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2. IFSI-guideline on chronic prurigo including prurigo nodularis

Author

Ständer, Sonja, Pereira, Manuel P., Berger, Timothy, Zeidler, Claudia, Augustin, Matthias, Bobko, Svetlana, Brenaut, Emilie, Chen, Suephy C., Chisolm, Sarah, Dalgard, Florence J., Elberling, Jesper, Elmariah, Sarina B., Evers, Andrea W.M., Garcovich, Simone, Gonçalo, Margarida, Halvorsen, Jon A., Kim, Brian S., Kupfer, Jörg, Kwatra, Shawn G., Lambert, Julien, Legat, Franz J., Lerner, Ethan A., Leslie, Tabi A., Lönndahl, Louise, Lvov, Andrey, Metz, Martin, Misery, Laurent, Papadavid, Evangelia, Potekaev, Nikolay N., Reich, Adam, Savk, Ekin, Schneider, Gudrun, Schut, Christina, Serra-Baldrich, Esther, Ständer, Hartmut F., Streit, Markus, Szepietowski, Jacek C., Tharp, Michael D., Wallengren, Joanna, Nast, Alexander, Weisshaar, Elke, and Yosipovitch, Gil

Published
2020
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4. Chronic prurigo: Insufficient disease control in spite of high healthcare usage

Author

Pereira, Manuel P., primary, Weisshaar, Elke, additional, Halvorsen, Jon Anders, additional, Wallengren, Joanna, additional, Legat, Franz J., additional, Garcovich, Simone, additional, Savk, Ekin, additional, Reich, Adam, additional, Bozek, Agnieszka, additional, Lvov, Andrey, additional, Bobko, Svetlana, additional, Metz, Martin, additional, Streit, Markus, additional, Misery, Laurent, additional, Brenaut, Emilie, additional, Serra‐Baldrich, Esther, additional, Gonçalo, Margarida, additional, Szepietowski, Jacek C., additional, Augustin, Matthias, additional, Nau, Teresa, additional, Zeidler, Claudia, additional, and Ständer, Sonja, additional

Published
2023
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7. List of Contributors

Author

Abdullah, Anthony, primary, Abrouk, Michael, additional, Ahad, Tashmeeta, additional, Ahmed, Imtiaz, additional, Al Hammadi, Anwar, additional, Allen, Caroline, additional, Almohssen, Amer Ali, additional, Alwan, Wisam, additional, Ameen, Mahreen, additional, Amini, Sadegh, additional, Anderson, Bryan E., additional, Anhalt, Grant J., additional, Baker, Donald J., additional, Bala, Harini Rajgopal, additional, Baltz, Julia, additional, Banach, David, additional, Banfield, Cedric C., additional, Baran, Robert, additional, Bardhan, Ajoy, additional, Barkham, Melissa C., additional, Bello, Ysabel M., additional, Benton, Emma, additional, Bergfeld, Wilma F., additional, Berkowitz, Eric, additional, Berman, Brian, additional, Bernhard, Jeffrey D., additional, Bernstein, Daniel, additional, Berth-Jones, John, additional, Bhate, Chinmoy, additional, Bhatia, Bhavnit K., additional, Blume, Jonathan E., additional, Bordet, Nevianna, additional, Borysiewicz, Catherine, additional, Brauner, Gary J., additional, Brodell, Robert T., additional, Brown, Marc D., additional, Burd, Robert M., additional, Burdick, Anne E., additional, Butala, Niraj, additional, Callen, Jeffrey P., additional, Camacho, Ivan D., additional, Camasmie, Helena, additional, Caplivski, Daniel, additional, Cappell, Mitchell S., additional, Casey, Genevieve A., additional, Chan, Lawrence S., additional, Chan, Loi-Yuen, additional, Chen, Jennifer K., additional, Chen, Chen “Mary”, additional, Chiang, Nicole Yi Zhen, additional, Chiaravalloti, Anthony J., additional, Child, Fiona J., additional, Chu, Anthony C., additional, Clayton, Timothy H., additional, Cohen, Steven R., additional, Cooper, Elizabeth A., additional, Cooper, Susan M., additional, Collier, Nick, additional, Correnti, Christina M., additional, Coulson, Ian H., additional, Council, M. Laurin, additional, Cowper, Shawn E., additional, Craven, Nicholas M., additional, Creamer, Daniel, additional, Cruz, Ponciano D., additional, Cusack, Carrie Ann R., additional, Daunton, Adam, additional, Davis, Mark D.P., additional, Dawe, Robert S., additional, D’Cruz, David P., additional, de Berker, David, additional, DeHoratius, Danielle M., additional, Deng, Min, additional, Desai, Seemal R., additional, Devlin, Georgina, additional, DiGiovanna, John J., additional, Doctoroff, Alexander, additional, Dodiuk-Gad, Roni P., additional, Eichenfield, Dawn Z., additional, Eichenfield, Lawrence F., additional, Eisen, Drore, additional, Eke, Ure, additional, Elston, Dirk M., additional, Emanuel, Patrick O.M., additional, Enos, Clinton W., additional, Ensanyat, Shaheen H., additional, Falabella, Anna F., additional, Farberg, Aaron S., additional, Feigenbaum, Lawrence S., additional, Fernandez, Kristen Heins, additional, Fett, Nicole, additional, Finlay, Andrew Y., additional, Firoz, Bahar F., additional, Firoz, Elnaz F., additional, Fitzpatrick, James E., additional, Flischel, Amy E., additional, Foley, Kelly A., additional, Freedman, Derek, additional, Fremlin, Georgina A., additional, Fried, Richard, additional, Friedlander, Philip, additional, Friedman, Adam, additional, Forrestel, Amy K., additional, Fuchs, Brian S., additional, Gach, Joanna E., additional, Galan, Anjela, additional, Ganesh, Jaya, additional, Garg, Amit, additional, Geller, Lauren, additional, Gelmetti, Carlo M., additional, Ghazi, Elizabeth, additional, Ghunawat, Sneha, additional, Goldberg, Leonard H., additional, Goodfield, Mark J.D., additional, Gordon, Marsha L., additional, Gowda, Asha, additional, Grabell, Daniel A., additional, Grant, Matthew, additional, Grattan, Clive E.H., additional, Greaves, Malcolm W., additional, Green, Justin J., additional, Griffiths, Christopher E.M., additional, Gropper, Charles A., additional, Grossberg, Anna L., additional, Gupta, Aditya K., additional, Hadi, Ali S., additional, Hadi, Suhail M., additional, Hagans, Iris A., additional, Hairston, Bethany R., additional, Halpern, Analisa Vincent, additional, Halverstam, Caroline, additional, Harper, Natasha, additional, Harries, Matthew J., additional, Harris, John, additional, Harrison, Shannon, additional, Hatch, Michael M., additional, Heagerty, Adrian H.M., additional, Hebert, Adelaide A., additional, Helms, Stephen E., additional, Hexsel, Camile L., additional, Hexsel, Doris M., additional, Heymann, Warren R., additional, Higgins, Elisabeth M., additional, Higgins, Claire L., additional, High, Whitney A., additional, Hönigsmann, Herbert, additional, Horenstein, Marcelo G., additional, Hruza, George J., additional, Hui, Andrea, additional, Huo, Ran, additional, Ibbotson, Sally H., additional, Ibrahim, Sherrif F., additional, Ilchyshyn, Andrew, additional, Ismail, Dina, additional, Jablonska, Stefania, additional, Jacobe, Heidi T., additional, James, William D., additional, Javed, Aysha, additional, Jemec, Gregor B.E., additional, Johnston, Graham A., additional, Jones, Stephen K., additional, Junkins-Hopkins, Jacqueline M., additional, Kaffenberger, Jessica, additional, Kane, Kelly R., additional, Kanelleas, Antonios, additional, Karadağ, Ayşe Serap, additional, Karas, Laura, additional, Katugampola, Ruwani P., additional, Katz, Bruce E., additional, Kellen, Roselyn, additional, Khan, Murtaza, additional, Khorasani, Hooman, additional, Kim, Ellen J., additional, Kim, Hee J., additional, Kirby, Brian, additional, Kirby, Joslyn S., additional, Klein, Rachel S., additional, Kleydman, Kate, additional, Koch, Dimitra, additional, Kohorst, John J., additional, Koo, John Y.M., additional, Kopp, Sandra A., additional, Korman, Neil J., additional, Kovarik, Carrie, additional, Kraemer, Kenneth H., additional, Krafchik, Bernice R., additional, Krishnamurthy, Karthik, additional, Kvernebo, Knut, additional, Lam, Charlene, additional, Lambert, Peter C., additional, Langtry, James A.A., additional, Larian, Amir A., additional, Larocca, Cecilia A., additional, Lawlor, E. Frances, additional, Lawrence, Clifford M., additional, Lebwohl, Mark G., additional, Lebwohl, Oscar, additional, Lehman, Julia S., additional, Leslie, Tabi A., additional, Lessin, Stuart R., additional, Levitt, Jacob O., additional, Lewis, Fiona M., additional, Liaqat, Maryam, additional, Liu, Kristina J., additional, Loosemore, Michael P., additional, Luger, Thomas A., additional, Lupi, Omar, additional, Lushniak, Boris D., additional, Lyon, Calum C., additional, Maderal, Andrea D., additional, Mahmoud, Bassel H., additional, Majewski, Slawomir, additional, Mallett, Richard B., additional, Manders, Steven M., additional, Mann, Ranon, additional, Mansouri, Yasaman, additional, Margolis, David J., additional, Markowitz, Orit, additional, Marsland, Alexander, additional, Martin-Clavijo, Agustin, additional, Martinez, Daniela, additional, Matiz, Catalina, additional, Maurer, Marcus, additional, McKerrow, Kevin, additional, Meah, Nekma, additional, Micali, Giuseppe, additional, Micheletti, Robert G., additional, Millard, Leslie G., additional, Miller, James E., additional, Wong Millsop, Jillian W., additional, Mimouni, Daniel, additional, Mirowski, Ginat W., additional, Mirza, Sultan A., additional, Molin, Sonja, additional, Morales-Burgos, Adisbeth, additional, Morison, Warwick L., additional, Mørk, Cato, additional, Morton, Colin A., additional, Motley, Richard J., additional, Mowbray, Megan, additional, Muldoon, Eavan G., additional, Muncaster, Anna E., additional, Murakawa, George J., additional, Murase, Jenny E., additional, Murdoch, Michele E., additional, Nabatian, Adam S., additional, Nakamura, Mio, additional, Nalluri, Rajani, additional, Nawas, Zeena Y., additional, Needham, Glen R., additional, Newell, Glenn C., additional, Newton-Bishop, Julia, additional, Nguyen, Adam V., additional, Nixon, Rosemary L., additional, O’Brien, Jack C., additional, Ogden, Stephanie, additional, Olbricht, Suzanne M., additional, O’Shea, Sally Jane, additional, Owen, Cindy E., additional, Pan, Michael, additional, Pappas-Taffer, Lisa, additional, Parish, Jennifer L., additional, Parish, Lawrence Charles, additional, Payette, Michael, additional, Peck, Gary L., additional, Pena, Sandra, additional, Peranteau, Jarad, additional, Pereira, Frederick A., additional, Perkins, William, additional, Perlis, Clifford S., additional, Phelps, Robert G., additional, Phillips, Tania J., additional, Poh-Fitzpatrick, Maureen B., additional, Pomeranz, Miriam Keltz, additional, Pop, Samantha R., additional, Porcu, Pierluigi, additional, Powell, James B., additional, Prok, Lori D., additional, Pyle, Tia M., additional, Qazaz, Surod, additional, Rajkomar, Vikram, additional, Rashid, Rabia S., additional, Rashighi, Mehdi, additional, Ratnavel, Ravi, additional, Regula, Christie G., additional, Renzi, Michael, additional, Revuz, Jean, additional, Reynolds, Rachel V., additional, Richard, Elisabeth, additional, Richard, Gabriele, additional, Rigel, Darrell S., additional, Robles, Wanda Sonia, additional, Rogge, Megan, additional, Rook, Alain H., additional, Manning, Jamie R., additional, Rosen, Ted, additional, Rosenbach, Misha, additional, Rosenfeld, David, additional, Rowland Payne, Christopher, additional, Rubin, Adam I., additional, Rubin, Courtney, additional, Rustin, Malcolm H.A., additional, Ruzicka, Thomas, additional, Samimi, Sara, additional, Schachner, Lawrence A., additional, Scheinfeld, Noah, additional, Schlosser, Bethanee J., additional, Schnur, Rhonda E., additional, Schwartz, Robert A., additional, Scorer, Matthew J., additional, Selkin, Bryan A., additional, Seymour, Jamie, additional, Shaver, Christine M., additional, Shea, Christopher R., additional, Shear, Neil H., additional, Shim, Tang Ngee, additional, Shimizu, Hiroshi, additional, Siegel, Julia, additional, Singer, Elisha, additional, Skelsey, Maral Kibarian, additional, Sladden, Chris, additional, Sladden, Michael, additional, Smith, Janellen, additional, Smucker, Joanne E., additional, Somani, Najwa, additional, Sommer, Lacy L., additional, Sommerlad, Mary, additional, Soon, Christine, additional, Sopkovich, Jennifer A., additional, Soter, Nicholas A., additional, Spencer, James M., additional, Staughton, Richard C.D., additional, Sterling, Jane C., additional, Sunderkötter, Cord, additional, Taibjee, Saleem M., additional, Tamura, Deborah, additional, Tan, Eunice, additional, Tang, William Y-M., additional, Taylor, Lynsey, additional, Thiers, Bruce H., additional, Thomas, Lucy J., additional, Thornton, Cody R., additional, Tobin, Anne-Marie, additional, Torgerson, Rochelle R., additional, Tosti, Antonella, additional, Tsatsou, Fragkiski, additional, Tsuji-Abe, Yukiko, additional, Tucker, William F.G., additional, Tyring, Stephen K., additional, Udkoff, Jeremy, additional, Unger, Robin H., additional, Unger, Walter P., additional, Utz, Sarah, additional, Valbuena, Martha C., additional, van de Kerkhof, Peter, additional, Van Voorhees, Abby S., additional, Vangipuram, Ramya, additional, Veitch, David, additional, Venning, Vanessa, additional, Versteeg, Sarah G., additional, Viera, Martha, additional, Vittorio, Carmela C., additional, Vleugels, Ruth Ann, additional, Wali, Gorav N., additional, Wallengren, Joanna, additional, Wan, Joy, additional, Wanat, Karolyn A., additional, Weichert, Gabriele, additional, Weidmann, Anja K., additional, Weinberg, Jeffrey M., additional, Werth, Victoria P., additional, White, Lucile E., additional, Wiener, Adam H., additional, Wilkin, Jonathan K., additional, Wilkin, Nathaniel K., additional, Williams, Jason, additional, Wilson, Niall, additional, Wiss, Karen, additional, Witkowski, Joseph A., additional, Wiznia, Lauren E., additional, Wong, Henry K., additional, Wong, Junie Li Chun, additional, Wright, Andrew L., additional, Wriston, Cooper C., additional, Wu, Benedict C., additional, Wulkan, Adam, additional, Zaenglein, Andrea L., additional, Zaki, Irshad, additional, Zeichner, Joshua A., additional, Zhu, Tian Hao, additional, Zone, John J., additional, Zouboulis, Christos C., additional, and Zuberbeir, Torstein, additional

Published
2018
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14. Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction

Author

Pereira, Manuel P, Zeidler, Claudia, Wallengren, Joanna, Halvorsen, Jon A, Weisshaar, Elke, Garcovich, Simone, Misery, Laurent, Brenaut, Emilie, Şavk, Ekin, Potekaev, Nikolay, Lvov, Andrey, Bobko, Svetlana, Szepietowski, Jacek C, Reich, Adam, Bozek, Agnieszka, Legat, Franz J, Metz, Martin, Streit, Marku, Serra-Baldrich, Esther, Gonçalo, Margarida, Storck, Michael, Nau, Teresa, Hoffmann, Vincent, Steinke, Sabine, Greiwe, Ina, Dugas, Martin, Augustin, Matthia, Ständer, Sonja, Garcovich, Simone (ORCID:0000-0001-8967-6688), Pereira, Manuel P, Zeidler, Claudia, Wallengren, Joanna, Halvorsen, Jon A, Weisshaar, Elke, Garcovich, Simone, Misery, Laurent, Brenaut, Emilie, Şavk, Ekin, Potekaev, Nikolay, Lvov, Andrey, Bobko, Svetlana, Szepietowski, Jacek C, Reich, Adam, Bozek, Agnieszka, Legat, Franz J, Metz, Martin, Streit, Marku, Serra-Baldrich, Esther, Gonçalo, Margarida, Storck, Michael, Nau, Teresa, Hoffmann, Vincent, Steinke, Sabine, Greiwe, Ina, Dugas, Martin, Augustin, Matthia, Ständer, Sonja, and Garcovich, Simone (ORCID:0000-0001-8967-6688)

Abstract

Chronic nodular prurigo is characterized by recalcitrant itch. Patient perspectives on therapeutic goals, satisfaction with therapy and efficacy of therapeutic regimens for this condition are unknown. This questionnaire study examined these issues in 406 patients with chronic nodular prurigo from 15 European dermatological centres. Improvements in itch, skin lesions and sleep were the most important goals. Emollients, topical corticosteroids and antihistamines were the most frequently used treatments, while a minority of patients were prescribed potent medications, such as systemic immunosuppressants and gabapentinoids. Most patients were not satisfied with their previous therapy (56.8%), while 9.8% did not receive any therapy despite having active disease. A substantial number of respondents (28.7%) considered none of the therapeutic options effective. Although chronic nodular prurigo is a severe disease, most patients were not treated with potent systemic drugs, which may contribute to the high levels of dissatisfaction and disbelief in available therapies. Specific guidelines for chronic nodular prurigo and the development of novel therapies are necessary to improve care.

Published
2020

21. European S2K Guidelines on chronic pruritus : in cooperation with the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV)

Author

Weisshaar, Elke, Szepietowski, Jacek C., Dalgard, Florence, Garcovich, Simone, Gieler, Uwe, Gimenez-Arnau, Ana, Lambert, Julien, Leslie, Tabi, Mettang, Thomas, Misery, Laurent, Savk, Ekin, Streit, Markus, Tschachler, Erwin, Wallengren, Joanna, and Staender, Sonja

Subjects
body regions, integumentary system, Human medicine, skin and connective tissue diseases
Abstract

Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Pruritus may be the result of a dermatological or non-dermatological disease. Especially in non-diseased skin it may be caused by systemic, neurological or psychiatric diseases, as well as being a side effect of medications. In a number of cases chronic pruritus may be of multifactorial origin. Pruritus needs a precise diagnostic work-up. Management of chronic pruritus comprises treatment of the underlying disease and topical treatment modalities, including symptomatic antipruritic treatment, ultraviolet phototherapy and systemic treatment. Treating chronic pruritus needs to be targeted, multimodal and performed in a step-wise procedure requiring an interdisciplinary approach. We present the updated and consensus based (S2k) European guideline on chronic pruritus by a team of European pruritus experts from different disciplines. This version is an updated version of the guideline that was published in 2012 and updated in 2014 (www. euroderm. org).

Published
2019

25. European S2k Guideline on Chronic Pruritus

Author

Weisshaar, Elke, Szepietowski, Jacek C., Dalgard, Florence, Garcovich, Simone, Gieler, Uwe, Giménez Arnau, Ana M, Lambert, Julien, Leslie, Tabi, Mettang, Thomas, Misery, Laurent, Şavk, Ekin, Streit, Markus, Tschachler, Erwin, Wallengren, Joanna, Ständer, Sonja, Universitat Autònoma de Barcelona. Departament de Medicina, Weisshaar, Elke, Szepietowski, Jacek C., Dalgard, Florence, Garcovich, Simone, Gieler, Uwe, Giménez Arnau, Ana M, Lambert, Julien, Leslie, Tabi, Mettang, Thomas, Misery, Laurent, Şavk, Ekin, Streit, Markus, Tschachler, Erwin, Wallengren, Joanna, Ständer, Sonja, and Universitat Autònoma de Barcelona. Departament de Medicina

Abstract

Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Pruritus may be the result of a dermatological or non-dermatological disease. Especially in non-diseased skin it may be caused by systemic, neurological or psychiatric diseases, as well as being a side effect of medications. In a number of cases chronic pruritus may be of multifactorial origin. Pruritus needs a precise diagnostic work-up. Management of chronic pruritus comprises treatment of the underlying disease and topical treatment modalities, including symptomatic antipruritic treatment, ultraviolet phototherapy and systemic treatment. Treating chronic pruritus needs to be targeted, multimodal and performed in a step-wise procedure requiring an interdisciplinary approach. We present the updated and consensus based (S2k) European guideline on chronic pruritus by a team of European pruritus experts from different disciplines. This version is an updated version of the guideline that was published in 2012 and updated in 2014 (www.euroderm.org).

Published
2019

26. Prurigo Simplex or "Itchy Red Bump" Disease: Review and Case Series.

Author

WALLENGREN, Joanna

Subjects
*PRURIGO, *ADULTS, *EOSINOPHILS, *METHOTREXATE, *AGE of onset
Abstract

Prurigo simplex or "itchy red bump" disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: "prurigo simplex", "prurigo simplex subacuta", "subacute prurigo", "chronic papular dermatitis in adults" and "itchy red bump disease". Medical charts of patients with prurigo diagnoses in a university setting were analysed. The literature search revealed 32 relevant studies (431 patients) on different aspects of the disease. Out of 50 patients with prurigo diagnoses, 5 patients (4 women, mean age at onset 54 years) matched the description in literature. Small, severely itchy papules without secondary skin lesions continued to appear for years (mean 5.6 years). Skin biopsies revealed lymphocytic perivascular infiltrates, few eosinophils and occasionally spongiosis. Treatment with long-term methotrexate or cyclosporine cleared the symptoms. Some major and minor diagnostic criteria for prurigo simplex are proposed and compared with chronic prurigo. [ABSTRACT FROM AUTHOR]

Published
2021
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34. List of Contributors

Author

Abdullah, Anthony, Abel, Mary Kathryn, Abudu, Boya, Abu-Hilal, Mohannad, Al Hammadi, Anwar, Al Awadhi, Ameen, Alexis, Andrew F., Aljefri, Khadija, Al-Kutubi, Huda, Almazan, Timothy H., Almohssen, Amer Ali, Alpsoy, Erkan, Ameen, Mahreen, Anderson, Bryan E., Anshelevich, Ellen, Bacik, Lindsay C., Baker, Donald J., Banach, David, Banfield, Cedric C., Baran, Robert, Barankin, Benjamin, Barkham, Melissa C., Bauer, Johann W., Begun, Zoe, Bell, Michael A., Benton, Emma, Bergfeld, Wilma F., Berman, Brian, Berth-Jones, John, Bhate, Chinmoy, Bhatia, Bhavnit K., Bilgiç, Asli, Bitterman, Avi, Black, Samantha, Blume, Jonathan E., Bohelay, Gérôme, Bordet, Nevianna, Brodell, Robert T., Brown, Marc D., Brownstone, Nicholas D., Burdick, Anne E., Butala, Niraj, Callen, Jeffrey P., Camacho, Ivan D., Camasmie, Helena, Caplivski, Daniel, Cappell, Mitchell S., Casey, Genevieve A., Caux, Frédéric, Chan, Cynthia X., Chan, Lawrence S., Chan, Loi-Yuen, Chan, Stephanie, Chao, Kevin Young, Chen, Jennifer K., Child, Fiona J., Choate, Keith, Chosidow, Olivier, Chousakos, Emmanouil, Chuh, Antonio A.T., Cices, Ahuva, Cobos, Gabriela A., Cohen, Steven R., Collier, Nicholas, Cooper, Elizabeth A., Coulson, Ian H., Cowen, Edward W., Craiglow, Brittany, Cruz, Ponciano D., Jr., Cummins, Donna, Cusack, Carrie Ann R., Daniel, Benjamin S., Daunton, Adam R.A., Davis, Mark D.P., Dawe, Robert S., D’Cruz, David P., de Berker, David, de Brito, Marianne, De Maeseneer, Hannelore, de Moll, Ellen H., Decker, Ashley, DeHoratius, Danielle M., Del Rosso, James Q., Desai, Seemal R., Dhawan, Gaurav K., DiGiovanna, John J., Dodiuk-Gad, Roni P., Duffy, Robert F., Dummer, Reinhard, Dunn, Annie, Duong, Tu-Anh, Dutz, Jan P., Eichenfield, Dawn Z., Eichenfield, Lawrence F., Eisen, Drore, Elman, Scott A., Elston, Dirk M., Elyoussfi, Sarah, Emanuel, Patrick O.M., Enos, Clinton W., Noliza Encarnacion, Maria Rosa, Epstein, Ervin H., Jr., Farberg, Aaron S., Farrugia, Michael E., Fassihi, Hiva, Fawaz, Bilal, Feigenbaum, Lawrence S., Felmingham, Claire, Femia, Alisa, Fenner, Justine, Ferguson, Felicity, Fett, Nicole, Finlay, Andrew Y., Firooz, Alireza, Firoz, Bahar F., Flischel, Amy E., Forrestel, Amy, Foley, Kelly A., Fourzali, Kayla, Frare, Cindy P., Freedman, Derek, Frey, Surina, Fried, Richard, Friedman, Adam J., Fuller, L. Claire, Gabel, Colleen, Gach, Joanna E., Ganesh, Jaya, Ganjoo, Shikhar, Gao, Jing Mia, Gaspari, Anthony A., Glaser, Katherine, Goenaga-Vázquez, Yamila, Goldberg, Leonard H., Goldfarb, Johanna, González Barreto, Reina M., Goon, Peter K.C., Gottlieb, Alice B., Gowda, Asha, Grada, Ayman A., Grande, Donald J., Grant, Matthew, Grattan, Clive E.H., Green, Justin J., Grimes, Pearl E., Gropper, Charles A., Grossberg, Anna L., Gupta, Aditya K., Guttman-Yassky, Emma, Guzman, Anthony K., Haddadi, Nazgol-Sadat, Hadi, Ali S., Hadi, Suhail M., Hagans, Iris A., Hairston, Bethany R., Halpern, Analisa Vincent, Halverstam, Caroline, Haque, Emily, Harries, Matthew, Harris, John E., Haw, William, Hazan, Ezra, Heaton, Henry, Hebert, Adelaide A., Helm, Matthew F., Helms, Stephen E., Hexsel, Camille L., Hexsel, Doris M., Heymann, Warren R., High, Whitney A., Hoffman, Melissa, Horenstein, Marcelo G., Hurst, Eva A., Hussain, Walayat, Ibbotson, Sally H., Ibrahim, Sherrif F., Inamadar, Arun C., Ingen-Housz-Oro, Saskia, Iorizzo, Matilde, Jacobe, Heidi, James, William D., Jemec, Gregor B.E., Jennings, Tara, Jibbe, Atieh S., Johnston, Graham A., Joly, Pascal, Joseph, Adrienne, Kanelleas, Antonios, Karadağ, Ayşe Serap, Katugampola, Ruwani P., Katz, Bruce E., Kavanagh, Gina M., Khan, Sidra S., Khattri, Saakshi, Khong, Brendan, Khorasani, Hooman, Kim, Ellen J., Kim, Hee J., Kim, Youn H., King, Brett, Kirby, Joslyn S., Kirby, Lisa, Kirsner, Robert S., Ko, Lauren, Koch, Dimitra, Koh, Wei-Liang, Koo, John Y.M., Kopp, Sandra A., Kouby, Floriane, Kovarik, Carrie, Kraemer, Kenneth H., Kreeshan, Firas C., Krishnamurthy, Karthik, Kroshinsky, Daniela, Krueger, Steven, Kvernebo, Knut, Laimer, Martin, Lalor, Leah, Lam, Charlene, Lambert, Peter C., Lang, Claudia, Lawlor, Frances, Lawrence, Naomi, Layher, Heather, Lebwohl, Mark G., Lebwohl, Oscar, Lee, Helen, Lehman, Julia S., Lemieux, Alexandre, Leslie, Tabi A., Leung, Alexander K.C., Levitt, Jacob O., Lewis, Daniel J., Lewis, Fiona M., Liaqat, Maryam, Ling, Tsui Chin, Litchman, Graham H., Liu, Stephanie, Luger, Thomas A., Luna, Paula C., Lupi, Omar, Lyon, Calum C., Maatouk, Ismael, MacGibeny, Margaret A., Maddukuri, Spandana, Mahmoud, Bassel H., Makkar, Timothy, Mallett, Richard B., Malta, Kiana, Manci, Rachel, Mancuso, Jennifer, Manders, Steven, Mann, Jasmine, Marghoob, Ashfaq A., Markova, Alina, Markowitz, Orit, Martinez, Daniela, Martinka, Michal, Maurer, Marcus, McGee, Jean S., McLarney, R. Matthew, Meah, Nekma, Metz, Martin, Micali, Giuseppe, Michalik, Daniel, Micheletti, Robert G., Mirowski, Ginat W., Mori, Shoko, Mørk, Cato, Morris, Caroline R., Morton, Colin A., Motaparthi, Kiran, Muldoon, Eavan G., Murase, Jenny E., Murdoch, Michele E., Murrell, Dedee F., Muthiah, Shareen, Myers, Bridget, Naeem, Zunaira, Nakamura, Mio, Nambi, Rabindranath, Nasca, Maria R., Navarrete-Dechent, Cristian, Needham, Glen R., Nehal, Kishwer, Newell, Glenn C., Nixon, Rosemary L., Noy, Mariana L., Nunns, David, Olbricht, Suzanne M., Oldenburg, Reid, Orekoya, Fikki, Osborne, Ruth A., Owen, Cindy E., Pandya, Amit G., Papaefthymiou, Vasileios, Paravar, Taraneh, Parish, Jennifer L., Parish, Lawrence Charles, Perz, Allison M., Peterson, Danielle, Phelps, Robert G., Philips, Rebecca C., Phillips, Tania J., Poh-Fitzpatrick, Maureen B., Polansky, Maxim, Pomeranz, Miriam Keltz, Pope, Elena, Privalle, Ashley N., Prost, Catherine, Que, Syril Keena T., Quint, Koen, Qureshi, Sumera, Rashid, Rabia S., Rashighi, Mehdi, Ratnavel, Ravi, Rawi, Sarah, Reddy, Vidhatha, Renzi, Michael A., Jr., Revuz, Jean, Richard, Gabriele, Rigel, Darrell S., Rivera, Sydney, Robles, Wanda S., Rodriguez, Ramiro, Jr., Rook, Alain H., Rosen, Ted, Rosenbach, Misha, Rowland, Emma, Rustin, Malcolm, Sadlier, Muriel, Salavastru, Carmen Maria, Samimi, Sara, Sandoval, Erika Romero, Sarkany, Robert P.E., Scerri, Lawrence, Schimmel, Joshua, Schmults, Chrysalyne D., Schnur, Rhonda E., Schoinas, Spyridon, Schwartz, Robert A., Scorer, Matthew J., Shah, Kalee, Shah, Nidhi, Shah, Radhika, Shah, Sheevam, Sharif, Jennifer, Shea, Christopher R., Shear, Neil H., Sheriff, Tabrez, Shields, Bridget E., Shimizu, Hiroshi, Shinkai, Kanade, Shiu, Jessica, Shivanna, Ragunatha, Shwayder, Tor, Silverberg, Nanette, Sinclair, Rodney, Singal, Archana, Smith, Janellen, Snyder, Margaret L., Sommer, Lacy L., Soter, Nicholas A., Stanger, Roselyn K., Stoll, Joseph R., Sun, Qisi, Sunderkötter, Cord, Swali, Ritu, Taibjee, Saleem M., Talasila, Sreya, Talebi-Liasi, Faezeh, Tamura, Deborah, Tan, Eunice, Y.-M. Tang, William, Thibodeaux, Quinn, Tian, Tina M., Tiplica, George Sorin, Tkachenko, Elizabeth, Tolkachjov, Stanislav N., Tolliver, Starling D., Tomecki, Kenneth, Torgerson, Rochelle R., Tosti, Antonella, Tsuji-Abe, Yukiko, Twaij, Sara, Tyring, Stephen K., van de Kerkhof, Peter, Van Gysel, Dirk, Van Voorhees, Abby S., Varma, Aakaash, Vasani, Resham, Verma, Shyam B., Vermeer, Maarten H., Vieira, Carlos, Vignes, Stéphane, Vleugels, Ruth Ann, Wallengren, Joanna, Wanat, Karolyn A., Wang, Erica B., Wei, Chapman, Weichert, Gabriele, Weigelt, Maximillian A., Weinberg, Jeffrey M., Weitzer, Danielle, Welponer, Tobias, Werth, Victoria P., White, Lucile E., Wilkin, Jonathan K., Wilson, Niall, Wiznia, Lauren E., Wollenberg, Andreas, Wollina, Uwe, Chun Wong, Junie Li, Wright, Andrew L., Wynne, Matthew, Yan, Daisy, Yosipovitch, Gil, Youssef, Molly J., Zaenglein, Andrea L., Zaki, Irshad, Zarbo, Allison, Zawar, Vijay, Zhu, Jane L., Zone, John J., and Zuberbier, Torsten

Published
2022
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36. Identification of core competencies for primary care of allergy patients using a modified Delphi technique

Author

Wallengren Joanna

Subjects
Special aspects of education, LC8-6691, Medicine
Abstract

Abstract Background The majority of allergy patients who seek medical advice are seen in primary care. In-service training of professionals in general practice is needed in order to increase knowledge among primary care clinicians about allergy. Therefore it is important to establish a consensus about what primary care professionals should be able to do, and what the public can expect. We sought to identify core competencies for good practice amongst primary care providers with respect to diagnosis and therapy of allergic diseases and to outline learning objectives for a postgraduate training programme in this field. Methods The study involved three rounds, involving a total of 43 expert panellists. In the first round, a panel was asked to indicate competencies (knowledge, diagnostics, therapy and communication) necessary for primary care providers. The second and third rounds were answered by primary care physicians (26) and nurses (10). A Likert scale 1-4 was applied in the second round and two choices ("agree"/"disagree") in the third round, with a criterion of 75% being adopted. Results The second round included 80 competencies and the third 50. The third round selected a consensus of 46 competencies defining nine learning outcomes for in-service medical training. Conclusions The competencies in the field of allergy recommended in this study may serve as a reference of what can be expected from primary care providers.

Published
2011
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38. Self-healing photo-neuropathy and cervical spinal arthrosis in four sisters with brachioradial pruritus

Author

Wallengren Joanna

Subjects
Orthopedic surgery, RD701-811, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four sisters suffering from brachioradial pruritus recurring every summer. The sisters spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervical radiographs indicated arthrosis. The density of sensory nerve fibers in the skin biopsies from the itchy skin of the arms, visualized by antibodies against a pan-neuronal marker, protein gene product 9.5, was reduced compared with biopsies from the same skin region during the symptom-free period in the winter. This data exemplifies that brachioradial pruritus is a self healing photoneuropathy occurring in middle aged adults predisposed by cervical arthrosis.

Published
2009
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42. European EADV network on assessment of severity and burden of Pruritus (PruNet):first meeting on outcome tools

Author

Ständer, S., Zeidler, C., Riepe, Carsten, Steinke-Lange, Verena, Fritz, Franziska, Bruland, P., Soto-Rey, I., Storck, M., Agner, T., Augustin, M, Blome, C, Dalgard, Florence J, Evers, Andrea W M, Garcovich, S., Goncalo, M., Lambert, Talley J, Legat, Franz J, Leslie, Toby, Misery, Laurent, Raap, Ulrike, Reich, Karl A, Şavk, E., Streit, M., Serra-Baldrich, E., Szepietowski, J.C., Wallengren, Joanna, Weisshaar, Elke, Dugas, Martin, Ständer, S., Zeidler, C., Riepe, Carsten, Steinke-Lange, Verena, Fritz, Franziska, Bruland, P., Soto-Rey, I., Storck, M., Agner, T., Augustin, M, Blome, C, Dalgard, Florence J, Evers, Andrea W M, Garcovich, S., Goncalo, M., Lambert, Talley J, Legat, Franz J, Leslie, Toby, Misery, Laurent, Raap, Ulrike, Reich, Karl A, Şavk, E., Streit, M., Serra-Baldrich, E., Szepietowski, J.C., Wallengren, Joanna, Weisshaar, Elke, and Dugas, Martin

Abstract

Background: Chronic pruritus is a frequently occurring symptom of various dermatoses that causes a high burden and impaired quality of life. An effective anti pruritic therapy is important for the patient, but its effectiveness is difficult to evaluate. Diverse methods and interpretations of pruritic metrics are utilized in clinical trials and the daily clinical practice in different countries, resulting in difficulties comparing collected data. Methods: We founded a European Network on Assessment of Severity and Burden of Pruritus (PruNet) that is supported by the EADV. PruNet consists of 28 experts from 15 EU countries (21 dermatologists, 5 medical informaticists, 2 psychologists) and aims to unify the assessment of itch in routine dermatological care. Following a preliminary survey, a consensus conference was held in order to agree upon the prioritization of patient-reported outcome tools. Results: Through utilizing the Delphi method, it was agreed that tools for measuring itch intensity (ex. the visual analogue scale) and quality of life (ex. ItchyQoL) are of primary importance and should urgently be foremost validated. Conclusion: The validation and harmonization of standards are needed for the improvement of quality care for patients suffering from pruritic dermatoses. This summer, the first validation studies in several EADV member countries already began.

Published
2016

44. European Guideline on Chronic Pruritus In cooperation with the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV)

Author

Weisshaar, Elke, Szepietowski, Jacek C., Darsow, Ulf, Misery, Laurent, Wallengren, Joanna, Mettang, Thomas, Gieler, Uwe, Lotti, Torello, Lambert, Julien, Maisel, Peter, Streit, Markus, Greaves, Malcolm W., Carmichael, Andrew, Tschachler, Erwin, Ring, Johannes, and Staenders, Sonja

Subjects
Dermatology and Venereal Diseases, ComputingMilieux_LEGALASPECTSOFCOMPUTING
Published
2012

45. Topical non-peptide antagonists of sensory neurotransmitters substance P and CGRP do not modify patch test and prick test reactions:a vehicle-controlled, double-blind pilot study

Author

Wallengren, Joanna, Edvinsson, Lars, Wallengren, Joanna, and Edvinsson, Lars

Abstract

Immunologic responses in the skin can be modulated by such neurotransmitters of sensory nerve fibers as substance P (SP) and calcitonin gene-related peptide (CGRP). The first-generation receptor antagonists were peptides with large molecules and had to be injected intracutaneously. The aim of this study was to examine the topical effects of non-peptide antagonists to substance P (aprepitant) and CGRP (telcagepant), respectively, on delayed and immediate reactions in the skin and on associated pruritus. A lipophilic formulation of aprepitant 5% and a hydrophilic formulation of telcagepant 1% were developed. Their effect on the skin barrier was measured in terms of transepidermal water loss (TEWL) while permeation was calculated using permeation coefficients. Patch tests in patients allergic to nickel and prick test reactions to histamine were used as models. None of the treatments increased TEWL, suggesting there to be no impairment of the skin barrier. Permeation coefficients indicated moderate permeation. Histamine prick tests induced a flare with a mean area of 662 + 275 mm(2) and a weal with a mean volume of 49 + 11 mm(3). These reactions as well as histamine-induced pruritus were not affected significantly by any of the treatments. Treatment with aprepitant and its vehicle alone resulted in a potentiating of the infiltration of nickel reactions compared with test reactions obtained after no treatment (1147 + 423 mm(3) and 1427 + 566 mm(3) vs 683 +202 mm(3)) (p = 0.03). Telcagepant induced vasoconstriction in the skin but did not change the infiltration of nickel reactions. None of the treatments influenced the nickel patch test induced pruritus. The data suggest that the topical application of non-peptide antagonists penetrates the skin but does not inhibit contact dermatitis or pruritus.

Published
2014

46. Cutaneous innervation before and after one treatment period of acupuncture

Author

Carlsson, Christer, Sundler, Frank, and Wallengren, Joanna

Subjects
Dermatology and Venereal Diseases
Abstract

BACKGROUND: The effect of acupuncture on nociceptive pain is well documented, but effects on nociceptive itch have been contradictory. OBJECTIVES: To evaluate possible effects of acupuncture on the occurrence, distribution and function of sensory nerve fibres in human skin. METHODS: Ten subjects were treated by inserting 10 acupuncture needles subcutaneously at the upper lateral aspect of one buttock. The subjects were recruited from an acupuncture clinic and were undergoing specific acupuncture treatment for their disorders. The needles were stimulated (rotated to and fro) twice during the twice-weekly 25-min sessions over 5 weeks. Skin biopsies, diameter 3 mm, were taken before and 3-6 days after local acupuncture. Antibodies to the pan-neuronal marker protein gene product 9.5 (PGP 9.5), calcitonin gene-related peptide (CGRP), vanilloid receptor 1 (VR1) and mu- and delta-opioid receptors were employed to study sensory unmyelinated nerve fibres that transmit nociceptive pain and itch. A histamine prick test using planimetry was used to record experimental itch after acupuncture on the treated area and on the corresponding control skin, and a visual analogue scale was used to evaluate itch. RESULTS: The mean +/- SEM number of CGRP-immunoreactive nerve fibres per biopsy section was reduced from 36.0 +/- 3.3 to 21.3 +/- 4.0 (P = 0.05) after the treatment. PGP 9.5-immunoreactive nerve fibres were found both in the epidermis and in the subpapillary dermis. The mean +/- SEM total number of PGP 9.5-immunoreactive nerve fibres decreased from 249.8 +/- 16.7 to 211.8 +/- 12.0 (P = 0.03). The PGP 9.5-immunoreactive nerve fibres occurring in the dermis appeared more fragmented after the acupuncture compared with pretreatment. VR1 immunoreactivity was found both in the free nerve fibres and in kite-like formations, possibly mast cells, throughout the dermis, sometimes occurring around hair follicles. The mean +/- SEM number of VR1-immunoreactive elements was not significantly influenced by acupuncture, at 33.5 +/- 4.6 vs. 43.0 +/- 4.4 (P = 0.09). No immunoreactivity was found in the skin against mu- and delta-opioid receptors with the antibodies used in this study. Neither histamine-induced itch nor cutaneous responses were influenced by acupuncture. CONCLUSIONS: The present data indicate an effect of acupuncture on neuropathic itch but not histamine-mediated itch. Our findings support the opinion that the pain-relieving effects of acupuncture partly depend on its effect on the peripheral innervation.

Published
2006

49. Identification of core competencies for primary care of allergy patients using a modified Delphi technique.

Author

Wallengren, Joanna and Wallengren, Joanna

Abstract

BACKGROUND: The majority of allergy patients who seek medical advice are seen in primary care. In-service training of professionals in general practice is needed in order to increase knowledge among primary care clinicians about allergy. Therefore it is important to establish a consensus about what primary care professionals should be able to do, and what the public can expect. We sought to identify core competencies for good practice amongst primary care providers with respect to diagnosis and therapy of allergic diseases and to outline learning objectives for a postgraduate training programme in this field. METHODS: The study involved three rounds, involving a total of 43 expert panellists. In the first round, a panel was asked to indicate competencies (knowledge, diagnostics, therapy and communication) necessary for primary care providers. The second and third rounds were answered by primary care physicians (26) and nurses (10). A Likert scale 1-4 was applied in the second round and two choices ("agree"/"disagree") in the third round, with a criterion of 75% being adopted. RESULTS: The second round included 80 competencies and the third 50. The third round selected a consensus of 46 competencies defining nine learning outcomes for in-service medical training. CONCLUSIONS: The competencies in the field of allergy recommended in this study may serve as a reference of what can be expected from primary care providers.

Published
2011

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