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1. Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda.

Author

Winters Muttamba, John Lusiba, Loryndah Olive Namakula, Pauline Byakika-Kibwika, Francis Ssali, Henry Ddungu, Levicatus Mugenyi, Noah Kiwanuka, Rogers Sekibira, Cissy Kityo, Dorothy Keyune, Susan Acana, Ambrose Musinguzi, Ayub Masasi, Joseph Byamugisha, David Mpanju, Walter Jack Musoki, Hellen Aanyu Tukamuhebwa, Fred Nakwagala, Bernard Sentalo Bagaya, Alex Kayongo, Ivan Kimuli, Rebecca Nantanda, Winceslaus Katagira, Esther Buregyeya, Rosemary Byanyima, Baterana Byarugaba, Trishul Siddharthan, Henry Mwebesa, Olaro Charles, Moses Lutaakome Joloba, William Bazeyo, and Bruce Kirenga

Subjects
Medicine, Science
Abstract

IntroductionEvidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment of COVID-19 is increasingly emerging. However, very few African countries have undertaken the collection and processing of CCP. The aim of this study was to assess the feasibility of collecting and processing of CCP, in preparation for a randomized clinical trial of CCP for treatment of COVID-19 in Uganda.MethodsIn a cross-sectional study, persons with documented evidence of recovery from COVID-19 in Uganda were contacted and screened for blood donation via telephone calls. Those found eligible were asked to come to the blood donation centre for further screening and consent. Whole blood collection was undertaken from which plasma was processed. Plasma was tested for transfusion transmissible infections (TTIs) and anti-SARS CoV-2 antibody titers. SARS-CoV-2 testing was also done on nasopharyngeal swabs from the donors.Results192 participants were contacted of whom 179 (93.2%) were eligible to donate. Of the 179 eligible, 23 (12.8%) were not willing to donate and reasons given included: having no time 7(30.4%), fear of being retained at the COVID-19 treatment center 10 (43.5%), fear of stigma in the community 1 (4.3%), phobia for donating blood 1 (4.3%), religious issues 1 (4.4%), lack of interest 2 (8.7%) and transport challenges 1 (4.3%). The median age was 30 years and females accounted for 3.7% of the donors. A total of 30 (18.5%) donors tested positive for different TTIs. Antibody titer testing demonstrated titers of more than 1:320 for all the 72 samples tested. Age greater than 46 years and female gender were associated with higher titers though not statistically significant.ConclusionCCP collection and processing is possible in Uganda. However, concerns about stigma and lack of time, interest or transport need to be addressed in order to maximize donations.

Published
2021
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2. Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda

Author

Olaro Charles, Noah Kiwanuka, Bernard Sentalo Bagaya, Dorothy Keyune, William Bazeyo, Fred Nakwagala, Henry Ddungu, John Lusiba, Moses Joloba, David Mpanju, Baterana Byarugaba, Susan Acana, Rosemary Byanyima, Levicatus Mugenyi, Ivan Kimuli, Ayub Masasi, Francis Ssali, Joseph Byamugisha, Loryndah Olive Namakula, Esther Buregyeya, Alex Kayongo, Trishul Siddharthan, Winters Muttamba, Rogers Sekibira, Pauline Byakika-Kibwika, Ambrose Musinguzi, Hellen Aanyu Tukamuhebwa, Bruce Kirenga, Walter Jack Musoki, Rebecca Nantanda, Winceslaus Katagira, Cissy Kityo, and Henry Mwebesa

Subjects
Male, RNA viruses, Viral Diseases, Convalescent plasma, Physiology, Cross-sectional study, Blood Donors, 030204 cardiovascular system & hematology, Antibodies, Viral, Pathology and Laboratory Medicine, Vascular Medicine, law.invention, Geographical Locations, Medical Conditions, 0302 clinical medicine, Immunodeficiency Viruses, Randomized controlled trial, law, Medicine and Health Sciences, Medicine, Uganda, 030212 general & internal medicine, Young adult, Virus Testing, media_common, Whole blood, Blood Specimen Collection, Multidisciplinary, Convalescence, Antibody titer, Hematology, Middle Aged, Clinical Laboratory Sciences, Body Fluids, Titer, Blood donor, Infectious Diseases, Blood, Medical Microbiology, Viral Pathogens, Viruses, Female, Anatomy, Pathogens, Research Article, Adult, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Science, media_common.quotation_subject, Stigma (botany), Microbiology, Blood Plasma, Young Adult, 03 medical and health sciences, Diagnostic Medicine, Internal medicine, Retroviruses, Humans, Blood Transfusion, Blood Donation, Microbial Pathogens, COVID-19 Serotherapy, Aged, SARS-CoV-2, Transfusion Medicine, business.industry, Lentivirus, Immunization, Passive, Organisms, COVID-19, Biology and Life Sciences, HIV, Covid 19, Cross-Sectional Studies, People and Places, Africa, Feasibility Studies, business
Abstract

IntroductionEvidence that supports the use of COVID-19 convalescent plasma (CCP) for treatment of COVID-19 is increasingly emerging. However, very few African countries have undertaken the collection and processing of CCP. The aim of this study was to assess the feasibility of collecting and processing of CCP, in preparation for a randomized clinical trial of CCP for treatment of COVID-19 in Uganda.MethodsIn a cross-sectional study, persons with documented evidence of recovery from COVID-19 in Uganda were contacted and screened for blood donation via telephone calls. Those found eligible were asked to come to the blood donation centre for further screening and consent. Whole blood collection was undertaken from which plasma was processed. Plasma was tested for transfusion transmissible infections (TTIs) and anti-SARS CoV-2 antibody titers. SARS-CoV-2 testing was also done on nasopharyngeal swabs from the donors.Results192 participants were contacted of whom 179 (93.2%) were eligible to donate. Of the 179 eligible, 23 (12.8%) were not willing to donate and reasons given included: having no time 7(30.4%), fear of being retained at the COVID-19 treatment center 10 (43.5%), fear of stigma in the community 1 (4.3%), phobia for donating blood 1 (4.3%), religious issues 1 (4.4%), lack of interest 2 (8.7%) and transport challenges 1 (4.3%). The median age was 30 years and females accounted for 3.7% of the donors. A total of 30 (18.5%) donors tested positive for different TTIs. Antibody titer testing demonstrated titers of more than 1:320 for all the 72 samples tested. Age greater than 46 years and female gender were associated with higher titers though not statistically significant.ConclusionCCP collection and processing is possible in Uganda. However, concerns about stigma and lack of time, interest or transport need to be addressed in order to maximize donations.

Published
2021

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