Author: "Walsh, S. L." - Searchworks@Jio Institute Digital Library Search Results

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111 results on '"Walsh, S. L."'

1. Automated computer-based CT stratification as a predictor of outcome in hypersensitivity pneumonitis

Author: Jacob, Joseph, Bartholmai, B. J., Rajagopalan, S., Karwoski, R., Mak, S. M., Mok, W., Della Casa, G., Sugino, K., Walsh, S. L. F., Wells, A. U., and Hansell, D. M.
Published: 2017
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2. Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study

Author: Abbas, Z., Abburu, S., Abd Ghaffar, M. K., Abdelhadi, M., Abdikadir, H. R., Abdulmajid, A., Abid, H., Abid, A., Abuhussein, N., Abul, M. H., Acquaah, F., Acres, M., Adams, R., Adams, R. D., Adebayo, A. A., Adeleja, I., Adjei, H., Afzal, Z., Agarwal, V., Ahern, N., Ahmad, K., Ahmad, S., Ahmed, M., Ahmed, H., Ahmed, N., Ahmed, S., Ahmed, F., Ahn, J. S., Aidoo-Micah, G. E., Aildasani, L., Aithie, J. M., Akhtar, S., Ali, S., Ali, A., Ali, B., Ali, M., Ali, H., Alizadeh, M., Allan, C., Allen, J. L. Y., Allot, R., Al-Mousawi, A., Al-Obaedi, O., Al-Robeye, A., Amajuoyi, A., Amin, H., Amin, O., Amphlett, A. H., Anandarajah, C., Anderson, L., Anderson, L. B., Anderson, S. M., Ang, A., Angelov, S., Anilkumar, A., Anim-Addo, N., Ansari, N., Antoniou, I., Archer, C. H., Arif, T., Asbjoernsen, C. A., Ashfaq, U., Ashken, L., Ashraf, S. F., Ashraf, S., Ashton, A. J., Ashwood, J., Aslanyan, A., Asmadi, A., Assadullah, S., Atayi, A., Atraszkiewicz, B. A., Attalla, M., Austreng, L., Auyoung, E., Avery, P., Axelson, T., Aziz, H., Aziz, N., Baker, A. N., Bakewell, Z. R., Bakhsh, A., Balaji, S., Balian, V., Bamgbose, F. A., Barai, I., Barnes, J., Barrow, T. R., Barthorpe, A. E., Bartlett, J., Bartlett, R. D., Barton, E. C., Bassam, N., Bassett, J., Bassiony, S., Bath, M. F., Batho, A., Batt, E., Bazeer, H. Z., Beckett, J., Beecroft, S., Behar, N., Bell, N., Bell, L., Bell, A., Bemand, T. P., Bergara, T., Bernstein, I., Bethell, G. S., Bhanderi, S., Bhangu, A., Bhaskaran, G., Bhatt, N., Bhatti, M., Bhome, R., Bhudia, R., Bingham, G., Blege, H. K., Blessed, R., Bloomer, J., Bloomfield, T., Blore, C. D., Bolton, W., Bolton, L., Bonsu, S., Bookless, L. R., Bose, R., Botchey, S., Boulton, A. J., Boxall, N., Boyle, J., Braganza, L., Brathwaite-Shirley, C., Bravo, M., Brecher, J., Bremner, R. H., Brennan, C., Brennan, E., Brennan, K., Brent, G., Brewer, C. F., Brewster, O., Bright, M., Brown, D., Brown, E., Brown, F. S., Brown, E. J., Broyd, A., Brzyska, K., Buakuma, P., Buchan, A. M., Buckle, R. T., Bucko, A. M., Bulley, F., Bullman, L. M., Bullock, N. P., Burgess, A., Burke, J., Burke, D., Burke, E., Burney, L. J., Callan, R., Campbell, J., Canning, N., Canning, E., Cao, Y., Cardwell, A. E., Carr, L., Carr, R., Carroll, A. F., Carter, D., Carthew, L., Chamberlain, M., Chan, N., Chan, C., Chandan, N., Chapman, S. J., Charalambos, M. A., Charalambous, G., Charania, A., Charavanamuttu, V., Chaudhary, M., Chaudhry, F. I., Chaudhry, W. W., Cheema, H., Chen, J. H., Chen, X., Chen, M., Cheng, K., Chervenkoff, J., Cheskes, L., Cheung, F., Chew, L. S., Chew, L., Chhabra, A., Chhina, C., Chilima, C. P., Chillarge, G., Chilvers, N. J., Chin, H., Chin, R., Chisholm, E. G., Chitnis, A. R., Chiu, S. M., Chong, B. F., Chong, J., Choo, K. P., Chrastek, D., Chua, E. Y., Chung, A., Claireaux, H. A., Clark, I. J., Clarke, A. K., Cleere, J., Clement, K. D., Clesham, K., Coates, A., Cody, A., Cody, N., Coffey, D., Coffey, C. J., Coffin, J., Cole, S. J., Collier, H., Collins, A., Collins, D., Collinson, S., Cooper, G. E., Cooper, D., Copley, H. C., Copley, P. C., Cornish, E., Cotton, A., Coulson, R., Cox, S. E., Craig, A. R., Craig, E., Craig-McQuaide, A., Crewdson, J. A., Croall, A., Crozier, L., Cullen, C., Cullen, S., Culleton, G., Cumber, E., Cumber, E. M., Cumming, S., Cundy, O. J., Cunha, P., Curran, A., Cuthbert, G., Cymes, W., Daoub, A., Darr, S., Das, M., Datta, U., Davies, N., Davies, J., Davies, J. E., Davies, K., Davis-Hall, M., Dawar, R., Dawson, P. M., de Bernier, G. L., Deall, C., Dean, R., Dean, S., Dean, W., Dear, K., Deas, G., Debenham, R., Deekonda, P., Delport, A., Demetri, A. M., Dennis, Y. F., Dennis, R., Derbyshire, L., Devabalan, Y., Devlin, E., Dewdney, C. J., Dhanji, A., Dhar, M., Dhutia, A. J., Diaper, C., Dickson, J., Din, W., Dindyal, S., Dinsmore, L., Doan, L., Dobson, J., Dogra, T., Doherty, C., Dolaghan, M., Dolbec, K. S., Dorman, C., Drake, T. M., Drislane, C., Dube, P., Duffy, A., Duke, K., Duncumb, J. W., Dunn, C. E., Durr, A., Durrani, B., Dutt, S., Dyal, A. R., Dynes, K., Edison, M. A., Edozie, F., Egan, R. J., Egerton, C., Elangovan, V., Elf, D., Elkawafi, M., Elliott, L. E., Elseedawy, M., Empey, J., English, W., Entwisle, J. H., Eparh, K., Eragat, M., Eraifej, J., Esteve, L., Farmer, J. D., Fautz, T., Favero, N., Fawaz, A. S., Fergurson, P., Fern, J., Filby, J. J., Filipescu, T., Fitzgerald, J. E., FitzPatrick, D., Fleck, R., Fletcher, L., Fong, J., Forrest, P. R., Forte, B., Foster, N. L., Francescon, C. T., Frank, A. L., Fung, T. M. P., Gabriel, J., Gaffney, S., Galloway, E., Gandhi, K., Gardiner, N., Gardner, E., Gardner, H., Gatfield, W. A., Gauntlett, L., Gentry, S., George, D., Geraghty, J. M., Ghaffar, A., Gilbert, H., Giles, J. E., Gill, P., Gill, C. K., Girling, C., Glasbey, J. C., Glover, T. E., Goh, B., Goh, R. W., Gohil, K., Gokani, S., Gold, D., Golding, D. M., Goldsmith, T., Goodier, R., Goradia, H., Gouda, P., Gouldthrope, C., Govinden, S., Graham, C. J., Gratton, R., Gray, L., Greenhalgh, A. D., Greig, R. J., Griffin, E. J., Grossart, C. M., Grundy, L., Gulati, J., Gundogan, B., Gupta, V., Gwozdz, A. M., Siddiqui, Z. H., Hague, A., Hameed, M., Hanrahan, M., Haq, H., Harbhajan Singh, G. S., Hardie, J., Harding, F., Hardy, M. R., Harries, P., Harris, R. T., Harris, L. N., Harrison, E. M., Harrison, P. L. M., Hartley, J., Hartley, S., Harvey, J., Hassan, S., Hayat, M., Hayat, U., Hayes, J. D. B., He, A., Healy, L., Heathcote, E., Heer, R. S., Heminway, R., Henderson, I., Henderson, L. A., Henderson, C., Heneghan, H., Henson, A. D., Heppenstall-Harris, G., Herron, J., Heskin, J., Hester, E., Hewitt, C. M., Heywood, E. G., Hibberd, A., Hickling, S. L., Higgins, A., Higgs, L., Hill, A., Hindle Fisher, I., Hirani, S., Hirst, F., Hitchen, N., Ho, W., Ho, S., Hoban, K. A., Holliday, R. B. S., Holloway, C., Holmes, C., Holmes, M. J. V., Holton, P., Holyoak, H., Horne, L., Horst, C., Horth, D., Hoskins, T. C., Howells, L., Hu, L., Huang, H. C., Hudson-Phillips, S., Hughes, F., Hughes, B. A., Hughes, R. K., Hulley, K., Hung, G., Hurst, P. C., Husnoo, S. B., Hussain, N., Hussain, O., Ibrahim, I., Ibrahim, A., Ingham, R., Ingram, E., Iqbal, S., Iqbal, A., Isaac, A., Jackson, H. R., Jackson, S., Jacob, L., Jafree, D. J., Jaitley, A., Jalota, P., Jamal, N., Jathanna, N., Jawad, A. S., Jayakody, N., Jenkin, S. L., Jenvey, C., Jewell, P. D., Jhala, H., Jindal, A., Johnston, A., Johnston, J., Johnstone, M., Jordan, H. E. M., Joshi, K. R., Joshi, D., Joyce, H. L., Joyner, C., Jubainville, C. L., Jull, P., Kadicheeni, M., Kahar, A., Kalra, N., Kanabar, S., Kane, T., Karia, M., Karia, P., Karsan, R. B., Karunakaran, P., Kaushal, A., Kazmi, Z., Keane, P., Keane, C. P., Keane, N., Kee, J. Y., Keeling, R. E., Keelty, N., Keevil, H., Kelly, M., Kelly, M. E., Kelly, N., Kennedy, E. D., Kennedy, H. R., Kerai, A., Kerr, A. L., Khajuria, A., Khalid, H., Khan, T., Khan, M., Khan, S., Khan, U., Khan, A., Khangura, J., Khanijau, R., Khatri, C., Khattak, M., Khetarpal, A. A., Khokhar, H. A., Khonat, Z., Khonsari, P., Kiff, R., Kim, S., Kim, J. W., Kimani, L., King, M., Kishore, A., Kisyov, I., Kitt, H., Knight, C. L., Kong, C. Y., Kong, C., Kosasih, S. R., Koshy, R. M., Kotecha, D., Koumpa, F., Kow, K., Koysombat, K., Kreibich, A., Kretzmer, L., Kumar, A. N., Kumaran, G., Kwan, M. L., Kwang, P., Lakhani, M., Lakhani, S. M., Lakshmipathy, G., Lalor, P., Lamont, J., Lankage, C. M., Lavery, J., Lazenby, D., Ledsam, A., Lee, A. H. Y., Lee, S., Lees, D. M., Lek, C., Leong, S., Leslie, K. E., Leung, W., Lewis, T., Li, N., Li, M. M., Liew, Y., Liew, W., Lim, K., Lim, J., Lim, D., Lim, A. E., Lim, S. J., Lim, S., Lim, E., Linton, A., Liu, S., Liu, C., Livesey, A., Lo, T., Lockey, J. W., Logan, A. E., Loke, W., Long, F., Lopes, S., Lotfallah, A., Lou, C. N., Loughran, D., Loveday, J., Low, J. Y. L., Lu, Q., Lua Boon Xuan, J., de Carvalho, J. Lucas, Luhishi, A., Luk, C. Y., Lunawat, S., Lwin, K. N., Lykoudis, P. M., Lynch, A. S., Lynne, S., Lyons, R., Maamari, R., MacAskill, A., MacDonald, J., Mackin, S., Maclennan, D., Mah, J., Mahboob, S., Maheswaran, Y., Mahmood, J., Majid, S., Major, C., Malaj, M., Malik, A., Mallick, S., Malys, M. K., Manson, R., Mansoor, S., Maple, N., Marchal, S. T., Markham, R. M., Marsden, M., Marsh, A., Marshall, D. C., Martin, A. L., Martin, R., Maru, D., Mason, J. D., Masood, M., Mastan, A., Matheson, J., Matthams, J., Matthews, B. W., Matthews, J. H., Maxwell-Armstrong, C., Mazan, K., Mazumdar, E., McAleer, S., McAleer, E., McAllister, R., McAuley, D., McBride, A., McCabe, G., McCance, E., McCann, M., McClymont, L. F., McCormack, D. R., McCrann, C., McDowell, M., McEnhill, P. M., McFarlane, H., McGalliard, R. J., McGarrigle, C., McGarvie, S., Mcgenity, C., McGowan, C., McGrath, A., McGregor, R. J., McIntyre, C. J., Mckean, E., McKelvey, L. L., McKerr, C. N., McKevitt, K. L., McLaughin, C., McLean, R. C., McLure, S. W., McMenamin, M., McMullan, R., McNamee, L., McRobbie, H. D., Meek, J., Mehdi, A., Mehta, J. K., Menon, A., Mian, A., Mills, E. D., Mills, M., Mills, H., Milne, S., Minhas, M., Miranda, B. H., Mirdavoudi, V., Mirza, M., Mishra, A., Mistry, S., Mistry, B. D., Mitchell, H., Mitha, N., Mithrakumar, P., Mitrasinovic, S., Mittapalli, D., Mogan, Y. P., Mohamud, M., Mohan, M., Mohan, K., Mohite, A., Momoh, Z., Moody, N., Moon, R. D. C., Moradzadeh, J., Morgan, F., Morgan, C., Morley, R., Morris, F., Morris, S., Morrison, P., Morrison, C. J., Mortimer, A., Murkin, C., Murphy, L., Murray, S. E., Murtaza, A., Mushtaq, J., Nachiappan, R., Nadanakumaran, K., Naqib, S., Narain, A., Naran, P., Narang, Y., Narayan, P., Narramore, R., Narwani, V., Navayogaarajah, V., Naveed, H., Nayee, H., Nehikhare, I., Nelaj, S., Neo, Y. N., Neophytou, C., Nepogodiev, D., Nesargikar, P. N., Ng, K., Ng, J. C. K., Ng, G. S., Ng, J. Q., Ng, A. Y. L., Ng, S., Ng, L., Nicholls, K., Nixon, G., Norris, J. M., North, A. S., Norton, J., Ntala, C., O’Bryan, M., O’Carroll, O., O’Connell, C., O’Connor, A., O’Connor, S., O’Flynn, L. D., O’Kane, A., O’Loughlin, R. A., O’Neill, S., O’Neill, E. M., O’Reilly, D., O’Sullivan, D. A., O’Sullivan, K., Obute, R. D., Odeleye, A., Omar, A., Omara, S., Omer, H. M., Ong, K. K., Oremule, B., Osei-Kuffour, D., Osman, S., Owasil, R., Owczarek, S., Williams, R. P., Paine, H. R., Pal, S., Palkhi, E., Palmer, C., Pandey, A., Pandey, G., Paraoan, V., Park, J. H., Parker, O., Parker, J., Parkin, J., Parsons, S., Parthiban, S., Patel, P., Patel, M., Patel, T., Patel, S., Patel, N., Patel, J. B., Patel, V., Patel, B. Y., Patel, B., Patel, B. A., Patel, K., Paul, J., Pearce, J., Pearse, R. J., Peck, F. S., Perera, M., Pericleous, A., Peroos, S., Peters, M., Petra, H., Petrarca, M., Pezas, T. P., Phan, P. N., Phillips, C., Pickard, J., Pinto, R., Piquet, A., Pitts-Tucker, T., Pizzolato, A., Player, C., Ponweera, A., Poo, S. X., Pope, S., Prabhudesai, A., Prakash, E., Preece, R., Prest-Smith, J., Priestland, R., Prys-Jones, O., Ptacek, I. B., Puan, L., Punj, R., Punjabi, N., Qamar, M. A., Qureshi, S., Qureshi, U., Qureshi, A., Rabinthiran, S., Radotra, A., Rafiq, N. M., Raghuvir, V., Raghvani, T., Rajan, N., Raji, K., Raman, K. P., Ramjeeawon, N., Ramnarine, A., Rampal, R., Ramsay, N., Ramtoola, T., Rangan, T., Rangedara, A., Raphael, M., Rashid, S., Rashid, M., Rasiah, M. G., Ratnakumaran, R., Rattan, G., Ratu, S. G., Raut, P., Reakes, T., Redgrave, N. A., Reed, A., Reeder, C., Reehal, R. S., Rees, C., Reeves, T., Reid, N. B., Reid, R., Reid, K. G., Remedios, J., Rhema, I. A., Rinkoff, S., Roberts, E. J., Roberts, A. W., Roberts, H. F., Roberts, C., Robertson, K. L., Robertson, V., Robertson, D. T., Robinson, M., Robinson, C., Robson, J., Rocke, A. S., Rogers, J. E., Rogers, S., Rojoa, D., Rookes, C. W., Rosen O’Sullivan, H., Ross, T., Ross, H., Rothwell, L., Roy, C. S. D., Ruiz, E. M., Russell, G., Ryan, M., Sabine, L. M., Sagar, R., Sagmeister, M., Sahathevan, A., Sait, M. S., Sajjad, U., Salam, G. J., Sale, T., Salem, M., Salih, A. E., Salmon, D., Sanders, J. A., Sandhu, K. K., Sandhu, S., Sangal, P., Sarvanandan, T., Sarwar, S., Sasapu, K., Satterthwaite, L., Schulz, T. M., Scotcher, S. E., Seager, E., Seedat, M., Segall, E., Sellathurai, J., Selvachandran, H., Semana, A. D., Semnani, S. A., Semple, E., Seneviratne, N., Sethi, R. K., Shafi, A. M. A., Shafiq, N. M., Shah, A., Shah, J. P., Shah, R., Shah, S., Shaheen, H., Shahid, S., Shahidi, S., Shakweh, E., Shanahan, D., Sharifpour, M., Shatkar, V., Shaunak, R., Sheldon, A., Shepherd, R., Shepherd, P., Sherif, M. A., Sherliker, G. X. J., Sheth, S., Shoa, M., Shufflebotham, H., Shuker, B. A., Shukla, A., Shumon, S., Shurovi, B. N., Shuttleworth, R. H., Siddiqui, M., Sii, S., Sim, N. K., Sim, P., Sim, D., Simpson, R., Simpson, A., Singagireson, S., Singh, B., Singh, K., Singh, R., Singh, S., Sinha, Y., Sirakaya, M., Sitta, O., Slade, R., Smith, N., Smith, D. N. E., Smith, A. C. D., Sng, S., Soo, Y. H., Soon, W. C., Sorah, T., Spence, O., Spencer, T., Springford, L. R., Sreh, A., Srikantharajah, M., Sritharan, P., Stanger, S. A., Stanley, G. H., Stather, P. W., Steel, M., Stein, J., Stevens, S., Stewart, G. E., Stezaker, S., Stoddart, M. T., Stokes, S., Stone, E. J., Stott, G. D., Strange, E., Street, A. N., Sukkari, M., Sukumar, S., Suleman, Y. N., Sullivan, J. A. L., Sun, E., Sundar-Singh, M., Suresh, S., Suresh, R. S., Syeed, J. A., Sykes, M. C., Szczap, A., Tahir, M., Tahmina, A., Tai, A., Talukdar, S. S., Tan, Y. H., Tan, R., Tan, E. T., Tan, D., Tan, Y., Tan, S., Tan, E. S. M., Tay, A. Y., Tayeh, S., Tear, A. K., Telfer, R., Teng, V., Teoh, P. J., Thacoor, A., Thakker, C. E., Thakur, H., Tharakan, R. G., Tharmachandirar, T., Theodoreson, M. D., Theodoropoulou, K., Thethi, R., Thevathasan, A. A., Thirumal, V., Thomas, G., Thomas, D., Thompson, O. D., Thompson, J. D., Tilston, T. W., Toale, C., Toh, C., Toner, E., Tongo, F., Tonkins, M., Topham, C., Torlot, G. E., Torrance, H. D., Trail, M., Traynor, B. P., Trecarten, S., Trimble, A., Trist, A. J., Tsui, A. Y., Tung, L., Turaga, S., Turley, H., Turnbull, J. A., Turner, L., Turner, M., Turner, E. J. H., Turner, J., Ungcharoen, N., Uppal, E., Valli, A., Vanmali, P., Varley, R., Varma, R. K., Varma, D., Varma, N., Vaughan, R., Venn, M., Ventre, C. M., Verma, K., Verma, S., Vernon, O. K., Vithanage, N. A., Vivekanantham, S., Wadanamby, S., Waldron, R. M., Walford, R. A., Wali, A., Wall, C., Walsh, S. L., Wan, J. C., Wang, S., Wang, A., Ward, N., Ward, T., Ward, A. E., Warren, N., Warwick, H. L., Watson, N., Watson, R. P., Weaver, R., Webb, E., Weinberg, D., Wells, M., Weston, C., Wetherall, N., Whacha, C., Whatling, E. A., Whewell, H., White, A., White, C. J., White, U., Whitehurst, K., Whitham, R. D. J., Whittingham, H., Wijesekera, M., Wild, J. R. L., Wilkinson, D., Williams, M., Williams, M. R., Williams, P., Wills, J., Wilson, H. C. P., Wilson, H., Wilson, R., Wiltshire, J. J., Winarski, A., Wing, V. C., Wingfield, L. R., Winslow, F., Woin, E., Wong, V., Wong, E., Wood, A. D., Woodcock, N., Woodward, H., Woon, E., Wright, A., Wright, E. V., Wye, J., Wylam, D., Wylie, J., Wynell-Mayow, W. M., Xiao, C., Xu, G. X., Xylas, D., Yan, A., Yang, T., Yates, J. A., Yener, A., Yim, N., Yoganathan, S., Yong, C. S., Yong, N., Yousif, A., Yow, L., Yuen, R., Zegeye, M. I., Zhao, J., Ziff, O., Ziprin, P., Zuhair, M., and STARSurg Collaborative
Published: 2017
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3. Collections Of Dufourea versatilis (Hymenoptera, Halictidae) From Idaho

Author: Walsh, S L and BioStor
Published: 1990

4. Evaluation of the mu and kappa opioid actions of butorphanol in humans through differential naltrexone blockade

Author: Walsh, S. L., Chausmer, A. E., Strain, E. C., and Bigelow, G. E.
Published: 2008
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5. Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers

Author: Strain, E. C., Stoller, K., Walsh, S. L., and Bigelow, G. E.
Published: 2000
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6. Pharmacokinetics of Intranasal Crushed OxyContin and Intravenous Oxycodone in Nondependent Prescription Opioid Abusers

Author: Lofwall, M. R., Moody, D. E., Fang, W. B., Nuzzo, P. A., and Walsh, S. L.
Published: 2012
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7. Onset, magnitude and duration of opioid blockade produced by buprenorphine and naltrexone in humans

Author: Schuh, Kory J., Walsh, S. L., and Stitzer, Maxine L.
Published: 1999
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8. S94 Ultrasound measurement of quadriceps wasting in early chronic obstructive pulmonary disease and its relationship with daily physical activity

Author: Shrikrishna, D, Tanner, R, Seymour, J M, Patel, M, Connolly, B A, Puthucheary, Z A, Walsh, S L F, Bloch, S A, Sidhu, P S, Hart, N, Moxham, J, Polkey, M I, and Hopkinson, N S
Published: 2011
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9. Effects of buprenorphine and methadone in methadone-maintained subjects

Author: Walsh, S. L., June, H. L., Schuh, K. J., Preston, K. L., Bigelow, G. E., and Stitzer, M. L.
Published: 1995
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10. Variable radiological lung nodule evaluation leads to divergent management recommendations

Author: Nair, A., Bartlett, E. C., Walsh, S. L. F., Wells, A. U., Navani, N., Hardavella, G., Bhalla, S., Calandriello, L., Devaraj, A., Goo, J. M., Klein, J. S., Macmahon, H., Schaefer-Prokop, C. M., Seo, J. -B., Sverzellati, N., Desai, S. R., Ahlfors, F., Bastos, A., Behr, J., Benes, J., Bozovic, G., Buzan, M. T., Castaner, E., Chaves, M., Choi, Y. W., Dalpiaz, G., David, S., De Jong, P. A., Dournes, G., Eberhard, M., Escuissato, D., Farchione, A., Flors, L., Franchi, P., Frauenfelder, T., Fujimoto, K., Gatti, M., Gavelli, G., Grgic, A., Haine, L., Haramati, L., Hartman, T., Hartmann, I., Hering, J. P., Herpels, V., Herraez, I., Hobbs, S., Hochhegger, B., Hursoy, N., Ip, J., Iyengar, S., Jimenez, J. A., Johnson, K., Kanne, J., Kapur, S., Karaman, C. Z., Karl, R., Kirova, G., Ko, J., Kramer, G., Kul, M., Larici, A. R., Lee, Y., Leifels, L., Ley, S., Machnicki, S., Maidas, P., Mak, S. M., Mariani, F., Meirelles, G., Hoesein, F. A. M., Montet, X., Murchison, J., Nath, H., Nenkina, T., Nganga, E., Nguyen-Kim, T. D. L., Niemann, T., Nunez, C. F. M., Occhipinti, M., Oikonomou, A., Ozawa, Y., Pandher, T., Parkar, A. P., Piciucchi, S., Pinheiro, D., Poerio, A., Polverosi, R., Pope, K., Prosch, H., Pulzato, I., Rampinelli, C., Rodrigues, J., Romanos, O., Romei, C., Roos, J., Rossi, S., Rubtsov, R., Ruggirello, M., Sanchez, M., Santos, M. K., Schubert, M., Senbanjo, T., Silva, C., Silva, M., Snoeckx, A., Sonavane, S., Sriharan, M., Stefanidis, K., Taydas, O., Tomiyama, N., Tran, S., Villanueva, A., Williams, M., and Lung Nodule Evaluation Grp
Subjects: Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Lung Neoplasms, Computed tomography, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, X ray computed, Pulmonary nodule, Radiologists, medicine, 80 and over, Aged, Aged, 80 and over, Female, Humans, Middle Aged, Multiple Pulmonary Nodules, Observer Variation, Practice Guidelines as Topic, Reproducibility of Results, Solitary Pulmonary Nodule, Tomography, X-Ray Computed, Tomography, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Solitary pulmonary nodule, medicine.diagnostic_test, business.industry, Nodule (medicine), medicine.disease, X-Ray Computed, Tomography x ray computed, 030220 oncology & carcinogenesis, Radiological weapon, Human medicine, Radiology, medicine.symptom, business
Abstract: Radiological evaluation of incidentally detected lung nodules on computed tomography (CT) influences management. We assessed international radiological variation in 1) pulmonary nodule characterisation; 2) hypothetical guideline-derived management; and 3) radiologists' management recommendations.107 radiologists from 25 countries evaluated 69 CT-detected nodules, recording: 1) first-choice composition (solid, part-solid or ground-glass, with percentage confidence); 2) morphological features; 3) dimensions; 4) recommended management; and 5) decision-influencing factors. We modelled hypothetical management decisions on the 2005 and updated 2017 Fleischner Society, and both liberal and parsimonious interpretations of the British Thoracic Society 2015 guidelines.Overall agreement for first-choice nodule composition was good (Fleiss' κ=0.65), but poorest for part-solid nodules (weighted κ 0.62, interquartile range 0.50–0.71). Morphological variables, including spiculation (κ=0.35), showed poor-to-moderate agreement (κ=0.23–0.53). Variation in diameter was greatest at key thresholds (5 mm and 6 mm). Agreement for radiologists' recommendations was poor (κ=0.30); 21% disagreed with the majority. Although agreement within the four guideline-modelled management strategies was good (κ=0.63–0.73), 5–10% of radiologists would disagree with majority decisions if they applied guidelines strictly.Agreement was lowest for part-solid nodules, while significant measurement variation exists at important size thresholds. These variations resulted in generally good agreement for guideline-modelled management, but poor agreement for radiologists' actual recommendations.
Published: 2018

11. Computed tomographic biomarkers in idiopathic pulmonary fibrosis: The future of quantitative analysis

Author: Wu, X., Kim, G. H., Salisbury, M. L., Barber, D., Bartholmai, B. J., Brown, K. K., Conoscenti, C. S., De Backer, J., Flaherty, K. R., Gruden, J. F., Hoffman, E. A., Humphries, S. M., Jacob, J., Maher, T. M., Raghu, G., Richeldi, Luca, Ross, B. D., Schlenker-Herceg, R., Sverzellati, N., Wells, A. U., Martinez, F. J., Lynch, D. A., Goldin, J., Walsh, S. L. F., Richeldi L. (ORCID:0000-0001-8594-1448), Wu, X., Kim, G. H., Salisbury, M. L., Barber, D., Bartholmai, B. J., Brown, K. K., Conoscenti, C. S., De Backer, J., Flaherty, K. R., Gruden, J. F., Hoffman, E. A., Humphries, S. M., Jacob, J., Maher, T. M., Raghu, G., Richeldi, Luca, Ross, B. D., Schlenker-Herceg, R., Sverzellati, N., Wells, A. U., Martinez, F. J., Lynch, D. A., Goldin, J., Walsh, S. L. F., and Richeldi L. (ORCID:0000-0001-8594-1448)
Published: 2019

12. Nintedanib in progressive fibrosing interstitial lung diseases

Author: Flaherty, K. R., Wells, A. U., Cottin, V., Devaraj, A., Walsh, S. L. F., Inoue, Y., Richeldi, Luca, Kolb, M., Tetzlaff, K., Stowasser, S., Coeck, C., Clerisme-Beaty, E., Rosenstock, B., Quaresma, M., Haeufel, T., Goeldner, R. -G., Schlenker-Herceg, R., Brown, K. K., Richeldi L. (ORCID:0000-0001-8594-1448), Flaherty, K. R., Wells, A. U., Cottin, V., Devaraj, A., Walsh, S. L. F., Inoue, Y., Richeldi, Luca, Kolb, M., Tetzlaff, K., Stowasser, S., Coeck, C., Clerisme-Beaty, E., Rosenstock, B., Quaresma, M., Haeufel, T., Goeldner, R. -G., Schlenker-Herceg, R., Brown, K. K., and Richeldi L. (ORCID:0000-0001-8594-1448)
Abstract: BACKGROUND Preclinical data have suggested that nintedanib, an intracellular inhibitor of tyrosine kinases, inhibits processes involved in the progression of lung fibrosis. Although the efficacy of nintedanib has been shown in idiopathic pulmonary fibrosis, its efficacy across a broad range of fibrosing lung diseases is unknown. METHODS In this double-blind, placebo-controlled, phase 3 trial conducted in 15 countries, we randomly assigned patients with fibrosing lung disease affecting more than 10% of lung volume on high-resolution computed tomography (CT) to receive nintedanib at a dose of 150 mg twice daily or placebo. All the patients met criteria for progression of interstitial lung disease in the past 24 months despite treatment and had a forced vital capacity (FVC) of at least 45% of the predicted value and a diffusing capacity of the lung for carbon monoxide ranging from 30 to less than 80% of the predicted value. Randomization was stratified according to the fibrotic pattern (a pattern of usual interstitial pneumonia [UIP] or other fibrotic patterns) on high-resolution CT. The primary end point was the annual rate of decline in the FVC, as assessed over a 52-week period. The two primary populations for analysis were the overall population and patients with a UIP-like fibrotic pattern. RESULTS A total of 663 patients were treated. In the overall population, the adjusted rate of decline in the FVC was −80.8 ml per year with nintedanib and −187.8 ml per year with placebo, for a between-group difference of 107.0 ml per year (95% confidence interval [CI], 65.4 to 148.5; P<0.001). In patients with a UIP-like fibrotic pattern, the adjusted rate of decline in the FVC was −82.9 ml per year with nintedanib and −211.1 ml per year with placebo, for a difference of 128.2 ml (95% CI, 70.8 to 185.6; P<0.001). Diarrhea was the most common adverse event, as reported in 66.9% and 23.9% of patients treated with nintedanib and placebo, respectively. Abnormalities on liver
Published: 2019

13. Diagnostic likelihood thresholds that define a working diagnosis of idiopathic pulmonary fibrosis

Author: Walsh, S. L. F., Lederer, D. J., Ryerson, C. J., Kolb, M., Maher, T. M., Nusser, R., Poletti, V., Richeldi, Luca, Vancheri, C., Wilsher, M. L., Antoniou, K. M., Behr, J., Bendstrup, E., Brown, K. K., Corte, T. J., Cottin, V., Crestani, B., Flaherty, K. R., Glaspole, I. N., Grutters, J., Inoue, Y., Kondoh, Y., Kreuter, M., Johannson, K. A., Ley, B., Martinez, F. J., Molina-Molina, M., Morais, A., Nunes, H., Raghu, G., Selman, M., Spagnolo, P., Taniguchi, H., Tomassetti, S., Valeyre, D., Wijsenbeek, M., Wuyts, W. A., Wells, A. U., Richeldi L. (ORCID:0000-0001-8594-1448), Walsh, S. L. F., Lederer, D. J., Ryerson, C. J., Kolb, M., Maher, T. M., Nusser, R., Poletti, V., Richeldi, Luca, Vancheri, C., Wilsher, M. L., Antoniou, K. M., Behr, J., Bendstrup, E., Brown, K. K., Corte, T. J., Cottin, V., Crestani, B., Flaherty, K. R., Glaspole, I. N., Grutters, J., Inoue, Y., Kondoh, Y., Kreuter, M., Johannson, K. A., Ley, B., Martinez, F. J., Molina-Molina, M., Morais, A., Nunes, H., Raghu, G., Selman, M., Spagnolo, P., Taniguchi, H., Tomassetti, S., Valeyre, D., Wijsenbeek, M., Wuyts, W. A., Wells, A. U., and Richeldi L. (ORCID:0000-0001-8594-1448)
Abstract: Rationale: The level of diagnostic likelihood at which physicians prescribe antifibrotic therapy without requesting surgical lung biopsy (SLB) in patients suspected of idiopathic pulmonary fibrosis (IPF) is unknown. Objectives: To determine how often physicians advocate SLB in patient subgroups defined by IPF likelihood and risk associated with SLB, and to identify the level of diagnostic likelihood at which physicians prescribe antifibrotic therapy with requesting SLB. Methods: An international cohort of respiratory physicians evaluated 60 cases of interstitial lung disease, giving: 1) differential diagnoses with diagnostic likelihood; 2) a decision on the need for SLB; and 3) initial management. Diagnoses were stratified according to diagnostic likelihood bands described by Ryerson and colleagues. Measurements and Main Results: A total of 404 physicians evaluated the 60 cases (24,240 physician-patient evaluations). IPF was part of the differential diagnosis in 9,958/24,240 (41.1%) of all physician-patient evaluations. SLB was requested in 8.1%, 29.6%, and 48.4% of definite, provisional high-confidence and provisional low-confidence diagnoses of IPF, respectively. In 63.0% of provisional high-confidence IPF diagnoses, antifibrotic therapy was prescribed without requesting SLB. No significant mortality difference was observed between cases given a definite diagnosis of IPF (90-100% diagnostic likelihood) and cases given a provisional high-confidence IPF diagnosis (hazard ratio, 0.97; P = 0.65; 95% confidence interval, 0.90-1.04). Conclusions: Most respiratory physicians prescribe antifibrotic therapy without requesting an SLB if a provisional high-confidence diagnosis or "working diagnosis" of IPF can be made (likelihood>70%). SLB is recommended in only a minority of patients with suspected, but not definite, IPF.
Published: 2019

14. The characterisation of interstitial lung disease multidisciplinary team meetings: A global study

Author: Richeldi, Luca, Launders, N., Martinez, F., Walsh, S. L. F., Myers, J., Wang, B., Jones, M., Chisholm, A., Flaherty, K. R., Richeldi L. (ORCID:0000-0001-8594-1448), Richeldi, Luca, Launders, N., Martinez, F., Walsh, S. L. F., Myers, J., Wang, B., Jones, M., Chisholm, A., Flaherty, K. R., and Richeldi L. (ORCID:0000-0001-8594-1448)
Abstract: Multidisciplinary team (MDT) diagnosis of interstitial lung disease (ILD) has been proposed as a gold standard, but there are no formal recommendations for MDT process or composition and limited knowledge regarding prevalence in routine practice. We performed a systematic evaluation of ILD diagnostic practice across a range of healthcare settings around the world. Electronic questionnaires were distributed across all global regions via society and collaborators networks. Responses from 457 unique centres across 64 countries were included in the analysis. Of the 350 (76.6%) centres holding formal meetings, the majority held face-to-face MDT meetings (80%), for a minimum of 30 min (93%), and discussed diagnosis (96.9%) and patient management (94.9%) at the meetings. Compared with non-academic and academic non-ILD centres, ILD academic centres reported a higher ILD caseload, held more formal MDT meetings, and were more likely to include histopathology and rheumatology specialists in their diagnostic team. Of the centres holding MDT meetings, 5.5% routinely discussed all new cases at such meetings. An MDT approach to ILD diagnosis is consistently interpreted and widely implemented across a range of routine care settings around the world. This observation will inform future ILD diagnostic agreement studies and diagnostic pathway recommendations.
Published: 2019

15. Subclinical interstitial lung abnormalities: Lumping and splitting revisited

Author: Walsh, S. L. F., Richeldi, Luca, Richeldi L. (ORCID:0000-0001-8594-1448), Walsh, S. L. F., Richeldi, Luca, and Richeldi L. (ORCID:0000-0001-8594-1448)
Published: 2019

16. Quantitative analysis of lung sounds for monitoring idiopathic pulmonary fibrosis: a prospective pilot study

Author: Sgalla, Giacomo, Larici, Anna Rita, Sverzellati, N., Bartholmai, B., Walsh, S. L. F., Nikolic, D., Barney, A., Fletcher, S., Jones, M., Davies, D. D., Richeldi, Luca, Sgalla G. (ORCID:0000-0003-3130-9388), Larici AR. (ORCID:0000-0002-1882-6244), Richeldi L. (ORCID:0000-0001-8594-1448), Sgalla, Giacomo, Larici, Anna Rita, Sverzellati, N., Bartholmai, B., Walsh, S. L. F., Nikolic, D., Barney, A., Fletcher, S., Jones, M., Davies, D. D., Richeldi, Luca, Sgalla G. (ORCID:0000-0003-3130-9388), Larici AR. (ORCID:0000-0002-1882-6244), and Richeldi L. (ORCID:0000-0001-8594-1448)
Published: 2019

17. Demystifying fibrotic hypersensitivity pneumonitis diagnosis: it's all about shades of grey

Author: Walsh, S. L. F., Richeldi, Luca, Richeldi L. (ORCID:0000-0001-8594-1448), Walsh, S. L. F., Richeldi, Luca, and Richeldi L. (ORCID:0000-0001-8594-1448)
Abstract: The spotlight on diagnosis in hypersensitivity pneumonitis (HP) intensifies. Over the past 18 months we have seen two pulmonary perspectives proposing diagnostic approaches to HP; an international Delphi survey and several imaging studies focused on clinical and imaging features predictive of HP; and clinical practice guideline initiatives for HP, sponsored by the American Thoracic Society and American College of Chest Physicians, are underway [1–5]. Despite this growing literature, HP continues to resist our best attempts to develop an accurate, reproducible case definition for this disorder. Making a diagnosis of HP is challenging because it is often shadowed by marginal exposure histories, borderline antigen positivity or discordant imaging patterns, and treatment decisions are often based on diagnostic probability rather than certainty [4, 5]. As in idiopathic pulmonary fibrosis (IPF), chest high-resolution computed tomography (HRCT) plays a central role in the initial evaluation of HP and involves the identification of specific patterns. For many years, the presence of mosaic attenuation (MA) on CT has been widelyaccepted as a cardinal imaging feature of HP
Published: 2019

18. Concurrent hereditary haemochromatosis and idiopathic Parkinson’s disease: a case report series

Author: Costello, D J, Walsh, S L, Harrington, H J, and Walsh, C H
Published: 2004

19. Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study

Author: Walsh S. L. F., Maher T. M., Kolb M., Poletti V., Nusser R., Richeldi L., Vancheri C., Wilsher M. L., Antoniou K. M., Behr J., Bendstrup E., Brown K., Calandriello L., Corte T. J., Cottin V., Crestani B., Flaherty K., Glaspole I., Grutters J., Inoue Y., Kokosi M., Kondoh Y., Kouranos V., Kreuter M., Johannson K., Judge E., Ley B., Margaritopoulos G., Martinez F. J., Molina-Molina M., Morais A., Nunes H., Raghu G., Ryerson C. J., Selman M., Spagnolo P., Taniguchi H., Tomassetti S., Valeyre D., Wijsenbeek M., Wuyts W., Hansell D., Wells A., Zhu P. S., Yuan Y., Yoshito Fukuda C., Yoshimatsu Y., Xaubet A., Wong A. M., White P., Westney G., West A., Wessendorf T., Waseda Y., Wang C., Vienna J. M., Videnovic Ivanov J., Vicens Zygmunt V., Venero Caceres M. C., Velasquez Pinto G., Veitch E., Vasakova M., Varone F., Varela B. E., Van Hal P., Van De Ven M., Van Der Lee I., Van Den Toorn L., Urrutia Gajate A., Urban J., Ugarte Fornell L. G., Tzouvelekis A., Twohig K., Turner A., Trujillo S., Triani A., Traila D., Torres V., Tomioka H., Tomii K., Tomic R., Toma C., Tokgoz Akyil F., Tobino K., Tobar R., Tiwari A., Tibana R., Tian X., Thillai M., Tham W., Teo F., Tekavec Trkanjec J., Teixeira P., Tarpey D., Tapias L., Tanizawa K., Tanino Y., Takada T., Tabaj G., Szolnoki E., Swarnakar R., Strambu I., Sterclova M., Spinks K., Soo C. I., Soltani A., Solanki S., Sobh E., Soares M. R., Smith J., Smith B., Slocum P., Slabbynck H., Sivokozov I., Shifren A., Shen S. M., Sharp C., Shanmuganathan A., Sebastiani A., Scarlata S., Savas R., Sasaki S., Santeliz J., Santana ANC., Sanchez R., Salinas M., Saito S., Ryan F., Royo Prats J. A., Rosi E., Rokadia H., Robles Perez A., Rivera Ortega P., Rio Ramirez M., Righetti S., Reichner C., Ravaglia C., Ratanawatkul P., Ramalingam V., Rajasekaran A., Radzikowska E., Ra S. W., Quadrelli S., Precerutti J., Prasad J., Popa D., Pizzalato S., Piotrowski W., Pineiro A., Piloni D., Peros Golubicic T., Perez R., Pereira C., Pereira B., Perch M., Patel N., Patel D., Papanikolaou I., Papakosta D., Panselinas E., Pang Y. K., Pandya P., Padrao E., Ozdemir Kumbasar O., Overbeek M. J., Otto Minasian A., O'Riordan D., Ora J., Oldham J., Okutan O., Ohshimo S., Oguzulgen I. K., Ogura T., O'Donnell T., O'Dochartaigh C., O'Beirne S., Novikova L., Novelli L., Noth I., Nogueira Mendes Neto N., Niroumand M., Nieto A., Neves A., Nambiar A., Nair S., Nadama R., Murtagh E., Mura M., Muller Quernheim J., Mukhopadhyay A., Mukherjee S., Morisset J., Moran O., Mooney J., Moller J., Mogulkoc N., Miyamoto A., Milenkovic B., Mette S., Mejia M., Mei F., Mazzei M., Matsuda T., Mason C., Martinez Frances M., Mannarino S., Mancuzo E., Malli F., Malhotra P., Maillo M., Maia J., Mahdavian M., Madsen F., Luckhardt T., Lucht W., Low S. Y., Lopez Miguel C. P., Lipchik R., Levy S., Levin K., Lee K. L., Lederer D., Lammi M. R., Kwan H. Y., Kukreja S., Kruavit A., Kotecki M., Kolilekas L., Knoop H., Kiyan E., Kishaba T., King Biggs M., Khor Y. H., Khan A., Khalil N., Kedia R., Kebba N., Kawano Dourado L., Kapitan K., Kan C. D., Kalyoncu A. F., Kalluri M., Kabasakal Y., Jyothula S., Juretschke M. A., Jovanovic D., Jonkers R., Jo H., Izumi S., Ishii H., Ikeda S., Ibrahim A., Hyldgaard C., Hunninghake G., Huie T., Hufton A., Hu X., Hseih W. C., Hoyos R., Hoyles R., Holguin Rodriguez O., Hogan M. P., Hodgson U., Hilkin Sogoloff H., Herrera E., Henry B. M., Hellemons M., Hecimovic A., Hayashi R., Hart S., Harari S., Haney S., Hambly N., Hakkim R., Gutierrez M., Gripaldo R., Gomez A., Goh N., Godoy R., Gilbert C., Giannarakis I., Gasparini S., Garcha P., Furtado S., Fois A., Flood Page P., Fletcher S., Fiss E., Figueroa Casas J., Figueroa Casas M., Fiddler C. A., Ferrara G., Fernandez Casares M., Felton C., Faverio P., Fabro A. T., Estrada A., Errhalt P., Enomoto N., Enghelmayer J. I., El Kersh K., Eiger G., Dubaniewicz A., Drakopanagiotakis F., Disayabutr S., Dijkstra A., Diaz Patino J. C., Diaz Castanon J. J., Dhooria S., Dhasmana D. J., De Rosa M., De Luca S., Delobbe A., Delgado D., Delgado C., De La Fuente I., De Kruif M., De Gier M., De Andrade J., Davidsen J. R., Daoud B., Dalhoff K., Cotera Solano J. V., Costa A. N., Coronel S., Confalonieri M., Conemans L., Comellas A., Colella S., Clemente S., Clark J., Ciuffreda M., Chung C. L., Chong S. G., Chirita D., Chen P. L., Chaudhuri N., Chambers D., Chalmers G., Chairman D., Chai G. T., Chacon Chaves R., Cetinsu V., Ceruti M., Ceballos Zuniga C. O., Castillo D., Carbone R. G., Caminati A., Callejas Gonzalez F. J., Butler M., Bustos C., Bukowczan M., Buendia I., Brunetti G., Brockway B., Bresser P., Breseghello J., Bouros D., Botero Zaccour J. A., Borzone G., Borie R., Blum H. C., Blank J., Biswas A., Bennett D., Benjamin M., Belaconi I. N., Beirne P., Beckert L., Bastiampillai S., Bascom R., Bartholmai B., Barros M., Ban AYL., Balestro E., Baldi B., Baddini Martinez J., Baburao A., Babu S., Averyanov A., Avdeev S., Athanazio R., Atahan E., Asuquo B., Assayag D., Antuni J., Antillon S., Anderson K. C., Anderson A., Alwani F., Altinisik G., Alsouofi N., Allam J. S., Al Jahdali H., Al Farttoosi A., Alfaro T., Al Busaidi N., Alavi Foumani A., Agreda Vedia M. G., Agarwal A., Afridi F., Adeyeye O. O., Adegunsoye A., Adamali H., Abedini A., Walsh, S. L. F., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., Wilsher, M. L., Antoniou, K. M., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., Corte, T. J., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., Inoue, Y., Kokosi, M., Kondoh, Y., Kouranos, V., Kreuter, M., Johannson, K., Judge, E., Ley, B., Margaritopoulos, G., Martinez, F. J., Molina-Molina, M., Morais, A., Nunes, H., Raghu, G., Ryerson, C. J., Selman, M., Spagnolo, P., Taniguchi, H., Tomassetti, S., Valeyre, D., Wijsenbeek, M., Wuyts, W., Hansell, D., Wells, A., Zhu, P. S., Yuan, Y., Yoshito Fukuda, C., Yoshimatsu, Y., Xaubet, A., Wong, A. M., White, P., Westney, G., West, A., Wessendorf, T., Waseda, Y., Wang, C., Vienna, J. M., Videnovic Ivanov, J., Vicens Zygmunt, V., Venero Caceres, M. C., Velasquez Pinto, G., Veitch, E., Vasakova, M., Varone, F., Varela, B. E., Van Hal, P., Van De Ven, M., Van Der Lee, I., Van Den Toorn, L., Urrutia Gajate, A., Urban, J., Ugarte Fornell, L. G., Tzouvelekis, A., Twohig, K., Turner, A., Trujillo, S., Triani, A., Traila, D., Torres, V., Tomioka, H., Tomii, K., Tomic, R., Toma, C., Tokgoz Akyil, F., Tobino, K., Tobar, R., Tiwari, A., Tibana, R., Tian, X., Thillai, M., Tham, W., Teo, F., Tekavec Trkanjec, J., Teixeira, P., Tarpey, D., Tapias, L., Tanizawa, K., Tanino, Y., Takada, T., Tabaj, G., Szolnoki, E., Swarnakar, R., Strambu, I., Sterclova, M., Spinks, K., Soo, C. 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K., Ogura, T., O'Donnell, T., O'Dochartaigh, C., O'Beirne, S., Novikova, L., Novelli, L., Noth, I., Nogueira Mendes Neto, N., Niroumand, M., Nieto, A., Neves, A., Nambiar, A., Nair, S., Nadama, R., Murtagh, E., Mura, M., Muller Quernheim, J., Mukhopadhyay, A., Mukherjee, S., Morisset, J., Moran, O., Mooney, J., Moller, J., Mogulkoc, N., Miyamoto, A., Milenkovic, B., Mette, S., Mejia, M., Mei, F., Mazzei, M., Matsuda, T., Mason, C., Martinez Frances, M., Mannarino, S., Mancuzo, E., Malli, F., Malhotra, P., Maillo, M., Maia, J., Mahdavian, M., Madsen, F., Luckhardt, T., Lucht, W., Low, S. Y., Lopez Miguel, C. P., Lipchik, R., Levy, S., Levin, K., Lee, K. L., Lederer, D., Lammi, M. R., Kwan, H. Y., Kukreja, S., Kruavit, A., Kotecki, M., Kolilekas, L., Knoop, H., Kiyan, E., Kishaba, T., King Biggs, M., Khor, Y. H., Khan, A., Khalil, N., Kedia, R., Kebba, N., Kawano Dourado, L., Kapitan, K., Kan, C. D., Kalyoncu, A. F., Kalluri, M., Kabasakal, Y., Jyothula, S., Juretschke, M. 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Altinisik, G, Alsouofi, N, Allam, J, Al Jahdali, H, Al Farttoosi, A, Alfaro, T, Al Busaidi, N, Alavi Foumani, A, Agreda Vedia, M, Agarwal, A, Afridi, F, Adeyeye, O, Adegunsoye, A, Adamali, H, Abedini, A, and Pulmonary Medicine
Subjects: Male, Pediatrics, International Cooperation, Respiratory System, Hospitals, University, Idiopathic pulmonary fibrosis, 0302 clinical medicine, Cohen's kappa, Diagnosis, UK, 030212 general & internal medicine, Medical diagnosis, Referral and Consultation, Pulmonologists, Idiopathic Pulmonary Fibrosi, Interstitial lung disease, 11 Medical And Health Sciences, Middle Aged, respiratory system, Prognosis, Hospitals, humanities, Dimensional Measurement Accuracy, Clinical Competence, Diagnosis, Differential, Diagnostic Techniques, Respiratory System, Female, Humans, Idiopathic Pulmonary Fibrosis, Quality of Health Care, Reproducibility of Results, Human, Cohort study, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Prognosi, education, MEDLINE, Reproducibility of Result, INTERSTITIAL PNEUMONIA, Interstitial Lung Diseases, 03 medical and health sciences, Internal medicine, PARENCHYMAL LUNG-DISEASE, MANAGEMENT, medicine, Idiopathic pulmonary fibrosis, diagnosis, Pulmonologist, University, business.industry, MORTALITY, Original Articles, medicine.disease, respiratory tract diseases, Diagnostic Techniques, IPF Project Consortium, 030228 respiratory system, Differential, INTEROBSERVER AGREEMENT, UPDATE, COOPERAÇÃO INTERNACIONAL, Differential diagnosis, business
Abstract: We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53–0.72, p20 years of experience (C-index=0.72, IQR 0.0–0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70–0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72–0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts., Academic status, access to MDT meetings and clinician experience predict accuracy of a clinical diagnosis of IPF http://ow.ly/k43W30cTMg1
Published: 2017

20. FIRST RANDOMIZED CONTROLLED TRIAL (RCT) OF METHADONE (M), LEVOMETHADYL ACETATE (LAAM) AND BUPRENORPHINE (BUP) IN OPIOID DEPENDENCE TREATMENT

Author: Johnson, R. E., Chutuape, M. A., Strain, E. C., Walsh, S. L., Stitzer, M. L., and Bigelow, G. E.
Published: 1999

21. LAAM Dose Comparison: A Clinical Trial: PII-97

Author: Johnson, R. E., Eissenberg, T., Strain, E. C., Walsh, S. L., Brooner, R. K., Liebson, I. A., Stitzer, M. L., and Bigelow, G. E.
Published: 1997

22. A Pilot Study of Less-than-Daily Dosing with Buprenorphine (B): PIII-91

Author: Johnson, R. E., Eissenberg, T., Bigelow, G. E., Walsh, S. L., Liebson, I. A., Strain, E. C., and Stitzer, M. L.
Published: 1996

23. Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis

Author: Blanco-Colino, R., Lee, S., Kamarajah, S. K., Vasko, P., Kuiper, S. Z., Farina, V., Chapman, S. J., Drake, T. M., Gavagna, L., Pasquali, S., Pata, F., Pellino, G., de la Rosa-Estadella, M., Stellingwerf, M. E., Stijns, R. C. H., Borrellas, A., Golding, D., Ngaage, M., Van Tol, R. R., de Groof, J., de Wilt, H., Bemelman, W. A., Mcnamee, L., Espin-Basany, E., Emre Baki, B., Gecim, I. E., Can Tatar, O., Bach, S., Bhangu, A., Bresges, K., Burke, J., Claireaux, H. A., Fearnhead, N., Fitzgerald, J. E., Gallagher, S., Glasbey, J. C., Gundogan, B., Harrison, E. M., Hernon, J., Khatri, C., Kong, C. Y., Lyons, A., Mohan, M., Morton, D., Pinkney, T. D., Arezzo, A., Foppa, C., Morino, M., Rubbini, M., Selvaggi, F., Sensi, B., Sica, G., Orhalmi, J., Naccari, P., Sgro, A., Burger, B. H. C. M., Fares, D. A., Spijkerman, R., van Elst, T. R., Wiersema, R., Stassen, L. P. S., Rodriguez Garcia, R., Ozkan, B. B., Tavuz, A. I., Demirci, Z. S., Baki, B. E., Choi, P. 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F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, R., Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. J., Alonso Goncalves, S., Parajo, A., Sanchez-Guillen, L., Lujan Mompean, J. A., Soria Aledo, V., Arenal, J. J., Blanco Antona, F., Badia, J. M., Roura, J., Garcia Garcia, J., Elia-Guedea, M., Millan, M., Vinas-Salas, J., Garcia-Olmo, D., Prieto-Nieto, M. I., Medina-Fernandez, F. J., Romero-Simo, M., Frasson, M., Espi Macias, A., Tirnaksiz, M. B., Leventoglu, S., Kara, E., Tasci, Y., Pehlivan, M., Guner, A., Ozben, V., Agalar, C., Albayrak, D., Ertekin, C., Oncel, M., Sakman, G., Guler, S. A., Firat, O., Akkucuk, S., Ozbalci, G. S., Sozuer, E. M., Sengul, N., Schizas, A., Horgan, P. G., Singh, B., Harikrishnan, A., Stechman, M., Hayat, J., Coyne, P., Wilson, T., Arun, C., Manvydas, V., Moroni, P., Lo Secco, G., Argenti, F., Romano, F., Calcagno, P., Steccanella, F., Cisternino, G., Bottini, C., Realis Luc, A., Apicella, M., Candilio, G., Gubbiotti, F., De Luca, E., Casagranda, B., Decorato, A., Aquilino, F., Badii, B., Rahmee, C. N. S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. H., Jindal, A., Hughes, F., Gouda, P., Fleck, R., Hanrahan, M., Karunakaran, P., Chen, J. H., Sykes, M. C., Sethi, R. K., Suresh, S., Patel, P., Patel, M., Varma, R. K., Mushtaq, J., Bolton, W., Khan, T., Morley, R., Favero, N., Adams, R., Thirumal, V., Kennedy, E. D., Ong, K. K., Tan, Y. H., Gabriel, J., Bakhsh, A., Low, J. Y. L., Yener, A., Paraoan, V., Preece, R., Tilston, T. W., Cumber, E., Dean, S., Ross, T., Mccance, E., Amin, H., Satterthwaite, L., Clement, K. D., Gratton, R., Mills, E. D., Chiu, S. M., Hung, G., Rafiq, N. M., Hayes, J. D. B., Robertson, K. L., Dynes, K., Huang, H. C., Assadullah, S., Duncumb, J. W., Moon, R. D. C., Poo, S. X., Mehta, J. K., Joshi, K. R., Callan, R., Norris, J. M., Chilvers, N. J., Keevil, H., Jull, P., Mallick, S., Elf, D., Carr, L., Player, C., Barton, E. C., Martin, A. L., Ratu, S. G., Roberts, E. J., Phan, P. N., Dyal, A. R., Rogers, J. E., Henson, A. D., Reid, N. B., Burke, D., Culleton, G., Lynne, S., Mansoor, S., Brennan, C., Blessed, R., Holloway, C., Hill, A., Goldsmith, T., Mackin, S., Kim, S., Woin, E., Brent, G., Coffin, J., Ziff, O., Momoh, Z., Debenham, R., Ahmed, M., Yong, C. S., Wan, J. C., Copley, H. C., Raut, P., Chaudhry, F. I., Nixon, G., Dorman, C., Tan, R., Kanabar, S., Canning, N., Dolaghan, M., Bell, N., Mcmenamin, M., Chhabra, A., Duke, K., Turner, L., Patel, T., Chew, L. S., Mirza, M., Lunawat, S., Oremule, B., Ward, N., Khan, M., Tan, E. T., Maclennan, D., Mcgregor, R. J., Chisholm, E. G., Griffin, E. J., Bell, L., Hughes, B. A., Davies, J., Haq, H., Ahmed, H., Ungcharoen, N., Whacha, C., Thethi, R., Markham, R. M., Lee, A. H. Y., Batt, E., Bullock, N. P., Francescon, C. T., Davies, J. E., Shafiq, N. M., Zhao, J., Vivekanantham, S., Barai, I., Allen, J. L. Y., Marshall, D. C., Mcintyre, C. J., Wilson, H. C. P., Ashton, A. J., Lek, C., Behar, N., Davis-Hall, M., Seneviratne, N., Esteve, L., Sirakaya, M., Ali, S., Pope, S., Ahn, J. S., Craig-McQuaide, A., Gatfield, W. A., Leong, S., Demetri, A. M., Kerr, A. L., Rees, C., Loveday, J., Liu, S., Wijesekera, M., Maru, D., Attalla, M., Smith, N., Brown, D., Sritharan, P., Shah, A., Charavanamuttu, V., Heppenstall-Harris, G., Ng, K., Raghvani, T., Rajan, N., Hulley, K., Moody, N., Williams, M., Cotton, A., Sharifpour, M., Lwin, K. N., Bright, M., Chitnis, A. R., Abdelhadi, M., Semana, A. D., Morgan, F., Reid, R., Dickson, J., Anderson, L., Mcmullan, R., Ahern, N., Asmadi, A., Anderson, L. B., Lua Boon Xuan, J., Crozier, L., Mcaleer, S., Lees, D. M., Adebayo, A. A., Das, M., Amphlett, A. H., Al-Robeye, A., Valli, A., Khangura, J., Winarski, A., Woodward, H., Gouldthrope, C., Turner, M., Sasapu, K., Tonkins, M., Wild, J. R. L., Robinson, M., Hardie, J., Heminway, R., Narramore, R., Ramjeeawon, N., Hibberd, A., Winslow, F., Ho, W., Chong, B. F., Lim, K., Ho, S., Crewdson, J. A., Singagireson, S., Kalra, N., Koumpa, F., Jhala, H., Soon, W. C., Karia, M., Rasiah, M. G., Xylas, D., Gilbert, H., Sundar-Singh, M., Wills, J., Akhtar, S., Patel, S., Hu, L., Brathwaite-Shirley, C., Nayee, H., Amin, O., Rangan, T., Turner, E. J. H., Mccrann, C., Shepherd, R., Patel, N., Prest-Smith, J., Auyoung, E., Murtaza, A., Coates, A., Prys-Jones, O., King, M., Gaffney, S., Dewdney, C. J., Nehikhare, I., Lavery, J., Bassett, J., Davies, K., Ahmad, K., Collins, A., Acres, M., Egerton, C., Cheng, K., Chen, X., Chan, N., Sheldon, A., Empey, J., Ingram, E., Malik, A., Johnstone, M., Goodier, R., Shah, J. P., Giles, J. E., Sanders, J. A., Mclure, S. W., Pal, S., Rangedara, A., Baker, A. N., Asbjoernsen, C. A., Girling, C., Gray, L., Gauntlett, L., Joyner, C., Qureshi, S., Mogan, Y. P., Ng, J. C. K., Kumar, A. N., Park, J. H., Tan, D., Choo, K. P., Raman, K. P., Buakuma, P., Xiao, C., Govinden, S., Thompson, O. D., Charalambos, M. A., Karsan, R. B., Dogra, T., Bullman, L. M., Dawson, P. M., Frank, A. L., Abid, H., Tung, L., Qureshi, U., Tahmina, A., Matthews, B. W., Harris, R. T., O'Connor, A., Mazan, K., Iqbal, S., Stanger, S. A., Thompson, J. D., Sullivan, J. A. L., Uppal, E., Macaskill, A., Bamgbose, F. A., Neophytou, C., Carroll, A. F., Rookes, C. W., Datta, U., Dhutia, A. J., Rashid, S., Ahmed, N., Lo, T., Bhanderi, S., Blore, C. D., Ahmed, S., Shaheen, H., Abburu, S., Majid, S., Abbas, Z., Talukdar, S. S., Burney, L. J., Patel, J. B., Al-Obaedi, O., Roberts, A. W., Mahboob, S., Sheth, S., Karia, P., Prabhudesai, A., Kow, K., Koysombat, K., Wang, S., Morrison, P., Maheswaran, Y., Keane, P., Copley, P. C., Brewster, O., Xu, G. X., Harries, P., Wall, C., Al-Mousawi, A., Bonsu, S., Cunha, P., Ward, T., Paul, J., Nadanakumaran, K., Tayeh, S., Holyoak, H., Remedios, J., Theodoropoulou, K., Luhishi, A., Jacob, L., Long, F., Atayi, A., Sarwar, S., Parker, O., Harvey, J., Ross, H., Rampal, R., Thomas, G., Vanmali, P., Mcgowan, C., Stein, J., Robertson, V., Carthew, L., Teng, V., Fong, J., Street, A. N., Thakker, C. E., O'Reilly, D., Bravo, M., Pizzolato, A., Khokhar, H. A., Ryan, M., Cheskes, L., Carr, R., Salih, A. E., Bassiony, S., Yuen, R., Chrastek, D., Rosen O'Sullivan, H., Amajuoyi, A., Wang, A., Sitta, O., Wye, J., Qamar, M. A., Major, C., Kaushal, A., Morgan, C., Petrarca, M., Allot, R., Verma, K., Dutt, S., Chilima, C. P., Peroos, S., Kosasih, S. R., Chin, H., Ashken, L., Pearse, R. J., O'Loughlin, R. A., Menon, A., Singh, K., Norton, J., Sagar, R., Jathanna, N., Rothwell, L., Watson, N., Harding, F., Dube, P., Khalid, H., Punjabi, N., Sagmeister, M., Gill, P., Shahid, S., Hudson-Phillips, S., George, D., Ashwood, J., Lewis, T., Dhar, M., Sangal, P., Rhema, I. A., Kotecha, D., Afzal, Z., Syeed, J. A., Prakash, E., Jalota, P., Herron, J., Kimani, L., Delport, A., Shukla, A., Agarwal, V., Parthiban, S., Thakur, H., Cymes, W., Rinkoff, S., Turnbull, J. A., Hayat, M., Darr, S., Khan, U., Lim, J., Higgins, A., Lakshmipathy, G., Forte, B., Canning, E., Jaitley, A., Lamont, J., Toner, E., Ghaffar, A., Mcdowell, M., Salmon, D., O'Carroll, O., Khan, A., Kelly, M. E., Clesham, K., Palmer, C., Lyons, R., Bell, A., Chin, R., Waldron, R. M., Trimble, A., Cox, S. E., Ashfaq, U., Campbell, J., Holliday, R. B. S., Mccabe, G., Morris, F., Priestland, R., Vernon, O. K., Ledsam, A., Vaughan, R., Lim, D., Bakewell, Z. R., Hughes, R. K., Koshy, R. M., Jackson, H. R., Narayan, P., Cardwell, A. E., Jubainville, C. L., Arif, T., Elliott, L. E., Gupta, V., Bhaskaran, G., Odeleye, A., Ahmed, F., Shah, R., Pickard, J., Suleman, Y. N., North, A. S., Mcclymont, L. F., Hussain, N., Ibrahim, I., Ng, G. S., Wong, V., Lim, A. E., Harris, L. N., Tharmachandirar, T., Mittapalli, D., Patel, V., Lakhani, M., Bazeer, H. Z., Narwani, V., Sandhu, K. K., Wingfield, L. R., Gentry, S., Adjei, H., Bhatti, M., Braganza, L., Barnes, J., Mistry, S., Chillarge, G., Stokes, S., Cleere, J., Bucko, A. M., Meek, J., Boxall, N., Heywood, E. G., Wiltshire, J. J., Toh, C., Ward, A. E., Shurovi, B. N., Horth, D., Patel, B. Y., Ali, B., Spencer, T., Axelson, T., Kretzmer, L., Chhina, C., Anandarajah, C., Fautz, T., Horst, C., Thevathasan, A. A., Ng, J. Q., Hirst, F., Brewer, C. F., Logan, A. E., Lockey, J. W., Forrest, P. R., Keelty, N., Wood, A. D., Springford, L. R., Avery, P., Schulz, T. M., Bemand, T. P., Howells, L., Collier, H., Khajuria, A., Tharakan, R. G., Parsons, S., Buchan, A. M., Mcgalliard, R. J., Mason, J. D., Cundy, O. J., Li, N., Redgrave, N. A., Watson, R. P., Pezas, T. P., Dennis, Y. F., Segall, E., Hameed, M., Lynch, A. S., Chamberlain, M., Peck, F. S., Neo, Y. N., Russell, G., Elseedawy, M., Foster, N. L., Soo, Y. H., Puan, L., Dennis, R., Goradia, H., Qureshi, A., Osman, S., Reeves, T., Dinsmore, L., Marsden, M., Lu, Q., Pitts-Tucker, T., Dunn, C. E., Walford, R. A., Heathcote, E., Martin, R., Pericleous, A., Brzyska, K., Reid, K. G., Williams, M. R., Wetherall, N., Mcaleer, E., Thomas, D., Kiff, R., Milne, S., Holmes, M. J. V., Bartlett, J., Lucas de Carvalho, J., Bloomfield, T., Tongo, F., Bremner, R. H., Yong, N., Atraszkiewicz, B. A., Mehdi, A., Tahir, M., Sherliker, G. X. J., Tear, A. K., Pandey, A., Broyd, A., Omer, H. M., Raphael, M., Chaudhry, W. W., Shahidi, S., Jawad, A. S., Gill, C. K., Hindle Fisher, I., Adeleja, I., Clark, I. J., Aidoo-Micah, G. E., Stather, P. W., Salam, G. J., Glover, T. E., Deas, G., Sim, N. K., Obute, R. D., Wynell-Mayow, W. M., Sait, M. S., Mitha, N., de Bernier, G. L., Siddiqui, M., Shaunak, R., Wali, A., Cuthbert, G., Bhudia, R., Webb, E., Shah, S., Ansari, N., Perera, M., Kelly, N., Mcallister, R., Stanley, G. H., Keane, C. P., Shatkar, V., Maxwell-Armstrong, C., Henderson, L. A., Maple, N., Manson, R., Adams, R. D., Semple, E., Mills, M., Daoub, A., Marsh, A., Ramnarine, A., Hartley, J., Malaj, M., Jewell, P. D., Whatling, E. A., Hitchen, N., Chen, M., Goh, B., Fern, J., Rogers, S., Derbyshire, L., Robertson, D. T., Deekonda, P., Abid, A., Harrison, P. L. M., Aildasani, L., Turley, H., Sherif, M. A., Pandey, G., Filby, J. J., Johnston, A., Burke, E., Mohamud, M., Gohil, K., Tsui, A. Y., Singh, R., Lim, S. J., O'Sullivan, K., Mckelvey, L. L., O'Neill, S., Roberts, H. F., Brown, F. S., Cao, Y., Buckle, R. T., Liew, Y., Sii, S., Ventre, C. M., Graham, C. J., Filipescu, T., Yousif, A., Dawar, R., Wright, A., Peters, M., Varley, R., Owczarek, S., Hartley, S., Khattak, M., Iqbal, A., Ali, M., Durrani, B., Narang, Y., Bethell, G. S., Horne, L., Pinto, R., Nicholls, K., Kisyov, I., Torrance, H. D., English, W., Lakhani, S. M., Ashraf, S. F., Venn, M., Elangovan, V., Kazmi, Z., Brecher, J., Sukumar, S., Mastan, A., Mortimer, A., Parker, J., Boyle, J., Elkawafi, M., Beckett, J., Mohite, A., Narain, A., Mazumdar, E., Sreh, A., Hague, A., Weinberg, D., Fletcher, L., Steel, M., Shufflebotham, H., Masood, M., Sinha, Y., Jenvey, C., Kitt, H., Slade, R., Craig, A. R., Deall, C., Reakes, T., Chervenkoff, J., Strange, E., O'Bryan, M., Murkin, C., Joshi, D., Bergara, T., Naqib, S., Wylam, D., Scotcher, S. E., Hewitt, C. M., Stoddart, M. T., Kerai, A., Trist, A. J., Cole, S. J., Knight, C. L., Stevens, S., Cooper, G. E., Ingham, R., Dobson, J., O'Kane, A., Moradzadeh, J., Duffy, A., Henderson, C., Ashraf, S., Mclaughin, C., Hoskins, T. C., Reehal, R. S., Bookless, L. R., Mclean, R. C., Stone, E. J., Wright, E. V., Abdikadir, H. R., Roberts, C., Spence, O., Srikantharajah, M., Ruiz, E. M., Matthews, J. H., Gardner, E., Hester, E., Naran, P., Simpson, R., Minhas, M., Cornish, E., Semnani, S. A., Rojoa, D., Radotra, A., Eraifej, J., Eparh, K., Smith, D. N. E., Mistry, B. D., Hickling, S. L., Din, W., Liu, C., Mithrakumar, P., Mirdavoudi, V., Rashid, M., Mcgenity, C., Hussain, O., Kadicheeni, M., Gardner, H., Anim-Addo, N., Pearce, J., Aslanyan, A., Ntala, C., Sorah, T., Parkin, J., Alizadeh, M., White, A., Edozie, F., Johnston, J., Kahar, A., Navayogaarajah, V., Carter, D., Khonsari, P., Burgess, A., Patel, B., Kong, C., Ponweera, A., Cody, A., Tan, Y., Ng, A. Y. L., Croall, A., Allan, C., Ng, S., Raghuvir, V., Telfer, R., Greenhalgh, A. D., Mckerr, C. N., Edison, M. A., Patel, B. A., Dear, K., Hardy, M. R., Williams, P., Hassan, S., Sajjad, U., O'Neill, E. M., Lopes, S., Healy, L., Jamal, N., Tan, S., Lazenby, D., Husnoo, S. B., Beecroft, S., Sarvanandan, T., Weston, C., Bassam, N., Rabinthiran, S., Hayat, U., Ng, L., Varma, D., Sukkari, M., Mian, A., Omar, A., Kim, J. W., Sellathurai, J., Mahmood, J., O'Connell, C., Bose, R., Heneghan, H., Lalor, P., Matheson, J., Doherty, C., Cullen, C., Cooper, D., Angelov, S., Drislane, C., Smith, A. C. D., Kreibich, A., Palkhi, E., Durr, A., Lotfallah, A., Gold, D., Mckean, E., Dhanji, A., Anilkumar, A., Thacoor, A., Siddiqui, Z. H., Lim, S., Piquet, A., Anderson, S. M., Mccormack, D. R., Gulati, J., Ibrahim, A., Murray, S. E., Walsh, S. L., Mcgrath, A., Ziprin, P., Chua, E. Y., Lou, C. N., Bloomer, J., Paine, H. R., Osei-Kuffour, D., White, C. J., Szczap, A., Gokani, S., Patel, K., Malys, M. K., Reed, A., Torlot, G. E., Cumber, E. M., Charania, A., Ahmad, S., Varma, N., Cheema, H., Austreng, L., Petra, H., Chaudhary, M., Zegeye, M. I., Cheung, F., Coffey, D., Heer, R. S., Singh, S., Seager, E., Cumming, S., Suresh, R. S., Verma, S., Ptacek, I. B., Gwozdz, A. M., Yang, T., Khetarpal, A. A., Shumon, S., Fung, T. M. P., Leung, W., Kwang, P., Chew, L., Loke, W., Curran, A., Chan, C., Mcgarrigle, C., Mohan, K., Cullen, S., Wong, E., Toale, C., Collins, D., Keane, N., Traynor, B. P., Shanahan, D., Yan, A., Jafree, D. J., Topham, C., Mitrasinovic, S., Omara, S., Bingham, G., Lykoudis, P. M., Miranda, B. H., Whitehurst, K., Kumaran, G., Devabalan, Y., Aziz, H., Shoa, M., Dindyal, S., Yates, J. A., Bernstein, I., Rattan, G., Coulson, R., Stezaker, S., Isaac, A., Salem, M., Mcbride, A., Mcfarlane, H., Yow, L., Macdonald, J., Bartlett, R. D., Turaga, S., White, U., Liew, W., Yim, N., Ang, A., Simpson, A., Mcauley, D., Craig, E., Murphy, L., Shepherd, P., Kee, J. Y., Abdulmajid, A., Chung, A., Warwick, H. L., Livesey, A., Holton, P., Theodoreson, M. D., Jenkin, S. L., Turner, J., Entwisle, J. H., Marchal, S. T., O'Connor, S., Blege, H. K., Aithie, J. M., Sabine, L. M., Stewart, G. E., Jackson, S., Kishore, A., Lankage, C. M., Acquaah, F., Joyce, H. L., Mckevitt, K. L., Coffey, C. J., Fawaz, A. S., Dolbec, K. S., O'Sullivan, D. A., Geraghty, J. M., Lim, E., Bolton, L., Fitzpatrick, D., Robinson, C., Ramtoola, T., Collinson, S., Grundy, L., Mcenhill, P. M., Harbhajan Singh, G. S., Loughran, D., Golding, D. M., Keeling, R. E., Williams, R. P., Whitham, R. D. J., Yoganathan, S., Nachiappan, R., Egan, R. J., Owasil, R., Kwan, M. L., He, A., Goh, R. W., Bhome, R., Wilson, H., Teoh, P. J., Raji, K., Jayakody, N., Matthams, J., Chong, J., Luk, C. Y., Greig, R. J., Trail, M., Charalambous, G., Rocke, A. S., Gardiner, N., Bulley, F., Warren, N., Brennan, E., Fergurson, P., Wilson, R., Whittingham, H., Brown, E. J., Khanijau, R., Gandhi, K., Morris, S., Boulton, A. J., Chandan, N., Barthorpe, A. E., Maamari, R., Sandhu, S., Mccann, M., Higgs, L., Balian, V., Reeder, C., Diaper, C., Sale, T., Ali, H., Archer, C. H., Clarke, A. K., Heskin, J., Hurst, P. C., Farmer, J. D., O'Flynn, L. D., Doan, L., Shuker, B. A., Stott, G. D., Vithanage, N. A., Hoban, K. A., Nesargikar, P. N., Kennedy, H. R., Grossart, C. M., Tan, E. S. M., Roy, C. S. D., Sim, P., Leslie, K. E., Sim, D., Abul, M. H., Cody, N., Tay, A. Y., Woon, E., Sng, S., Mah, J., Robson, J., Shakweh, E., Wing, V. C., Mills, H., Li, M. M., Barrow, T. R., Balaji, S., Jordan, H. E. M., Phillips, C., Naveed, H., Hirani, S., Tai, A., Ratnakumaran, R., Sahathevan, A., Shafi, A. M. A., Seedat, M., Weaver, R., Batho, A., Punj, R., Selvachandran, H., Bhatt, N., Botchey, S., Khonat, Z., Brennan, K., Morrison, C. J., Devlin, E., Linton, A., Galloway, E., Mcgarvie, S., Ramsay, N., Mcrobbie, H. D., Whewell, H., Dean, W., Nelaj, S., Eragat, M., Mishra, A., Kane, T., Zuhair, M., Wells, M., Wilkinson, D., Woodcock, N., Sun, E., Aziz, N., Abd Ghaffar, M. K., Bath, M. F., Nepogodiev, D., and Coco C. (ORCID:0000-0002-4713-7093)
Abstract: Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
Published: 2018

24. Validation of a Method for Automatic Detection of Lung Sounds in Fibrotic Interstitial Lung Disease

Author: Giacomo Sgalla, Nikolic, D., Walsh, S. L., Fletcher, S., Cerri, S., Luppi, F., Jones, M. G., Davies, D. E., Sverzellati, N., Hansell, D., Barney, A., Richeldi, L., Sgalla, G, Nikolic, D, Walsh, S, Fletcher, S, Cerri, S, Luppi, F, Jones, M, Davies, D, Sverzellati, N, Hansell, D, Barney, A, and Richeldi, L
Subjects: Pulmonary fibrosis
Abstract: BACKGROUND Delayed diagnosis of fibrotic interstitial lung disease (ILD) is characterized by significant repercussions for management and survival. A timely assessment of “velcro-type” crackles at lung auscultation might prompt a proper diagnostic process in these patients. The accuracy of objective, computerized methods in detecting ILD from respiratory sounds has not been systematically assessed in a clinical setting. We aimed to validate automatic detection of “velcro-type” crackles by comparing the results of lung sounds analysis with chest high resolution computed tomography (HRCT) scans. METHODS Lung sounds were recorded using an electronic stethoscope (Littmann 3200) from anatomically defined sites in 56 subjects (derivation cohort) undergoing a chest HRCT scan in Modena (Italy). Three-hundred anonymized, single-layer HRCT images corresponding to the sites of sound recording were reviewed by two radiologists with expertise in ILD and scored for the signs indicating lung fibrosis. All audio recordings were analyzed by extracting a set of global acoustic features from each file and different classification algorithms were employed on a subset of the best ranked features to classify the data into two groups. The gold standard used to label the ground truth for each sound file was based on the evidence of fibrosis in the corresponding HRCT image. Two ILD physicians were also asked to independently assess the sound files for the presence of “velcro-type” crackles. The results were validated in a further cohort of 59 patients (validation cohort) undergoing chest HRCT in Parma (Italy). Three-hundred nineteen HRCT images and corresponding sound files were obtained. RESULTS In the derivation cohort, accuracy of 74.4% was achieved in automatic detection of lung sounds associated with fibrotic HRCT images. However, although specificity was high (87.3%), sensitivity was lower (48.5%). The two respiratory physicians showed comparable performance, with accuracy 71.6%, specificity 82.3% and sensitivity 49.9%. The results of the automated detection were substantially reproduced in the validation cohort (accuracy 70.2%, specificity 84.7%, sensitivity 45.8%). CONCLUSION An automated method can identify lung sounds associated with pulmonary fibrosis at HRCT, and replicates the performance of experienced clinicians on the same data set. This suggests that there are substantial grounds for developing an automated method for clinical detection of fibrotic ILD.
Published: 2016

25. Increased sensitivity of mice to tremorogenic agents following MPP+

Author: Wagner, G. C. and Walsh, S. L.
Published: 1987
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26. High-resolution CT of complications of idiopathic fibrotic lung disease

Author: Lloyd, C R, primary, Walsh, S L F, additional, and Hansell, D M, additional
Published: 2011
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27. The atoll sign

Author: Walsh, S. L. F., primary and Roberton, B. J., additional
Published: 2010
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28. Genetic basis for expression of the major globotetraose-containing lipopolysaccharide from H-influenzae strain Rd (RM118)

Author: Hood, D W, Cox, A D, Wakarchuk, W W, Schur, M, Schweda, Elke K H, Walsh, S L, Deadman, M E, Martin, A, Moxon, E R, Richards, J C, Hood, D W, Cox, A D, Wakarchuk, W W, Schur, M, Schweda, Elke K H, Walsh, S L, Deadman, M E, Martin, A, Moxon, E R, and Richards, J C
Abstract: A genetic basis for the biosynthetic assembly of the globotetraose containing lipopolysaccharide (LPS) of Haemophilus influenzae strain RM118 (Rd) was determined by structural analysis of LPS derived from mutant strains. We have previously shown that the parent strain RM118 elaborates a population of LPS molecules made up of a series of related glycoforms differing in the degree of oligosaccharide chain extension from the distal heptose residue of a conserved phosphorylated inner-core element, L-alpha -D-Hepp-(1-->2)-L-alpha -D-Hepp-(1-->3)-[beta -D-Glcp-(1-->4)-]-L-alpha -D-Hepp-(1-->5)-alpha -Kdo. The fully extended LPS glycoform expresses the globotetraose structure, beta -D-GalpNAc-(1-->3)-alpha -D-Galp(1-->4)-beta -D-Galp-(1-->4)-beta -D-Glcp. A fingerprinting strategy was employed to establish the structure of LPS from strains mutated in putative glycosyltransferase genes compared to the parent strain. This involved glycose and linkage analysis on intact LPS samples and analysis of O-deacylated LPS samples by electrospray ionization mass spectrometry and 1D H-1-nuclear magnetic resonance spectroscopy. Four genes, lpsA, lic2A, lgtC, and lgtD, were required for sequential addition of the glycoses to the terminal inner-core heptose to give the globotetraose structure. lgtC and lgtD were shown to encode glycosyltransferases by enzymatic assays with synthetic acceptor molecules. This is the first genetic blueprint determined for H. influenzae LPS oligosaccharide biosynthesis, identifying genes Involved in the addition of each glycose residue.
Published: 2001
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29. Evaluation of the mu and kappa opioid actions of butorphanol in humans through differential naltrexone blockade

Author: Walsh, S. L., primary, Chausmer, A. E., additional, Strain, E. C., additional, and Bigelow, G. E., additional
Published: 2007
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30. Effect of Repeated Cocaine Administration on Detection Times in Oral Fluid and Urine

Author: Jufer, R., primary, Walsh, S. L., additional, Cone, E. J., additional, and Sampson-Cone, A., additional
Published: 2006
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31. Genetic basis for expression of the major globotetraose-containing lipopolysaccharide from H. influenzae strain Rd (RM118)

Author: Hood, D. W., primary, Cox, A. D., additional, Wakarchuk, W. W., additional, Schur, M., additional, Schweda, E. K.H., additional, Walsh, S. L., additional, Deadman, M. E., additional, Martin, A., additional, Moxon, E. R., additional, and Richards, J. C., additional
Published: 2001
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32. Elimination of Cocaine and Metabolites in Plasma, Saliva, and Urine Following Repeated Oral Administration to Human Volunteers

Author: Jufer, R. A., primary, Wstadik, A., additional, Walsh, S. L., additional, Levine, B. S., additional, and Cone, E. J., additional
Published: 2000
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33. A Gas Chromatographic-Positive Ion Chemical Ionization-Mass Spectrometric Method for Determination of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Norcocaine in Plasma: Detection of Norcocaine in Plasma After Oral Administration of Cocaine

Author: Spanbauer, A. C., primary, Moody, D. E., additional, Foltz, R. L., additional, and Walsh, S. L., additional
Published: 2000
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34. Cocaine and Metabolite Concentrations in Plasma During Repeated Oral Administration: Development of a Human Laboratory Model of Chronic Cocaine Use

Author: Jufer, R. A., primary, Walsh, S. L., additional, and Cone, E. J., additional
Published: 1998
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35. Determination of Naltrexone and 6- -Naltrexol in Plasma by Solid-Phase Extraction and Gas Chromatography-Negative Ion Chemical Ionization-Mass Spectrometry

Author: Huang, W., primary, Moody, D. E., additional, Foltz, R. L., additional, and Walsh, S. L., additional
Published: 1997
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36. Clinical Pharmacology of Buprenorphine

Author: WALSH, S. L., primary, PRESTON, K. L., additional, STITZER, M. L., additional, CONE, E. J., additional, and BIGELOW, G. E., additional
Published: 1995
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37. Buprenorphine, morphine and naloxone effects during ascending morphine maintenance in humans.

Author: Schuh, K J, Walsh, S L, Bigelow, G E, Preston, K L, and Stitzer, M L
Abstract: One purpose of this study was to characterize the acute effects of the partial mu-opioid agonist buprenorphine administered to human subjects undergoing maintenance treatment with ascending doses of morphine. A second purpose was to examine the development of tolerance, cross-tolerance and physical dependence under the same morphine maintenance conditions. Six opioid-dependent volunteers were treated chronically with ascending morphine doses of 15, 30, 60 and 120 mg/day. Each morphine dosing level was maintained for 2 weeks, with test drugs administered during the second week of maintenance of each morphine dose. Both morphine (30 mg i.m.) and buprenorphine (6 mg i.m.) constricted pupils and produced reports of opioid-like subjective effects. The magnitude of these effects was inversely related to the morphine maintenance dose, with no effects being detected at higher maintenance levels. Naloxone (0.3 mg) produced little effect at lower morphine maintenance doses but precipitated withdrawal at higher maintenance doses. Buprenorphine failed to precipitate withdrawal even when subjects were treated with 120 mg/day morphine. These findings indicate that dose-dependent tolerance to morphine, cross-tolerance to buprenorphine and physical dependence develop during morphine maintenance. The finding that buprenorphine does not act as an antagonist under these dosing conditions further supports the clinical observation that there are conditions under which patients dependent on short-acting opioids can be comfortably transferred directly to buprenorphine maintenance treatment.
Published: 1996

38. Effects of naltrexone on response to intravenous cocaine, hydromorphone and their combination in humans.

Author: Walsh, S L, Sullivan, J T, Preston, K L, Garner, J E, and Bigelow, G E
Abstract: This study evaluated the effects of i.v. cocaine, hydromorphone and their combination, and assessed the ability of oral naltrexone, an opioid antagonist, to modulate these effects. Volunteers with cocaine and heroin abuse histories (n = 8) participated in this placebo-controlled, cross-over study while residing on a closed research unit. Daily treatment with capsules containing placebo or naltrexone in ascending doses (3.125, 12.5, 50 and 200 mg) were given for 7-day periods. In thrice weekly experimental sessions, cocaine, hydromorphone and their combination were given in random order. Drug doses were given in an ascending order 1 hr apart as follows: cocaine at 0,20 and 40 mg, hydromorphone at 0, 1.5 and 3.0 mg, and the combination of 0 and 0 mg, 20 mg cocaine and 1.5 mg hydromorphone and 40 mg cocaine and 3.0 mg hydromorphone. Hydromorphone and cocaine produced distinct pharmacodynamic profiles, and the combination produced effects similar to both drugs. In some cases, the magnitude of effects produced by the combination was greater than that produced by either drug alone. Naltrexone produced dose-related blockade of hydromorphone effects, but did not after any of the physiological or subjective effects of cocaine. All naltrexone doses partially attenuated the effects of the combination and this appeared to be attributable to selective opioid blockade. These data do not support the use of naltrexone as a treatment for cocaine abuse, but suggest it may be useful for treating patients with concurrent cocaine and heroin abuse.
Published: 1996

39. Controlled opioid withdrawal evaluation during 72 h dose omission in buprenorphine-maintained patients

Author: Eissenberg, T., Johnson, R. E., Bigelow, G. E., Walsh, S. L., Liebson, I. A., Strain, E. C., and Stitzer, M. L.
Published: 1997
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40. Motor impairments after methamphetamine-induced neurotoxicity in the rat.

Author: Walsh, S L and Wagner, G C
Abstract: Methamphetamine is a psychomotor stimulant which, given in high doses, produces neurodegenerative changes in the dopamine and serotonin systems. This study was designed to assess motoric deficits in the rat following a high-dose regimen of methamphetamine. Long-Evans male rats received either four injections of saline or methamphetamine (12.5 mg/kg, every 2 hr), a dose sufficient to produce 45 and 36% reductions in striatal dopamine and serotonin, respectively. Before treatment, subjects were trained to perform one of the following motor tasks: one-way active avoidance, inhibitory avoidance, rotorod or the balance beam. After recovery, performance under base-line and drug challenge conditions revealed that methamphetamine treatment caused significant deficits in active avoidance performance (24% increase in response latency) and balance beam performance (2- to 3-fold increase in footfalls), but had no effect on inhibitory avoidance or rotorod performance. Administration of l-dopa (100 mg/kg) significantly improved the methamphetamine-treated subjects' performance on the balance beam, but had no effect on the control subjects' performance. The methamphetamine-treated subjects exhibited a significant decrease in sensitivity to the effects of fenfluramine in comparison to the controls on both the rotorod and active avoidance tasks. We conclude that high-dose methamphetamine treatment produces long-lasting motor deficits associated with chronic reductions of striatal dopamine and serotonin. These data and the utility of the motor tasks are discussed in reference to a laboratory model of Parkinson's disease.
Published: 1992

41. Acute administration of buprenorphine in humans: partial agonist and blockade effects.

Author: Walsh, S L, Preston, K L, Bigelow, G E, and Stitzer, M L
Abstract: Buprenorphine, a mixed opioid agonist-antagonist, is being investigated as a treatment for opioid dependence. This study compared the acute subjective and physiological effects of sublingual buprenorphine to those of p.o. methadone over a wide range of doses and compared the ability of both drugs to alter the effects of an opioid challenge. Male inpatient volunteers (n = 9) with histories of opioid abuse participated in this double-blind, double-dummy study. Sublingual buprenorphine (0, 0.5, 2, 8, 16 and 32 mg) and p.o. methadone (3.75, 15 and 60 mg) were administered once weekly according to a Latin-square design, and subjects were monitored on a variety of physiological and subjective measures. Twenty-four hours later, subjects were tested with ascending doses of i.m. hydromorphone (0, 1 and 4 mg) given 45 min apart. Buprenorphine and methadone produced typical opioid agonist effects of long duration, including pupillary constriction, respiratory depression and elevations on subject-rated and observer-rated indices of euphoria, sedation and opioid-like symptoms. The buprenorphine dose-effect curves were nonlinear and maximal effects for most physiological and subjective measures were observed between 4 and 8 mg, with no greater effects observed at higher doses. The methadone dose-effect curves were linear across the range of doses tested. High doses of buprenorphine and methadone both attenuated the response to hydromorphone challenge 24 hr later. These data indicate that there is a ceiling on the effects of buprenorphine in humans that may reduce its abuse liability and increase its safety, and indicate that opioid blockade occurs after acute administration of buprenorphine or methadone.
Published: 1995

42. Treatment of sarcoidosis-associated pulmonary hypertension: A single centre retrospective experience using targeted therapies

Author: Keir, G. J., Walsh, S. L. F., Gatzoulis, M. A., Marino, P. S., Dimopoulos, K., Alonso, R., SERGIO RAPOSEIRAS-ROUBIN, Renzoni, E. A., Maher, T. M., Wells, A. U., and Wort, S. J.

43. ULTRASOUND MEASUREMENT OF QUADRICEPS WASTING IN EARLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS RELATIONSHIP WITH DAILY PHYSICAL ACTIVITY.

Author: Shrikrishna, D., Tanner, R., Seymour, J. M., Patel, M., Connolly, B. A., Puthucheary, Z. A., Walsh, S. L. F., Bloch, S. A., Sidhu, P. S., Hart, N., Moxham, J., Polkey, M. I., and Hopkinson, N. S.
Subjects: PHYSICAL activity, OBSTRUCTIVE lung diseases, QUADRICEPS muscle, REGRESSION analysis, ACCELEROMETERS
Abstract: Introduction Quadriceps weakness is recognised as an important complication of COPD but few data exist about loss of muscle bulk in early disease. We hypothesised that quadriceps wasting, measured by ultrasound rectus femoris cross-sectional (USRFCSA), would be observed in patients with mild COPD compared to healthy age-matched subjects and that this would correlate with daily physical activity levels. Methods Rectus femoris cross-sectional area was measured using ultrasound (USRFCSA) and daily physical activity (step count and physical activity level--PAL) recorded using a multisensor biaxial armband accelerometer. Fat free mass index (FFMI) and the impedance ratio (Z200/Z5) were determined by bioelectrical impedance analysis. Quadriceps maximum voluntary contraction (QMVC) was used as a measure of strength. Results 150 patients with stable COPD, GOLD stage I (n=38), II (n=38), III (n=37) and IV (n=37), mean (SD) age 66 (9) years, 54% male and 40 age-matched healthy subjects participated in the study. USRFCSA was significantly reduced in stage I COPD patients compared to controls (530 mm² vs 640 mm²; p=0.0002) (Abstract S94 figure 1); USRFCSA was also reduced in stages II (526 mm²), III (503 mm²) and IV (509 mm²) disease (p=0.0001). Daily physical activity was reduced in stage I patients (steps; p<0.0001, PAL; p=0.002) and stage II-IV COPD (steps and PAL; p<0.0001) compared to healthy subjects. Using multivariate linear regression, USRFCSA (p=0.0003), FFMI (p=0.0003) and the impedance ratio (p=0.001) were all independent predictors of quadriceps strength in COPD. In stage I patients, only USRFCSA was shown to be independently associated with daily physical activity (steps, p=0.03; PAL, p=0.003), while in stage II-IV disease, FEV1% predicted was retained as the only independent correlate with daily physical activity (steps and PAL, p<0.0001). Conclusions Quadriceps wasting identified by USRFCSA exists in patients with early, as well as advanced, COPD when compared to healthy age-matched controls. Quadriceps bulk is associated with daily physical activity independent of airflow obstruction, in early but not advanced disease. Our data suggest that, rather than being an end-stage phenomenon, quadriceps wasting is present in a substantial minority of COPD patients and is related to physical inactivity in the absence of severe airflow limitation. [ABSTRACT FROM AUTHOR]
Published: 2011
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44. Absence of acute cocaine interactions with the MAO-B inhibitor selegiline

Author: Haberny, K. A., Walsh, S. L., Ginn, D. H., and Wilkins, J. N.
Published: 1995
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45. Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients.

Author: Lucas SEM, Raspin K, Mackintosh J, Glaspole I, Reynolds PN, Chia C, Grainge C, Kendall P, Troy L, Schwartz DA, Wood-Baker R, Walsh SLF, Moodley Y, Robertson J, Macansh S, Walters EH, Chambers D, Corte TJ, and Dickinson JL
Subjects: Humans, Lung, Pulmonary Fibrosis genetics, Lung Diseases, Interstitial diagnosis, Lung Diseases, Interstitial genetics
Abstract: Competing Interests: Conflicts of interest None.
Published: 2023
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46. Post-processing applications in thoracic computed tomography.

Author: Walsh SL, Nair A, and Hansell DM
Subjects: Humans, Imaging, Three-Dimensional methods, Lung diagnostic imaging, Image Processing, Computer-Assisted methods, Lung Diseases diagnostic imaging, Tomography, X-Ray Computed methods
Abstract: The rapid evolution of multidetector computed tomography (MDCT) and the introduction of dual-energy CT (DECT) have been paralleled by an unprecedented advancement in post-processing techniques. This has provided complementary methods of two- and three-dimensional visualization of the airways and lung parenchyma, many of which are easily available and not too time-consuming. In addition, advanced imaging has paved the way for methods of quantification of disease that may have a role to play in monitoring chronic obstructive pulmonary disease (COPD) and interstitial lung disease. Computer-aided detection also continues to be explored in lung cancer and pulmonary embolism detection. However, many of these techniques have not yet found widespread adoption in clinical practice. In this article, we review the imaging techniques (used in both single-energy and DECT) that can benefit from post-processing, describe the various post-processing tools available, and consider their clinical application with specific reference to COPD, diffuse lung disease, lung cancer, and pulmonary embolism., (Copyright © 2012 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.)
Published: 2013
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47. The role of human drug self-administration procedures in the development of medications.

Author: Comer SD, Ashworth JB, Foltin RW, Johanson CE, Zacny JP, and Walsh SL
Subjects: Choice Behavior, Cocaine-Related Disorders drug therapy, Cocaine-Related Disorders prevention & control, Cocaine-Related Disorders psychology, Conditioning, Operant, Drug Interactions, Humans, Illicit Drugs adverse effects, Illicit Drugs pharmacology, Narcotic Antagonists pharmacology, Opioid-Related Disorders drug therapy, Opioid-Related Disorders prevention & control, Opioid-Related Disorders psychology, Reinforcement Schedule, Reinforcement, Psychology, Substance-Related Disorders prevention & control, Drug Design, Drug Evaluation methods, Drug-Related Side Effects and Adverse Reactions, Pharmaceutical Preparations administration & dosage, Self Administration methods, Self Administration psychology, Substance-Related Disorders drug therapy, Substance-Related Disorders psychology
Abstract: The purpose of this review is to illustrate the utility and value of employing human self-administration procedures in medication development, including abuse liability assessments of novel medications and evaluation of potential pharmacotherapies for substance use disorders. Traditionally, human abuse liability testing has relied primarily on subjective reports describing drug action by use of questionnaires; similarly, drug interactions between putative treatment agents and the drugs of abuse have relied on these measures. Subjective reports are highly valued because they provide qualitative and quantitative information about the characteristics of central and peripheral pharmacodynamic effects as well as safety and tolerability. However, self-administration procedures directly examine the behavior of interest-that is, drug taking. The present paper (1) reviews the most commonly used human self-administration procedures, (2) discusses the concordance of subjective reports and self-administration within the context of medications development for substance use disorders, focusing primarily on illustrative examples from development efforts with opioid and cocaine dependence, and (3) explores the utility of applying self-administration procedures to assess the abuse liability of novel compounds, including "abuse-deterrent" formulations (ADFs). The review will focus on opioid and cocaine dependence because a rich database from both clinical laboratory and clinical trial research exists for these two drug classes. The data reviewed suggest that drug-induced changes in self-administration and subjective effects are not always concordant. Therefore, assessment of self-administration in combination with subjective effects provides a more comprehensive picture that may have improved predictive validity for translating to the clinical setting.
Published: 2008
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48. Effect of flupenthixol on subjective and cardiovascular responses to intravenous cocaine in humans.

Author: Evans SM, Walsh SL, Levin FR, Foltin RW, Fischman MW, and Bigelow GE
Subjects: Adult, Analysis of Variance, Behavior, Addictive psychology, Blood Pressure drug effects, Blood Pressure physiology, Cocaine pharmacokinetics, Cocaine-Related Disorders drug therapy, Cocaine-Related Disorders psychology, Dopamine Antagonists pharmacokinetics, Dopamine Uptake Inhibitors pharmacokinetics, Dose-Response Relationship, Drug, Double-Blind Method, Flupenthixol pharmacokinetics, Heart Rate drug effects, Heart Rate physiology, Humans, Injections, Intravenous, Male, Behavior, Addictive drug therapy, Cardiovascular System drug effects, Cocaine administration & dosage, Dopamine Antagonists administration & dosage, Dopamine Uptake Inhibitors administration & dosage, Flupenthixol administration & dosage
Abstract: The effects of oral flupenthixol and intramuscular (i.m.) flupenthixol decanoate in combination with intravenous (i.v.) cocaine were evaluated in male cocaine abusers. Participants resided at an inpatient research unit for 27 days followed by an 11-day outpatient period. Oral flupenthixol (2.5 or 5.0 mg; p.o.) followed by flupenthixol decanoate (10 or 20 mg; i.m.) and placebo were investigated in individuals who were randomly assigned to one of three groups under double-blind conditions (placebo, low or high dose flupenthixol). During the inpatient period, participants had four fixed cocaine dosing sessions; each session they were administered four doses of i.v. cocaine (approx. 48 mg/70 kg), spaced 14 min apart. These sessions occurred once before medication (baseline phase), once following oral medication (oral phase), and twice following intramuscular medication (IM phase). Out of 23 participants, 18 completed the study; 4 of the 5 non-completers were in the high dose flupenthixol group. Overall, there were few subjective, cardiovascular, or cocaine pharmacokinetic differences between the placebo group and the low dose flupenthixol group, indicating that the low dose of flupenthixol was well tolerated, but ineffective. In the high dose flupenthixol group, two out of seven individuals (29%) experienced a dystonic reaction following oral flupenthixol and were medically discharged. Taken together, these findings indicate that flupenthixol is not a good candidate for treating cocaine abusers.
Published: 2001
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49. Enadoline and butorphanol: evaluation of kappa-agonists on cocaine pharmacodynamics and cocaine self-administration in humans.

Author: Walsh SL, Geter-Douglas B, Strain EC, and Bigelow GE
Subjects: Adult, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Injections, Intramuscular, Male, Reinforcement, Psychology, Analgesics, Opioid pharmacology, Benzofurans pharmacology, Butorphanol pharmacology, Cocaine pharmacokinetics, Cocaine pharmacology, Cocaine-Related Disorders psychology, Dopamine Uptake Inhibitors pharmacokinetics, Dopamine Uptake Inhibitors pharmacology, Neuroprotective Agents pharmacology, Pyrrolidines pharmacology, Receptors, Opioid, kappa agonists
Abstract: Preclinical studies have demonstrated that kappa-opioid agonists can attenuate the neurochemical and behavioral effects of cocaine that are related to its reinforcing efficacy, suggesting that kappa-agonists may serve as pharmacotherapies for cocaine dependence. This 8-week inpatient study examined the ability of enadoline, a selective and high-efficacy kappa-agonist, and butorphanol, a mixed agonist with intermediate efficacy at both mu- and kappa-receptors, to reduce the direct pharmacodynamic effects and self-administration of intravenous cocaine in humans (n = 8). Acute doses of intramuscular enadoline (20, 40, and 80 microg/kg), butorphanol (1.5, 3, and 6 mg/70 kg) and placebo were examined separately as pretreatments during each of three test sessions with cocaine in a constrained random order. A cocaine dose-effect session (0, 20, and 40 mg cocaine i.v., 1 h apart) examined direct pharmacodynamic interactions on subjective and physiological indices; self-administration sessions examined choice behavior for cocaine (40 mg i.v. for six trials) versus money 1) in the presence of a sample cocaine dose with money choices presented in ascending value, and 2) in the absence of a sample dose with money choices presented in descending values. Enadoline (80 microg/70 kg) significantly (p < 0.05) reduced some of the positive subjective effects of cocaine (e.g., ratings of "high"), while butorphanol failed to modify subjective responses. Both agents were safely tolerated in combination with cocaine without adverse physiological responses. Cocaine self-administration was significantly greater across all pretreatment conditions when the sample dose was given and ascending money choices were used. Enadoline and butorphanol failed to modify cocaine self-administration. These data suggest that these kappa-agonists may be safely administered in the presence of cocaine but do not produce significant attenuation of cocaine's direct effects or self-administration under these acute dosing conditions.
Published: 2001

50. Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans.

Author: Walsh SL, Strain EC, Abreu ME, and Bigelow GE
Subjects: Adult, Analysis of Variance, Benzofurans therapeutic use, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Female, Heroin Dependence drug therapy, Humans, Male, Middle Aged, Neuroprotective Agents therapeutic use, Pilot Projects, Pyrrolidines therapeutic use, Receptors, Opioid, kappa physiology, Analgesics, Opioid pharmacology, Benzofurans pharmacology, Butorphanol pharmacology, Hydromorphone pharmacology, Neuroprotective Agents pharmacology, Pyrrolidines pharmacology, Receptors, Opioid, kappa agonists
Abstract: Rationale: The availability of the highly selective and specific kappa opioid agonist enadoline provides an opportunity to explore the function of kappa receptors in humans and their potential utility as a target for substance abuse pharmacotherapy development., Objectives: The purpose of this study was to characterize the pharmacodynamic effects of enadoline, a selective kappa agonist, and to compare it with butorphanol, a mixed mu/kappa agonist, and hydromorphone, a mu agonist, in humans., Methods: Pilot evaluation (n=3) served to establish intramuscular doses of enadoline (20, 40, 80, and 160 microg/70 kg), butorphanol (1.5, 3, 6, and 12 mg/70 kg), and hydromorphone (1.5, 3, and 6 mg/70 kg) of comparable activity. These acute doses were examined under double-blind, placebo-controlled and constrained randomized conditions with a minimum of 72 h between tests in volunteers with polysubstance abuse histories (n=6). Physiological and subject- and observer-rated measures were collected 30 min before and for 4 h after administration., Results: Enadoline significantly increased measures of sedation, confusion and dizziness, produced visual distortions and feelings of depersonalization, and increased urinary output. The highest dose (160 microg/70 kg) was not tolerated and led to psychotomimetic effects. Hydromorphone produced prototypic mu opioid effects including respiratory depression, miosis, and euphoria. Butorphanol was most similar to hydromorphone and shared few effects with enadoline., Conclusions: These results are discussed with respect to the potential use and safety of kappa agonists for clinical indications.
Published: 2001
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