159,427 results on '"Walters, As"'
Search Results
2. The Funayama envelope as the $T_D$-hull of a frame
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Bezhanishvili, Guram, Raviprakash, Ranjitha, Suarez, Anna Laura, and Walters-Wayland, Joanne
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Mathematics - Category Theory ,Mathematics - Analysis of PDEs - Abstract
We introduce proximity morphisms between MT-algebras and show that the resulting category is equivalent to the category of frames. This is done by utilizing the Funayama envelope of a frame, which is viewed as the $T_D$-hull. Our results have some spatial ramifications, including a generalization of the $T_D$-duality of Banaschewski and Pultr.
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- 2025
3. Reducing the Sensitivity of Neural Physics Simulators to Mesh Topology via Pretraining
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Vaska, Nathan, Goodwin, Justin, Walters, Robin, and Caceres, Rajmonda S.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,I.2.6 ,I.2.10 - Abstract
Meshes are used to represent complex objects in high fidelity physics simulators across a variety of domains, such as radar sensing and aerodynamics. There is growing interest in using neural networks to accelerate physics simulations, and also a growing body of work on applying neural networks directly to irregular mesh data. Since multiple mesh topologies can represent the same object, mesh augmentation is typically required to handle topological variation when training neural networks. Due to the sensitivity of physics simulators to small changes in mesh shape, it is challenging to use these augmentations when training neural network-based physics simulators. In this work, we show that variations in mesh topology can significantly reduce the performance of neural network simulators. We evaluate whether pretraining can be used to address this issue, and find that employing an established autoencoder pretraining technique with graph embedding models reduces the sensitivity of neural network simulators to variations in mesh topology. Finally, we highlight future research directions that may further reduce neural simulator sensitivity to mesh topology., Comment: 5 pages, 3 figures
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- 2025
4. MatrixNet: Learning over symmetry groups using learned group representations
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Laird, Lucas, Hsu, Circe, Bapat, Asilata, and Walters, Robin
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Mathematics - Representation Theory - Abstract
Group theory has been used in machine learning to provide a theoretically grounded approach for incorporating known symmetry transformations in tasks from robotics to protein modeling. In these applications, equivariant neural networks use known symmetry groups with predefined representations to learn over geometric input data. We propose MatrixNet, a neural network architecture that learns matrix representations of group element inputs instead of using predefined representations. MatrixNet achieves higher sample efficiency and generalization over several standard baselines in prediction tasks over the several finite groups and the Artin braid group. We also show that MatrixNet respects group relations allowing generalization to group elements of greater word length than in the training set., Comment: NeurIPS 2024
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- 2025
5. Simons Observatory: Characterization of the Large Aperture Telescope Receiver
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Bhandarkar, Tanay, Haridas, Saianeesh K., Iuliano, Jeff, Kofman, Anna, Manduca, Alex, Sarmiento, Karen Perez, Orlowski-Scherer, John, Satterthwaite, Thomas P., Wang, Yuhan, Ahmed, Zeeshan, Austermann, Jason E., Bae, Kyuyoung, Coppi, Gabriele, Devlin, Mark J., Dicker, Simon R, Dow, Peter N., Duff, Shannon M., Dutcher, Daniel, Galitzki, Nicholas, Gudmundsson, Jon E., Henderson, Shawn W., Hubmayr, Johannes, Johnson, Bradley R., Koc, Matthew A., Koopman, Brian J., Limon, Michele, Link, Michael J, Lucas, Tammy J., Moore, Jenna E., Nati, Federico, Niemack, Michael D., Sierra, Carlos E., Silva-Feaver, Max, Singh, Robinjeet, Staggs, Suzanne T., Sonka, Rita F., Thornton, Robert J., Tsan, Tran, Van Lanen, Jeff L., Vavagiakis, Eve M., Vissers, Michael R, Walters, Liam, Zannoni, Mario, and Zheng, Kaiwen
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Simons Observatory (SO) is a ground-based cosmic microwave background (CMB) survey experiment that currently consists of three 0.42m small-aperture telescopes (SATs) and one 6m large-aperture telescope (LAT), located at an elevation of 5200m in the Atacama Desert in Chile. At the LAT's focal plane, SO will install >62,000 transition-edge sensor detectors across 13 optics tubes (OTs) within the Large Aperture Telescope Receiver (LATR), the largest cryogenic camera ever built to observe the CMB. Here we report on the validation of the LATR in the laboratory and the subsequent dark testing and validation within the LAT. We show that the LATR meets cryogenic, optical, and detector specifications required for high-sensitivity measurements of the CMB. At the time of writing, the LATR is installed in the LAT with six OTs (corresponding to >31,000 detectors), and the LAT mirrors and remaining seven OTs are undergoing development.
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- 2025
6. Autonomous Electrochemistry Platform with Real-Time Normality Testing of Voltammetry Measurements Using ML
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Al-Najjar, Anees, Rao, Nageswara S. V., Bridges, Craig A., Dai, Sheng, and Walters, Alex
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Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Robotics - Abstract
Electrochemistry workflows utilize various instruments and computing systems to execute workflows consisting of electrocatalyst synthesis, testing and evaluation tasks. The heterogeneity of the software and hardware of these ecosystems makes it challenging to orchestrate a complete workflow from production to characterization by automating its tasks. We propose an autonomous electrochemistry computing platform for a multi-site ecosystem that provides the services for remote experiment steering, real-time measurement transfer, and AI/ML-driven analytics. We describe the integration of a mobile robot and synthesis workstation into the ecosystem by developing custom hub-networks and software modules to support remote operations over the ecosystem's wireless and wired networks. We describe a workflow task for generating I-V voltammetry measurements using a potentiostat, and a machine learning framework to ensure their normality by detecting abnormal conditions such as disconnected electrodes. We study a number of machine learning methods for the underlying detection problem, including smooth, non-smooth, structural and statistical methods, and their fusers. We present experimental results to illustrate the effectiveness of this platform, and also validate the proposed ML method by deriving its rigorous generalization equations., Comment: 10 pages, 14 figures, accepted in the IEEE 20th International Conference on e-Science (e-Science), 2024
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- 2025
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7. Eliza: A Web3 friendly AI Agent Operating System
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Walters, Shaw, Gao, Sam, Nerd, Shakker, Da, Feng, Williams, Warren, Meng, Ting-Chien, Chow, Amie, Han, Hunter, He, Frank, Zhang, Allen, Wu, Ming, Shen, Timothy, Hu, Maxwell, and Yan, Jerry
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Computer Science - Artificial Intelligence - Abstract
AI Agent, powered by large language models (LLMs) as its cognitive core, is an intelligent agentic system capable of autonomously controlling and determining the execution paths under user's instructions. With the burst of capabilities of LLMs and various plugins, such as RAG, text-to-image/video/3D, etc., the potential of AI Agents has been vastly expanded, with their capabilities growing stronger by the day. However, at the intersection between AI and web3, there is currently no ideal agentic framework that can seamlessly integrate web3 applications into AI agent functionalities. In this paper, we propose Eliza, the first open-source web3-friendly Agentic framework that makes the deployment of web3 applications effortless. We emphasize that every aspect of Eliza is a regular Typescript program under the full control of its user, and it seamlessly integrates with web3 (i.e., reading and writing blockchain data, interacting with smart contracts, etc.). Furthermore, we show how stable performance is achieved through the pragmatic implementation of the key components of Eliza's runtime. Our code is publicly available at https://github.com/ai16z/eliza., Comment: 20 pages, 5 figures
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- 2025
8. Synthetic accessibility and sodium ion conductivity of the Na$_{8-x}$A$^{x}$P$_2$O$_9$ (NAP) high-temperature sodium superionic conductor framework
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Walters, Lauren N., Fei, Yuxing, Rendy, Bernardus, Yang, Xiaochen, Diallo, Mouhamad, Jun, KyuJung, Wei, Grace, McDermott, Matthew J., Giunto, Andrea, Mishra, Tara, Shen, Fengyu, Milsted, David, Oo, May Sabai, Kim, Haegyeom, Tucker, Michael C., and Ceder, Gerbrand
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Condensed Matter - Materials Science - Abstract
Advancement of solid state electrolytes (SSEs) for all solid state batteries typically focuses on modification of a parent structural framework for improved conductivity, \textit{e.g.} cation substitution for an immobile ion or varying the concentration of the mobile ion. Therefore, novel frameworks can be disruptive by enabling fast ion conduction aided by different structure and diffusion mechanisms, and unlocking optimal conductors with different properties (\textit{e.g.} mechanical properties, sintering needs, electrochemical stability) than previously published. Herein, we perform a high throughput survey of an understudied structural framework for sodium ion conduction, Na$_{8-x}$A$^x$P$_2$O$_9$ (NAP), to understand the family's thermodynamic stability, synthesizability, and ionic conduction. We first show that the parent phase Na$_4$TiP$_2$O$_9$ (NTP) undergoes a structural distortion (with accompanying conductivity transition) due to unstable phonons from a pseduo-Jahn Teller mode in the 1D titanium chains. Then, screening of cation-substituted structural candidates with \textit{ab initio} and machine-learned potential calculations reveal a number of candidates that are thermodynamically stable, likely synthesizable, and have high predicted ionic conductivities. High throughput experimental trials and subsequent methodology optimization of one Na$_4$SnP$_2$O$_9$ (NSP) highlight collective challenges to the synthesis pathways for sodium phosphate materials via solid state synthesis. Our results demonstrate that NAP is a highly tunable conduction framework whose high temperature conductivity transition has heretofore eliminated it from significant research interest. By expanding the structural toolkit for SSE design, we increase the number of useful sodium ion electrolytes for integration into safe and accessible solid state batteries., Comment: 15 page manuscript, 42 total pages
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- 2025
9. EraseAnything: Enabling Concept Erasure in Rectified Flow Transformers
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Gao, Daiheng, Lu, Shilin, Walters, Shaw, Zhou, Wenbo, Chu, Jiaming, Zhang, Jie, Zhang, Bang, Jia, Mengxi, Zhao, Jian, Fan, Zhaoxin, and Zhang, Weiming
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Removing unwanted concepts from large-scale text-to-image (T2I) diffusion models while maintaining their overall generative quality remains an open challenge. This difficulty is especially pronounced in emerging paradigms, such as Stable Diffusion (SD) v3 and Flux, which incorporate flow matching and transformer-based architectures. These advancements limit the transferability of existing concept-erasure techniques that were originally designed for the previous T2I paradigm (e.g., SD v1.4). In this work, we introduce EraseAnything, the first method specifically developed to address concept erasure within the latest flow-based T2I framework. We formulate concept erasure as a bi-level optimization problem, employing LoRA-based parameter tuning and an attention map regularizer to selectively suppress undesirable activations. Furthermore, we propose a self-contrastive learning strategy to ensure that removing unwanted concepts does not inadvertently harm performance on unrelated ones. Experimental results demonstrate that EraseAnything successfully fills the research gap left by earlier methods in this new T2I paradigm, achieving state-of-the-art performance across a wide range of concept erasure tasks., Comment: 24 pages, 18 figures
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- 2024
10. Using machine learning to inform harvest control rule design in complex fishery settings
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Montealegre-Mora, Felipe, Boettiger, Carl, Walters, Carl J., and Cahill, Christopher L.
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Quantitative Biology - Populations and Evolution ,Computer Science - Machine Learning ,Quantitative Biology - Quantitative Methods - Abstract
In fishery science, harvest management of size-structured stochastic populations is a long-standing and difficult problem. Rectilinear precautionary policies based on biomass and harvesting reference points have now become a standard approach to this problem. While these standard feedback policies are adapted from analytical or dynamic programming solutions assuming relatively simple ecological dynamics, they are often applied to more complicated ecological settings in the real world. In this paper we explore the problem of designing harvest control rules for partially observed, age-structured, spasmodic fish populations using tools from reinforcement learning (RL) and Bayesian optimization. Our focus is on the case of Walleye fisheries in Alberta, Canada, whose highly variable recruitment dynamics have perplexed managers and ecologists. We optimized and evaluated policies using several complementary performance metrics. The main questions we addressed were: 1. How do standard policies based on reference points perform relative to numerically optimized policies? 2. Can an observation of mean fish weight, in addition to stock biomass, aid policy decisions?, Comment: 25 pages, 4 figures, 2 tables
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- 2024
11. Equivariant Action Sampling for Reinforcement Learning and Planning
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Zhao, Linfeng, Howell, Owen, Zhu, Xupeng, Park, Jung Yeon, Zhang, Zhewen, Walters, Robin, and Wong, Lawson L. S.
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Reinforcement learning (RL) algorithms for continuous control tasks require accurate sampling-based action selection. Many tasks, such as robotic manipulation, contain inherent problem symmetries. However, correctly incorporating symmetry into sampling-based approaches remains a challenge. This work addresses the challenge of preserving symmetry in sampling-based planning and control, a key component for enhancing decision-making efficiency in RL. We introduce an action sampling approach that enforces the desired symmetry. We apply our proposed method to a coordinate regression problem and show that the symmetry aware sampling method drastically outperforms the naive sampling approach. We furthermore develop a general framework for sampling-based model-based planning with Model Predictive Path Integral (MPPI). We compare our MPPI approach with standard sampling methods on several continuous control tasks. Empirical demonstrations across multiple continuous control environments validate the effectiveness of our approach, showcasing the importance of symmetry preservation in sampling-based action selection., Comment: Published at International Workshop on the Algorithmic Foundations of Robotics (WAFR) 2024. Website: http://lfzhao.com/EquivSampling
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- 2024
12. Improving the predictive power of empirical shell-model Hamiltonians
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Purcell, J. A., Brown, B. A., He, B. C., Stroberg, S. R., and Walters, W. B.
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Nuclear Theory - Abstract
We present two developments which enhance the predictive power of empirical shell model Hamiltonians for cases in which calibration data is sparse. A recent improvement in the ab initio derivation of effective Hamiltonians leads to a much better starting point for the optimization procedure. In addition, we introduce a protocol to avoid over-fitting, enabling a more reliable extrapolation beyond available data. These developments will enable more robust predictions for exotic isotopes produced at rare isotope beam facilities and in astrophysical environments., Comment: 11 pages, 6 figures
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- 2024
13. Primary Beam Chromaticity in HIRAX: I. Characterization from Simulations and Power Spectrum Implications
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Sampath, Ajith, Crichton, Devin, Moodley, Kavilan, Chiang, H. Cynthia, Acedo, Eloy De Lera, Dlamini, Simthembile, Gaddam, Sindhu, Gerodias, Kit M., Gueuning, Quentin, Gupta, N., Hitz, Pascal, Madhusudhan, Aditya Krishna Karigiri, Krishna, Shreyam Parth, Mugundhan, V., Retana-Montenegro, Edwin, Saliwanchik, Benjamin R. B., Santos, Mario G., and Walters, Anthony
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Hydrogen Intensity and Real-time Analysis eXperiment (HIRAX) is an upcoming radio interferometric telescope designed to constrain dark energy through the 21cm intensity mapping of Baryon Acoustic Oscillations (BAO). Instrumental systematics must be controlled and carefully characterized to measure the 21cm power spectrum with fidelity and achieve high-precision constraints on the cosmological parameters. The chromaticity of the primary beam is one such complicated systematic, which can leak the power of spectrally smooth foregrounds beyond the ideal horizon limits due to the complex spatial and spectral structures of the sidelobes and the mainlobe. This paper studies the chromaticity of the HIRAX Stokes I primary beam and its effects on accurate measurements of the 21cm power spectrum. To investigate the effect of chromaticity in the 21cm power spectrum, we present a physically motivated beam modeling technique, which uses a flexible basis derived from traditional optics that can account for higher-order radial and azimuthal structures in the primary beam. We investigate the impact of imperfect knowledge of the mainlobe and sidelobes chromaticity in the power spectrum space by subtracting a simple foreground model in simulated snapshot visibilities to recover the H$\textsc{i}$ power spectrum. Additionally, we find that modeling up to the octupolar azimuthal order feature (fourth-order angular variation) in the primary beam is sufficient to reduce the leakage outside the wedge with minimal bias., Comment: 20 pages, 12 figures. Prepared for submitting in the Astrophysical Journal (ApJ)
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- 2024
14. Deep-Learning Based Docking Methods: Fair Comparisons to Conventional Docking Workflows
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Jain, Ajay N., Cleves, Ann E., and Walters, W. Patrick
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Computer Science - Artificial Intelligence ,Quantitative Biology - Biomolecules - Abstract
The diffusion learning method, DiffDock, for docking small-molecule ligands into protein binding sites was recently introduced. Results included comparisons to more conventional docking approaches, with DiffDock showing superior performance. Here, we employ a fully automatic workflow using the Surflex-Dock methods to generate a fair baseline for conventional docking approaches. Results were generated for the common and expected situation where a binding site location is known and also for the condition of an unknown binding site. For the known binding site condition, Surflex-Dock success rates at 2.0 Angstroms RMSD far exceeded those for DiffDock (Top-1/Top-5 success rates, respectively, were 68/81% compared with 45/51%). Glide performed with similar success rates (67/73%) to Surflex-Dock for the known binding site condition, and results for AutoDock Vina and Gnina followed this pattern. For the unknown binding site condition, using an automated method to identify multiple binding pockets, Surflex-Dock success rates again exceeded those of DiffDock, but by a somewhat lesser margin. DiffDock made use of roughly 17,000 co-crystal structures for learning (98% of PDBBind version 2020, pre-2019 structures) for a training set in order to predict on 363 test cases (2% of PDBBind 2020) from 2019 forward. DiffDock's performance was inextricably linked with the presence of near-neighbor cases of close to identical protein-ligand complexes in the training set for over half of the test set cases. DiffDock exhibited a 40 percentage point difference on near-neighbor cases (two-thirds of all test cases) compared with cases with no near-neighbor training case. DiffDock has apparently encoded a type of table-lookup during its learning process, rendering meaningful applications beyond its reach. Further, it does not perform even close to competitively with a competently run modern docking workflow., Comment: Post-Conclusion addendum added with additional reference and context, 19 pages including references and appendices, 7 figures
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- 2024
15. Improving Object Detection by Modifying Synthetic Data with Explainable AI
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Mital, Nitish, Malzard, Simon, Walters, Richard, De Melo, Celso M., Rao, Raghuveer, and Nockles, Victoria
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Computer Science - Computer Vision and Pattern Recognition - Abstract
In many computer vision domains the collection of sufficient real-world data is challenging and can severely impact model performance, particularly when running inference on samples that are unseen or underrepresented in training. Synthetically generated images provide a promising solution, but it remains unclear how to design synthetic data to optimally improve model performance, for example whether to introduce more realism or more abstraction in such datasets. Here we propose a novel conceptual approach to improve the performance of computer vision models trained on synthetic images, by using robust Explainable AI (XAI) techniques to guide the modification of 3D models used to generate these images. Importantly, this framework allows both modifications that increase and decrease realism in synthetic data, which can both improve model performance. We illustrate this concept using a real-world example where data are sparse; the detection of vehicles in infrared imagery. We fine-tune an initial YOLOv8 model on the ATR DSIAC infrared dataset and synthetic images generated from 3D mesh models in the Unity gaming engine, and then use XAI saliency maps to guide modification of our Unity models. We show that synthetic data can improve detection of vehicles in orientations unseen in training by 4.6\% (to mAP50 scores of 94.6\%). We further improve performance by an additional 1.5\% (to 96.1\%) through our new XAI-guided approach, which reduces misclassifications through both increasing and decreasing the realism of different parts of the synthetic data. These proof-of-concept results pave the way for fine, XAI-controlled curation of synthetic datasets through detailed feature modifications, tailored to improve object detection performance.
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- 2024
16. Exact decomposition of non-Markovian dynamics in open quantum systems
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Ivanchenkoa, Mariia, Walters, Peter L., and Wang, Fei
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Quantum Physics ,Physics - Chemical Physics - Abstract
In this work, we developed a rigorous procedure for mapping the exact non-Markovian propagator to the generalized Lindblad form. It allows us to extract the negative decay rate that is the indicator of the non-Markovian effect. As a consequence, we can investigate the influence of the non-Markovian bath on the system's properties such as coherence and equilibrium state distribution. The understanding of the non-Markovian contribution to the dynamical process points to the possibility of leveraging non-Markovianity for quantum control.
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- 2024
17. Variational quantum algorithm for non-Markovian quantum dynamics
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Walters, Peter L., Sherazi, Mohammad U., and Wang, Fei
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Quantum Physics ,Physics - Chemical Physics - Abstract
The simulation of non-Markovian quantum dynamics plays an important role in the understanding of charge and exciton dynamics in the condensed phase environment, and yet it remains computationally expensive on classical computers. We have developed a variational quantum algorithm that is capable of simulating non-Markovian quantum dynamics. The algorithm captures the non-Markovian effect by employing the Ehrenfect trajectories in the path integral formulation and the Monte Carlo sampling of the thermal distribution. We tested the algorithm with the spin-boson model on the quantum simulator and the results match well with the exact ones. The algorithm naturally fits into the parallel computing platform of the NISQ devices and is well suited for anharmonic system-bath interactions and multi-state systems.
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- 2024
18. Indirect detection of the QCD axion
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Visinelli, Luca, Johnson, Bradley, Kavanagh, Bradley J., Marsh, David J. E., Shroyer, Jordan E., and Walters, Liam
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Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
The QCD axion, originally proposed to solve the strong CP problem in QCD, is a prominent candidate for dark matter (DM). In the presence of strong magnetic fields, such as those around neutron stars, axions can theoretically convert into photons, producing detectable electromagnetic signals. This axion-photon coupling provides a unique experimental pathway to probe axions within a specific mass range. We investigate a novel observational approach using the Green Bank Telescope (GBT) to search for radio transients that could arise from interactions between neutron stars and dense DM clumps known as axion miniclusters. By observing the core of Andromeda with the VErsatile GBT Astronomical Spectrometer (VEGAS) and the X-band receiver (8 to 10 GHz), we achieve sensitivity to axions with masses in the range of (33 - 42)$\,\mu$eV, with a mass resolution of $3.8 \times 10^{-4}\,\mu$eV. We detail our observational and analytical strategies developed to capture transient signals from axion-photon conversion, achieving an instrumental sensitivity of $2\,$mJy per spectral channel. Despite our sensitivity threshold, no candidate signals exceeding the 5$\sigma$ level were identified. Future implementations will extend this search across additional spectral bands and refine the modeling used for the processes involved, strengthening the constraints on axion DM models., Comment: 9 pages, 1 figure. Contribution to: 2nd General Meeting of the COST Action: Cosmic WISPers (CA21106), 3-6 September 2024, Istanbul (Turkey). Based on arXiv:2407.13060, arXiv:2011.05378, arXiv:2011.05377
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- 2024
19. Polynomial time and space quantum algorithm for the simulation of non-Markovian quantum dynamics
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Seneviratne, Avin, Walters, Peter L., and Wang, Fei
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Quantum Physics - Abstract
In this work, we developed an efficient quantum algorithm for the simulation of non-Markovian quantum dynamics, based on the Feynman path integral formulation. The algorithm scales polynomially with the number of native gates and the number of qubits, and has no classical overhead. It demonstrates the quantum advantage by overcoming the exponential cost on classical computers. In addition, the algorithm is efficient regardless of whether the temporal entanglement due to non-Markovianity is low or high, making it a unified framework for simulating non-Markovian dynamics in open quantum system.
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- 2024
20. An Ensemble Approach for Brain Tumor Segmentation and Synthesis
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Rivera, Juampablo E. Heras, Chopra, Agamdeep S., Ren, Tianyi, Oswal, Hitender, Pan, Yutong, Sordo, Zineb, Walters, Sophie, Henry, William, Mohammadi, Hooman, Olson, Riley, Rezayaraghi, Fargol, Lam, Tyson, Jaikanth, Akshay, Kancharla, Pavan, Ruzevick, Jacob, Ushizima, Daniela, and Kurt, Mehmet
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Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
The integration of machine learning in magnetic resonance imaging (MRI), specifically in neuroimaging, is proving to be incredibly effective, leading to better diagnostic accuracy, accelerated image analysis, and data-driven insights, which can potentially transform patient care. Deep learning models utilize multiple layers of processing to capture intricate details of complex data, which can then be used on a variety of tasks, including brain tumor classification, segmentation, image synthesis, and registration. Previous research demonstrates high accuracy in tumor segmentation using various model architectures, including nn-UNet and Swin-UNet. U-Mamba, which uses state space modeling, also achieves high accuracy in medical image segmentation. To leverage these models, we propose a deep learning framework that ensembles these state-of-the-art architectures to achieve accurate segmentation and produce finely synthesized images.
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- 2024
21. Approximate Equivariance in Reinforcement Learning
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Park, Jung Yeon, Bhatt, Sujay, Zeng, Sihan, Wong, Lawson L. S., Koppel, Alec, Ganesh, Sumitra, and Walters, Robin
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Computer Science - Machine Learning - Abstract
Equivariant neural networks have shown great success in reinforcement learning, improving sample efficiency and generalization when there is symmetry in the task. However, in many problems, only approximate symmetry is present, which makes imposing exact symmetry inappropriate. Recently, approximately equivariant networks have been proposed for supervised classification and modeling physical systems. In this work, we develop approximately equivariant algorithms in reinforcement learning (RL). We define approximately equivariant MDPs and theoretically characterize the effect of approximate equivariance on the optimal Q function. We propose novel RL architectures using relaxed group convolutions and experiment on several continuous control domains and stock trading with real financial data. Our results demonstrate that approximate equivariance matches prior work when exact symmetries are present, and outperforms them when domains exhibit approximate symmetry. As an added byproduct of these techniques, we observe increased robustness to noise at test time., Comment: Preprint
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- 2024
22. "Oriental Leaven": Anna and Rose Strunsky in the Unpublished Writings of Jack London and Sinclair Lewis
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Walters, Ashley
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- 2020
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23. The Price of Pathways: Student Borrowing Behavior across Postsecondary Pathways Revisited
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Roger Pizarro Milian, Dylan Reynolds, Trisha Einmann, David Walters, Rob Brown, and Gillian Parekh
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Transfer pathways are commonly associated with cost savings to students within the policy world. However, few have ventured to empirically examine whether traveling transfer pathways result in savings for students. Through this article, we report on analyses of this topic drawing on a custom linkage between Toronto District School Board, Postsecondary Student Information System, and Canada Student Loans Program administrative data. Such rich data allow us to estimate the relationship between traveling various pathways through Ontario postsecondary education (PSE) and (i) student's propensity to borrow from the CSLP, along with (ii) the total amount they borrowed, while (iii) controlling for a broader range of potential confounders than ever before. Our analyses provide the most conclusive evidence of the cost savings available through transfer pathways in Ontario PSE, and have implications for policy discourse on this topic across comparable jurisdictions.
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- 2024
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24. A School-Based Evaluation of the FRIENDS Resilience Programs: Implications for Mental Health Concerns in Rural Students
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Rebecca A. Schwartz-Mette, Hannah R. Lawrence, Eliot Fearey, Jessica Shankman, Janet Nichols, Joy Walters, Elena Perello, and Susan Smith
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The FRIENDS Resilience programs provide cognitive-behavioral skills across the developmental spectrum and can be applied as a universal or selective prevention program. In the current study, we assessed whether, relative to the schools' existing counseling curriculum ("guidance"), FRIENDS improved social skills, problem behaviors, and academic competence in a sample of 650 students in kindergarten, 2nd, 5th, and 7th grade in a rural community in the northeastern United States. Student, parent, and teacher reports were obtained pre-intervention, post-intervention, and 4 months later. Analyses examined FRIENDS as a universal prevention program in the general school population and as a selective intervention for at-risk students (those with elevated existing symptoms). Teachers reported improvements in social skills, problem behaviors, and academic competence, and parents reported improved problem behaviors immediately post-intervention for all students receiving FRIENDS and guidance. However, at-risk students who received FRIENDS experienced significantly greater improvements in teacher-reported problem behaviors compared to those who received guidance. When assessing changes over time once all students had received FRIENDS, teacher-rated social skills and academic competence improved, and student- and parent-rated problem behaviors decreased from pre- to post-FRIENDS and 4-month follow-up. Effects were consistent for the overall sample and at-risk students, with stronger effects for those at-risk. These small yet significant effects of FRIENDS as universal prevention may be more limited relative to usual guidance curriculum, but preventative effects may be enhanced for those students in more immediate need of support. Directions for future evaluation of FRIENDS are discussed.
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- 2024
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25. A Delphi Study to Generate, Clarify, and Prioritize Professional Recommendations on Age of Majority-Related Practice in Special Education
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Charles B. Walters and Anthony J. Plotner
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A confluence of research and current events in the United States has brought guardianship for people with disabilities into focus in recent years. In the process, the field of special education has been confronted with an unpleasant reality. In their action or inaction, special education professionals may play a role in parents of students with disabilities pursuing undue and overbroad guardianship. The purpose of this study was to work with researchers and practitioners supporting alternatives to guardianship to gather their foremost recommendations for the field of special education on addressing the use of undue guardianship. To this end, the researchers conducted a three-round Delphi study with these established professionals to solicit, rate, and revise their ratings of related recommendations toward achieving consensus. The 30 top recommendations they offered have been collected here and discussed in terms of their relevance for policy, practice, and research in the field.
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- 2024
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26. Effective Engagement Strategies in HyFlex Modality Based on Intrinsic Motivation in Students
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Kristi M. Bockorny, Theresa M. Giannavola, Shalini Mathew, and Hannah D. Walters
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In order to navigate enrollment challenges, universities are scheduling more online and blended courses including HyFlex courses which offer students flexibility in their method of attendance. The goal of this study is to explore student engagement in HyFlex courses. However, there is limited research supporting the effectiveness of HyFlex courses in terms of student engagement. This two-pronged study, conducted at a regional state university in the U.S., utilized quantitative and qualitative data to explore the engagement levels between students attending the three different modalities offered in HyFlex courses. The findings of the quantitative study showed no difference in engagement levels between students attending face-to-face, virtually synchronously on Zoom, or virtually asynchronously. The results from the qualitative study generated five themes: (1) decreased stress; (2) positive learning experience; (3) flexibility to choose based on learning styles; (4) increased control on learning; and (5) increased accountability. These findings are discussed and strategies for effective engagement in HyFlex courses are shared.
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- 2024
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27. A Path toward Racial Justice in Education: Anti-Racist Policy Decision Making in School Districts
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Sarah Diem, Deonte E. Iverson, Anjalé D. Welton, and Sarah W. Foster Walters
- Abstract
The U.S. education system has been a critical site in the nation's ongoing fight for racial equity. Yet, despite many attempts to promote equity within and across schools, efforts fall short in a system designed to uphold norms rooted in whiteness and white supremacy. We need anti-racist educational leaders who can identify and push back at the racial bias embedded in educational policies. Through a research-practice partnership with a Midwestern high school, we sought to understand how an anti-racist policy decision-making protocol can be used to redress inequitable policies to be racially just. The anti-racist policy decision-making protocol promotes social justice by empowering school practitioners to become policy agents. Implications from our findings point to the need for school practitioners to be critically introspective and identify and directly address the politics of whiteness that can ensue when working in partnership to do anti-racist policy change.
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- 2024
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28. 'It's Like an Elephant in the Room with My Family': LGBTQ+ College Students' Identity Expression during the COVID-19 Pandemic
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Veronica Hanna-Walker, Samantha E. Lawrence, Alyssa N. Clark, Tracy L. Walters, and Eva S. Lefkowitz
- Abstract
The COVID-19 pandemic led many college campuses to close and transition to remote learning. For lesbian, gay, bisexual, transgender, queer, questioning, or otherwise non-heterosexual or cisgender (LGBTQ+) college students, these disruptions may have affected their ability to express their sexual orientation and gender identity (SOGI). We used a developmental assets framework and minority stress theory with open-ended survey responses to examine LGBTQ+ students' (N = 411, Mage = 20.5; 38.4% bisexual; 48.7% women) perceptions of whether and how their SOGI expression changed due to the pandemic. We found the majority of LGBTQ+ students described their SOGI expression as restricted. However, some students perceived no change or improvements in their SOGI expression. We also examined whether perceived change in expression differed by gender identity (transgender and gender non-conforming [TGNC] compared to cisgender), and whether students lived with family. TGNC students and students who lived with family were more likely than their peers to report restricted expression and TGNC students were more likely than cisgender students to perceive improvements in their expression. Our findings highlight the internal and external assets that promote positive developmental outcomes for adolescents with minoritized identities and how universities might support LGBTQ+ students.
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- 2024
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29. Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease.
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John, Tami, Walters, Mark, Rangarajan, Hemalatha, Rahim, Mahvish, McKinney, Christopher, Bollard, Catherine, Abusin, Ghada, Eapen, Mary, Kassim, Adetola, and DeBaun, Michael
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Humans ,Anemia ,Sickle Cell ,Child ,Adolescent ,Male ,Child ,Preschool ,Female ,Hematopoietic Stem Cell Transplantation ,Transplantation ,Haploidentical ,Patient Selection - Abstract
The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 1507 leadership and the data safety monitoring board (DSMB) established incremental entry criteria for children aged 5 to 14.99 years with sickle cell disease (SCD) enrolling in a phase 2 trial of HLA-haploidentical hematopoietic stem cell transplantation. First, the enrollment was limited to overt stroke in the first 10 participants (stage 4). Subsequently, the DSMB reviewed the interim results and expanded the eligibility to include children with silent cerebral infarcts or abnormal transcranial Doppler velocities with magnetic resonance angiography-defined cerebral vasculopathy (stage 3). A third cohort was enrolled after the DSMB reviewed the clinical outcomes in these cumulative initial enrollments (n = 18) and additions were made to the entry criteria that included nonneurologic morbidities (stage 2). Added eligibility criteria included the following: (1) life-threatening acute chest syndrome requiring exchange transfusion; (2) right heart catheterization confirmed pulmonary hypertension; (3) persistent systemic hypertension despite maximum medical therapy; (4) acute pain despite maximum medical therapy in the absence of psychosocial factors and unmanaged asthma after adjudication; and (5) 2 major priapism episodes in 12 months or 3 in 24 months. Children with SCD who did not meet the criteria for stages 4, 3, and 2 were not eligible. To our knowledge, for the first time, we introduce a staged strategy for eligibility in a curative therapy trial for children with SCD concordant with 45 Code of Federal Regulations § 46.405(b). The research governance-mandated eligibility strategy used within the BMT CTN 1507 phase 2 study may apply to future pediatric SCD curative therapy trials. This trial was registered at www.ClinicalTrials.gov as #NCT032635590.
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- 2024
30. Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients.
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Kennedy, April, Griffiths, Anne, Muise, Aleixo, Walters, Thomas, Ricciuto, Amanda, Huynh, Hien, Wine, Eytan, Jacobson, Kevan, Lawrence, Sally, Carman, Nicholas, Mack, David, deBruyn, Jennifer, Otley, Anthony, Deslandres, Colette, El-Matary, Wael, Zachos, Mary, Benchimol, Eric, Critch, Jeffrey, Schneider, Rilla, Crowley, Eileen, Li, Michael, Warner, Neil, McGovern, Dermot, Li, Dalin, Haritunians, Talin, Rudin, Sarah, and Cohn, Iris
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NUDT15 ,TPMT ,genetic ancestry ,pharmacogenetics ,thiopurines ,Humans ,Pyrophosphatases ,Female ,Canada ,Male ,Child ,Methyltransferases ,Adolescent ,Azathioprine ,Inflammatory Bowel Diseases ,Mercaptopurine ,Pharmacogenomic Variants ,Pharmacogenetics ,Cohort Studies ,Crohn Disease ,Genotype ,Child ,Preschool ,Immunosuppressive Agents ,Colitis ,Ulcerative ,Pharmacogenomic Testing ,Nudix Hydrolases - Abstract
BACKGROUND: Patients with inflammatory bowel disease (IBD) exhibit considerable interindividual variability in medication response, highlighting the need for precision medicine approaches to optimize and tailor treatment. Pharmacogenetics (PGx) offers the ability to individualize dosing by examining genetic factors underlying the metabolism of medications such as thiopurines. Pharmacogenetic testing can identify individuals who may be at risk for thiopurine dose-dependent adverse reactions including myelosuppression. We aimed to evaluate PGx variation in genes supported by clinical guidelines that inform dosing of thiopurines and characterize differences in the distribution of actionable PGx variation among diverse ancestral groups. METHODS: Pharmacogenetic variation in TPMT and NUDT15 was captured by genome-wide genotyping of 1083 pediatric IBD patients from a diverse Canadian cohort. Genetic ancestry was inferred using principal component analysis. The proportion of PGx variation and associated metabolizer status phenotypes was compared across 5 genetic ancestral groups within the cohort (Admixed American, African, East Asian, European, and South Asian) and to prior global estimates from corresponding populations. RESULTS: Collectively, 11% of the cohort was categorized as intermediate or poor metabolizers of thiopurines, which would warrant a significant dose reduction or selection of alternate therapy. Clinically actionable variation in TPMT was more prevalent in participants of European and Admixed American/Latino ancestry (8.7% and 7.5%, respectively), whereas variation in NUDT15 was more prevalent in participants of East Asian and Admixed American/Latino ancestry (16% and 15% respectively). CONCLUSIONS: These findings demonstrate the considerable interpopulation variability in PGx variation underlying thiopurine metabolism, which should be factored into testing diverse patient populations.
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- 2024
31. AlabOS: a Python-based reconfigurable workflow management framework for autonomous laboratories
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Fei, Yuxing, Rendy, Bernardus, Kumar, Rishi, Dartsi, Olympia, Sahasrabuddhe, Hrushikesh P, McDermott, Matthew J, Wang, Zheren, Szymanski, Nathan J, Walters, Lauren N, Milsted, David, Zeng, Yan, Jain, Anubhav, and Ceder, Gerbrand
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Information and Computing Sciences ,Software Engineering ,MSD-General ,MSD-D2S2 ,MSD-Materials Project - Abstract
The recent advent of autonomous laboratories, coupled with algorithms for high-throughput screening and active learning, promises to accelerate materials discovery and innovation. As these autonomous systems grow in complexity, the demand for robust and efficient workflow management software becomes increasingly critical. In this paper, we introduce AlabOS, a general-purpose software framework for orchestrating experiments and managing resources, with an emphasis on automated laboratories for materials synthesis and characterization. AlabOS features a reconfigurable experiment workflow model and a resource reservation mechanism, enabling the simultaneous execution of varied workflows composed of modular tasks while eliminating conflicts between tasks. To showcase its capability, we demonstrate the implementation of AlabOS in a prototype autonomous materials laboratory, the A-Lab, with around 3500 samples synthesized over 1.5 years.
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- 2024
32. Nitrogen isotopes reveal high NOx emissions from arid agricultural soils in the Salton Sea Air Basin
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Lieb, Heather C, Maldonado, Matthew, Ruiz, Edgar, Torres, Christian, Olmedo, Luis, Walters, Wendell W, and Faloona, Ian C
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Earth Sciences ,Atmospheric Sciences ,Environmental Sciences ,Pollution and Contamination ,Climate-Related Exposures and Conditions ,Zero Hunger ,Climate Action - Abstract
Air quality management commonly aims to mitigate nitrogen oxide (NOx) emissions from combustion, reducing ozone (O3) and particulate matter (PM) pollution. Despite such ongoing efforts, regulations have recently proven ineffective in rural areas like the Salton Sea Air Basin of Southern California, which routinely violates O3 and PM air quality standards. With over $2 billion in annual agricultural sales and low population density, air quality in the region is likely influenced by the year-round farming activity. We conducted a source apportionment of NOx (an important precursor to both O3 and PM) using nitrogen stable isotopes of ambient NO2, which revealed a significant contribution from soil-emitted NOx to the regional budget. The soil source strength was estimated based on the mean δ15N-NOx from each emission category in the California Air Resources Board's NOx inventory. Our annual average soil emission estimate for the air basin was 11.4 ± 4 tons/d, representing ~ 30% of the extant NOx inventory, 10× larger than the state's inventory for soil emissions. Unconstrained environmental factors such as nutrient availability, soil moisture, and temperature have a first-order impact on soil NOx production in this agriculturally intensive region, with fertilization and irrigation practices likely driving most of the emissions variability. Without spatially and temporally accurate data on fertilizer application rates and irrigation schedules, it is difficult to determine the direct impacts that these variations have on our observations. Nevertheless, comparative analysis with previous studies indicates that soil NOx emissions in the Imperial Valley are likely underrepresented in current inventories, highlighting the need for more detailed and localized observational data to constrain the sizeable and variable emissions from these arid, agricultural soils.
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- 2024
33. GPT-4o System Card
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OpenAI, Hurst, Aaron, Lerer, Adam, Goucher, Adam P., Perelman, Adam, Ramesh, Aditya, Clark, Aidan, Ostrow, AJ, Welihinda, Akila, Hayes, Alan, Radford, Alec, Mądry, Aleksander, Baker-Whitcomb, Alex, Beutel, Alex, Borzunov, Alex, Carney, Alex, Chow, Alex, Kirillov, Alex, Nichol, Alex, Paino, Alex, Renzin, Alex, Passos, Alex Tachard, Kirillov, Alexander, Christakis, Alexi, Conneau, Alexis, Kamali, Ali, Jabri, Allan, Moyer, Allison, Tam, Allison, Crookes, Amadou, Tootoochian, Amin, Tootoonchian, Amin, Kumar, Ananya, Vallone, Andrea, Karpathy, Andrej, Braunstein, Andrew, Cann, Andrew, Codispoti, Andrew, Galu, Andrew, Kondrich, Andrew, Tulloch, Andrew, Mishchenko, Andrey, Baek, Angela, Jiang, Angela, Pelisse, Antoine, Woodford, Antonia, Gosalia, Anuj, Dhar, Arka, Pantuliano, Ashley, Nayak, Avi, Oliver, Avital, Zoph, Barret, Ghorbani, Behrooz, Leimberger, Ben, Rossen, Ben, Sokolowsky, Ben, Wang, Ben, Zweig, Benjamin, Hoover, Beth, Samic, Blake, McGrew, Bob, Spero, Bobby, Giertler, Bogo, Cheng, Bowen, Lightcap, Brad, Walkin, Brandon, Quinn, Brendan, Guarraci, Brian, Hsu, Brian, Kellogg, Bright, Eastman, Brydon, Lugaresi, Camillo, Wainwright, Carroll, Bassin, Cary, Hudson, Cary, Chu, Casey, Nelson, Chad, Li, Chak, Shern, Chan Jun, Conger, Channing, Barette, Charlotte, Voss, Chelsea, Ding, Chen, Lu, Cheng, Zhang, Chong, Beaumont, Chris, Hallacy, Chris, Koch, Chris, Gibson, Christian, Kim, Christina, Choi, Christine, McLeavey, Christine, Hesse, Christopher, Fischer, Claudia, Winter, Clemens, Czarnecki, Coley, Jarvis, Colin, Wei, Colin, Koumouzelis, Constantin, Sherburn, Dane, Kappler, Daniel, Levin, Daniel, Levy, Daniel, Carr, David, Farhi, David, Mely, David, Robinson, David, Sasaki, David, Jin, Denny, Valladares, Dev, Tsipras, Dimitris, Li, Doug, Nguyen, Duc Phong, Findlay, Duncan, Oiwoh, Edede, Wong, Edmund, Asdar, Ehsan, Proehl, Elizabeth, Yang, Elizabeth, Antonow, Eric, Kramer, Eric, Peterson, Eric, Sigler, Eric, Wallace, Eric, Brevdo, Eugene, Mays, Evan, Khorasani, Farzad, Such, Felipe Petroski, Raso, Filippo, Zhang, Francis, von Lohmann, Fred, Sulit, Freddie, Goh, Gabriel, Oden, Gene, Salmon, Geoff, Starace, Giulio, Brockman, Greg, Salman, Hadi, Bao, Haiming, Hu, Haitang, Wong, Hannah, Wang, Haoyu, Schmidt, Heather, Whitney, Heather, Jun, Heewoo, Kirchner, Hendrik, Pinto, Henrique Ponde de Oliveira, Ren, Hongyu, Chang, Huiwen, Chung, Hyung Won, Kivlichan, Ian, O'Connell, Ian, Osband, Ian, Silber, Ian, Sohl, Ian, Okuyucu, Ibrahim, Lan, Ikai, Kostrikov, Ilya, Sutskever, Ilya, Kanitscheider, Ingmar, Gulrajani, Ishaan, Coxon, Jacob, Menick, Jacob, Pachocki, Jakub, Aung, James, Betker, James, Crooks, James, Lennon, James, Kiros, Jamie, Leike, Jan, Park, Jane, Kwon, Jason, Phang, Jason, Teplitz, Jason, Wei, Jason, Wolfe, Jason, Chen, Jay, Harris, Jeff, Varavva, Jenia, Lee, Jessica Gan, Shieh, Jessica, Lin, Ji, Yu, Jiahui, Weng, Jiayi, Tang, Jie, Yu, Jieqi, Jang, Joanne, Candela, Joaquin Quinonero, Beutler, Joe, Landers, Joe, Parish, Joel, Heidecke, Johannes, Schulman, John, Lachman, Jonathan, McKay, Jonathan, Uesato, Jonathan, Ward, Jonathan, Kim, Jong Wook, Huizinga, Joost, Sitkin, Jordan, Kraaijeveld, Jos, Gross, Josh, Kaplan, Josh, Snyder, Josh, Achiam, Joshua, Jiao, Joy, Lee, Joyce, Zhuang, Juntang, Harriman, Justyn, Fricke, Kai, Hayashi, Kai, Singhal, Karan, Shi, Katy, Karthik, Kavin, Wood, Kayla, Rimbach, Kendra, Hsu, Kenny, Nguyen, Kenny, Gu-Lemberg, Keren, Button, Kevin, Liu, Kevin, Howe, Kiel, Muthukumar, Krithika, Luther, Kyle, Ahmad, Lama, Kai, Larry, Itow, Lauren, Workman, Lauren, Pathak, Leher, Chen, Leo, Jing, Li, Guy, Lia, Fedus, Liam, Zhou, Liang, Mamitsuka, Lien, Weng, Lilian, McCallum, Lindsay, Held, Lindsey, Ouyang, Long, Feuvrier, Louis, Zhang, Lu, Kondraciuk, Lukas, Kaiser, Lukasz, Hewitt, Luke, Metz, Luke, Doshi, Lyric, Aflak, Mada, Simens, Maddie, Boyd, Madelaine, Thompson, Madeleine, Dukhan, Marat, Chen, Mark, Gray, Mark, Hudnall, Mark, Zhang, Marvin, Aljubeh, Marwan, Litwin, Mateusz, Zeng, Matthew, Johnson, Max, Shetty, Maya, Gupta, Mayank, Shah, Meghan, Yatbaz, Mehmet, Yang, Meng Jia, Zhong, Mengchao, Glaese, Mia, Chen, Mianna, Janner, Michael, Lampe, Michael, Petrov, Michael, Wu, Michael, Wang, Michele, Fradin, Michelle, Pokrass, Michelle, Castro, Miguel, de Castro, Miguel Oom Temudo, Pavlov, Mikhail, Brundage, Miles, Wang, Miles, Khan, Minal, Murati, Mira, Bavarian, Mo, Lin, Molly, Yesildal, Murat, Soto, Nacho, Gimelshein, Natalia, Cone, Natalie, Staudacher, Natalie, Summers, Natalie, LaFontaine, Natan, Chowdhury, Neil, Ryder, Nick, Stathas, Nick, Turley, Nick, Tezak, Nik, Felix, Niko, Kudige, Nithanth, Keskar, Nitish, Deutsch, Noah, Bundick, Noel, Puckett, Nora, Nachum, Ofir, Okelola, Ola, Boiko, Oleg, Murk, Oleg, Jaffe, Oliver, Watkins, Olivia, Godement, Olivier, Campbell-Moore, Owen, Chao, Patrick, McMillan, Paul, Belov, Pavel, Su, Peng, Bak, Peter, Bakkum, Peter, Deng, Peter, Dolan, Peter, Hoeschele, Peter, Welinder, Peter, Tillet, Phil, Pronin, Philip, Tillet, Philippe, Dhariwal, Prafulla, Yuan, Qiming, Dias, Rachel, Lim, Rachel, Arora, Rahul, Troll, Rajan, Lin, Randall, Lopes, Rapha Gontijo, Puri, Raul, Miyara, Reah, Leike, Reimar, Gaubert, Renaud, Zamani, Reza, Wang, Ricky, Donnelly, Rob, Honsby, Rob, Smith, Rocky, Sahai, Rohan, Ramchandani, Rohit, Huet, Romain, Carmichael, Rory, Zellers, Rowan, Chen, Roy, Chen, Ruby, Nigmatullin, Ruslan, Cheu, Ryan, Jain, Saachi, Altman, Sam, Schoenholz, Sam, Toizer, Sam, Miserendino, Samuel, Agarwal, Sandhini, Culver, Sara, Ethersmith, Scott, Gray, Scott, Grove, Sean, Metzger, Sean, Hermani, Shamez, Jain, Shantanu, Zhao, Shengjia, Wu, Sherwin, Jomoto, Shino, Wu, Shirong, Shuaiqi, Xia, Phene, Sonia, Papay, Spencer, Narayanan, Srinivas, Coffey, Steve, Lee, Steve, Hall, Stewart, Balaji, Suchir, Broda, Tal, Stramer, Tal, Xu, Tao, Gogineni, Tarun, Christianson, Taya, Sanders, Ted, Patwardhan, Tejal, Cunninghman, Thomas, Degry, Thomas, Dimson, Thomas, Raoux, Thomas, Shadwell, Thomas, Zheng, Tianhao, Underwood, Todd, Markov, Todor, Sherbakov, Toki, Rubin, Tom, Stasi, Tom, Kaftan, Tomer, Heywood, Tristan, Peterson, Troy, Walters, Tyce, Eloundou, Tyna, Qi, Valerie, Moeller, Veit, Monaco, Vinnie, Kuo, Vishal, Fomenko, Vlad, Chang, Wayne, Zheng, Weiyi, Zhou, Wenda, Manassra, Wesam, Sheu, Will, Zaremba, Wojciech, Patil, Yash, Qian, Yilei, Kim, Yongjik, Cheng, Youlong, Zhang, Yu, He, Yuchen, Zhang, Yuchen, Jin, Yujia, Dai, Yunxing, and Malkov, Yury
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Computers and Society ,Computer Science - Machine Learning ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
GPT-4o is an autoregressive omni model that accepts as input any combination of text, audio, image, and video, and generates any combination of text, audio, and image outputs. It's trained end-to-end across text, vision, and audio, meaning all inputs and outputs are processed by the same neural network. GPT-4o can respond to audio inputs in as little as 232 milliseconds, with an average of 320 milliseconds, which is similar to human response time in conversation. It matches GPT-4 Turbo performance on text in English and code, with significant improvement on text in non-English languages, while also being much faster and 50\% cheaper in the API. GPT-4o is especially better at vision and audio understanding compared to existing models. In line with our commitment to building AI safely and consistent with our voluntary commitments to the White House, we are sharing the GPT-4o System Card, which includes our Preparedness Framework evaluations. In this System Card, we provide a detailed look at GPT-4o's capabilities, limitations, and safety evaluations across multiple categories, focusing on speech-to-speech while also evaluating text and image capabilities, and measures we've implemented to ensure the model is safe and aligned. We also include third-party assessments on dangerous capabilities, as well as discussion of potential societal impacts of GPT-4o's text and vision capabilities.
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- 2024
34. On Isbell's Density Theorem for bitopological pointfree spaces II
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Moshier, M. Andrew, Carollo, Imanol Mozo, and Walters-Wayland, Joanne
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Mathematics - General Topology ,06D22, 54B05, 54E55 - Abstract
With the aim of studying subspaces in pointfree bitopology, we characterize extremal epimorphism in biframes and show that a smallest dense one always exists, providing an analogue of Isbell's Density Theorem. Further we study the functoriality of assigning to each biframe its lattice of subbilocales and its smallest dense subbilocale.
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- 2024
35. MATCH POLICY: A Simple Pipeline from Point Cloud Registration to Manipulation Policies
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Huang, Haojie, Liu, Haotian, Wang, Dian, Walters, Robin, and Platt, Robert
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Computer Science - Robotics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Many manipulation tasks require the robot to rearrange objects relative to one another. Such tasks can be described as a sequence of relative poses between parts of a set of rigid bodies. In this work, we propose MATCH POLICY, a simple but novel pipeline for solving high-precision pick and place tasks. Instead of predicting actions directly, our method registers the pick and place targets to the stored demonstrations. This transfers action inference into a point cloud registration task and enables us to realize nontrivial manipulation policies without any training. MATCH POLICY is designed to solve high-precision tasks with a key-frame setting. By leveraging the geometric interaction and the symmetries of the task, it achieves extremely high sample efficiency and generalizability to unseen configurations. We demonstrate its state-of-the-art performance across various tasks on RLBench benchmark compared with several strong baselines and test it on a real robot with six tasks., Comment: project url: https://haojhuang.github.io/match_page/
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- 2024
36. Degrees of join-distributivity via Bruns-Lakser towers
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Bezhanishvili, G., Dashiell Jr, F., Moshier, A., and Walters-Wayland, J.
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Mathematics - Logic ,18F70, 06D22, 06D20, 06D05, 06B23, 06A12, 06E15 - Abstract
We utilize the Bruns-Lakser completion to introduce Bruns-Lakser towers of a meet-semilattice. This machinery enables us to develop various hierarchies inside the class of bounded distributive lattices, which measure $\kappa$-degrees of distributivity of bounded distributive lattices and their Dedekind-MacNeille completions. We also use Priestley duality to obtain a dual characterization of the resulting hierarchies. Among other things, this yields a natural generalization of Esakia's representation of Heyting lattices to proHeyting lattices.
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- 2024
37. Random Geometric Graphs in Reflexive Banach Spaces
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Balogh, József, Walters, Mark, and Zsák, András
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Mathematics - Functional Analysis ,Mathematics - Combinatorics - Abstract
We investigate a random geometric graph model introduced by Bonato and Janssen. The vertices are the points of a countable dense set $S$ in a (necessarily separable) normed vector space $X$, and each pair of points are joined independently with some fixed probability $p$ (with $0
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- 2024
38. Electron Influence on the Parallel Proton Firehose Instability in 10-Moment, Multi-Fluid Simulations
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Walters, Jada, Klein, Kristopher G., Lichko, Emily, Juno, James, and TenBarge, Jason M.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics - Abstract
Instabilities driven by pressure anisotropy play a critical role in modulating the energy transfer in space and astrophysical plasmas. For the first time, we simulate the evolution and saturation of the parallel proton firehose instability using a multi-fluid model without adding artificial viscosity. These simulations are performed using a 10-moment, multi-fluid model with local and gradient relaxation heat-flux closures in high-$\beta$ proton-electron plasmas. When these higher-order moments are included and pressure anisotropy is permitted to develop in all species, we find that the electrons have a significant impact on the saturation of the parallel proton firehose instability, modulating the proton pressure anisotropy as the instability saturates. Even for lower $\beta$s more relevant to heliospheric plasmas, we observe a pronounced electron energization in simulations using the gradient relaxation closure. Our results indicate that resolving the electron pressure anisotropy is important to correctly describe the behavior of multi-species plasma systems., Comment: 10 pages, 7 figures, under review in ApJ
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- 2024
39. Fostering Equity in Computer Science Education: Principles from a Feminist Standpoint Conceptual Framework
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Ceren Ocak, Katherine Walters, and Theodore J. Kopcha
- Abstract
In this article, we present a conceptual framework for teaching computer science (CS) to address the unique challenges faced by marginalized groups. The framework is grounded in feminist standpoint theory and describes three key practitioner-focused areas aimed at broadening participation and increasing participation in CS education (CSEd). These principles are (1) Creating dialogic and dialectical relationships with the CS community, (2) Embracing intersectionality in CSEd, and (3) Framing CS education as a lived experience. It also offers a distinct perspective in that it is concerned with how "both sides of the dialogue" (i.e., the oppressed and the oppressor) grow and change in relation to one another. The strategies, along with the framework detailed in this paper, provide scholars and educators with new avenues for unpacking underrepresentation in CSEd and potential methods to address it.
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- 2024
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- View/download PDF
40. Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease.
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Lessard, Samuel, Rimmelé, Pauline, Ling, Hui, Moran, Kevin, Vieira, Benjamin, Lin, Yi-Dong, Rajani, Gaurav, Hong, Vu, Reik, Andreas, Boismenu, Richard, Hsu, Ben, Chen, Michael, Cockroft, Bettina, Uchida, Naoya, Tisdale, John, Alavi, Asif, Krishnamurti, Lakshmanan, Abedi, Mehrdad, Galeon, Isobelle, Reiner, David, Wang, Lin, Ramezi, Anne, Rendo, Pablo, Walters, Mark, Levasseur, Dana, Peters, Robert, Harris, Timothy, and Hicks, Alexandra
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Anemia ,Sickle Cell ,Fetal Hemoglobin ,Humans ,Gene Editing ,Hematopoietic Stem Cells ,Zinc Finger Nucleases ,Female ,Male ,Adult ,Hematopoietic Stem Cell Transplantation ,Animals ,Mice ,Repressor Proteins - Abstract
BIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle cell disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that target and disrupt a specific regulatory GATAA motif in the BCL11A erythroid enhancer to reactivate fetal hemoglobin (HbF). We characterized ZFN-edited HSC from healthy donors and donors with SCD. Results of preclinical studies show that ZFN-mediated editing is highly efficient, with enriched biallelic editing and high frequency of on-target indels, producing HSC capable of long-term multilineage engraftment in vivo, and express HbF in erythroid progeny. Interim results from the Phase 1/2 PRECIZN-1 study demonstrated that BIVV003 was well-tolerated in seven participants with SCD, of whom five of the six with more than 3 months of follow-up displayed increased total hemoglobin and HbF, and no severe vaso-occlusive crises. Our data suggest BIVV003 represents a compelling and novel cell therapy for the potential treatment of SCD.
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- 2024
41. Comparing Multipin Clamps With Outriggers With Standard Clamps for Lower Extremity Periarticular External Fixation: Similar Radiographic and Clinical Outcomes.
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Tse, Shannon, Saade, Aziz, Ikwuezunma, Ijezie, Walters, Cody, Simister, Samuel, Saiz, Augustine, Fitzpatrick, Ellen, Soles, Gillian, Lee, Mark, and Campbell, Sean
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Humans ,Tibial Fractures ,Retrospective Studies ,External Fixators ,Male ,Female ,Middle Aged ,Adult ,Fracture Fixation ,Treatment Outcome ,Radiography ,Aged - Abstract
INTRODUCTION: Staged treatment of high-energy periarticular tibia fractures involves temporization with closed reduction and external fixation, aiming to provide early reduction and stabilization while mitigating soft-tissue complications. Various external fixator configurations exist, including those that use a multipin clamp capable of holding multiple pins but limiting pin placement to a single plane. The purpose of this study was to compare clinical and radiographic outcomes and associated costs of standard and multipin outrigger clamp constructs in tibial plateau and pilon fractures treated with temporary external fixation. We hypothesized that use of the multipin clamp may be associated with poorly aligned reductions and increased complication rates. METHODS: A retrospective review of 100 patients with periarticular tibial plateau (AO/OTA: 41B/C) or pilon (43B/C) fracture at a Level 1 trauma center from 2014 to 2023 was conducted. Patient, injury, and complication characteristics were collected. Patients were categorized based on the external fixator clamp used: multipin (MP) or standard (S). Clinical outcomes and complication rates were assessed. Radiographic alignment was evaluated by the change in anterior and lateral distal tibial angles, and sagittal plane translation for pilon fractures, and medial and posterior proximal tibial angles for plateau fractures. RESULTS: 70 patients underwent standard (25 pilon, 45 plateau) and 30 multipin (10 pilon, 20 plateau) external fixation. MP and S groups showed no notable differences in demographics or injury characteristics. Both groups demonstrated comparable complication rates and radiological alignment outcomes, with no notable differences observed. MP constructs were more costly than standard systems. CONCLUSION: In this retrospective study of 100 patients, there was no difference in radiographic or clinical outcomes between the standard frame and multipin frame groups. Typical costs for the multipin frame constructs were $635 to $1249 more than the standard frame constructs.
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- 2024
42. Emergency Department Food Insecurity Screening, Food Voucher Distribution and Utilization: A Prospective Cohort Study
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Ulintz, Alexander J., Patel, Seema S., Anderson, Katherine, Walters, Kevin, Stepsis, Tyler J., Lyons, Michael S., and Pang, Peter S.
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emergency department ,Food Insecurity ,Social Risks ,social determinants of health ,social emergency medicine - Abstract
Objective: Food insecurity is a prevalent social risk among emergency department (ED) patients. Patients who may benefit from food insecurity resources may be identified via ED-based screening; however, many patients experience difficulty accessing resources after discharge. Co-locating resources in or near the ED may improve utilization by patients, but this approach remains largely unstudied. This study characterized the acceptance and use of a food voucher redeemable at a hospital food market for patients who screened positive for food insecurity during their ED visit.Methods: This prospective cohort study, conducted at a single county-funded ED, included consecutive adult patients who presented on weekdays between 8 AM–8 PM from July–October 2022 and consented to research participation. We excluded patients who required resuscitation on arrival or could not provide written informed consent in English. Study participants completed a paper version of the two-question Hunger Vital Sign screening tool, administered by research staff. Participants who screened positive received a uniquely numbered $30 food voucher redeemable at the hospital’s co-located food market. Voucher redemption was quantified through regular evaluation of market receipt records at 30-day intervals. The primary outcome was the proportion of redeemed vouchers. Secondary outcomes included the proportion of participants screening positive for food insecurity, proportion of participants accepting vouchers, and associated descriptive statistics.Results: Of the 396 eligible individuals approached, 377 (95.2%) consented and completed food insecurity screening. Most were middle-aged (median 53 years, interquartile range 30–58 years), 191 were female (50.4%), 242 were Black (63.9%), and 343 were non-Hispanic (91.0%). Of the participants, 228 (60.2%) screened positive for food insecurity and 224 received vouchers (98.2%), of which 86 were redeemed (38.4%) a median of nine days after the ED visit.Conclusion: A high proportion of participants screened positive for food insecurity and accepted food vouchers; however, less than half of all vouchers were redeemed at the co-located food market. These results imply ED food voucher distribution for food insecurity is feasible, but co-location of resources alone may be insufficient in addressing the social risk and alludes to a limited understanding of facilitators and barriers to resource utilization following ED-based social needs screening.
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- 2024
43. Impact of a Mobile Harm Reduction Program on Sterile Syringe and Naloxone Use in San Joaquin County
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Walters, Cody, Jan, Amanda, Morales, Jacqueline, and Virk, Harjot
- Abstract
In 2022, San Joaquin County had approximately 2,319 unhoused/unsheltered individuals, with 66% residing in Stockton. Studies have found that approximately 75% of unhoused individuals reported drug use of any kind and 12% reported opioid use. Additionally, drug overdosedeaths increased in the United States by more than 30% from 2019 to 2020. Transmission rates of infections associated with injection drug use have also been increasing. Harm reduction services, including syringe exchange and naloxone distribution, have been shown toreduce the rates of disease transmission and drug overdose death within communities.In 2016, the rate of drug-induced deaths was 56% higher in San Joaquin County than the California state average. Developed in July 2020, The Stockton Harm ReductionProgram (SHRP) provides sterile syringes and injection equipment, condoms, naloxone, hygiene products, and referrals for health and housing services to people in San Joaquin County. The purpose of this study is to determine the impact of a mobile harm reduction program on usage of sterilesyringes and naloxone by program participants.
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- 2024
44. Relaxed Equivariant Graph Neural Networks
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Hofgard, Elyssa, Wang, Rui, Walters, Robin, and Smidt, Tess
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Computer Science - Machine Learning - Abstract
3D Euclidean symmetry equivariant neural networks have demonstrated notable success in modeling complex physical systems. We introduce a framework for relaxed $E(3)$ graph equivariant neural networks that can learn and represent symmetry breaking within continuous groups. Building on the existing e3nn framework, we propose the use of relaxed weights to allow for controlled symmetry breaking. We show empirically that these relaxed weights learn the correct amount of symmetry breaking., Comment: Extended abstract presented at the Geometry-grounded Representation Learning and Generative Modeling Workshop (GRaM) at the 41st International Conference on Machine Learning, July 2024, Vienna, Austria
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- 2024
45. Impact of electron correlations on two-particle charge response in electron- and hole-doped cuprates
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Nag, Abhishek, Zinni, Luciano, Choi, Jaewon, Li, J., Tu, Sijia, Walters, A. C., Agrestini, S., Hayden, S. M., Bejas, Matías, Lin, Zefeng, Yamase, H., Jin, Kui, García-Fernández, M., Fink, J., Greco, Andrés, and Zhou, Ke-Jin
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Condensed Matter - Strongly Correlated Electrons - Abstract
Estimating many-body effects that deviate from an independent particle approach, has long been a key research interest in condensed matter physics. Layered cuprates are prototypical systems, where electron-electron interactions are found to strongly affect the dynamics of single-particle excitations. It is however, still unclear how the electron correlations influence charge excitations, such as plasmons, which have been variously treated with either weak or strong correlation models. In this work, we demonstrate the hybridised nature of collective valence charge fluctuations leading to dispersing acoustic-like plasmons in hole-doped La$_{1.84}$Sr$_{0.16}$CuO$_{4}$ and electron-doped La$_{1.84}$Ce$_{0.16}$CuO$_{4}$ using the two-particle probe, resonant inelastic x-ray scattering. We then describe the plasmon dispersions in both systems, within both the weak mean-field Random Phase Approximation (RPA) and strong coupling $t$-$J$-$V$ models. The $t$-$J$-$V$ model, which includes the correlation effects implicitly, accurately describes the plasmon dispersions as resonant excitations outside the single-particle intra-band continuum. In comparison, a quantitative description of the plasmon dispersion in the RPA approach is obtained only upon explicit consideration of re-normalized electronic band parameters. Our comparative analysis shows that electron correlations significantly impact the low-energy plasmon excitations across the cuprate doping phase diagram, even at long wavelengths. Thus, complementary information on the evolution of electron correlations, influenced by the rich electronic phases in condensed matter systems, can be extracted through the study of two-particle charge response., Comment: 6 Figures
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- 2024
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46. Axions in Andromeda: Searching for Minicluster -- Neutron Star Encounters with the Green Bank Telescope
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Walters, Liam, Shroyer, Jordan, Edenton, Madeleine, Agrawal, Prakamya, Johnson, Bradley, Kavanagh, Bradley J., Marsh, David J. E., and Visinelli, Luca
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Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Phenomenology - Abstract
The QCD axion and axion-like particles are compelling candidates for galactic dark matter. Theoretically, axions can convert into photons in the presence of a strong external magnetic field, which means it is possible to search for them experimentally. One approach is to use radio telescopes with high-resolution spectrometers to look for axion-photon conversion in the magnetospheres of neutron stars. In this paper, we describe the results obtained using a novel approach where we used the Green Bank Telescope (GBT) to search for radio transients produced by collisions between neutron stars and dark matter clumps known as axion miniclusters. We used the VErsatile GBT Astronomical Spectrometer (VEGAS) and the X-band receiver (8 to 10 GHz) to observe the core of Andromeda. Our measurements are sensitive to axions with masses between 33 and 42 $\mu$eV with $\Delta$$m_a$ = 3.8$\times10^{-4}$ $\mu$eV. This paper gives a description of the search method we developed, including observation and analysis strategies. Given our analysis algorithm choices and the instrument sensitivity ($\sim$2 mJy in each spectral channel), we did not find any candidate signals greater than 5$\sigma$. We are currently implementing this search method in other spectral bands., Comment: 19 pages, 12 figures, accepted to PRD
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- 2024
47. OrbitGrasp: $SE(3)$-Equivariant Grasp Learning
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Hu, Boce, Zhu, Xupeng, Wang, Dian, Dong, Zihao, Huang, Haojie, Wang, Chenghao, Walters, Robin, and Platt, Robert
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Computer Science - Robotics - Abstract
While grasp detection is an important part of any robotic manipulation pipeline, reliable and accurate grasp detection in $SE(3)$ remains a research challenge. Many robotics applications in unstructured environments such as the home or warehouse would benefit a lot from better grasp performance. This paper proposes a novel framework for detecting $SE(3)$ grasp poses based on point cloud input. Our main contribution is to propose an $SE(3)$-equivariant model that maps each point in the cloud to a continuous grasp quality function over the 2-sphere $S^2$ using spherical harmonic basis functions. Compared with reasoning about a finite set of samples, this formulation improves the accuracy and efficiency of our model when a large number of samples would otherwise be needed. In order to accomplish this, we propose a novel variation on EquiFormerV2 that leverages a UNet-style encoder-decoder architecture to enlarge the number of points the model can handle. Our resulting method, which we name $\textit{OrbitGrasp}$, significantly outperforms baselines in both simulation and physical experiments., Comment: Conference on Robot Learning 2024
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- 2024
48. Equivariant Diffusion Policy
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Wang, Dian, Hart, Stephen, Surovik, David, Kelestemur, Tarik, Huang, Haojie, Zhao, Haibo, Yeatman, Mark, Wang, Jiuguang, Walters, Robin, and Platt, Robert
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Computer Science - Robotics ,Computer Science - Machine Learning - Abstract
Recent work has shown diffusion models are an effective approach to learning the multimodal distributions arising from demonstration data in behavior cloning. However, a drawback of this approach is the need to learn a denoising function, which is significantly more complex than learning an explicit policy. In this work, we propose Equivariant Diffusion Policy, a novel diffusion policy learning method that leverages domain symmetries to obtain better sample efficiency and generalization in the denoising function. We theoretically analyze the $\mathrm{SO}(2)$ symmetry of full 6-DoF control and characterize when a diffusion model is $\mathrm{SO}(2)$-equivariant. We furthermore evaluate the method empirically on a set of 12 simulation tasks in MimicGen, and show that it obtains a success rate that is, on average, 21.9% higher than the baseline Diffusion Policy. We also evaluate the method on a real-world system to show that effective policies can be learned with relatively few training samples, whereas the baseline Diffusion Policy cannot., Comment: Conference on Robot Learning 2024, Oral Presentation
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- 2024
49. Open-vocabulary Pick and Place via Patch-level Semantic Maps
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Jia, Mingxi, Huang, Haojie, Zhang, Zhewen, Wang, Chenghao, Zhao, Linfeng, Wang, Dian, Liu, Jason Xinyu, Walters, Robin, Platt, Robert, and Tellex, Stefanie
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Computer Science - Robotics - Abstract
Controlling robots through natural language instructions in open-vocabulary scenarios is pivotal for enhancing human-robot collaboration and complex robot behavior synthesis. However, achieving this capability poses significant challenges due to the need for a system that can generalize from limited data to a wide range of tasks and environments. Existing methods rely on large, costly datasets and struggle with generalization. This paper introduces Grounded Equivariant Manipulation (GEM), a novel approach that leverages the generative capabilities of pre-trained vision-language models and geometric symmetries to facilitate few-shot and zero-shot learning for open-vocabulary robot manipulation tasks. Our experiments demonstrate GEM's high sample efficiency and superior generalization across diverse pick-and-place tasks in both simulation and real-world experiments, showcasing its ability to adapt to novel instructions and unseen objects with minimal data requirements. GEM advances a significant step forward in the domain of language-conditioned robot control, bridging the gap between semantic understanding and action generation in robotic systems.
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- 2024
50. Imagination Policy: Using Generative Point Cloud Models for Learning Manipulation Policies
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Huang, Haojie, Schmeckpeper, Karl, Wang, Dian, Biza, Ondrej, Qian, Yaoyao, Liu, Haotian, Jia, Mingxi, Platt, Robert, and Walters, Robin
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Humans can imagine goal states during planning and perform actions to match those goals. In this work, we propose Imagination Policy, a novel multi-task key-frame policy network for solving high-precision pick and place tasks. Instead of learning actions directly, Imagination Policy generates point clouds to imagine desired states which are then translated to actions using rigid action estimation. This transforms action inference into a local generative task. We leverage pick and place symmetries underlying the tasks in the generation process and achieve extremely high sample efficiency and generalizability to unseen configurations. Finally, we demonstrate state-of-the-art performance across various tasks on the RLbench benchmark compared with several strong baselines and validate our approach on a real robot.
- Published
- 2024
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