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1. SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

Author

Choy, Cecily, Chen, Joseph, Li, Jiangyuan, Gallagher, D. Travis, Lu, Jian, Wu, Daichao, Zou, Ainslee, Hemani, Humza, Baptiste, Beverly A., Wichmann, Emily, Yang, Qian, Ciffelo, Jeffrey, Yin, Rui, McKelvy, Julia, Melvin, Denise, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Chia, Chee W., Fan, Jinshui, Ruffolo, Jeannie, Zukley, Linda, Shi, Guixin, Amano, Tomokazu, An, Yang, Meirelles, Osorio, Wu, Wells W., Chou, Chao-Kai, Shen, Rong-Fong, Willis, Richard A., Ko, Minoru S. H., Liu, Yu-Tsueng, De, Supriyo, Pierce, Brian G., Ferrucci, Luigi, Egan, Josephine, Mariuzza, Roy, and Weng, Nan-Ping

Published
2023
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3. DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity

Author

Roy, Roshni, Ramamoorthy, Senthilkumar, Shapiro, Benjamin D., Kaileh, Mary, Hernandez, Dena, Sarantopoulou, Dimitra, Arepalli, Sampath, Boller, Sören, Singh, Amit, Bektas, Arsun, Kim, Jaekwan, Moore, Ann Zenobia, Tanaka, Toshiko, McKelvey, Julia, Zukley, Linda, Nguyen, Cuong, Wallace, Tonya, Dunn, Christopher, Wersto, Robert, Wood, William, Piao, Yulan, Becker, Kevin G., Coletta, Christopher, De, Supriyo, Sen, Jyoti Misra, Battle, Alexis, Weng, Nan-ping, Grosschedl, Rudolf, Ferrucci, Luigi, and Sen, Ranjan

Published
2021
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4. Epigenetic signature of human immune aging in the GESTALT study

Author

Roy, Roshni, primary, Kuo, Pei-Lun, additional, Candia, Julián, additional, Sarantopoulou, Dimitra, additional, Ubaida-Mohien, Ceereena, additional, Hernandez, Dena, additional, Kaileh, Mary, additional, Arepalli, Sampath, additional, Singh, Amit, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, Moore, Ann Z, additional, Tanaka, Toshiko, additional, McKelvey, Julia, additional, Zukley, Linda, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Dunn, Christopher, additional, Wood, William, additional, Piao, Yulan, additional, Coletta, Christopher, additional, De, Supriyo, additional, Sen, Jyoti, additional, Weng, Nan-ping, additional, Sen, Ranjan, additional, and Ferrucci, Luigi, additional

Published
2023
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5. Microglial Nogo delays recovery following traumatic brain injury in mice

Author

Glotfelty, Elliot J., primary, Hsueh, Shih‐Chang, additional, Claybourne, Quia, additional, Bedolla, Alicia, additional, Kopp, Katherine O., additional, Wallace, Tonya, additional, Zheng, Binhai, additional, Luo, Yu, additional, Karlsson, Tobias E., additional, McDevitt, Ross A., additional, Olson, Lars, additional, and Greig, Nigel H., additional

Published
2023
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6. Author response: Epigenetic signature of human immune aging in the GESTALT study

Author

Roy, Roshni, primary, Kuo, Pei-Lun, additional, Candia, Julián, additional, Sarantopoulou, Dimitra, additional, Ubaida-Mohien, Ceereena, additional, Hernandez, Dena, additional, Kaileh, Mary, additional, Arepalli, Sampath, additional, Singh, Amit, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, Moore, Ann Z, additional, Tanaka, Toshiko, additional, McKelvey, Julia, additional, Zukley, Linda, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Dunn, Christopher, additional, Wood, William, additional, Piao, Yulan, additional, Coletta, Christopher, additional, De, Supriyo, additional, Sen, Jyoti, additional, Weng, Nan-ping, additional, Sen, Ranjan, additional, and Ferrucci, Luigi, additional

Published
2023
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7. Characterization of CD8 +T cells recognizing a dominant epitope of SARS-CoV-2 spike protein in COVID-19 convalescent, vaccinated, and unexposed individuals

Author

Zou, Ainslee J, primary, Li, Jiangyuan, additional, Choy, Cecily, additional, Chen, Joseph, additional, Hemani, Humza, additional, Baptiste, Beverly, additional, McKelvey, Julia, additional, Melvin, Denise, additional, Ruffolo, Jeannie, additional, Zukley, Linda, additional, Wallace, Tonya, additional, Dunn, Christopher, additional, Nguyen, Cuong, additional, Fan, Jinshui, additional, De, Supriyo, additional, Chia, Chee, additional, Ferrucci, Luigi, additional, Egan, Josephine, additional, and Weng, Nan-ping, additional

Published
2023
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8. Deciphering molecular and functional codes of human memory lymphocytes

Author

Singh, Amit K, primary, Roy, Roshni, additional, Kaileh, Mary, additional, Sarantopoulou, Dimitra, additional, Hernandez, Dena, additional, Arepalli, Sampath, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, McKelevy, Julia, additional, Zukley, Linda, additional, Dunn, Christopher, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Wood, William, additional, Piao, Yulan, additional, De, Supriyo K, additional, Sen, Jyoti Misra, additional, Weng, Nan-ping, additional, Ferrucci, Luigi, additional, and Sen, Ranjan, additional

Published
2023
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9. Epigenetic signature of human immune aging: the GESTALT study

Author

Roy, Roshni, primary, Kuo, Pei-Lun, additional, Candia, Julián, additional, Sarantopoulou, Dimitra, additional, Ubaida-Mohien, Ceereena, additional, Hernandez, Dena, additional, Kaileh, Mary, additional, Arepalli, Sampath, additional, Singh, Amit, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, Moore, Ann Zenobia, additional, Tanaka, Toshiko, additional, McKelvey, Julia, additional, Zukley, Linda, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Dunn, Christopher, additional, Wood, William, additional, Piao, Yulan, additional, Coletta, Christopher, additional, De, Supriyo, additional, Sen, Jyoti Misra, additional, Weng, Nan-ping, additional, Sen, Ranjan, additional, and Ferrucci, Luigi, additional

Published
2023
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10. SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors.

Author

Choy, Cecily, Chen, Joseph, Li, Jiangyuan, Gallagher, D. Travis, Lu, Jian, Wu, Daichao, Zou, Ainslee, Hemani, Humza, Baptiste, Beverly A., Wichmann, Emily, Yang, Qian, Ciffelo, Jeffrey, Yin, Rui, McKelvy, Julia, Melvin, Denise, Wallace, Tonya, Dunn, Christopher, Nguyen, Cuong, Chia, Chee W., and Fan, Jinshui

Subjects
T cells, T cell receptors, SARS-CoV-2, PEPTIDES, CELLULAR immunity
Abstract

The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-CoV-2 before and after infection remains incomplete. Here, we analyzed CD8+ T cells recognizing six epitopes from the SARS-CoV-2 nucleocapsid (N) protein and found that SARS-CoV-2 infection slightly increased the frequencies of N-recognizing CD8+ T cells but significantly enhanced activation-induced proliferation compared to that of the uninfected donors. The frequencies of N-specific CD8+ T cells and their proliferative response to stimulation did not decrease over one year. We identified the N222-230 peptide (LLLDRLNQL, referred to as LLL thereafter) as a dominant epitope that elicited the greatest proliferative response from both convalescent and uninfected donors. Single-cell sequencing of T cell receptors (TCR) from LLL-specific CD8+ T cells revealed highly restricted Vα gene usage (TRAV12-2) with limited CDR3α motifs, supported by structural characterization of the TCR–LLL–HLA-A2 complex. Lastly, transcriptome analysis of LLL-specific CD8+ T cells from donors who had expansion (expanders) or no expansion (non-expanders) after in vitro stimulation identified increased chromatin modification and innate immune functions of CD8+ T cells in non-expanders. These results suggests that SARS-CoV-2 infection induces LLL-specific CD8+ T cell responses with a restricted TCR repertoire. Although SARS-CoV2 epitope characterization has been the focus of extensive research, these efforts have largely focused on the spike protein. Here, the authors demonstrate that CD8+ T cell responses can be directed against a dominant nucleocapsid epitope and rely on a highly focused T cell receptor repertoire. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

Author

Krasniewski, Linda K, primary, Chakraborty, Papiya, additional, Cui, Chang-Yi, additional, Mazan-Mamczarz, Krystyna, additional, Dunn, Christopher, additional, Piao, Yulan, additional, Fan, Jinshui, additional, Shi, Changyou, additional, Wallace, Tonya, additional, Nguyen, Cuong, additional, Rathbun, Isabelle A, additional, Munk, Rachel, additional, Tsitsipatis, Dimitrios, additional, De, Supriyo, additional, Sen, Payel, additional, Ferrucci, Luigi, additional, and Gorospe, Myriam, additional

Published
2022
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12. Author response: Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

Author

Krasniewski, Linda K, primary, Chakraborty, Papiya, additional, Cui, Chang-Yi, additional, Mazan-Mamczarz, Krystyna, additional, Dunn, Christopher, additional, Piao, Yulan, additional, Fan, Jinshui, additional, Shi, Changyou, additional, Wallace, Tonya, additional, Nguyen, Cuong, additional, Rathbun, Isabelle A, additional, Munk, Rachel, additional, Tsitsipatis, Dimitrios, additional, De, Supriyo, additional, Sen, Payel, additional, Ferrucci, Luigi, additional, and Gorospe, Myriam, additional

Published
2022
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13. DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity

Author

Roy, Roshni, primary, Ramamoorthy, Senthilkumar, additional, Shapiro, Benjamin D., additional, Kaileh, Mary, additional, Hernandez, Dena, additional, Sarantopoulou, Dimitra, additional, Arepalli, Sampath, additional, Boller, Sö ren, additional, Singh, Amit, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, Moore, Ann Zenobia, additional, Tanaka, Toshiko, additional, McKelvey, Julia, additional, Zukley, Linda, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Dunn, Christopher, additional, Wersto, Robert, additional, Wood, William, additional, Piao, Yulan, additional, Becker, Kevin G., additional, Coletta, Christopher, additional, De, Supriyo, additional, Sen, Jyoti Misra, additional, Battle, Alexis, additional, Weng, Nan-ping, additional, Grosschedl, Rudolf, additional, Ferrucci, Luigi, additional, and Sen, Ranjan, additional

Published
2022
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14. Unique and shared molecular features of human B and T lymphocyte memory differentiation

Author

Singh, Amit K, primary, Roy, Roshni, additional, Kaileh, Mary, additional, Sarantopoulou, Dimitra, additional, Hernandez, Dena, additional, Arepalli, Sampath, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, McKelevy, Julia, additional, Zukely, Linda, additional, Dunn, Christopher, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Wood, William, additional, Piao, Yulan, additional, De, Supriyo, additional, Sen, Jyoti Misra, additional, Weng, Nan-ping, additional, Ferrucci, Luigi, additional, and Sen, Ranjan, additional

Published
2022
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15. Characterization of SARS-CoV-2-specific CD8+ T cells in COVID-19 convalescent, vaccinated, and individuals with respect to age

Author

Choy, Cecily, primary, Lu, Jian, additional, Li, Jiangyuan, additional, Hemani, Humza, additional, Chen, Joseph, additional, Lustig, Ana, additional, McKelvey, Julia, additional, Melvin, Denise, additional, Ruffolo, Jeannie, additional, Zukley, Linda, additional, Wallace, Tonya, additional, Dunn, Christopher, additional, Nguyen, Cuong, additional, Fan, Jinshui, additional, De, Supriyo, additional, Chia, Chee, additional, Ferrucci, Luigi, additional, Egan, Josephine, additional, and Weng, Nan-ping, additional

Published
2022
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16. Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

Author

Krasniewski, Linda K., primary, Chakraborty, Papiya, additional, Cui, Chang-Yi, additional, Mazan-Mamczarz, Krystyna, additional, Dunn, Christopher, additional, Piao, Yulan, additional, Fan, Jinshui, additional, Shi, Changyou, additional, Wallace, Tonya, additional, Nguyen, Cuong, additional, Rathbun, Isabelle A., additional, Munk, Rachel, additional, Tsitsipatis, Dimitrios, additional, De, Supriyo, additional, Sen, Payel, additional, Ferrucci, Luigi, additional, and M Gorospe, Myriam, additional

Published
2022
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17. Additional file 1 of Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults

Author

Lu, Jian, Chen, Guobing, Sorokina, Arina, Nguyen, Thomas, Wallace, Tonya, Nguyen, Cuong, Dunn, Christopher, Wang, Stephanie, Ellis, Samantha, Shi, Guixin, McKelvey, Julia, Sharov, Alexei, Liu, Yu-Tsueng, Schneck, Jonathan, and Weng, Nan-ping

Abstract

Additional file 1: Supplementary Figure 1. Expression of different markers inantigen-specific CD8+ cells. Supplementary Figure 2. Percentageof CD28+ antigen-specific TN, TCM and totalCD8+ Tcells. Supplementary Figure 3. ERK1/2 phosphorylation in sorted IAV+and CMV+ TCM cells. Supplementary Figure 4. CD70 expression in Jurkat cells and CD27-CD70 signaling.

Published
2022
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18. Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults.

Author

Lu, Jian, Chen, Guobing, Sorokina, Arina, Nguyen, Thomas, Wallace, Tonya, Nguyen, Cuong, Dunn, Christopher, Wang, Stephanie, Ellis, Samantha, Shi, Guixin, McKelvey, Julia, Sharov, Alexei, Liu, Yu-Tsueng, Schneck, Jonathan, and Weng, Nan-ping

Subjects
IMMUNOLOGIC memory, CYTOMEGALOVIRUS diseases, MIDDLE-aged persons, T cells, OLDER people, AUTOBIOGRAPHICAL memory
Abstract

Background: Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8+ T cells in CMV infected healthy young and middle-aged adults has not been fully characterized. Results: We compared CD8+ T cells specific for a CMV epitope (pp65495-503, NLV) and an influenza A virus (IAV) epitope (M158-66, GIL) from the same young and middle-aged healthy adults with serum positive for anti-CMV IgG. Compared to the IAV-specific CD8+ T cells, CMV-specific CD8+ T cells contained more differentiated effector memory (TEM and TEMRA) cells. Isolated CMV-specific central memory (TCM) but not naïve (TN) cells had a significant reduced activation-induced expansion in vitro compared to their IAV-specific counterparts. Furthermore, we found that CD70 expression was reduced in CMV-specific CD28+CD8+ TCM and that CD70+ TCM had better expansion in vitro than did CD70- TCM. Mechanistically, we showed that CD70 directly enhanced MAPK phosphorylation and CMV-specific CD8+ TCM cells had a reduced MAPK signaling upon activation. Lastly, we showed that age did not exacerbate reduced CD70 expression in CMV- specific CD8+ TCM cells. Conclusion: Our findings showed that CMV infection causes mild expansion of CMV-NLV-specific CD8+ T cells, reduced CD70 expression and signaling, and proliferation of CMV-NLV-specific CD8+ TCM cells in young and middle-aged healthy adults and revealed an age-independent and CMV infection-specific impact on CD8+ memory T cells. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Cell-specific transcriptional signature of human immune cells in GESTALT

Author

Kaila, Mary, primary, Shapiro, Benj, additional, Dunn, Christopher, additional, Singh, Amit, additional, Bektas, Arsun, additional, Kim, Jaekwan, additional, Piao, Yulan, additional, Wood, William, additional, Nguyen, Cuong, additional, Wallace, Tonya, additional, Mckelvey, Julia, additional, Zukley, Linda, additional, Battle, Alexis, additional, De, Supriyo, additional, Weng, Nan-Ping, additional, and Sen, Ranjan, additional

Published
2020
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21. Examining the Relationship Between Beliefs and Perceived Experiences During Assistant Principal Preparation for the Role of Principal

Author

Wallace, Tonya Holcomb and Wallace, Tonya Holcomb

Abstract

Principals have been expected to serve as managers and leaders of curriculum and instruction while facing intense accountability and had to be good communicators capable of building relationships within their school and with community stakeholders. School complexity increased challenges leaders faced, so educational leaders utilized research-based strategies to develop professional resilience and grow in the face of adversity. In preparation for school principalship, assistant principals needed to move beyond school operation and management roles to become a viable candidate for career advancement. Limited research exists describing the preparation of assistant principals for advancement. The purpose of this convergent mixed methods research study was to examine the relationship between beliefs and perceived experiences during assistant principalship and readiness to assume the role of principal. The 33 participants in this study were public school principals currently employed in a school district in Middle Georgia. The three data sources in this study included a Demographic Survey, Principal Readiness Inventory, and Qualitative Questionnaire, which were combined into one online measure for data collection purposes. A stepwise multiple regression analysis was conducted using the quantitative data, and a thematic analysis was utilized to analyze the qualitative data by principal readiness group. According to the data collected, participants reported higher levels of mentoring prior to the initial educational leadership certification compared to the level of mentoring after the initial educational leadership certification. This information could be useful in developing effective leadership development programs that would help assistant principals make a transition into the principalship role.

Published
2019

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