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16 results on '"Walsh, Seema"'

16. SULT1A1 and SULT1A2 Associated Extensive Prolapse-Type Inflammatory Polyposis in Crohn's Colitis.

Author

Zhou T, Patel K, Harris RA, Seghers V, Walsh SM, Rodriguez R, Kellermayer R, and Wu H

Subjects
Adolescent, Cell Adhesion genetics, Colitis diagnostic imaging, Colitis etiology, Colitis pathology, Colonoscopy methods, Genetic Testing methods, Humans, Magnetic Resonance Imaging methods, Male, Polymorphism, Single Nucleotide, Severity of Illness Index, Adenomatous Polyposis Coli diagnosis, Adenomatous Polyposis Coli etiology, Arylsulfotransferase genetics, Colectomy methods, Crohn Disease diagnosis, Crohn Disease genetics, Crohn Disease physiopathology, Intestinal Mucosa diagnostic imaging, Intestinal Mucosa pathology, Rectal Prolapse diagnosis, Rectal Prolapse etiology, Tumor Necrosis Factor Inhibitors therapeutic use
Abstract

Mucosal prolapse syndrome most commonly involves the rectum and presents as solitary rectal ulcer syndrome and proctitis cystica profunda. Symptoms and endoscopic appearances are nonspecific. Histologically, mucosal prolapse is characterized by fibromuscular obliteration of the lamina propria, and displacement of crypts into submucosa and muscularis mucosae. Mucosal prolapse presenting as polyposis is rare and has only been reported involving the rectosigmoid colon. In this report, we describe a case of mucosal prolapse syndrome presenting as diffuse polyposis and colitis cystica profunda involving the hepatic, splenic flexures and descending colon in a teenage boy suffering from refractory fibrostenosing Crohn's disease. This patient was found to have possibly deleterious homozygous single nucleotide polymorphisms in both SULT1A1 and SULT1A2 genes within a unique polygenic variation of altered cell adhesion., (© 2021 by the Association of Clinical Scientists, Inc.)

Published
2021

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