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195 results on '"Walshe, J.M."'

3. P008 Real-world analysis of the clinical and economic impact of 21-gene recurrence score (RS) testing in early-stage node positive breast cancer in Ireland

Author

Browne, I.M., primary, McLaughlin, R.A., additional, Prichard, R.S., additional, McCartan, D.P., additional, Millen, S.J., additional, Higgins, M.J., additional, Crown, J.P., additional, Hennessy, B.T., additional, Quinn, C.M., additional, Morris, P.G., additional, and Walshe, J.M., additional

Published
2023
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6. 310P Substantial reduction in the percentage of metastatic breast cancer (MBC) which is HER-2 positive (HER-2+) over two decades: Sequential cohort analysis from the 1000 patient HER-2 study

Author

Berenguer-Pina, J.J., primary, Quinn, C.M., additional, Gullo, G., additional, Skrobo, D., additional, Buckley, C., additional, Walshe, J.M., additional, Fennelly, D., additional, Higgins, M., additional, Ballot, J., additional, Mccartan, D., additional, Walsh, N., additional, and Crown, J.P., additional

Published
2021
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7. 234P Effect of palbociclib (PAL) + endocrine therapy (ET) on time to chemotherapy (TTC) across subgroups of patients (pts) with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC): Post hoc analyses from PALOMA-2 (P2) and PALOMA-3 (P3)

Author

Rugo, H.S., primary, Im, S-A., additional, Joy, A.A., additional, Yaroslav, S., additional, Walshe, J.M., additional, Sleckman, B., additional, Loi, S., additional, Puyana Theall, K., additional, Kim, S., additional, Huang, X., additional, Bananis, E., additional, Mahtani, R., additional, Finn, R.S., additional, and Diéras, V., additional

Published
2021
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8. Treatment of hepatic encephalopathy

Author

Blei, Andres T., Cordova, Juan, Minguez, Beatriz, Vergara, Mercedes, Walshe, J.M., Shawcross, Debbie, and Jalan, Rajiv

Published
2005

18. Clinical outcomes in patients (pts) with estrogen receptor–positive (ER+)/human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer (ABC) with objective response (OR) or without objective response (non-OR) in PALOMA-2

Author

Rugo, H.S., primary, Finn, R.S., additional, Gelmon, K.A., additional, Joy, A.A., additional, Lipatov, O.N., additional, Harbeck, N., additional, Castrellon, A., additional, Mukai, H., additional, Walshe, J.M., additional, Mori, A., additional, Gauthier, E., additional, Lu, D.R., additional, Bananis, E., additional, Martín, M., additional, and Dieras, V., additional

Published
2018
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19. 332P - Clinical outcomes in patients (pts) with estrogen receptor–positive (ER+)/human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer (ABC) with objective response (OR) or without objective response (non-OR) in PALOMA-2

Author

Rugo, H.S., Finn, R.S., Gelmon, K.A., Joy, A.A., Lipatov, O.N., Harbeck, N., Castrellon, A., Mukai, H., Walshe, J.M., Mori, A., Gauthier, E., Lu, D.R., Bananis, E., Martín, M., and Dieras, V.

Published
2018
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31. Penicillamine neurotoxicity: an hypothesis.

Author

Walshe, J.M.

Abstract

Penicillamine, dimethyl cysteine, thiovaline, remains the drug of choice for the treatment of patience with Wilson disease. It is also of value in the treatment of cysteinuria and rheumatoid arthritis, it has also been suggested that it has value in the management of other rare diseases. It also has multiple toxicities. The majority of these can be explained as chemical toxicity, for instance its weak antipyridoxine action and its ability to interfere with lysyloxidea resulting in skin lesions. More important are its ability to induce immune reactions such as SLE, immune complex nephritis, the Ehlers Danlos syndrome and Goodpasture's syndrome. However the sudden increase in neurological signs which may occur in a small number of patients remains unexplained. The theory is proposed that this is due to lethal synthesis. In susceptible patients the--SH radical is liberated from penicillamine and will inhibit--SH dependent enzymes in the Krebs cycle leading to death in neurones. Other toxic metabolites may also be produced such as methyl mercaptan and ethyl mercaptan either of which could produce a similar metabolic block. [ABSTRACT FROM AUTHOR]

Published
2011

33. CORRESPONDENCE.

Author

Bain, J., Drennan, P.C., Miller, M.G., Redding, Penelope J., McGovern, Theresa, Ledingham, I. McA, Walshe, J.M., Robbins, G., Britt, R.P., Greenhalgh, Trisha, Gold, Nicholas, Barley, S.L., Reddi, Kurri, Grant, Robert, Weller, Malcolm P.I., Clark, C.R., David, J., and Hall, R.

Subjects
HALLUCINATIONS, CELLULITIS, NEUROLEPTIC malignant syndrome
Abstract

Presents several letters concerning medicine. Occurrence of visual hallucinations in children receiving decongestants; Manifestation of myocardial depression in streptococcal cellulitis; Details on the neuroleptic malignant syndrome.

Published
1984

34. A Ring Precipitin Test in Chronic Liver Disease: A Study of the False Positive.

Author

Walshe, J.M., Lachmann, P.J., and Orrego-Matte, H.

Subjects
*PRECIPITIN reaction, *ANTIGENS, *IMMUNOGLOBULINS, *GAMMA globulins, *BLOOD proteins, *IMMUNOLOGY
Abstract

A ring precipitation has been found when saline is layered on sera from certain patients with abnormal globulins. Positive reactions were found mainly, but not entirely, in the sera from patients with chronic liver disease. The precipitate formed appeared to be a gamma globulin. The phenomenon may be confused with a true precipitin test but does not give false positive results when studied by the agar diffusion or tanned cell techniques. [ABSTRACT FROM AUTHOR]

Published
1961

35. The Liver and the Brain.

Author

Walshe, J.M.

Subjects
PATHOLOGICAL physiology, BRAIN physiology, LIVER physiology
Abstract

Editorial. Discusses the relationship between the liver and brain. Pathological states in which the liver and brain are related; Enzyme defects resulting in disease of the brain and liver.

Published
1961
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36. EDITORIAL.

Author

Walshe, J.M.

Subjects
PERIODICALS, EDITORS, INTERNAL medicine
Abstract

Editorial. Discusses developments in the periodical 'Annals of Internal Medicine.' Appointment of editor for the periodical; Implications for practicing physicians; Focus on advances in pure and applied biological science.

Published
1960

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