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2. Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.

Author

Giri, Veda N, Knudsen, Karen E, Kelly, William K, Abida, Wassim, Andriole, Gerald L, Bangma, Chris H, Bekelman, Justin E, Benson, Mitchell C, Blanco, Amie, Burnett, Arthur, Catalona, William J, Cooney, Kathleen A, Cooperberg, Matthew, Crawford, David E, Den, Robert B, Dicker, Adam P, Eggener, Scott, Fleshner, Neil, Freedman, Matthew L, Hamdy, Freddie C, Hoffman-Censits, Jean, Hurwitz, Mark D, Hyatt, Colette, Isaacs, William B, Kane, Christopher J, Kantoff, Philip, Karnes, R Jeffrey, Karsh, Lawrence I, Klein, Eric A, Lin, Daniel W, Loughlin, Kevin R, Lu-Yao, Grace, Malkowicz, S Bruce, Mann, Mark J, Mark, James R, McCue, Peter A, Miner, Martin M, Morgan, Todd, Moul, Judd W, Myers, Ronald E, Nielsen, Sarah M, Obeid, Elias, Pavlovich, Christian P, Peiper, Stephen C, Penson, David F, Petrylak, Daniel, Pettaway, Curtis A, Pilarski, Robert, Pinto, Peter A, Poage, Wendy, Raj, Ganesh V, Rebbeck, Timothy R, Robson, Mark E, Rosenberg, Matt T, Sandler, Howard, Sartor, Oliver, Schaeffer, Edward, Schwartz, Gordon F, Shahin, Mark S, Shore, Neal D, Shuch, Brian, Soule, Howard R, Tomlins, Scott A, Trabulsi, Edouard J, Uzzo, Robert, Vander Griend, Donald J, Walsh, Patrick C, Weil, Carol J, Wender, Richard, and Gomella, Leonard G

Subjects
Humans, Prostatic Neoplasms, Genetic Predisposition to Disease, Prognosis, Risk Factors, Predictive Value of Tests, Pedigree, Age Factors, Heredity, Phenotype, Adult, Aged, Middle Aged, Male, Genetic Testing, Biomarkers, Tumor, Clinical Decision-Making, Genetics, Aging, Cancer, Prevention, Prostate Cancer, Urologic Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Purpose Guidelines are limited for genetic testing for prostate cancer (PCA). The goal of this conference was to develop an expert consensus-driven working framework for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, testing, and genetically informed management. Methods An expert consensus conference was convened including key stakeholders to address genetic counseling and testing, PCA screening, and management informed by evidence review. Results Consensus was strong that patients should engage in shared decision making for genetic testing. There was strong consensus to test HOXB13 for suspected hereditary PCA, BRCA1/2 for suspected hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome. There was strong consensus to factor BRCA2 mutations into PCA screening discussions. BRCA2 achieved moderate consensus for factoring into early-stage management discussion, with stronger consensus in high-risk/advanced and metastatic setting. Agreement was moderate to test all men with metastatic castration-resistant PCA, regardless of family history, with stronger agreement to test BRCA1/2 and moderate agreement to test ATM to inform prognosis and targeted therapy. Conclusion To our knowledge, this is the first comprehensive, multidisciplinary consensus statement to address a genetic evaluation framework for inherited PCA in the multigene testing era. Future research should focus on developing a working definition of familial PCA for clinical genetic testing, expanding understanding of genetic contribution to aggressive PCA, exploring clinical use of genetic testing for PCA management, genetic testing of African American males, and addressing the value framework of genetic evaluation and testing men at risk for PCA-a clinically heterogeneous disease.

Published
2018

7. The Melbourne Consensus Statement on the early detection of prostate cancer.

Author

Murphy, Declan G, Ahlering, Thomas, Catalona, William J, Crowe, Helen, Crowe, Jane, Clarke, Noel, Cooperberg, Matthew, Gillatt, David, Gleave, Martin, Loeb, Stacy, Roobol, Monique, Sartor, Oliver, Pickles, Tom, Wootten, Addie, Walsh, Patrick C, and Costello, Anthony J

Subjects
Humans, Prostatic Neoplasms, Prostate-Specific Antigen, Tumor Markers, Biological, Mass Screening, Risk Factors, Consensus, Decision Making, Aged, Middle Aged, Australia, Male, Digital Rectal Examination, Randomized Controlled Trials as Topic, Practice Guidelines as Topic, Early Detection of Cancer, PSA testing, guideline, prostate cancer, risk stratification, screening, Biomarkers, Tumor, Tumor Markers, Biological, Biomarkers, Tumor, Urology & Nephrology, Clinical Sciences
Abstract

Various conflicting guidelines and recommendations about prostate cancer screening and early detection have left both clinicians and their patients quite confused. At the Prostate Cancer World Congress held in Melbourne in August 2013, a multidisciplinary group of the world's leading experts in this area gathered together and generated this set of consensus statements to bring some clarity to this confusion. The five consensus statements provide clear guidance for clinicians counselling their patients about the early detection of prostate cancer.

Published
2014

8. Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment

Author

Moyer, C. Leigh, Phillips, Ryan, Deek, Matthew P., Radwan, Noura, Ross, Ashley E., Antonarakis, Emmanuel S., Reyes, Diane, Wright, Jean, Terezakis, Stephanie A., Song, Daniel Y., DeVille, Curtiland, Walsh, Patrick C., DeWeese, Theodore L., Carducci, Michael, Schaeffer, Edward M., Pienta, Kenneth J., Eisenberger, Mario, and Tran, Phuoc T.

Published
2019
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10. Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

Author

Smith, Jeffrey R., Freije, Diha, Carpten, John D., Grönberg, Henrik, Xu, Jianfeng, Isaacs, Sarah D., Brownstein, Michael J., Bova, G. Steven, Guo, Hong, Bujnovszky, Piroska, Nusskern, Deborah R., Damber, Jan-Erik, Bergh, Anders, Emanuelsson, Monika, Kallioniemi, Olli P., Walker-Daniels, Jennifer, Bailey-Wilson, Joan E., Beaty, Terri H., Meyers, Deborah A., Walsh, Patrick C., Collins, Francis S., Trent, Jeffrey M., and Isaacs, William B.

Published
1996

11. Supplementary Figure 1 from Germ-Line Mutation of NKX3.1 Cosegregates with Hereditary Prostate Cancer and Alters the Homeodomain Structure and Function

Author

Zheng, S. Lilly, primary, Ju, Jeong-ho, primary, Chang, Bao-li, primary, Ortner, Elizabeth, primary, Sun, Jielin, primary, Isaacs, Sarah D., primary, Sun, Jishang, primary, Wiley, Kathy E., primary, Liu, Wennuan, primary, Zemedkun, Micheas, primary, Walsh, Patrick C., primary, Ferretti, James, primary, Gruschus, James, primary, Isaacs, William B., primary, Gelmann, Edward P., primary, and Xu, Jianfeng, primary

Published
2023
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12. Supplementary Figure 1 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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13. Supplementary Table 3 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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14. Data from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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15. Supplementary Table 2 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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16. Supplementary Table 4 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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17. Supplementary Table 1 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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18. Association of rare, recurrent nonsynonymous variants in the germline of prostate cancer patients of African ancestry

Author

Wei, Jun, primary, Beebe‐Dimmer, Jennifer, additional, Shi, Zhuqing, additional, Sample, Christopher, additional, Yan, Guifang, additional, Rifkin, Andrew S., additional, Sadeghpour, Azita, additional, Gielzak, Marta, additional, Choi, Sodam, additional, Moon, David, additional, Zheng, S. Lilly, additional, Helfand, Brian T., additional, Walsh, Patrick C., additional, Xu, Jianfeng, additional, Cooney, Kathleen A., additional, and Isaacs, William B., additional

Published
2022
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21. Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Author

Teerlink, Craig C., Leongamornlert, Daniel, Dadaev, Tokhir, Thomas, Alun, Farnham, James, Stephenson, Robert A., Riska, Shaun, McDonnell, Shannon K., Schaid, Daniel J., Catalona, William J., Zheng, S. Lilly, Cooney, Kathleen A., Ray, Anna M., Zuhlke, Kimberly A., Lange, Ethan M., Giles, Graham G., Southey, Melissa C., Fitzgerald, Liesel M., Rinckleb, Antje, Luedeke, Manuel, Maier, Christiane, Stanford, Janet L., Ostrander, Elaine A., Kaikkonen, Elina M., Sipeky, Csilla, Tammela, Teuvo, Schleutker, Johanna, Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Isaacs, William B., Xu, Jianfeng, Cancel-Tassin, Geraldine, Cussenot, Olivier, Mandal, Diptasri, Laurie, Cecelia, Laurie, Cathy, Thibodeau, Stephen N., Eeles, Rosalind A., Kote-Jarai, Zsofia, Cannon-Albright, Lisa, The PRACTICAL consortium, and International Consortium for Prostate Cancer Genetics

Published
2016
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23. Hereditary Prostate Cancer

Author

Isaacs, William B., Xu, Jianfeng, Walsh, Patrick C., Chung, Leland W. K., editor, Isaacs, William B., editor, and Simons, Jonathan W., editor

Published
2001
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27. A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry

Author

Darst, Burcu F., Hughley, Raymond, Pfennig, Aaron, Hazra, Ujani, Fan, Caoqi, Wan, Peggy, Sheng, Xin, Xia, Lucy, Andrews, Caroline, Chen, Fei, Berndt, Sonja I., Kote-Jarai, Zsofia, Govindasami, Koveela, Bensen, Jeannette T., Ingles, Sue A., Rybicki, Benjamin A., Nemesure, Barbara, John, Esther M., Fowke, Jay H., Huff, Chad D., Strom, Sara S., Isaacs, William B., Park, Jong Y., Zheng, Wei, Ostrander, Elaine A., Walsh, Patrick C., Carpten, John, Sellers, Thomas A., Yamoah, Kosj, Murphy, Adam B., Sanderson, Maureen, Crawford, Dana C., Gapstur, Susan M., Bush, William S., Aldrich, Melinda C., Cussenot, Olivier, Petrovics, Gyorgy, Cullen, Jennifer, Neslund-Dudas, Christine, Kittles, Rick A., Xu, Jianfeng, Stern, Mariana C., Chokkalingam, Anand P., Multigner, Luc, Parent, Marie-Elise, Menegaux, Florence, Cancel-Tassin, Geraldine, Kibel, Adam S., Klein, Eric A., Goodman, Phyllis J., Stanford, Janet L., Drake, Bettina F., Hu, Jennifer J., Clark, Peter E., Blanchet, Pascal, Casey, Graham, Hennis, Anselm J.M., Lubwama, Alexander, Thompson, Ian M., Jr, Leach, Robin J., Gundell, Susan M., Pooler, Loreall, Mohler, James L., Fontham, Elizabeth T.H., Smith, Gary J., Taylor, Jack A., Brureau, Laurent, Blot, William J., Biritwum, Richard, Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Tettey, Yao, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Jalloh, Mohamed, Magueye Gueye, Serigne, Niang, Lamine, Ogunbiyi, Olufemi, Oladimeji Idowu, Michael, Popoola, Olufemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Yeboah, Edward D., Mensah, James E., Anthony Adjei, Andrew, Diop, Halimatou, Cook, Michael B., Chanock, Stephen J., Watya, Stephen, Eeles, Rosalind A., Chiang, Charleston W.K., Lachance, Joseph, Rebbeck, Timothy R., Conti, David V., and Haiman, Christopher A.

Published
2022
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37. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease

Author

Teerlink, Craig C., Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Rinckleb, Antje, Maier, Christiane, Vogel, Walther, Cancel-Tassin, Geraldine, Egrot, Christophe, Cussenot, Olivier, Foulkes, William D., Giles, Graham G., Hopper, John L., Severi, Gianluca, Eeles, Ros, Easton, Douglas, Kote-Jarai, Zsofia, Guy, Michelle, Cooney, Kathleen A., Ray, Anna M., Zuhlke, Kimberly A., Lange, Ethan M., FitzGerald, Liesel M., Stanford, Janet L., Ostrander, Elaine A., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Isaacs, William B., Wahlfors, Tiina, Tammela, Teuvo, Schleutker, Johanna, Wiklund, Fredrik, Grönberg, Henrik, Emanuelsson, Monica, Carpten, John, Bailey-Wilson, Joan, Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Catalona, William J., Zheng, S. Lilly, Jin, Guangfu, Lu, Lingyi, Xu, Jianfeng, Camp, Nicola J., Cannon-Albright, Lisa A., and International Consortium for Prostate Cancer Genetics

Published
2014
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46. The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients

Author

Na, Rong, primary, Wei, Jun, additional, Sample, Chris J., additional, Gielzak, Marta, additional, Choi, Sodam, additional, Cooney, Kathleen A., additional, Rabizadeh, Daniel, additional, Walsh, Patrick C., additional, Zheng, Lilly S., additional, Xu, Jianfeng, additional, and Isaacs, William B., additional

Published
2021
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