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2. Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study
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Abraham, Rachael, Ager, Arijan, Aguilar, Franchesca A., Ahmadi-Izad, Ghazal, Ahmed, Dilshad R., Alvarez, Alicarmen, Anderson, Blake, Asencios, Walter D., Atha, Mary, Beaty, Casey L., Bedi, Brahmchetna, Berry, Jasmine A., Boone, Donchel, Bower, Mary, Bremner, James D., Brent, Corbin, Brown-Smith, Ke'Ara, Bull, Rachel, Bush, Patricia A., Capo, Gustavo, Carl-Igwe, Kelechi, Chitadze, Calista, Chukwumerije, Nachi, Clyburn, Erna, Collins, Shelby, Costello, Julie, Couture, Grace, Craft, Angel, Cribbs, Sushma K., Cui, Xiangqin, Dandy, Annette, Rio, Carlos del, Jasarevic, Rijalda, Detelich, Joshua F., Dixon, Cartia, Dow, Jeanne, Doyle, D'Andrea, Elchommali, Jannah, Ibeawuchi, Carmel, Elsey, Imani, Fineman, Rebecca, Francis, Anyssa G., Franks, Nicole, Gallini, Julia, Gander, Jennifer C., Gray, Natalie, Grimes, Ash, Gutter, Evan, Han, Jenny E., Hang, Tina P., Harding, Jess, Hernandez, Liliana, Hewitt, Lauren N., Holloway, Carla, Hudgins, Alex F., Huerta, Christopher, Ifejika, Cynthia, Ingram, 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Stewart de Ramirez, Sarah A., Sudhindra, Praveen, Sun, Jun, Tartt, Nancy, Terlinde, Tracy, Thompson, Tiffany, Vanden Hoek, Terry L., Kelly, Sara Warfield, Villanueva, Laura, Welter, Hannah, Woolley, Brittany, Yazici, Cemal, Charney, Alexander W., Kovatch, Patricia, Merad, Miriam, Nadkarni, Girish N., Wisnivesky, Juan P., Aberg, Judith A., Ascolillo, Steven, Assenso, Esther, Bagiella, Emilia, Bartram, Logan, Becker, Jacqueline, Beckmann, Noam D., Bendl, Ashley, Chen, Benjamin K., Civil, Alyssa, Dhar, Kaberi, Evo-Ortega, Lorraine, Fierer, Daniel, Gallagher, Emily J., Garcia-Sastre, Adolfo, Gnjatic, Sacha, Guliyeva, Sabina, Harvey-Ingram, Lori, Herrera-Moreno, Julia, Hill, Matthew, Horowitz, Carol R., Jackson, Rachel, Kastrat, Din, Lala-Trindade, Anu, Lin, Jenny, Macaluso, Nick, Marcon, Kathryn, Meyer, Dara, Morinigo, Janice, Natelson, Benjamin H., Nussenzweig, Maya, Padua, Tiffani, Putrino, David, Quazi, Nawreen, Ramos, Michelle, Richardson, Lynne, Russo, Scott, Seifert, Alan C., Serri, Abdullah, Walker, Jordan, Yee, Michell, Adolphi, Natalie L., Alekhina, Natalya, Archuleta, David A., Barlocker, Jackson, Bateman, Lucinda, Bradfute, Steven B., Brito, Rebecca, Bryan, Tanner W., Buck, Kaitlin E., Davis, Debra, Deakyne Davies, Sara J., Decker, Lauren A., Elifritz, Jamie, Erlandson, Kristine M., Facelli, Julio C., Fudge, Harrison Z., Tran, Huong, Pitch, Chloe, Feuerriegel, Elen M., Ford, Isaac, Friedman, Naomi P., Garcia-Soberanez, Noella D., Gardner, Edward M., Stringham, Caitlyn, Ling, Leah, Gebremariam, Tewodros H., Gentry, Frederick D., Gouripeddi, Ramkiran, Graham, Paige, Gronert, Eve G., Harkins, Michelle S., Hawkins, Kellie L., Hess, Rachel, Johnny, Jace D., Johnson, Brandon M., Jolley, Sarah E., Lloyd, Jennifer, Ludwig, Katelyn R., Martinez, Noah I., McCandless, Sean A., Montoya, Lorenzo A., Oakes, Judy L., Parada, Alisha N., Quinn, Davin K., Raissy, Hengameh, Ramos, Alfredo, Reid, Kayleigh M., Reusch, Jane E., Sheehan, Elyce B., Sokol, Ron J., Treacher, Irena S., Trinity, Joel D., Truong, Dongngan T., West, Shelby C., Molden, Joie, Sharareh, Nasser, Weaver, Lisa J., Spivak, Adam M., Brown, Jeanette P., Shah, Kevin S., Pace, Laura A., Scholand, Mary Beth, Velinder, Matt, Cortez, Melissa, Morimoto, Sarah Shizuko, Vernon, Suzanne D., Lu, Yue, Owen, Megan, Hermansen, Jessica A., Lindsay, Ashton M., Donohue, Dagny K., Garg, Lohit, Wodushek, Thomas, Higgins, Janine, Lockie, Tim, Brightman, Marisa, Thurman, Brook, Powell, Jenny M., Freston, Dylan C., Medina, Juliemar C., Aguirre, Bailee, Anderson, Jeff, Bair, Tami, Bosh, Lindsay, Evans, Lorlie, Garrett, Chase, Harris, Dixie, Herrera, Katherine, Horne, Benjamin D., Juan, James, Knight, Stacey, Knowlton, Kirk, Leither, Lindsay, Maestas, Heather, May, Heidi T., Najarian, Gabriel, Woller, Scott C., Zubal, Shyanne, Jensen, McKenna M., Webb, Tiaura, Iverson, Leslie, Ayache, Mirna, Baloi, Alexis, Barnboym, Emma, Boldt, Nicholas, Bukulmez, Hulya, Chesnick, Hailey, Conrad, Ann, Consolo, Mary, Curtis, Lynette, 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Tananshi, Chu, Helen Y., Del Alcazar, James, Duven, Alexandria M., Edmark, Rick, Emerson, Sarah, Goldman, Jason D., Gutierrez, Vanessa, Hadlock, Jennifer, Harteloo, Alex, Heath, James R., Hood, Susan, Jackman, Susan, Kaneko, John, Kemp, Megan, Kim, Christina, Kuykendall, Kelli, Li, Sarah, Logue, Jennifer K., Magis, Andrew T., Manner, Paula, Mason, Carly, McCaffrey, Kathryn, McDonald, Connor, McDonald, Dylan, Murray, Kim M., Nackviseth, Callista, Nguyen, Helen, Parimon, Tanyalak, Poussier, Rachel, Rowen, Lee, Satira, Richard, Torbati, Sam, Tuttle, Katherine R., Wallick, Julie A., Yuan, Dan, Watanabe, Kino, Wilcox, Lauren E., Contreras, Fatima, Dahlke, Lea, Gudipudi, Lasya, Modes, Matthew, Muttera, Nicole, Salinas, Nancy, Tadeo, Josie, White, Shane, Alvarado, Stephanie, Anderson, Reed, Arellanes, Azaneth, Barajas, Rose A., Chauhan, Suneet P., Clarke, Geoffrey D., Farner, Cheryl E., Fischer, Melinda S., Goldberg, Mark P., Hasbani, Keren, Hastings, Gabrielyd, Heard, Patricia, Herrera, Italia, Infante, Edgar, Johnson, Hillary, Jones, Johnnie, Kellogg, Dean L., Kraig, Ellen, Longoria, Lisa, Nambiar, Anoop M., Okafor, Emeka, Paredes, Claudia C., Patterson, Thomas F., Patterson, Jan E., Pinones, Alexis, Potter, Jennifer S., Reeves, W.B., Saade, George R., Salehi, Marzieh, Scholler, Irma, Seshadri, Sudha, Shah, Dimpy P., Shah, Pankil, Sharma, Kumar, Sharma, Kavita, Soileau, Bridgette, Solis, Pamela, Stoebner, Carmen, Sullivan, Michael, Taylor, Barbara S., Tragus, Robin, Tsevat, Joel, Verduzco-Gutierrez, Monica, Ahuja, Neera, Blish, Catherine A., Blomkalns, Andra L., Bonilla, Hector, Brotherton, Richard, Clinton, Kimberly, Dingankar, Vaidehi, Geng, Linda N., Go, Minjoung, Haddad, Francois, Jagannathan, Prasanna, Jamero, Christopher, Jee, Kathryn, Jia, Xiaolin K., Khurana, Naresh, Kumar, Andre, Maldonado, Yvonne, Miglis, Mitchell G., O'Conor, Ellen, Olszewski, Kelly, Pathak, Divya, Quintero, Orlando, Scott, Jake, Singh, Upinder, Urdaneta, Alfredo E., Utz, Paul J., Varkey, 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Manickas-Hill, Zachary, Yu, Xu G., Li, Jonathan Z., Alter, Galit, Kelly, J. Daniel, Goldberg, Sarah A., Talla, Aarthi, Li, Xiaojun, Skene, Peter, Bumol, Thomas F., Torgerson, Troy R., Czartoski, Julie L., McElrath, M. Juliana, and Walt, David R.
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- 2024
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3. Heterologous SARS-CoV-2 booster vaccine for individuals with hematological malignancies after a primary SARS-CoV-2 mRNA vaccine series
- Author
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Sherman, Amy C., van Haren, Simon D., Borberg, Ella, Swank, Zoe, Aleissa, Muneerah, Tong, Alexandra, Rooks, Rebecca, Kanwal, Urwah, Levine, Hannah, Yates, Bridget, Izaguirre, Natalie, Ryff, Kevin, Thomas, Sanya, Parisi, Lindsey, Li, Xiaofang, Walt, David R., Levy, Ofer, Walsh, Stephen R., Issa, Nicolas C., and Baden, Lindsey R.
- Published
- 2024
- Full Text
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4. New views of old proteins: clarifying the enigmatic proteome
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Functional, Participants in a NIH Workshop on, Proteomics, Integrative, Johnson, Kristin E. Burnum, Conrads, Thomas P., Drake, Richard R., Herr, Amy E., Iyengar, Ravi, Kelly, Ryan T., Lundberg, Emma, MacCoss, Michael J., Naba, Alexandra, Nolan, Garry P., Pevzner, Pavel A., Rodland, Karin D., Sechi, Salvatore, Slavov, Nikolai, Spraggins, Jeffrey M., Van Eyk, Jennifer E., Vidal, Marc, Vogel, Christine, Walt, David R., and Kelleher, Neil L.
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Quantitative Biology - Biomolecules - Abstract
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide provocative projections for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we offer potential futures for a next generation of disruptive approaches to define, quantify and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade., Comment: Submitted to Nature. 22 Pages. 6 Figures. Corresponding author Neil L. Kelleher
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- 2021
5. Ultrasensitive Protein Detection Technologies for Extracellular Vesicle Measurements
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Shami-Shah, Adnan, Norman, Maia, and Walt, David R.
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- 2023
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6. A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma
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Najjar, Devora, Rainbow, Joshua, Sharma Timilsina, Sanjay, Jolly, Pawan, de Puig, Helena, Yafia, Mohamed, Durr, Nolan, Sallum, Hani, Alter, Galit, Li, Jonathan Z., Yu, Xu G., Walt, David R., Paradiso, Joseph A., Estrela, Pedro, Collins, James J., and Ingber, Donald E.
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- 2022
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7. Response by Yonker et al to Letter Regarding Article, “Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis”
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Yonker, Lael M., Fasano, Alessio, and Walt, David R.
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- 2023
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8. Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
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Yonker, Lael M., Swank, Zoe, Bartsch, Yannic C., Burns, Madeleine D., Kane, Abigail, Boribong, Brittany P., Davis, Jameson P., Loiselle, Maggie, Novak, Tanya, Senussi, Yasmeen, Cheng, Chi-An, Burgess, Eleanor, Edlow, Andrea G., Chou, Janet, Dionne, Audrey, Balaguru, Duraisamy, Lahoud-Rahme, Manuella, Arditi, Moshe, Julg, Boris, Randolph, Adrienne G., Alter, Galit, Fasano, Alessio, and Walt, David R.
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- 2023
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9. A Multiplexed Digital Platform Enables Detection of Attomolar Protein Levels with Minimal Cross-Reactivity.
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Zhang, Stephanie J., Wu, Connie, and Walt, David R.
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- 2024
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10. How many human proteoforms are there?
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Aebersold, Ruedi, Agar, Jeffrey N, Amster, I Jonathan, Baker, Mark S, Bertozzi, Carolyn R, Boja, Emily S, Costello, Catherine E, Cravatt, Benjamin F, Fenselau, Catherine, Garcia, Benjamin A, Ge, Ying, Gunawardena, Jeremy, Hendrickson, Ronald C, Hergenrother, Paul J, Huber, Christian G, Ivanov, Alexander R, Jensen, Ole N, Jewett, Michael C, Kelleher, Neil L, Kiessling, Laura L, Krogan, Nevan J, Larsen, Martin R, Loo, Joseph A, Ogorzalek Loo, Rachel R, Lundberg, Emma, MacCoss, Michael J, Mallick, Parag, Mootha, Vamsi K, Mrksich, Milan, Muir, Tom W, Patrie, Steven M, Pesavento, James J, Pitteri, Sharon J, Rodriguez, Henry, Saghatelian, Alan, Sandoval, Wendy, Schlüter, Hartmut, Sechi, Salvatore, Slavoff, Sarah A, Smith, Lloyd M, Snyder, Michael P, Thomas, Paul M, Uhlén, Mathias, Van Eyk, Jennifer E, Vidal, Marc, Walt, David R, White, Forest M, Williams, Evan R, Wohlschlager, Therese, Wysocki, Vicki H, Yates, Nathan A, Young, Nicolas L, and Zhang, Bing
- Subjects
Humans ,Proteins ,Protein Isoforms ,Proteome ,Ubiquitin ,Proteomics ,Protein Biosynthesis ,Protein Processing ,Post-Translational ,Phenotype ,Genome ,Human ,Databases ,Protein ,Mass Spectrometry ,Genetics ,Underpinning research ,1.1 Normal biological development and functioning ,Generic health relevance ,Medicinal and Biomolecular Chemistry ,Biochemistry and Cell Biology ,Biochemistry & Molecular Biology - Abstract
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease. We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?" We also explore prospects for improving measurements to better regularize protein-level biology and efficiently associate PTMs to function and phenotype.
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- 2018
11. Heterotypic immunity from prior SARS-CoV-2 infection but not COVID-19 vaccination associates with lower endemic coronavirus incidence
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Bean, David J., primary, Monroe, Janet, additional, Liang, Yan Mei, additional, Borberg, Ella, additional, Senussi, Yasmeen, additional, Swank, Zoe, additional, Chalise, Sujata, additional, Walt, David, additional, Weinberg, Janice, additional, and Sagar, Manish, additional
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- 2024
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12. COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children
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Tang, Ying, primary, Boribong, Brittany P., additional, Swank, Zoe N., additional, Demokritou, Melina, additional, Luban, Maria A.F., additional, Fasano, Alessio, additional, Du, Michelle, additional, Wolf, Rebecca L., additional, Griffiths, Joseph, additional, Shultz, John, additional, Borberg, Ella, additional, Chalise, Sujata, additional, Gonzalez, Wanda I., additional, Walt, David R., additional, Yonker, Lael M., additional, and Horwitz, Bruce H., additional
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- 2024
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13. Detectable plasma severe acute respiratory syndrome coronavirus 2 spike antigen is associated with poor antibody response following third messenger RNA vaccination in kidney transplant recipients
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Karaba, Andrew H., primary, Swank, Zoe, additional, Hussain, Sarah, additional, Chahoud, Margaret, additional, Durand, Christine M., additional, Segev, Dorry L., additional, Robien, Mark A., additional, Heeger, Peter S., additional, Larsen, Christian P., additional, Tobian, Aaron A. R., additional, Walt, David R., additional, and Werbel, William A., additional
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- 2024
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14. High Frequency of Prior SARS-CoV-2 Infection by Sensitive Nucleocapsid Assays
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Nkolola, Joseph P, primary, Liu, Jinyan, additional, Collier, Ai-ris Y, additional, Jacob-Dolan, Catherine, additional, Senussi, Yasmeen, additional, Borberg, Ella, additional, Swank, Zoe, additional, Walt, David R, additional, and Barouch, Dan H, additional
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- 2024
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15. Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens
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Mysore, Vijayashree, Cullere, Xavier, Settles, Matthew L., Ji, Xinge, Kattan, Michael W., Desjardins, Michaël, Durbin-Johnson, Blythe, Gilboa, Tal, Baden, Lindsey R., Walt, David R., Lichtman, Andrew H., Jehi, Lara, and Mayadas, Tanya N.
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- 2021
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16. L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
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Norman, Maia, Ter-Ovanesyan, Dmitry, Trieu, Wendy, Lazarovits, Roey, Kowal, Emma J. K., Lee, Ju Hyun, Chen-Plotkin, Alice S., Regev, Aviv, Church, George M., and Walt, David R.
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- 2021
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17. High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays.
- Author
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Nkolola, Joseph P, Liu, Jinyan, Collier, Ai-ris Y, Jacob-Dolan, Catherine, Senussi, Yasmeen, Borberg, Ella, Swank, Zoe, Walt, David R, and Barouch, Dan H
- Subjects
COVID-19 ,STAINS & staining (Microscopy) ,SARS-CoV-2 ,SEROLOGY - Abstract
Prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is typically measured by nucleocapsid serology assays. In this study, we show that the Simoa serology assay and T-cell intracellular cytokine staining assay are more sensitive than the clinical Elecsys assay for detection of nucleocapsid-specific immune responses. These data suggest that the prevalence of prior SARS-CoV-2 infection in the population may be higher than currently appreciated. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Efficient discovery of antibody binding pairs using a photobleaching strategy for bead encoding.
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Roth, Shira, Ferrante, Tom, and Walt, David R.
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IMMUNOASSAY ,HEAT sinks ,IMMUNOGLOBULINS ,ANTIBODY titer ,FLOW cytometry ,ENCODING ,PHOTOPLETHYSMOGRAPHY - Abstract
Dye-encoded bead-based assays are widely used for diagnostics. Multiple bead populations are required for multiplexing and can be produced using different dye colors, labeling levels, or combinations of dye ratios. Ready-to-use multiplex bead populations restrict users to specific targets, are costly, or require specialized instrumentation. In-house methods produce few bead plexes or require many fine-tuning steps. To expand bead encoding strategies, we present a simple, safe, and cost-effective bench-top system for generating bead populations using photobleaching. By photobleaching commercially available dye-encoded magnetic beads for different durations, we produce three times as many differentiable bead populations on flow cytometry from a single dye color. Our photobleaching system uses a high-power LED module connected to a light concentrator and a heat sink. The beads are photobleached in solution homogeneously by constant mixing. We demonstrate this photobleaching method can be utilized for cross-testing antibodies, which is the first step in developing immunoassays. The assay uses multiple photobleached encoded beads conjugated with capture antibodies to test many binding pairs simultaneously. To further expand the number of antibodies that can be tested at once, several antibodies were conjugated to the same bead, forming a pooled assay. Our assay predicts the performance of antibody pairs used in ultrasensitive Simoa assays, narrowing the number of cross-tested pairs that need to be tested by at least two-thirds and, therefore, providing a rapid alternative for an initial antibody pair screening. The photobleaching system can be utilized for other applications, such as multiplexing, and for photobleaching other particles in solution. [ABSTRACT FROM AUTHOR]
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- 2024
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19. The Present and Future Landscapes of Molecular Diagnostics
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Rolando, Justin C., primary, Melkonian, Arek V., additional, and Walt, David R., additional
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- 2024
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20. Toward the quantification of α-synuclein aggregates with digital seed amplification assays
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Gilboa, Tal, primary, Swank, Zoe, additional, Thakur, Rohan, additional, Gould, Russell A., additional, Ooi, Kean Hean, additional, Norman, Maia, additional, Flynn, Elizabeth A., additional, Deveney, Brendan T., additional, Chen, Anqi, additional, Borberg, Ella, additional, Kuzkina, Anastasia, additional, Ndayisaba, Alain, additional, Khurana, Vikram, additional, Weitz, David A., additional, and Walt, David R., additional
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- 2024
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21. Supplementary Figure 6 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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22. Supplementary Figure 24 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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23. Supplementary Figure 5 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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24. Supplementary Figure 17 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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25. Supplementary Tables S1-S12 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
- Author
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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26. Supplementary Figure 9 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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27. Supplementary Figure 7 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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28. Supplementary Data 1 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
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- 2024
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29. Data from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
- Author
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
- Published
- 2024
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30. Supplementary Figure 4 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
- Published
- 2024
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31. Supplementary Data 2 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
- Author
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
- Published
- 2024
- Full Text
- View/download PDF
32. Supplementary Figure 8 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
- Author
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
- Published
- 2024
- Full Text
- View/download PDF
33. Supplementary Figure 3 from Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker
- Author
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Taylor, Martin S., primary, Wu, Connie, primary, Fridy, Peter C., primary, Zhang, Stephanie J., primary, Senussi, Yasmeen, primary, Wolters, Justina C., primary, Cajuso, Tatiana, primary, Cheng, Wen-Chih, primary, Heaps, John D., primary, Miller, Bryant D., primary, Mori, Kei, primary, Cohen, Limor, primary, Jiang, Hua, primary, Molloy, Kelly R., primary, Chait, Brian T., primary, Goggins, Michael G., primary, Bhan, Irun, primary, Franses, Joseph W., primary, Yang, Xiaoyu, primary, Taplin, Mary-Ellen, primary, Wang, Xinan, primary, Christiani, David C., primary, Johnson, Bruce E., primary, Meyerson, Matthew, primary, Uppaluri, Ravindra, primary, Egloff, Ann Marie, primary, Denault, Elyssa N., primary, Spring, Laura M., primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, Fairman, Jennifer E., primary, Jung, Euihye, primary, Arora, Kshitij S., primary, Yilmaz, Osman H., primary, Cohen, Sonia, primary, Sharova, Tatyana, primary, Chi, Gary, primary, Norden, Bryanna L., primary, Song, Yuhui, primary, Nieman, Linda T., primary, Pappas, Leontios, primary, Parikh, Aparna R., primary, Strickland, Matthew R., primary, Corcoran, Ryan B., primary, Mustelin, Tomas, primary, Eng, George, primary, Yilmaz, Ömer H., primary, Matulonis, Ursula A., primary, Chan, Andrew T., primary, Skates, Steven J., primary, Rueda, Bo R., primary, Drapkin, Ronny, primary, Klempner, Samuel J., primary, Deshpande, Vikram, primary, Ting, David T., primary, Rout, Michael P., primary, LaCava, John, primary, Walt, David R., primary, and Burns, Kathleen H., primary
- Published
- 2024
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34. Research
- Author
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Walt, David
- Published
- 2021
35. Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19
- Author
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Norman, Maia, Gilboa, Tal, Ogata, Alana F., Maley, Adam M., Cohen, Limor, Busch, Evan L., Lazarovits, Roey, Mao, Chih-Ping, Cai, Yongfei, Zhang, Jun, Feldman, Jared E., Hauser, Blake M., Caradonna, Timothy M., Chen, Bing, Schmidt, Aaron G., Alter, Galit, Charles, Richelle C., Ryan, Edward T., and Walt, David R.
- Published
- 2020
- Full Text
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36. Zonulin Antagonist, Larazotide (AT1001), As an Adjuvant Treatment for Multisystem Inflammatory Syndrome in Children: A Case Series
- Author
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Yonker, Lael M., Swank, Zoe, Gilboa, Tal, Senussi, Yasmeen, Kenyon, Victoria, Papadakis, Lena, Boribong, Brittany P., Carroll, Ryan W., Walt, David R., and Fasano, Alessio
- Published
- 2022
- Full Text
- View/download PDF
37. Impact of clinical sample handling and processing on ultra-low level measurements of plasma cytokines
- Author
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Cohen, Limor, Keegan, Alissa, Melanson, Stacy E.F., and Walt, David R.
- Published
- 2019
- Full Text
- View/download PDF
38. Monitoring Melanoma Responses to STING Agonism and Focused Ultrasound Thermal Ablation Using Microneedles and Ultrasensitive Single Molecule Arrays (Adv. Funct. Mater. 50/2023)
- Author
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Dahis, Daniel, primary, Dion, Michelle Z., additional, Cryer, Alexander M., additional, Dosta, Pere, additional, Gilboa, Tal, additional, Alonso, Mariana, additional, Lewandowski, Michael, additional, Puigmal, Núria, additional, Taboada, Gonzalo Muñoz, additional, Azhari, Haim, additional, Ahmad, Rushdy, additional, Walt, David R., additional, and Artzi, Natalie, additional
- Published
- 2023
- Full Text
- View/download PDF
39. Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection
- Author
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Peluso, Michael J., primary, Swank, Zoe N., additional, Goldberg, Sarah A., additional, Lu, Scott, additional, Dalhuisen, Thomas, additional, Borberg, Ella, additional, Senussi, Yasmeen, additional, Luna, Michael A., additional, Chang Song, Celina, additional, Viswanathan, Badri, additional, Huang, Beatrice, additional, Anglin, Khamal, additional, Hoh, Rebecca, additional, Hsue, Priscilla Y., additional, Durstenfeld, Matthew S., additional, Spinelli, Matthew A., additional, Glidden, David V., additional, Henrich, Timothy J., additional, Kelly, J. D., additional, Deeks, Steven G., additional, Walt, David R., additional, and Martin, Jeffrey N., additional
- Published
- 2023
- Full Text
- View/download PDF
40. Heterotypic responses against nsp12/nsp13 from prior SARS-CoV-2 infection associates with lower subsequent endemic coronavirus incidence
- Author
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Bean, David J, primary, Monroe, Janet, additional, Liang, Yan Mei, additional, Borberg, Ella, additional, Senussi, Yasmeen, additional, Swank, Zoe, additional, Chalise, Sujata, additional, Walt, David, additional, Weinberg, Janice, additional, and Sagar, Manish, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Bottom-up single-molecule strategy for understanding subunit function of tetrameric β-galactosidase
- Author
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Li, Xiang, Jiang, Yu, Chong, Shaorong, and Walt, David R.
- Published
- 2018
42. Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom
- Author
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Yang, Xinmiao, Hartman, Mark R., Harrington, Kristin T., Etson, Candice M., Fierman, Matthew B., Slonim, Donna K., and Walt, David R.
- Abstract
With the development of new sequencing and bioinformatics technologies, concepts relating to personal genomics play an increasingly important role in our society. To promote interest and understanding of sequencing and bioinformatics in the high school classroom, we developed and implemented a laboratory-based teaching module called "The Genetics of Race." This module uses the topic of race to engage students with sequencing and genetics. In the experimental portion of this module, students isolate their own mitochondrial DNA using standard biotechnology techniques and collect next-generation sequencing data to determine which of their classmates are most and least genetically similar to themselves. We evaluated the efficacy of this module by administering a pretest/posttest evaluation to measure student knowledge related to sequencing and bioinformatics, and we also conducted a survey at the conclusion of the module to assess student attitudes. Upon completion of our Genetics of Race module, students demonstrated significant learning gains, with lower-performing students obtaining the highest gains, and developed more positive attitudes toward scientific research.
- Published
- 2017
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43. Plasma-based antigen persistence in the post-acute phase of COVID-19
- Author
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Peluso, Michael J, Swank, Zoe N, Goldberg, Sarah A, Lu, Scott, Dalhuisen, Thomas, Borberg, Ella, Senussi, Yasmeen, Luna, Michael A, Chang Song, Celina, Clark, Alexus, Zamora, Andhy, Lew, Megan, Viswanathan, Badri, Huang, Beatrice, Anglin, Khamal, Hoh, Rebecca, Hsue, Priscila Y, Durstenfeld, Matthew S, Spinelli, Matthew A, Glidden, David V, Henrich, Timothy J, Kelly, J Daniel, Deeks, Steven G, Walt, David R, and Martin, Jeffrey N
- Published
- 2024
- Full Text
- View/download PDF
44. Competencies: a cure for pre-med curriculum.
- Author
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Anderson, Winston A, Amasino, Richard M, Ares, Manuel, Jr, Banerjee, Utpal, Bartel, Bonnie, Corces, Victor G, Drennan, Catherine L, Elgin, Sarah C R, Epstein, Irving R, Fanning, Ellen, Guillette, Louis J, Jr, Handelsman, Jo, Hatfull, Graham F, Hoy, Ronald Raymond, Kelley, Darcy, Leinwand, Leslie A, Losick, Richard, Lu, Yi, Lynn, David G, Neuhauser, Claudia, O'Dowd, Diane K, Olivera, Toto, Pevzner, Pavel, Richards-Kortum, Rebecca R, Rine, Jasper, Sah, Robert L, Strobel, Scott A, Walker, Graham C, Walt, David R, Warner, Isiah M, Wessler, Sue, Willard, Huntington F, and Zare, Richard N
- Subjects
Curriculum ,Education ,Premedical ,Educational Status ,School Admission Criteria ,Schools ,Medical ,Universities ,curriculum ,curriculum development ,engineering ,letter ,mathematics ,medical education ,medical school ,priority journal ,science ,United States ,Curriculum ,Education ,Premedical ,Educational Status ,School Admission Criteria ,Schools ,Medical ,Universities - Published
- 2011
45. Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research
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Weis, Brenda K., Balshaw, David, Barr, John R., Brown, David, Ellisman, Mark, Lioy, Paul, Omenn, Gilbert, Potter, John D., Smith, Martyn T., Sohn, Lydia, Suk, William A., Sumner, Susan, Swenberg, James, Walt, David R., Watkins, Simon, Thompson, Claudia, and Wilson, Samuel H.
- Published
- 2005
46. Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker
- Author
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Taylor, Martin S., primary, Wu, Connie, additional, Fridy, Peter C., additional, Zhang, Stephanie J., additional, Senussi, Yasmeen, additional, Wolters, Justina C., additional, Cajuso, Tatiana, additional, Cheng, Wen-Chih, additional, Heaps, John D., additional, Miller, Bryant D., additional, Mori, Kei, additional, Cohen, Limor, additional, Jiang, Hua, additional, Molloy, Kelly R., additional, Chait, Brian T., additional, Goggins, Michael G., additional, Bhan, Irun, additional, Franses, Joseph W., additional, Yang, Xiaoyu, additional, Taplin, Mary-Ellen, additional, Wang, Xinan, additional, Christiani, David C., additional, Johnson, Bruce E., additional, Meyerson, Matthew, additional, Uppaluri, Ravindra, additional, Egloff, Ann Marie, additional, Denault, Elyssa N., additional, Spring, Laura M., additional, Wang, Tian-Li, additional, Shih, Ie-Ming, additional, Fairman, Jennifer E., additional, Jung, Euihye, additional, Arora, Kshitij S., additional, Yilmaz, Osman H., additional, Cohen, Sonia, additional, Sharova, Tatyana, additional, Chi, Gary, additional, Norden, Bryanna L., additional, Song, Yuhui, additional, Nieman, Linda T., additional, Pappas, Leontios, additional, Parikh, Aparna R., additional, Strickland, Matthew R., additional, Corcoran, Ryan B., additional, Mustelin, Tomas, additional, Eng, George, additional, Yilmaz, Omer H., additional, Matulonis, Ursula A., additional, Skates, Steven J., additional, Rueda, Bo R., additional, Drapkin, Ronny, additional, Klempner, Samuel J., additional, Deshpande, Vikram, additional, Ting, David T., additional, Rout, Michael P., additional, LaCava, John, additional, Walt, David R., additional, and Burns, Kathleen H., additional
- Published
- 2023
- Full Text
- View/download PDF
47. Single-Molecule Arrays for Ultrasensitive Detection of Blood-Based Biomarkers for Immunotherapy
- Author
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Cohen, Limor, primary, Keegan, Alissa, additional, and Walt, David R., additional
- Published
- 2019
- Full Text
- View/download PDF
48. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours
- Author
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Haug, Valentin, Kollar, Branislav, Tasigiorgos, Sotirios, Endo, Yori, Kauke, Martin, Safi, Ali-Farid, Veeramani, Anamika, Abdulrazzak, Obada, Bausk, Bruce, Walt, David, and Pomahac, Bohdan
- Published
- 2020
- Full Text
- View/download PDF
49. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier
- Author
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Yonker, Lael M., Gilboa, Tal, Ogata, Alana F., Senussi, Yasmeen, Lazarovits, Roey, Boribong, Brittany P., Bartsch, Yannic C., Loiselle, Maggie, Rivas, Magali Noval, Porrit, Rebecca A., Lima, Rosiane, Davis, Jameson P., Farkas, Eva J., Burns, Madeleine D., Young, Nicola, Mahajan, Vinay S., Hajizadeh, Soroush, Lopez, Xcanda I. Herrera, Kreuzer, Johannes, Morris, Robert, Martinez, Enid E., Han, Isaac, Griswold, Kettner, Jr., Barry, Nicholas C., Thompson, David B., Church, George, Edlow, Andrea G., Haas, Wilhelm, Pillai, Shiv, Arditi, Moshe, Alter, Galit, Walt, David R., and Fasano, Alessio
- Subjects
Gastrointestinal mucosa -- Health aspects -- Physiological aspects ,Membrane proteins -- Health aspects -- Physiological aspects ,Pediatric research ,Health care industry - Abstract
BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in children (MIS-C). Gastrointestinal (GI) symptoms are common in patients with MIS-C, and a severe hyperinflammatory response ensues with potential for cardiac complications. The cause of MIS-C has not been identified to date. METHODS. Here, we analyzed biospecimens from 100 children: 19 with MIS-C, 26 with acute COVID-19, and 55 controls. Stools were assessed for SARS-CoV-2 by reverse transcription PCR (RT-PCR), and plasma was examined for markers of breakdown of mucosal barrier integrity, including zonulin. Ultrasensitive antigen detection was used to probe for SARS-CoV-2 antigenemia in plasma, and immune responses were characterized. As a proof of concept, we treated a patient with MIS-C with larazotide, a zonulin antagonist, and monitored the effect on antigenemia and the patient's clinical response. RESULTS. We showed that in children with MIS-C, a prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, with subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, leading to hyperinflammation. The patient with MIS-C treated with larazotide had a coinciding decrease in plasma SARSCoV-2 spike antigen levels and inflammatory markers and a resultant clinical improvement above that achieved with currently available treatments. CONCLUSION. These mechanistic data on MIS-C pathogenesis provide insight into targets for diagnosing, treating, and preventing MIS-C, which are urgently needed for this increasingly common severe COVID-19-related disease in children., Introduction Most children who are acutely infected with SARS-CoV-2 develop mild upper respiratory symptoms or experience asymptomatic infection. Several days to weeks after resolution of the initial infection, some of [...]
- Published
- 2021
- Full Text
- View/download PDF
50. Supplementary Data from Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer
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Rajurkar, Mihir, primary, Parikh, Aparna R., primary, Solovyov, Alexander, primary, You, Eunae, primary, Kulkarni, Anupriya S., primary, Chu, Chong, primary, Xu, Katherine H., primary, Jaicks, Christopher, primary, Taylor, Martin S., primary, Wu, Connie, primary, Alexander, Katherine A., primary, Good, Charly R., primary, Szabolcs, Annamaria, primary, Gerstberger, Stefanie, primary, Tran, Antuan V., primary, Xu, Nova, primary, Ebright, Richard Y., primary, Van Seventer, Emily E., primary, Vo, Kevin D., primary, Tai, Eric C., primary, Lu, Chenyue, primary, Joseph-Chazan, Jasmin, primary, Raabe, Michael J., primary, Nieman, Linda T., primary, Desai, Niyati, primary, Arora, Kshitij S., primary, Ligorio, Matteo, primary, Thapar, Vishal, primary, Cohen, Limor, primary, Garden, Padric M., primary, Senussi, Yasmeen, primary, Zheng, Hui, primary, Allen, Jill N., primary, Blaszkowsky, Lawrence S., primary, Clark, Jeffrey W., primary, Goyal, Lipika, primary, Wo, Jennifer Y., primary, Ryan, David P., primary, Corcoran, Ryan B., primary, Deshpande, Vikram, primary, Rivera, Miguel N., primary, Aryee, Martin J., primary, Hong, Theodore S., primary, Berger, Shelley L., primary, Walt, David R., primary, Burns, Kathleen H., primary, Park, Peter J., primary, Greenbaum, Benjamin D., primary, and Ting, David T., primary
- Published
- 2023
- Full Text
- View/download PDF
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