Groot, Anne S., Moise, Leonard, McMurry, Julie A., Wambre, Erik, Van Overtvelt, Laurence, Moingeon, Philippe, Scott, David W., and Martin, William
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- 2008
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20. Erratum to: Human Immune Monitoring Techniques during Food Allergen Immunotherapy
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Rust, Blake J. and Wambre, Erik
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- 2017
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21. Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells
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Renand, Amedee, Newbrough, Sally, Wambre, Erik, DeLong, Jonathan H., Robinson, David, and Kwok, William W.
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- 2014
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22. Clinical and immunological evaluation of cat-allergic asthmatics living with or without a cat
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Wambre, Erik, primary, Bajzik, Veronique, additional, DeVeaux, Michelle, additional, Meier, Pretty, additional, Ruddy, Marcella, additional, DeBerg, Hannah, additional, Wang, Claire Q, additional, Farrington, Mary, additional, and Radin, Allen, additional
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- 2020
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23. Development of peanut allergy is associated with coding SNPs in the C-terminus of the IL-33 receptor that impact signaling and TH2 effector function
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Cerosaletti, Karen, primary, Chen, Janice, additional, Johnson, Eleanor, additional, Garabatos, Nahir, additional, Calise, Justine, additional, Robinson, David, additional, Jeong, David, additional, Farrington, Mary, additional, Winters, Alex, additional, Mathias, Rasika, additional, Lim, Noha, additional, Nepom, Gerald, additional, Londei, Marco, additional, Wambre, Erik, additional, and Ziegler, Steven, additional
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- 2020
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24. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
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Wambre, Erik, DeLong, Jonathan H., James, Eddie A., LaFond, Rebecca E., Robinson, David, and Kwok, William W.
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- 2012
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25. Direct ex vivo analysis of allergen-specific CD4+ T cells
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Kwok, William W., Roti, Michelle, DeLong, Jonathan H., Tan, Venus, Wambre, Erik, James, Eddie A., and Robinson, David
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- 2010
26. Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects
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Lombardi, Vincent, Beuraud, Chloé, Neukirch, Catherine, Moussu, Hélène, Morizur, Lise, Horiot, Stéphane, Luce, Sonia, Wambre, Erik, Linsley, Peter, Chollet-Martin, Sylvie, Baron-Bodo, Véronique, Aubier, Michel, and Moingeon, Philippe
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- 2016
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27. T cell function test in food allergy
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Wambre, Erik
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- 2016
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28. Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers
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Menard, Laurence C., primary, Fischer, Paul, additional, Kakrecha, Bijal, additional, Linsley, Peter S., additional, Wambre, Erik, additional, Liu, Maochang C., additional, Rust, Blake J., additional, Lee, Deborah, additional, Penhallow, Becky, additional, Manjarrez Orduno, Nataly, additional, and Nadler, Steven G., additional
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- 2018
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29. Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects
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Renand, Amedee, primary, Farrington, Marry, additional, Whalen, Elizabeth, additional, Wambre, Erik, additional, Bajzik, Veronique, additional, Chinthrajah, Sharon, additional, Nadeau, Kari C., additional, and Kwok, William W., additional
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- 2018
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30. Synchronous immune alterations mirror clinical response during allergen immunotherapy
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Renand, Amedee, primary, Shamji, Mohamed H., additional, Harris, Kristina M., additional, Qin, Tielin, additional, Wambre, Erik, additional, Scadding, Guy W., additional, Wurtzen, Peter A., additional, Till, Stephen J., additional, Togias, Alkis, additional, Nepom, Gerald T., additional, Kwok, William W., additional, and Durham, Stephen R., additional
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- 2018
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31. Targeting IL-33 in Food Allergy: Toward patient stratification
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Wambre, Erik R., primary, Garabatos Leitón, Nahir, additional, Bajzik, Veronique, additional, Londei, Marco, additional, Cerosaletti, Karen, additional, and Ziegler, Steven, additional
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- 2018
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32. A distinct T helper subset contributes to the pathogenesis of classical Th2-mediated food allergy disorders
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Garabatos, Nahir, primary, Bajzik, Veronique, additional, DeBerg, Hannah, additional, and Wambre, Erik R., additional
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- 2018
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33. Dynamics of antigen-specific T effector and T regulatory cell responses during pollen allergy season
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Rust, Blake J., primary, DeBerg, Hannah, additional, and Wambre, Erik R., additional
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- 2018
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34. Biomarkers of T cell responses in allergic diseases
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Wambre, Erik, primary
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- 2018
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35. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel, Guillaume, Claverie, Claire, Labreuche, Julien, Renaudin, Jean-Marie, Dorkenoo, Aimée, Eb, Mireille, Moneret-Vautrin, Anne, Deschildre, Antoine, Leteurtre, Stephane, Grabenhenrich, Linus, Worm, Margitta, Dölle, Sabine, Scherer, Kathrin, Hutteger, Isidor, Christensen, Morten, Bindslev-Jensen, Carsten, Mortz, Charlotte, Eller, Esben, Kjaer, Henrik F, Carneiro-Leão, Leonor, Badas, Jenny, Coimbra, Alice, Levy, Dikla P, Ben-Shoshan, Moshe, Rimon, Ayelet, Benor, Shira, Arends, Nicolette J T, Edelbroek, Nikki, de Groot, Hans, Emons, Joyce A M, Brand, H. K A, Verhoeven, Dirk, van Veen, Leonieke N, de Jong, Nicolette W, Noh, Geunwoong, Jang, Eun H, Pascal, Mariona, Dominguez, Olga, Piquer, Mònica, Alvaro, Montserrat, Jimenez-Feijoo, Rosa, Lozano, Jaime, Machinena, Adriana, del Mar Folqué, Maria, Giner, Maria T, Plaza, Ana M, Turner, Paul, Patel, Nandinee, Vazquez-Ortiz, Marta, Lindsley, Sarah, Walker, Lucy, Rosenberg, Simon, Mari, Adriano, Alessandri, Claudia, Giangrieco, Ivana, Tuppo, Lisa, Rafaiani, Chiara, Mitterer, Georg, Ciancamerla, Michela, Ferrara, Rosetta, Bernardi, Maria L, Zennaro, Danila, Tamburrini, Maurizio, Ciardiello, Maria A, Harwanegg, Christian, Fernandez, Antonio, Selb, Regina, Egenmann, Philippe, Epstein, Michelle, Hoffmann-Sommergruber, Karin, Koning, Frits, Lovik, Martinus, Clare Mills, E. N, Moreno, Javier, van Loveren, Henk, Wal, Jean-Michel, Diesner, Susanne, Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera E, Starkl, Philipp, Endesfelder, David, Eiwegger, Thomas, Szepfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, Untersmayr, Eva, Wille, Soren, Meyer, Peter, Klingebiel, Caroline, Lidholm, Jonas, Ehrenberg, Angelica, Östling, Jonas, Cleach, Isabelle, Mège, Jean-Louis, Vitte, Joana, Aina, Roberta, Dubiela, Pawel, Pfeifer, Sabine, Bublin, Merima, Radauer, Christian, Humeniuk, Piotr, Kabasser, Stefan, Asero, Riccardo, Bogas, Gador, Gomez, Francisca, Campo, Paloma, Salas, Maria, Doña, Inmaculada, Barrionuevo, Esther, Guerrero, Maria A, Mayorga, Cristobalina, Prieto, Ana, Barber, Domingo, Torres, Maria J, Jamin, Annette, Wangorsch, Andrea, Ballmer, Barbara, Vieths, Stefan, Scheurer, Stephan, Apostolovic, Danijela, Mihailovic, Jelena, Krstic, Maja, Starkhammar, Maria, Velickovic, Tanja C, Hamsten, Carl, van Hage, Marianne, van Erp, Francine C, Knol, Edward F, Kansen, Hannah M, Pontoppidan, Bo, Meijer, Yolanda, van der Ent, Cornelis K, Knulst, André C, Sayers, Rebekah, Brown, Helen, Custovic, Adnan, Simpson, Angela, Mills, Claire, Schulz, Juliane, Akkerdaas, Jaap, Totis, Muriel, Capt, Annabelle, Herouet-Guicheney, Corinne, van Ree, Ronald, Banerjee, Tushar, Banerjee, Antima, Claude, Mathilde, Bouchaud, Grégory, Lupi, Roberta, Castan, Laure, Tranquet, Olivier, Denery-Papini, Sandra, Bodinier, Marie, Brossard, Chantal, De Poi, Rosella, Gritti, Elisa, De Dominicis, Emiliano, Popping, Bert, de Laureto, Patrizia P, Palosuo, Kati, Kukkonen, Anna K, Pelkonen, Anna, Mäkelä, Mika, Lee, Nanju A, Rost, Johanna, Muralidharan, Sridevi, Campbell, Dianne, Mehr, Sam, Nock, Catherine, Baumert, Joseph, Taylor, Steve, Mastrorilli, Carla, Tripodi, Salvatore, Caffarelli, Carlo, Perna, Serena, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Dondi, Arianna, Bianchi, Annamaria, Dascola, Carlotta P, Ricci, Giampaolo, Cipriani, Francesca, Maiello, Nunzia, del Giudice, Michele M, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Pistoletti, Chiara, Iacono, Iride D, Patria, Maria F, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Olcese, Roberta, Moretti, Matteo, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Verga, Maria C, Calvani, Mauro, Giordani, Paolo, Matricardi, Paolo M, Ontiveros, Noe, Cabrera-Chavez, Francisco, Galand, Julie, Beaudouin, Etienne, Pineau, Florence, Sakai, Shinobu, Matsunaga, Kayoko, Teshima, Reiko, Larré, Colette, Denery, Sandra, Tschirner, Sebastian, Trendelenburg, Valérie, Schulz, Gabriele, Niggemann, Bodo, Beyer, Kirsten, Bouferkas, Youcef, Belabbas, Younes, Saidi, Djamel, Kheroua, Omar, Mecherfi, Kamel E E, Guendouz, Malika, Haddi, Abir, Kaddouri, Hanane, Amaral, Luis, Pereira, Ana, Rodrigues, Susana, Datema, Mareen, Jongejan, Laurian, Clausen, Michael, Knulst, Andre, Papadopoulos, Nikolaos, Kowalski, Marek, de Blay, Frédéric, Zwinderman, Aeilko, Hoffman-Sommergruber, Karin, Ballmer-Weber, Barbara, Fernandez-Rivas, Montserrat, Deng, Shan, Yin, Jia, Eisenmann, Charlotte, Nassiri, Maria, Reinert, Rabea, van der Valk, Johanna P M, van Wijk, Roy G, Vergouwe, Yvonne, Steyerberg, Ewout W, Reitsma, Marit, Wichers, Harry J, Savelkoul, Huub F J, Vlieg-Boerstra, Berber, Dubois, Anthony E J, Carolino, Fabrícia, Rodolfo, Ana, Cernadas, Josefina, Roa-Medellín, Dasha, Rodriguez-Fernandez, Ana, Navarro, Joaquín, Albendiz, Vicente, Baeza, María L, Intente-Herrero, Sonsoles, Mikkelsen, Andrea, Mehlig, Kirsten, Lissner, Lauren, Verrill, Linda, Luccioli, Stefano, van Bilsen, Jolanda, Kuper, Frieke, Wolterbeek, André, Rankouhi, Tanja R, Verschuren, Lars, Cnossen, Hilde, Jeurink, Prescilla, Garssen, Johan, Knippels, Léon, Garthoff, Jossie, Houben, Geert, Leeman, Winfried, Eleonore Pettersson, M., Schins, Afke M M, Koppelman, Gerard H, Kollen, Boudewjin J, Zubchenko, Svitlana, Kuntz, Sarah, Mérida, Pablo, Álvaro, Montserrat, Piquer, Monica, Riggioni, Carmen, Castellanos, Juan H, Jimenez, Rosa, Cap, Melanie, Drumez, Elodie, Lejeune, Stéphanie, Thumerelle, Caroline, Mordacq, Clémence, Nève, Véronique, Ricò, Sonia, Varini, Margherita, Nocerino, Rita, Cosenza, Linda, Amoroso, Antonio, Di Costanzo, Margherita, Di Scala, Carmen, Bedogni, Giorgio, Canani, Roberto B, Turner, Paul J, Poza-Guedes, Paloma, González-Pérez, Ruperto, Sánchez-Machín, Inmaculada, Matheu-Delgado, Victor, Wambre, Erik, Ballegaard, Anne-Sofie, Madsen, Charlotte, Gregersen, Juliane, Bøgh, Katrine L, Aubert, Philippe, Neunlist, Michel, Magnan, Antoine, Lozano-Ojalvo, Daniel, Pablos-Tanarro, Alba, Pérez-Rodríguez, Leticia, Molina, Elena, López-Fandiño, Rosina, Rekima, Akila, Macchiaverni, Patricia, Turfkruyer, Mathilde, Holvoet, Sebastien, Dupuis, Lénaïck, Baiz, Nour, Annesi-Maesano, Isabella, Mercenier, Annick, Nutten, Sophie, Verhasselt, Valérie, Mrakovcic-Sutic, Ines, Banac, Srdan, Sutic, Ivana, Baricev-Novakovic, Zdenka, Sutic, Ingrid, Pavisic, Valentino, Muñoz-Cano, Rosa, Jiménez-Rodríguez, Teodoríkez, Corbacho, Daniel, Roca-Ferrer, Jordi, Bartra, Joan, Bulog, Aleksandar, Micovic, Vladimir, Markiewicz, Lidia, Szymkiewicz, Agata, Szyc, Anna, Wróblewska, Barbara, Harvey, Bryan M, Harthoorn, Lucien F, Wesley Burks, A., Rentzos, Georgios, Björk, Anna-Lena B, Bengtsson, Ulf, Barber, Colin, Kalicinsky, Chrystyna, Breynaert, Christine, Coorevits, Lieve, Jansen, Cornelia, Van Hoeyveld, Erna, Verbeke, Kristin, Kochuyt, Anne-Marie, Schrijvers, Rik, Deleanu, Diana, Muntean, Adriana, Konstantakopoulou, Maria, Pasioti, Maria, Papadopoulou, Anastasia, Iliopoulou, Anna, Mikos, Nikolaos, Kompoti, Evangelia, de Castro, Eunice D, Bartalomé, Borja, Ue, Kok L, Griffiths, Elizabeth, Till, Stephen, Grimshaw, Kate, Roberts, Graham, Selby, Anna, Butiene, Indre, Larco, Jose I, Dubakiene, Ruta, Fiandor, Ana, Fiocchi, Alessandro, Papadopoulos, Nikos, Sigurdardottir, Sigurveig, Sprikkelman, Aline, Schoemaker, Anne-Fleur, Xepapadaki, Paraskevi, Keil, Thomas, Cojocariu, Zizi, Barbado, Beatriz S, Iancu, Vasti, Arroabarren, Esozia, Esarte, Marta G, Arteaga, Miren, Andrade, Mayra C, Borges, Denise, Kalil, Jorge, Bianchi, Pedro G, Agondi, Rosana C, Gupta, Rinkesh K, Sharma, Akanksha, Gupta, Kriti, Das, Mukul, Dwivedi, Premendra, Karseladze, Rusudan, Jorjoliani, Liana, Saginadze, Lali, Tskhakaia, Mariam, Basello, Katia, Piuri, Gabriele, Speciani, Attilio F, Speciani, Michela C, Camerotto, Carla, Zinno, Francesco, Pakholchuk, Olga, Nedelska, Svitlana, Pattini, Stefano, Costantino, Maria T, Peveri, Silvia, Villalta, Danilo, Savi, Eleonora, Costanzi, Andrea, Revyakina, Vera A, Kiseleva, Marina A, Kuvshinova, Elena D, Larkova, Inna A, Shekhetov, Anton A, Silva, Diana, Moreira, André, Plácido, José, van der Kleij, Hanneke, van Twuijver, Esther, Sutorius, Robbert, de Kam, Pieter-Jan, van Odijk, Jenny, Lindqvist, Helen, 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Canto, Gabriela, Rodrigues, Alexandra, Forno, Andreia, Cabral, António J, Gonçalves, Rute, Vorozhko, Ilya, Sentsova, Tatyana, Chernyak, Olga, Denisova, Svetlana, Ilènko, Lidia, Muhortnich, Valery, Zimmermann, Caroline, Rohrbach, Alexander, Bakhsh, Faisal R, Boudewijn, Kollen, Oomkes-Pilon, Anne-Marie, Van Ginkle, Dorien, Šilar, Mira, Jeverica, Anja, Vesel, Tina, Avčin, Tadej, Korošec, Peter, van der Valk, Johanna, Berends, Irene, Arends, Nicolette, van Maaren, Maurits, Wichers, Harry, Emons, Joyce, Dubois, Anthony, de Jong, Nicolette, Matsyura, Oksana, Besh, Lesya, Huang, Chung-Hsiung, Jan, Tong-Rong, Stiefel, Gary, Tratt, Jean, Kirk, Kerrie, Carolino, Fabricia, Arasi, Stefania, Caminiti, Lucia, Crisafulli, Giuseppe, Fiamingo, Chiara, Fresta, Jlenia, Pajno, Giovanni, Remington, Ben, Kruizinga, Astrid, Marty Blom, W., Westerhout, Joost, Bijlsma, Sabina, Baumert, Joe, Blankestijn, Mark, Otten, Henny, Klemans, Rob, Michelsen-Huisman, Anouska D, van Os-Medendorp, Harmieke, Kruizinga, Astrid G, Versluis, Astrid, van Duijn, Gert, de Zeeuw-Brouwer, H. M, Castenmiller, Jacqueline J M, Noteborn, Hub P J M, Houben, Geert F, Bravin, Kristian, Luyt, David, Javed, Bushra, Couch, Phil, Munro, Christopher, Padfield, Phil, Sperrin, Matt, Byrne, Aideen, Oosthuizen, Lizalet, Kelleher, Carina, Ward, Fiona, Brosnan, Niamh, King, Graham, Corbet, Eva, Guzmán, Josué A H, García, Montserrat B, Asensio, Oscar, Navarrete, Laura V, Larramona, Helena, Miró, Xavier D, Pyrz, Katarzyna, Austin, Moira, Boloh, Yanne, Couch, Philip, Galloway, Deirdre, Hernandez, Pilar, Hourihane, Jonathan O, Kenna, Fiona, Majkowska-Wojciechowska, Barbara, Regent, Lynne, Themisb, Marina, Schnadt, Sabine, Semic-Jusufagic, Aida, Galvin, Audrey D, Kauppila, Tiina, Kuitunen, Mikael, Kitsioulis, Nikolaos A, Douladiris, Nikolaos, Kostoudi, Sofia, Manolaraki, Ioanna, Mitsias, Dimitris, Manousakis, Emmanouil, Papadopoulos, Nikolaos G, Knibb, Rebecca, Hammond, Jennifer, Cooke, Richard, Yrjänä, Jaakko, Hanni, Anna-Maija, Vähäsarja, Päivi, Mustonen, Oona, Dunder, Teija, Kulmala, Petri, Lasa, Eva, D’Amelio, Carmen, Martínez, Sara, Joral, Alejandro, Gastaminza, Gabriel, Goikoetxea, Maria J, Candy, David C A, Van Ampting, Marleen T J, Oude Nijhuis, Manon M, Butt, Assad M, Peroni, Diego G, Fox, Adam T, Knol, Jan, Michaelis, Louise J, Padua, Ines, Padrao, Patricia, Moreira, Pedro, Barros, Renata, Sharif, Hanan, Ahmed, Manzoor, Gomaa, Nehad, Mens, Joris, Smit, Koen, Timmermans, Frans, Poredoš, Tomaž, Jeverica, Anja K, Sedmak, Marjeta, Benedik, Evgen, Accetto, Meta, Zupančič, Mirjana, Yonamine, Glauce, Soldateli, Gustavo, Aquilante, Bruna, Pastorino, Antonio C, de Moraes Beck, Cleonir L, Gushken, Andrea K, de Barros Dorna, Mayra, dos Santos, Cristiane N, Castro, Ana P M, Al-Qahtani, Abdulhadi, Arnaout, Rand, Khaliq, Agha R, Amin, Rashid, Sheikh, Farrukh, Alvarez, Jorge, Anda, Marta, Palacios, Miriam, De Prada, Montserrat, Ponce, Carmen, Balbino, Bianca, Sibilano, Riccardo, Marichal, Thomas, Gaudenzio, Nicolas, Karasuyama, Hajime, Bruhns, Pierre, Tsai, Mindy, Reber, Laurent L, Galli, Stephen J, Ferreira, Ana R, Cernadas, Josefina R, del Campo García, Aida, Fernández, Sara P, Carrera, Nerea S, Sánchez-Cruz, Fernando B, Lorenzo, José R F, Claus, Stephanie, Pföhler, Claudia, Ruëff, Franziska, Treudler, Regina, Jaume, Mercedes E, Madroñero, Agustin, Perez, Maria T G, Julia, Juan C, Plovdiv, Charlotte H, Gethings, Lee, Langridge, Jim, Adel-Patient, Karine, Bernard, Hervé, Barcievic-Jones, Ivona, Sokolova, Raditsa, Yankova, Rumyana, Ivanovska, Mariya, Murdjeva, Marianna, Popova, Tatyana, Dermendzhiev, Svetlan, Karjalainen, Martin, Lehnigk, Ulrike, Brown, Duncan, Locklear, Julie C, Locklear, Julie, Maris, Ioana, Hourihane, Jonathan, Ornelas, Cristina, Caiado, Joana, Ferreira, Manuel B, Pereira-Barbosa, Manuel, Puente, Yolanda, Daza, Juan C, Monteseirin, Francisco J, Ukleja-Sokolowska, Natalia, Gawronska-Ukleja, Ewa, Zbikowska-Gotz, Magdalena, Bartuzi, Zbigniew, Sokolowski, Lukasz, Adams, Aine, Mahon, Bernard, English, Karen, Gourdon-Dubois, Nelly, Sellam, Laetitia, Pereira, Bruno, Michaud, Elodie, Messaoudi, Khaled, Evrard, Bertrand, Fauquert, Jean-Luc, Palomares, Francisca, Gomez, Gador, Rodriguez, Maria J, Galindo, Luisa, Molina, Ana, Paparo, Lorella, Mennini, Maurizio, Aitoro, Rosita, Wawrzeńczyk, Adam, Przybyszewski, Michał, Wawrzeńczyk, Anna, Sarıcoban, Hulya E, Ugras, Meltem, Yalvac, Zerrin, Flokstra-de Blok, Bertine M J, van der Velde, J. L, Vereda, Andrea, Ippolito, Clara, Traversa, Amaranta, Adriano, Daniela, Bianchi, Daniela M, Gallina, Silvia, Decastelli, Lucia, Makatsori, Melina, Miles, Anne, Devetak, Sonja P, Devetak, Iztok, Tabet, Soraya A, Trandbohus, Jeanette F, Winther, Pernille, Malling, Hans-Jørgen, Hansen, Kirsten S, Garvey, Lene H, Wang, Chia-Chi, Cheng, Yin-Hua, Tung, Chun-Wei, Dietrich, Mariola, Marenholz, Ingo, Kalb, Birgit, Grosche, Sarah, Blümchen, Katharina, Schlags, Rupert, Price, Mareike, Rietz, Sylke, Esparza-Gordillo, Jorge, Lau, Susanne, Lee, Young-Ae, Almontasheri, Ali, Bahkali, Mohammad A, Elshorbagi, Sahar, Alfhaid, Abdullah, Altamimi, Mashary, Madbouly, Eman, Al-Dhekri, Hassan, Arnaout, Rand K, Basagaña, Maria, Miquel, Sira, Bartolomé, Borja, Brix, Bettina, Rohwer, Stefanie, Brandhoff, Sandra, Berger, Alena, Suer, Waltraud, Weimann, Alf, Bueno, Cristina, Martín-Pedraza, Laura, Abián, Sara, Segundo-Acosta, Pablo S, López-Rodríguez, Juan C, Barderas, Rodrigo, Batanero, Eva, Cuesta-Herranz, Javier, Villalba, María T, Correia, Magna, Benito-Garcia, Filipe, Arêde, Cristina, Piedade, Susana, Morais-Almeida, Mário, Hindley, James, Yarham, Ross, Kuklinska-Pijanka, Anna, Gillick, David, Patient, Karine, Chapman, Martin D, Miranda, Ana, Matos, Eugénia, Sokolova, Anna, Rao, Huan, Baricevic-Jones, Ivona, Smith, Frances, Xue, Wentong, Magnusdottir, Helga, Vidarsdottir, Anna G, Lund, Sigrun, Jensen, Anders B, Ludviksson, Bjorn R, Simon, Reyna, Elfont, Robert, Bennett, Sean, Voyksner, Robert, de Lurdes Torre, Maria, Yürek, Songül, Faber, Margaretha A, Bastiaensen, Annick, Mangodt, Evelyne, van Gasse, Athina, Decuyper, Ine, Sabato, Vito, Hagendorens, Margo M, Bridts, Chris H, De Clerck, Luc S, Ebo, Didier, Schwarz, Susanne, Ziegert, Mandy, Albroscheit, Saskia, Schwager, Christian, Kull, Skadi, Behrends, Jochen, Röckendorf, Niels, Schocker, Frauke, Frey, Andreas, Homann, Arne, Becker, Wolf-Meinhard, Jappe, Uta, Zaabat, Nesrine, Osscini, Sylvia, Agabriel, Chantal, Sterling, Benoît, Carsin, Ania, Liabeuf, Valérie, Maćków, Monica, Zbróg, Alina, Bronkowska, Monica, Courtois, Justine, Gadisseur, Romy, Bertholet, Catherine, Lukas, Pierre, Cavalier, Etienne, Delahaut, Philippe, Quinting, Birgit, Gertmo, Margareta B, Hasseus, Ewa T, Barzylovych, Vladyslava, Oliveira, Júlio, Ensina, Luis F, Aranda, Carolina S, Dopazo, Leire, Lopez, Rebeca, Perez, Raquel, Santos-Diez, Laura, Bilbao, Agurtzane, Garcia, Juan M, Núñez, Ignacio G, Mármol, María Á A, Villarejo, María J B, Martos, José A B, Vergara, Marina S, García, José M I, Michalska, Agata, Sergiejko, Grzegorz, Zacniewski, Robert, Ghiordanescu, Ileana-Maria, Deaconu, Cristina, Popescu, Mihaela, Bumbacea, Roxana S, Ibranji, Alkerta, Nikolla, Elida, Loloci, Gjustina, Juel-Berg, Nanna, Larsen, Lau F, Poulsen, Lars K, Marcelino, João, Prata, Ricardo, Costa, Ana C, Duarte, Fátima, Neto, Marta, Santos, Jennifer, Pestana, Luís C, Sampaio, Daniel, Minale, Paola, Dignetti, Paola, Bignardi, Donatella, Nedelea, Irena, Popescu, Florin-Dan, Vieru, Mariana, Secureanu, Florin-Adrian, Ganea, Carmen S, Vieira, Miguel, Silva, José P M, Watts, Timothy, Watts, Sophia, Lomikovska, Marta, Peredelskaya, Marina, Nenasheva, Natalia, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Higgs, Jennette, Warner, Amena, and Jones, Carla
- Published
- 2017
36. A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders
- Author
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Wambre, Erik, primary, Bajzik, Veronique, additional, DeLong, Jonathan H., additional, O’Brien, Kimberly, additional, Nguyen, Quynh-Anh, additional, Speake, Cate, additional, Gersuk, Vivian H., additional, DeBerg, Hannah A., additional, Whalen, Elizabeth, additional, Ni, Chester, additional, Farrington, Mary, additional, Jeong, David, additional, Robinson, David, additional, Linsley, Peter S., additional, Vickery, Brian P., additional, and Kwok, William W., additional
- Published
- 2017
- Full Text
- View/download PDF
37. Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
- Author
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Cerosaletti, Karen, primary, Barahmand-pour-Whitman, Fariba, additional, Yang, Junbao, additional, DeBerg, Hannah A., additional, Dufort, Matthew J., additional, Murray, Sara A., additional, Israelsson, Elisabeth, additional, Speake, Cate, additional, Gersuk, Vivian H., additional, Eddy, James A., additional, Reijonen, Helena, additional, Greenbaum, Carla J., additional, Kwok, William W., additional, Wambre, Erik, additional, Prlic, Martin, additional, Gottardo, Raphael, additional, Nepom, Gerald T., additional, and Linsley, Peter S., additional
- Published
- 2017
- Full Text
- View/download PDF
38. Role of IL-33 in modulating human allergen specific CD4+ T cell responses
- Author
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Garabatos, Nahir, primary, Bajzik, Veronique, additional, Rust, Blake J., additional, Londei, Marco, additional, and Wambre, Erik R., additional
- Published
- 2017
- Full Text
- View/download PDF
39. Dual assessment of peanut-specific effector and regulatory T cells in patients undergoing oral immunotherapy
- Author
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Rust, Blake J., primary, Bajzik, Veronique, additional, Vickery, Brian P., additional, and Wambre, Erik R., additional
- Published
- 2017
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- View/download PDF
40. Peanut Specific-CD4+ T Cells Responses in Peanut Allergic and Peanut Sensitized but Tolerant Subjects
- Author
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Kwok, William W., primary, Farrington, Mary L., additional, Whalen, Elizabeth, additional, Wambre, Erik R., additional, Nadeau, Kari, additional, and Renand, Amedee, additional
- Published
- 2017
- Full Text
- View/download PDF
41. Non-Atopic Individuals Exhibit a Distinct Immune Reactivity Patterns in Response to Timothy Grass Pollen in and out-of-Season
- Author
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Hinz, Denise, primary, Seumois, Gregory, additional, Greenbaum, Jason, additional, White, Brandie, additional, Schulten, Veronique M., additional, Broide, David H., additional, Sidney, John, additional, Oseroff, Carla, additional, Wambre, Erik R., additional, James, Eddie A., additional, Kwok, William W., additional, Vijayanand, Pandurangan, additional, Peters, Bjoern, additional, and Sette, Alessandro, additional
- Published
- 2016
- Full Text
- View/download PDF
42. Role of T Cell Sub-Populations in Food Allergy
- Author
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Archila Diaz, Luis Diego, primary, Jeong, David K., additional, Robinson, David, additional, Farrington, Mary L., additional, Wambre, Erik R., additional, and Kwok, William W., additional
- Published
- 2016
- Full Text
- View/download PDF
43. Chronic cat allergen exposure induces a T H 2 cell–dependent IgG 4 response related to low sensitization
- Author
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Renand, Amedee, primary, Archila, Luis D., additional, McGinty, John, additional, Wambre, Erik, additional, Robinson, David, additional, Hales, Belinda J., additional, Thomas, Wayne R., additional, and Kwok, William W., additional
- Published
- 2015
- Full Text
- View/download PDF
44. Effect of allergen-specific immunotherapy on CD4+ T cells
- Author
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Wambre, Erik, primary
- Published
- 2015
- Full Text
- View/download PDF
45. Ara h 1-Reactive T Cells in Peanut Allergic Individuals
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DeLong, Jonathan H., Hetherington, Kelly A., Wambre, Erik, James, Eddie A., Robinson, David, and Kwok, William W.
- Subjects
Adult ,CD4-Positive T-Lymphocytes ,Male ,Receptors, CCR4 ,Arachis ,Molecular Sequence Data ,Epitopes, T-Lymphocyte ,Membrane Proteins ,Antigens, Plant ,Middle Aged ,Article ,Young Adult ,Cytokines ,Humans ,Female ,Peanut Hypersensitivity ,Amino Acid Sequence ,Interleukin-4 ,Immunologic Memory ,Epitope Mapping ,Glycoproteins ,Plant Proteins - Abstract
Effective immunotherapy for peanut allergy is hampered by a lack of understanding of peanut-reactive CD4(+) T cells.To identify, characterize, and track Ara h 1-reactive cells in subjects with peanut allergy by using Ara h 1-specific class II tetramers.Tetramer-guided epitope mapping was used to identify the antigenic peptides within the peanut allergen Ara h 1. Subsequently, HLA class II/Ara h 1-specific tetramers were used to determine the frequency and phenotype of Ara h 1-reactive T cells in subjects with peanut allergy. Cytokine profiles of Ara h 1-reactive T cells were also determined.Multiple Ara h 1 epitopes with defined HLA restriction were identified. Ara h 1-specific CD4(+) T cells were detected in all of the subjects with peanut allergy tested. Ara h 1-reactive T cells in subjects with allergy expressed CCR4 but did not express CRTH2. The percentage of Ara h1-reactive cells that expressed the β7 integrin was low compared with total CD4(+) T cells. Ara h 1- reactive cells that secreted IFN-γ, IL-4, IL-5, IL-10, and IL-17 were detected.In individuals with peanut allergy, Ara h 1-reactive T cells occurred at moderate frequencies, were predominantly CCR4(+) memory cells, and produced IL-4. Class II tetramers can be readily used to detect Ara h 1-reactive T cells in the peripheral blood of subjects with peanut allergy without in vitro expansion and would be effective for tracking peanut-reactive CD4(+) T cells during immunotherapy.
- Published
- 2011
46. Allergic Disease-Related Phenotypic Differences Emerges in Type 2 Immune Responses
- Author
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Wambre, Erik R., primary, Bajzik, Veronique, additional, Renand, Amedee, additional, James, Eddie A., additional, Robinson, David, additional, and Kwok, William W., additional
- Published
- 2015
- Full Text
- View/download PDF
47. Arginine kinase Pen m 2 as an important shrimp allergen recognized by T H 2 cells
- Author
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Renand, Amedee, primary, Newbrough, Sally, additional, Wambre, Erik, additional, DeLong, Jonathan H., additional, Robinson, David, additional, and Kwok, William W., additional
- Published
- 2014
- Full Text
- View/download PDF
48. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders.
- Author
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Wambre, Erik, Bajzik, Veronique, DeLong, Jonathan H., O'Brien, Kimberly, Quynh-Anh Nguyen, Speake, Cate, Gersuk, Vivian H., DeBerg, Hannah A., Whalen, Elizabeth, Ni, Chester, Farrington, Mary, Jeong, David, Robinson, David, Linsley, Peter S., Vickery, Brian P., and Kwok, William W.
- Subjects
T cells ,ALLERGENS ,ASTHMATICS ,INFLAMMATION ,PATHOGENIC microorganisms - Abstract
The article discusses the role of T cells in initiating and orchestrating the allergic and asthmatic inflammatory response pathways. It examines the functional attributes of T cells to identify and differentiate nonpathogenic cell types. It also stresses the elimination of T cells in the initiation of pathogenic responses to allergen.
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- 2017
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- View/download PDF
49. Heterogeneity Of Specific CD4+ T Cell Responses To Peanut Allergic Components: Prospects For Specific Immunotherapy
- Author
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Wambre, Erik R., primary, Kwok, William W., additional, and Robinson, David, additional
- Published
- 2014
- Full Text
- View/download PDF
50. Characterization of CD4+ T cell subsets in allergy
- Author
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Wambre, Erik, primary, James, Eddie A, additional, and Kwok, William W, additional
- Published
- 2012
- Full Text
- View/download PDF
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