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4. Pattern of nodal metastasis of cutaneous squamous cell carcinoma involving the temporal bone.

Author

Hintze, Justin M., O'Riordan, Isobel, Jones, Holly, McHugh, Alison, Gendre, Adrien, Timon, Conrad, Kinsella, John, Lennon, Paul, Walsh, Rory McConn, Shine, Neville, and O'Neill, James P.

Subjects
SQUAMOUS cell carcinoma, TEMPORAL bone, METASTASIS
Abstract

Objective: The objective of this study was to explore the pattern of lymph‐node spread of SCCs involving the temporal bone. Methods: We retrospectively reviewed all cutaneous SCCs involving the temporal bone over a 20‐year time‐period. Forty‐one patients were eligible. Results: Mean age was 72.8 years. The diagnosis was cutaneous SCC in all cases. All patients underwent a temporal bone resection, 70.7% had a neck‐dissection and 78.0% a parotidectomy. Level 2 was the most common area of neck metastasis, and occurred in 12.2%. The parotid had disease in 34.1%. 51.2% of patients underwent free‐flap reconstruction. Mean overall survival of the cohort was 4.2 years. Conclusions: Overall, the rate of cervical nodal metastasis was 22.0% and 13.5% in the occult setting. The parotid was involved in 34.1% and 10.0% in the occult setting. Results from the present study support consideration for performing a parotidectomy at the time of temporal bone resection, while a neck dissection can be performed for adequate staging of the nodal basin. Level of Evidence: 3 The objective of the present study was to evaluate the pattern of spread of SCCs involving the temporal bone. The risk of cervical and parotid metastasis was 22.0% and 34.1%, respectively, while the risk of occult disease was 13.5% and 10.0%, respectively. [ABSTRACT FROM AUTHOR]

Published
2023
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5. CONTRIBUTORS

Author

Abbott, Richard L., primary, Afshari, Natalie A., additional, Agrawal, Jaya, additional, Agrawal, Shishir, additional, Agrawal, Trilok P., additional, Akduman, Levent, additional, Akpek, Esen K., additional, Al-Sayyed, Amal, additional, Albini, Thomas A., additional, Alcorn, Deborah M., additional, Alwitry, Amar, additional, Amzel, Anouk, additional, Anderson, Nicole J., additional, Ansari, Ejaz A., additional, Antoszyk, Andrew, additional, Antoszyk, James H., additional, Aquavella, James V., additional, Arain, Sumaira A., additional, Arévalo, J. Fernando, additional, Arunagiri, Guruswami, additional, Arzabe, Carlos W., additional, Atchaneeyasakul, La-ongsri, additional, Atilla, Huban, additional, Aykan, Ümit, additional, Ayres, Brandon D., additional, Barbón, Juan J., additional, Bailey, Kristi, additional, Baloh, Frank G., additional, Barequet, Irina S., additional, Barkhuizen, André, additional, Bearn, Michael A., additional, Belfort, Rubens, additional, Bellows, A. Robert, additional, Berrocal, Audina M., additional, Bettink-Remeijer, Marijke Wefers, additional, Bhandari, Anuja, additional, Bhatti, M. Tariq, additional, Blumenkranz, Mark S., additional, Boboridis, Kostas G., additional, Bolling, James P., additional, Boniuk, Vivien, additional, Botelho, Paul Jorge, additional, Brazis, Paul W., additional, Bremner, Fion D., additional, Buckley, Edward G., additional, Bullock, John D., additional, Bushley, David Matthew, additional, Caldeira, Jorge Alberto F., additional, Carricajo, Anne, additional, Cavallini, Gian Maria, additional, Chan, Matilda Frances, additional, Chandler, Damon B., additional, Channa, H., additional, Char, Devron H., additional, Charles, Steve, additional, Chen, Teresa C., additional, Ching, Steven S.T., additional, Chiquet, Christophe, additional, Hyunchul, Phillip, additional, Chou, Timothy Y., additional, Christiansen, Stephen P., additional, Chung, Kelly D., additional, Cioffi, George A., additional, Clarke, Michael P., additional, Coats, David K., additional, Cohen, Elisabeth J., additional, Conway, R. Max, additional, Creuzot-Garcher, Catherine, additional, Cunningham, Emmett T., additional, Curtis, Theodore H., additional, Dailey, Roger A., additional, Davis, Richard M., additional, Cock, Romain De, additional, de Faber, Jan-Tjeerd H.N., additional, de la Mano, Daniel, additional, Dekkers, Nick W.H.M., additional, Monte, Monte Anthony Del, additional, Rocca, David A. Della, additional, Rocca, Robert C. Della, additional, Dhaliwal, Deepinder K., additional, Do, Diana V., additional, Dolman, Peter J., additional, Donahue, Sean P., additional, Donnenfeld, Eric D., additional, Duguid, Graham, additional, Duker, Jay S., additional, Dunn, James P., additional, Dunn, Steven P., additional, Duong, Hon-Vu Q., additional, Egan, Robert A., additional, Eichler, Michael D., additional, El-Dairi, Mays, additional, Ellis, Forrest J., additional, Emerson, Geoffrey, additional, Emerson, M. Vaughn, additional, Enyedi, Laura B., additional, Evans, Teodoro, additional, Falardeau, Julie, additional, Faris, Bishara M., additional, Feitl, Marianne E., additional, Felton, Warren L., additional, Feman, Stephen S., additional, ffytche, Timothy J, additional, Flaxel, Christina J., additional, Foroozan, Rod, additional, Foster, Allen, additional, Fraunfelder, Frederick T., additional, Fraunfelder, Frederick W., additional, Freeman, H. Mackenzie, additional, Friedlaender, Mitchell H., additional, Frohman, Larry P., additional, Fung, Wayne E., additional, Gain, Philippe, additional, Gaitan, Jaime R., additional, Gancher, Stephen, additional, Gard, Tim, additional, Gattey, Devin M., additional, Gehlbach, Peter L., additional, Ghajarnia, Mehdi, additional, Ghanem, Vinícius Coral, additional, Ghosh, Amit Kumar, additional, Ghosh, Chandak, additional, Giegengack, Matthew, additional, Gladstone, Geoffrey, additional, Gold, Daniel H., additional, Golub, Richard L., additional, Gombos, Dan S., additional, Gombos, George M., additional, Good, William V., additional, Goodman, Shawn, additional, Gottsch, John D., additional, Goverdhan, Srinivas, additional, Grimson, Baird S., additional, Güemes, Adolfo, additional, Guerra, Roberto, additional, Haller, Julia A., additional, Hammersmith, Kristin M., additional, Handelman, Irvin L., additional, Hargrove, Roderick N., additional, Harney, Michael S., additional, Harper, Richard A., additional, Hatt, Sarah R., additional, Hawkins, Barbara S., additional, Hayreh, Sohan S., additional, Heiligenhaus, Arnd, additional, Heinz, Carsten, additional, Herndon, Leon W., additional, Hickman, Simon J., additional, Hirano, Koji, additional, Holland, Edward J., additional, Holland, Gary N., additional, Holz, Eric R., additional, Hommura, Sachiko, additional, Horn, Jeffrey D., additional, Hornick, Richard B., additional, Hoskins, H. Dunbar, additional, Hung, James W., additional, Hunter, Brian A., additional, Hunter, Krista A., additional, Hunyor, Alex P., additional, Hurwitz, Brian, additional, Hwang, Thomas S., additional, Hyndiuk, Robert A., additional, Ilhan-Sarac, Ozge, additional, Ing, Edsel, additional, Ino-ue, Masanori, additional, Isada, Carlos M., additional, Iturriaga, Saylin, additional, Iuorno, Joseph D., additional, Iwach, Andrew G., additional, Iyer, Mohan N., additional, Izquierdo, Natalio J., additional, Jampol, Lee M., additional, Johnston, Suzanne, additional, Kadayifçilar, Sibel, additional, Kaden, Ian H., additional, Kaimbo, Dieudonne Kaimbo Wa, additional, Kapur, Rashmis, additional, Kastl, Peter R., additional, Katsavounidou, Garyfallia, additional, Kazerouni, Ayat, additional, Kazim, Michael, additional, Kedhar, Sanjay R., additional, Keech, Ronald V., additional, Kersten, Robert C., additional, Keys, Marshall P., additional, Khanna, Sangeeta, additional, Khaw, Peng Tee, additional, Kinyoun, James L., additional, Kirwan, Caitriona, additional, Kivelä, Tero, additional, Klein, Michael L., additional, Klotz, Stephen A., additional, Ko, John, additional, Kowalski, Regis P., additional, Krachmer, Jay H., additional, Krupin, Theodore, additional, Kuhn, Ferenc, additional, Kulkarni, Abhaya Vivek, additional, Kwun, Robert C., additional, Laibson, Peter R., additional, Lakhanpal, Rohit R., additional, Lam, Byron L., additional, Lamer, Laurent, additional, Lawlor, David P., additional, Lawton, Andrew W., additional, Leahey, Alan B., additional, LeBoyer, Russell, additional, Lee, Andrew G., additional, Lee, Wen-Hsiang, additional, Lee, William Barry, additional, Lehman, Sharon S., additional, Leibowitz, Howard M., additional, Leong, James, additional, Levin, Alex V., additional, Levin, Leonard A., additional, Levine, Mark R., additional, Levy, Norman S., additional, Liesegang, Thomas J., additional, Lim, Lyndell L., additional, Lin, Linda H., additional, Lisman, Richard D., additional, Litoff, David, additional, Liu, James C., additional, Loft, Evan, additional, Lubritz, Ronald R., additional, Mabey, David C.W., additional, Mackie, Ian A., additional, Maguluri, Srilakshmi, additional, Maliki, M., additional, Mamalis, Nick, additional, Mannis, Mark J., additional, Mansberger, Steven L., additional, Mansour, Ahmad M., additional, Marcon, Alexandre S., additional, Marcon, Italo M., additional, Marsh, Peter B., additional, Mather, Rookaya, additional, Mathers, William D., additional, Saari, K. Matti, additional, Mawn, Louise A., additional, McAllum, Penny J., additional, McCallum, Rex M., additional, McCluskey, Peter, additional, McCormick, Gregory J., additional, McCormick, Steven A., additional, McCulley, James P., additional, McHenry, John G., additional, McNab, Alan A., additional, Mee, Jared J., additional, Meier, Douglas L., additional, Meisler, David M., additional, Merin, Saul C., additional, Meyer, Dale R., additional, Meyer, Roger F., additional, Michels, Kevin S., additional, Milman, Tatyana, additional, Mintz, Roni, additional, Morel, Chantal F, additional, Morris, William R., additional, Moster, Mark L., additional, Mourani, John, additional, Muccioli, Cristina, additional, Mudumbai, Raghu C., additional, Murillo-Lopez, Fernando H., additional, Myint, Shoib, additional, Nagra, Parveen K, additional, Naoumi, A, additional, Nassif, John, additional, Nee, Michelle T., additional, Netto, Marcelo V., additional, Ng, John D., additional, Nguyen, Hau T., additional, Nguyen, Quan Dong, additional, O'Day, Denis M., additional, O'Day, A. Justin, additional, O'Halloran, Henry S., additional, O'Keefe, Michael, additional, Okamoto, Fumiki, additional, Olson, Richard J., additional, Orcutt, James C., additional, Dundar, Sema Oruc, additional, Osbourne, Aaron, additional, Palazzi, Maristela Amaral, additional, Palmer, Earl A., additional, Papadopoulos, Maria, additional, Parnell, Jeffrey R., additional, Parsa, Cameron F., additional, Patel, Sanjay V., additional, Patterson, Emily, additional, Pendergast, Scott D., additional, Perry, Henry D., additional, Peters, Keith Roberson, additional, Po, Stephanie M., additional, Pokroy, Russell, additional, Putterman, Allen Michael, additional, Queiro, Rubén, additional, Rafiei, Nastaran, additional, Rahmani, Bahram, additional, Rapuano, Christopher J, additional, Rasheed, Karim, additional, Rathinam, S.R., additional, Raymond, Lawrence A., additional, Read, Russell W., additional, Lafayette, August, additional, Recchia, Franco M., additional, Reidy, James J., additional, Reynolds, Adam C., additional, Rich, Larry F., additional, Ritch, Robert, additional, Robb, Richard M., additional, Robert, Pierre-Yves, additional, Robertson, Joseph E., additional, Roh, Shiyoung, additional, Romanet, Jean-Paul, additional, Rootman, Jack, additional, Roque, Barbara L., additional, Roque, Manolette R., additional, Rosenbaum, Arthur L., additional, Rosenbaum, James Todd, additional, Roy, F. Hampton, additional, Rundle, Paul A., additional, Sadun, Alfredo A., additional, Saffra, Norman A., additional, Salim, Sarwat, additional, Samples, John R., additional, Santiago, Alvina Pauline D, additional, Saperstein, David A., additional, Saunders, Richard A., additional, Savage, James A., additional, Scheufele, Tina A., additional, Schiedler, Vivian, additional, Schlesinger, Thomas K., additional, Schlossman, Abraham, additional, Schwartz, Lee K., additional, Scott, Ingrid U., additional, Scruggs, Jennifer, additional, Segal, Ernesto I., additional, Shalaby, Ismail A., additional, Sheikh, Aziz, additional, Sheppard, John D., additional, Sherman, Mark D., additional, Shields, Carol L., additional, Shields, Jerry A., additional, Singh, Amarpreet, additional, Singh, Christopher N., additional, Singman, Eric L., additional, Siracuse-Lee, Donna, additional, Smalley, Aaron D., additional, Smith, Patricia W., additional, Solomon, Anthony W., additional, Souhail, Hassane, additional, Spitzberg, Daniel H., additional, Spoor, Thomas C., additional, Stamper, Robert L., additional, Stark, Walter J., additional, Steele, Eric A., additional, Steinemann, Thomas L., additional, Stout, Ann U., additional, Stout, J. Timothy, additional, Stulting, R. Doyle, additional, Sugar, Alan, additional, Sugar, Joel, additional, Suh, Donny W., additional, Suhler, Eric B., additional, Sullivan, John H., additional, Sutphin, John Everett, additional, Swan, Kenneth C., additional, Tabbara, Khalid F., additional, Tamber, Mandeep S., additional, Tanna, Angelo P., additional, Tatlipinar, Sinan, additional, Tayani, Ramin, additional, Teichmann, Klaus D., additional, Terry, Mark A., additional, Tham, Clement Chee Yung, additional, Therzaz, A., additional, Thuret, Gilles, additional, Tinley, Christopher Graham, additional, Tongue, Andrea C., additional, Torres, Rodrigo J., additional, Tower, Robert N., additional, Traboulsi, Elias I, additional, Trikha, Rupan, additional, Tripathi, Brenda J., additional, Tripathi, Ramesh C., additional, Tugal-Tutkun, Ilknur, additional, Tung, Irene, additional, Evendingen, Judith A. M. Van, additional, Vaudaux, Jean D., additional, Wairagkar, Niteen S, additional, Walrath, Joseph D., additional, Walsh, Rory McConn, additional, Walton, David S., additional, Warwar, Ronald E., additional, Watson, Peter G., additional, Weiter, John J., additional, Weleber, Richard G., additional, Wertz, Fleming D., additional, Westra, Igor, additional, Wheeler, David T., additional, Wilkinson, Charles P., additional, Wilson, David J., additional, Wilson, M. Edward, additional, Wilson, Matthew W., additional, Wilson, Steven E, additional, Wobig, John L., additional, Wood, Terry D., additional, Wu, Lihteh, additional, Yalcinbayir, Ozgur, additional, Ying, Howard Shann-Cherng, additional, Youssef, Peter N., additional, and Zaidman, Gerald W., additional

Published
2008
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7. Necrotizing otitis externa: a new trend? Report of 6 atypical cases

Author

Glynn, Fergal and Walsh, Rory McConn

Subjects
Antibiotics -- Usage, Antibiotics -- Health aspects, CT imaging -- Usage, CT imaging -- Health aspects, Immunocompromised host -- Diseases, Immunocompromised host -- Medical examination, Otitis externa -- Risk factors, Otitis externa -- Development and progression, Otitis externa -- Care and treatment, Otitis externa -- Patient outcomes, Otitis externa -- Case studies
Abstract

Abstract Necrotizing otitis externa (OE) is traditionally seen in elderly diabetics and immunocompromised patients. During a 7-year period at our institution, we treated 6 patients with necrotizing OE who were [...]

Published
2009

8. Aberrant ectatic internal carotid artery in the middle ear

Author

Safdar, Adnan, Hughes, Joseph P., and Walsh, Rory McConn

Subjects
Carotid artery diseases -- Diagnosis -- Care and treatment -- Case studies -- Health aspects, Middle ear -- Health aspects -- Case studies, Health
Abstract

Abstract We report the case of a 34-year-old man with pulsatile tinnitus and a reddish mass in the anteroinferior quadrant of the middle ear. Physical examination and imaging were unable [...]

Published
2008

10. Bilateral peritonsillar abscess revisited

Author

Safdar, Adnan, Hughes, Joseph P., Walsh, Rory McConn, and Walsh, Michael

Subjects
Peritonsillar abscess -- Health aspects, Peritonsillar abscess -- Care and treatment
Abstract

Abstract Bilateral peritonsillar abscess is uncommon. When it does occur, patients usually present with sore throat; other clinical signs and symptoms may differ from those usually associated with unilateral peritonsillar [...]

Published
2005

11. Contributors

Author

Akinwuntan, Abiodun E., Ashford, Stephen, Bassile, Clare, Brown, (Elizabeth) Caroline, Bunn, Lisa, Busse, Monica, Capp, Adrian, Carr, Aisling, Cassidy, Elizabeth, Chen, Chih-Chung, Bello-Haas, Vanina Dal, Dawes, Helen, De Baets, Liesbet, Devos, Hannes, Freeman, Jennifer A., Graziano, Mariella, Gunn, Hilary, Hexter, Benita, Holt, Kate, Inbar, Noit, Jones, Fiona, Kulnik, Stefan Tino, Kunkel, Dorit, Lange, Belinda, Laurá, Matilde, Lennon, Sheila, Magnus Levack, William Mark, Johnson, Mark I., Marsden, Jonathan, Walsh, Rory McConn, McLoughlin, James, Meldrum, Dara, Nielsen, Glenn, Paddison, Sue, Pietrusz, Aleksandra, Platt, Louise, Pompeu, José Eduardo, Quinlivan, Ros, Quinn, Lori, Ramaswamy, Bhanu, Ramdharry, Gita, Stack, Emma, Tyson, Sarah F., Veerbeek, Janne M., Verheyden, Geert, Wallace, Amanda, Williams, Gavin, and Wilson, F. Colin

Published
2019
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12. Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis

Author

Thornton, Margaret A., primary, Akasheh, Nadim, additional, Walsh, Marie-Therese, additional, Moloney, Michael, additional, Sheahan, Patrick O., additional, Smyth, Claire M., additional, Walsh, Rory McConn, additional, Morgan, Ross M., additional, Curran, David R., additional, Walsh, Michael T., additional, Gleich, Gerald J., additional, and Costello, Richard W., additional

Published
2013
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13. vCJD risk in the Republic of Ireland

Author

Harney, Michael S, primary, Ghani, Azra C, additional, Donnelly, CA, additional, Walsh, Rory McConn, additional, Walsh, Michael, additional, Howley, Rachel, additional, Brett, Francesca, additional, and Farrell, Michael, additional

Published
2003
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16. Cavernous angioma of the internal auditory canal

Author

Aquilina, Kristian, Nanra, Jagdeep S., Brett, Francesca, Walsh, Rory McConn, and Rawluk, Daniel

Abstract

Cavernous angiomas of the internal auditory canal are rare lesions. The authors present a case of a 29-year-old lady with multiple infratentorial cavernous angiomas, whose sister had previously undergone surgery for a similar supratentorial lesion. She initially presented with an acute brainstem haematoma, secondary to a pontine cavernous angioma. Three years later she developed progressive right-sided sensorineural hearing loss and facial nerve paresis due to an internal auditory canal lesion. This was removed via the translabyrinthine approach and was found to be a cavernous angioma. This report underlines the multiple and dynamic nature of familial cavernous angiomas, as well as the importance of follow up to determine whether new symptoms are due to the enlargement of known angiomas or the development of new ones. As far as the authors are aware, this is the first report describing a cavernous angioma of the internal auditory canal in the context of familial and multiple infratentorial angiomas.

Published
2004

17. Frontal osteomyelitis: a serious complication of sinusitis

Author

Walshe, Peter, Walsh, Rory McConn, and Walsh, Michael

Abstract

A12-year-old girl presented with a 6-day history of swelling of the forehead (Figure 1). She had complained of frontal headaches for the previous 2 weeks, but was otherwise well. She denied any history of trauma. The headaches were of a dull boring nature, and the pain extended to the mid-facial region. She complained of a loss of smell and nasal congestion. Neurological examination was normal, as was a subsequent skull X-ray. Computed tomography (CT) of the skull was performed, and indicated osteomyelitis of the frontal bone (Figure 2). There was also evidence of pus in the paranasal sinuses.

Published
2002
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18. Role of the muscarinic M2 receptor in human nasal mucosa.

Author

Sheahan P, Thornton M, Walsh RM, Walsh MA, and Costello RW

Subjects
Adult, Bradykinin pharmacology, Female, Humans, Male, Muscarinic Agonists pharmacology, Nasal Mucosa metabolism, Pilocarpine pharmacology, Polymerase Chain Reaction, Vasodilator Agents pharmacology, Nasal Mucosa physiology, Receptor, Muscarinic M2 physiology, Rhinitis, Allergic, Perennial physiopathology
Abstract

Introduction: Neurally mediated secretory hyperresponsiveness is a feature of allergic rhinitis (AR). Muscarinic M2 receptors are inhibitory autoreceptors which limit acetylcholine release at postganglionic parasympathetic nerve terminals, dysfunction of which has been implicated as a cause of bronchial hyperresponsiveness in asthma. The purpose of this study was to investigate the presence and function of M2 receptors in the human nose., Methods: In the first part of the study, nasal biopsies from subjects with AR (n = 12) and normal controls (n = 10) were examined for the presence of M2 receptor mRNA using polymerase chain reaction (PCR). In the second part, subjects with symptomatic AR (n = 17), with established contralateral secretory reflexes to bradykinin, underwent unilateral bradykinin challenge after premedication with pilocarpine, a M2 receptor agonist. The effect of pilocarpine on contralateral secretory reflexes was studied., Results: M2 receptor mRNA was detected in 12 subjects (54%). Pilocarpine premedication led to a significant reduction of the contralateral secretory reflex to bradykinin., Conclusion: M2 receptors are present in the human nasal mucosa, though not universally. The function of M2 receptors in subjects with AR can be demonstrated using pilocarpine, however, more work is required to define their importance and potential role in nasal hyperresponsiveness

Published
2007

19. Atypical clinical presentations of vestibular schwannomas.

Author

Mackle T, Rawluk D, and Walsh RM

Subjects
Adult, Aged, Audiometry, Cerebellopontine Angle pathology, Hearing Loss, Sensorineural etiology, Humans, Magnetic Resonance Imaging, Male, Neuroma, Acoustic complications, Neuroma, Acoustic pathology, Tinnitus etiology, Vertigo etiology, Neuroma, Acoustic diagnosis
Abstract

Unlabelled: A significant number of patients with vestibular schwannomas present atypically, with none of the classical symptoms of unilateral sensorineural hearing loss, tinnitus, and/or dysequilibrium. The aim of this study is to highlight those patients with unusual clinical symptoms., Study Design: The clinical data of all patients who presented to the vestibular schwannoma clinic at Beaumont Hospital over the past 12 years was prospectively recorded in a computerized database. This paper reviews the atypical presenting symptoms., Results: Three hundred ninety-eight patients were included in this study. A total of 3.7% of patients presented with atypical symptoms only., Conclusion: A significant subgroup, 3.7% in our study, did not present with the audiovestibular symptoms classically associated with vestibular schwannoma. Clinician awareness of the atypical clinical symptoms may lead to earlier detection of these lesions.

Published
2007
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20. Use of an intra-operative nerve stimulator in identifying the hypoglossal nerve.

Author

Walshe P, Shandilya M, Rowley H, Zahirovich A, Walsh RM, Walsh M, and Timon C

Subjects
Electric Stimulation instrumentation, Electrodes, Humans, Monitoring, Intraoperative instrumentation, Pilot Projects, Risk Factors, Electric Stimulation methods, Hypoglossal Nerve physiology, Monitoring, Intraoperative methods, Neck Dissection methods
Abstract

Previously, the hypoglossal nerve has not undergone intra-operative monitoring during neck operations in which the nerve is at risk. As society becomes increasingly litigious, this may change. This study describes the technique and the microvoltages used in 10 patients for intra-operative stimulation of the hypoglossal nerve with the Magstim nerve stimulator. We confirm that the technique is possible, simple and safe, with minimal disturbance to the patient, anaesthetist and surgeon.

Published
2006
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21. Hyperresponsiveness of congestive nasal reflexes in allergic rhinitis.

Author

Sheahan P, Walsh RM, Walsh MA, and Costello RW

Subjects
Adult, Bradykinin, Female, Humans, Irritants, Male, Nasal Mucosa blood supply, Nasal Mucosa metabolism, Rhinometry, Acoustic, Thymol, Vasodilator Agents, Nasal Mucosa physiopathology, Nasal Provocation Tests, Reflex, Abnormal, Rhinitis, Allergic, Seasonal physiopathology
Abstract

Background: Nasal secretory hyperresponsiveness is well documented in allergic rhinitis, and is mediated in part by neural mechanisms. In contrast, reflex-mediated congestion is poorly documented in both normal and allergic subjects., Objective: To characterize congestive responses to unilateral nasal bradykinin challenge in normal and allergic subjects, and to investigate whether congestive hyperresponsiveness is present in allergic rhinitis., Methods: Normal subjects (n = 13), and subjects with out-of-season seasonal allergic rhinitis (SAR) (n = 16) underwent a unilateral nasal challenge protocol using filter paper disks, using Hartman's solution and bradykinin as challenge substances. Congestive responses were measured using acoustic rhinometry., Results: Normal subjects demonstrated a transient ipsilateral congestive response, and a circumscribed contralateral congestive response away from the major flow limiting section. Subjects with SAR demonstrated a more persistent ipsilateral congestive response, and a more pronounced, generalized contralateral congestive response affecting all areas of the contralateral nasal cavity. Significant differences were present between normal and SAR subjects., Conclusion: Congestive reflexes are present in normal and allergic subjects. Congestive hyperresponsiveness is present in allergic rhinitis.

Published
2006

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