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2. Global and regional epidemiology of HIV-1 recombinants in 1990–2015: a systematic review and global survey

Author

Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buvé, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Hervé, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Kirtley, Shona, Gouws-Williams, Eleanor, and Ghys, Peter D

Published
2020
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3. Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

Author

Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buve, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Herve, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano Kaleebu, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Fleminger, Isabella, Kirtley, Shona, Williams, Brian, Gouws-Williams, Eleanor, and Ghys, Peter D

Published
2019
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5. Human retrovirus infection in the West of Scotland

Author

Wallace, Lesley A.

Subjects
616.9
Abstract

Cases of AIDS have been reported in the U.S.A. since 1981 and its aetiological agent, human immunodeficiency virus type 1, HIV-1, has been spreading in the population for longer. A testing system was established at the hepatitis Reference Laboratory, HRL, to identify those infected in the Glasgow and West of Scotland population. The performance of commercial screening tests was examined using sera locally available at the HRL. Confirmation of reactivity was confirmed by western blot analysis; other methods of confirmation were examined. The criteria of positivity on a western blot were established from observation of the antibody response in seroconversion and weakly reactive samples compared to false reactive or indeterminate samples. In this way genuine HIV-1 infection could be reliably diagnosed.

Published
1991

6. Epidemiology of SARS-CoV-2 during the first three waves in Scotland: a national record linkage study

Author

Leslie, Kirstin, primary, Findlay, Beth, additional, Ryan, Theresa, additional, Green, Leonardo I, additional, Harvey, Ciaran, additional, Whettlock, Alice E, additional, Bishop, Jen, additional, Ponce Hardy, Vicki, additional, Went, April, additional, Wallace, Lesley, additional, McLeod, Allan, additional, Weir, Amanda, additional, and Marsh, Kimberly, additional

Published
2022
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8. I-MOVE-COVID-19 European hospital surveillance: Sixth surveillance bulletin

Author

Mutch, Heather, Sadiq, Fatima, Hamilton, Mark, Harvey, Ciaran, Young, Johanna, McMahon, James, Mokogwu, Damilola, Wallace, Lesley, Ladbury, Georgia, Evans, Josie, Rose, Angela MC, and Murray, Josie

Abstract

This sixth surveillance report summarises the information from the I-MOVE-COVID-19 hospital surveillance networks to monitor the COVID-19 pandemic in nine European countries.

Published
2022
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10. Establishing a novel European hospital surveillance platform in response to a newly emerging infection lessons from the I-MOVE-COVID-19 hospital network

Author

Ladbury, Georgia, Hamilton, Mark, Harvey, Ciaran, Mutch, Heather, McMahon, James, Mokogwu, Damilola, Sadiq, Fatima, Young, Johanna, Wallace, Lesley, Murray, Josie, Lopez‑Bernal, Jamie, Andrews, Nick, Castilla, Jesús, Casado, Itziar, Larrauri, Amparo, Mazagatos, Clara, Duval, Xavier, Bino, Silvia, Demuyser, Thomas, Machado, Ausenda, Mickiene, Aukse, Lazar, Mihaela, Stavaru, Crina, Rath, Barbara, Harrabi, Myriam, Rekacewicz, Claire, Kapisyszi, Perlat, Seyler, Lucie, Gómez, Verónica, Jancoriene, Ligita, and Rose, Angela

Subjects
Infecções Respiratórias, Surveillance, SARS-CoV-2, COVID-19, Determinantes da Saúde e da Doença, Hospital Admission, I-MOVE-COVID-19
Abstract

Background: The first signal of a new infection is often severe cases presenting at hospital. Enhanced surveillance of these cases is critical to learning more about disease epidemiology and patient outcomes, but nationallevel surveillance can lack power to draw conclusions. In response to the emergence of SARS-CoV-2, the Influenza-Monitoring Vaccine Effectiveness (I-MOVE) network, founded in 2007, expanded to establish the I-MOVE-COVID-19 Consortium in February 2020. The Consortium’s surveillance objectives included using pooled data to describe clinical and epidemiological characteristics of hospitalised COVID-19 patients across Europe, in order to contribute to the knowledge base, guide patient management, and inform public health response. Methods: Eleven study sites participated in the surveillance, including 23 hospitals across six EU Member States and Albania, and hospitals nationally in England and Scotland. A standardised protocol and dataset for collection was agreed by April 2020. In England and Scotland, data were generated by linkage of routine datasets; other sites used bespoke paper or electronic questionnaires. Data were submitted, pooled and analysed quarterly. Results: Data were received regarding 84,297 COVID-19 patients hospitalised between 1 February 2020 and 31 January 2021. Three surveillance bulletins were published between September 2020 and March 2021, providing key insights into severe COVID-19 at European level. However, the unexpected, overwhelming workload at participating sites, and difficulties securing data protection and ethics permissions, delayed data submissions and presented challenges for timely analysis. Conclusions: Building on an existing network facilitated a novel European multicentre hospital surveillance system to be implemented during a pandemic; however, timeliness was nonetheless problematic. In future, processes could be streamlined e.g. by developing pre-approved template protocols with information governance and ethical approvals in place during the inter- pandemic period. The I-MOVE-COVID-19 network has received funding from the European Commission (from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 101003673). N/A

Published
2021

11. MOVE-COVID-19 European hospital surveillance: Fifth surveillance bulletin

Author

Mokogwu, Damilola, Hamilton, Mark, Mutch, Heather, Harvey, Ciaran, Rose, Angela MC, Young, Johanna, Wallace, Lesley, Sadiq, Fatima, Ladbury, Georgia, and Murray, Josie

Abstract

This fifth surveillance report summarises the information from the I-MOVE-COVID-19 hospital surveillance networks to monitor the COVID-19 pandemic in nine European countries.

Published
2021
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12. Epidemiology of SARS- CoV-2 during the first three waves in Scotland: a national record linkage study.

Author

Leslie, Kirstin, Findlay, Beth, Ryan, Theresa, Green, Leonardo I., Harvey, Ciaran, Whettlock, Alice E., Bishop, Jen, Hardy, Vicki Ponce, Went, April, Wallace, Lesley, McLeod, Allan, Weir, Amanda, and Marsh, Kimberly

Subjects
PUBLIC health, SOCIAL isolation, DESCRIPTIVE statistics, POLYMERASE chain reaction, DATA analysis software, COVID-19 pandemic, DISEASE management
Published
2023
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16. Australia's first prime ministerial library: past and future

Author

Carman-Brown, Lesley, Henderson, Kandy-Jane, and Wallace, Lesley

Subjects
Prime ministers -- Records and correspondence, Governmental libraries, Library and information science
Abstract

In creating Australia's first prime ministerial library, a new cultural institution was developed which blends professional practice from the fields of librarianship, education, archives, journalism and museums. The John Curtin Prime Ministerial Library honours the contribution of wartime prime minister John Curtin, works towards the advancement of knowledge and the enrichment of culture, and provides a gateway for the community to learn about its past in order to build a better future. It aims to fulfil this purpose by, developing a unique research collection and a varied outreach program for the educational sector and general community., When the Western Australian Institute of Technology became Curtin University of Technology in 1987, there was a strong feeling that the new university needed 'a heart'. What better way to [...]

Published
2005

17. Lymphogranuloma venereum diagnoses among men who have sex with men in the UK: interpreting a cross-sectional study using an epidemic phase-specific framework

Author

Hughes, Gwenda, Alexander, Sarah, Simms, Ian, Conti, Stefano, Ward, Helen, Powers, Cassandra, Ison, Catherine, Evans, Barry, Fenton, Kevin, Jebbari, Heather, French, Patrick, Dean, Gillian, Parkhouse, Andy, Warwick, Zoe, Reeves, Iain, Sullivan, Anne, Pallawela, Sanjeeva, Seaton, Gary, Hardie, James, Annan, Naa Torshie, Irvine, Neil, White, John, Macdonald, Neil, Eastick, Kirstine, Winter, Andy, Wallace, Lesley, Thomas, Daniel Rh, Northey, Gemma, Macmillan, Alexander, Clutterbuck, Dan, Tunstall, Ben, Thompson, Marc, Watson, Rod, Maguire, Helen, Crook, Paul, Forde, Josh, and Hickey, Lorraine

Published
2013
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20. Global and regional epidemiology of HIV-1 recombinants in 1990–2015: a systematic review and global survey

Author

Hemelaar, Joris, primary, Elangovan, Ramyiadarsini, additional, Yun, Jason, additional, Dickson-Tetteh, Leslie, additional, Kirtley, Shona, additional, Gouws-Williams, Eleanor, additional, Ghys, Peter D, additional, Abimiku, Alash'le G, additional, Agwale, Simon, additional, Archibald, Chris, additional, Avidor, Boaz, additional, Barbás, María Gabriela, additional, Barre-Sinoussi, Francoise, additional, Barugahare, Banson, additional, Belabbes, El Hadj, additional, Bertagnolio, Silvia, additional, Birx, Deborah, additional, Bobkov, Aleksei F, additional, Brandful, James, additional, Bredell, Helba, additional, Brennan, Catherine A, additional, Brooks, James, additional, Bruckova, Marie, additional, Buonaguro, Luigi, additional, Buonaguro, Franco, additional, Buttò, Stefano, additional, Buvé, Anne, additional, Campbell, Mary, additional, Carr, Jean, additional, Carrera, Alex, additional, Carrillo, Manuel Gómez, additional, Celum, Connie, additional, Chaplin, Beth, additional, Charles, Macarthur, additional, Chatzidimitriou, Dimitrios, additional, Chen, Zhiwei, additional, Chijiwa, Katsumi, additional, Cooper, David, additional, Cunningham, Philip, additional, Dagnra, Anoumou, additional, de Gascun, Cillian F, additional, Del Amo, Julia, additional, Delgado, Elena, additional, Dietrich, Ursula, additional, Dwyer, Dominic, additional, Ellenberger, Dennis, additional, Ensoli, Barbara, additional, Essex, Max, additional, Gao, Feng, additional, Fleury, Hervé, additional, Fonjungo, Peter N, additional, Foulongne, Vincent, additional, Gadkari, Deepak A, additional, García, Federico, additional, Garsia, Roger, additional, Gershy-Damet, Guy Michel, additional, Glynn, Judith R, additional, Goodall, Ruth, additional, Grossman, Zehava, additional, Lindenmeyer-Guimarães, Monick, additional, Hahn, Beatrice, additional, Hamers, Raph L, additional, Hamouda, Osamah, additional, Handema, Ray, additional, He, Xiang, additional, Herbeck, Joshua, additional, Ho, David D, additional, Holguin, Africa, additional, Hosseinipour, Mina, additional, Hunt, Gillian, additional, Ito, Masahiko, additional, Bel Hadj Kacem, Mohamed Ali, additional, Kahle, Erin, additional, Kaleebu, Pontiano, additional, Kalish, Marcia, additional, Kamarulzaman, Adeeba, additional, Kang, Chun, additional, Kanki, Phyllis, additional, Karamov, Edward, additional, Karasi, Jean-Claude, additional, Kayitenkore, Kayitesi, additional, Kelleher, Tony, additional, Kitayaporn, Dwip, additional, Kostrikis, Leondios G, additional, Kucherer, Claudia, additional, Lara, Claudia, additional, Leitner, Thomas, additional, Liitsola, Kirsi, additional, Lingappa, Jai, additional, Linka, Marek, additional, Lorenzana de Rivera, Ivette, additional, Lukashov, Vladimir, additional, Maayan, Shlomo, additional, Mayr, Luzia, additional, McCutchan, Francine, additional, Meda, Nicolas, additional, Menu, Elisabeth, additional, Mhalu, Fred, additional, Mloka, Doreen, additional, Mokili, John L, additional, Montes, Brigitte, additional, Mor, Orna, additional, Morgado, Mariza, additional, Mosha, Fausta, additional, Moussi, Awatef, additional, Mullins, James, additional, Najera, Rafael, additional, Nasr, Mejda, additional, Ndembi, Nicaise, additional, Neilson, Joel R, additional, Nerurkar, Vivek R, additional, Neuhann, Florian, additional, Nolte, Claudine, additional, Novitsky, Vlad, additional, Nyambi, Philippe, additional, Ofner, Marianna, additional, Paladin, Fem J, additional, Papa, Anna, additional, Pape, Jean, additional, Parkin, Neil, additional, Parry, Chris, additional, Peeters, Martine, additional, Pelletier, Alexandra, additional, Pérez-Álvarez, Lucía, additional, Pillay, Deenan, additional, Pinto, Angie, additional, Quang, Trinh Duy, additional, Rademeyer, Cecilia, additional, Raikanikoda, Filimone, additional, Rayfield, Mark A, additional, Reynes, Jean-Marc, additional, Rinke de Wit, Tobias, additional, Robbins, Kenneth E, additional, Rolland, Morgane, additional, Rousseau, Christine, additional, Salazar-Gonzales, Jesus, additional, Salem, Hanan, additional, Salminen, Mika, additional, Salomon, Horacio, additional, Sandstrom, Paul, additional, Santiago, Mario L, additional, Sarr, Abdoulaye D, additional, Schroeder, Bryan, additional, Segondy, Michel, additional, Selhorst, Philippe, additional, Sempala, Sylvester, additional, Servais, Jean, additional, Shaik, Ansari, additional, Shao, Yiming, additional, Slim, Amine, additional, Soares, Marcelo A, additional, Songok, Elijah, additional, Stewart, Debbie, additional, Stokes, Julie, additional, Subbarao, Shambavi, additional, Sutthent, Ruengpung, additional, Takehisa, Jun, additional, Tanuri, Amilcar, additional, Tee, Kok Keng, additional, Thapa, Kiran, additional, Thomson, Michael, additional, Tran, Tyna, additional, Urassa, Willy, additional, Ushijima, Hiroshi, additional, van de Perre, Philippe, additional, van der Groen, Guido, additional, van Laethem, Kristel, additional, van Oosterhout, Joep, additional, van Sighem, Ard, additional, van Wijngaerden, Eric, additional, Vandamme, Anne-Mieke, additional, Vercauteren, Jurgen, additional, Vidal, Nicole, additional, Wallace, Lesley, additional, Williamson, Carolyn, additional, Wolday, Dawit, additional, Xu, Jianqing, additional, Yang, Chunfu, additional, Zhang, Linqi, additional, and Zhang, Rong, additional

Published
2020
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21. Investigating the decline in Lymphogranuloma venereum diagnoses in men who have sex with men in the United Kingdom since 2016: an analysis of surveillance data

Author

Allen, Hester, primary, Pitt, Rachel, additional, Bardsley, Megan, additional, Smolarchuk, Christa, additional, Sullivan, Ann, additional, Mohammed, Hamish, additional, Cole, Michelle, additional, Fifer, Helen, additional, Wallace, Lesley, additional, Thomas, Daniel, additional, Irvine, Neil, additional, Templeton, Kate, additional, Hughes, Gwenda, additional, and Simms, Ian, additional

Published
2020
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27. Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

Author

Hemelaar, Joris, Elangovan, Ramyiadarsini, Yun, Jason, Dickson-Tetteh, Leslie, Fleminger, Isabella, Kirtley, Shona, Williams, Brian, Gouws-Williams, Eleanor, Ghys, Peter D, Abimiku, Alash'le G, Agwale, Simon, Archibald, Chris, Avidor, Boaz, Barbás, María Gabriela, Barre-Sinoussi, Francoise, Barugahare, Banson, Belabbes, El Hadj, Bertagnolio, Silvia, Birx, Deborah, Bobkov, Aleksei F, Brandful, James, Bredell, Helba, Brennan, Catherine A, Brooks, James, Bruckova, Marie, Buonaguro, Luigi, Buonaguro, Franco, Buttò, Stefano, Buve, Anne, Campbell, Mary, Carr, Jean, Carrera, Alex, Carrillo, Manuel Gómez, Celum, Connie, Chaplin, Beth, Charles, Macarthur, Chatzidimitriou, Dimitrios, Chen, Zhiwei, Chijiwa, Katsumi, Cooper, David, Cunningham, Philip, Dagnra, Anoumou, de Gascun, Cillian F, Del Amo, Julia, Delgado, Elena, Dietrich, Ursula, Dwyer, Dominic, Ellenberger, Dennis, Ensoli, Barbara, Essex, Max, Gao, Feng, Fleury, Herve, Fonjungo, Peter N, Foulongne, Vincent, Gadkari, Deepak A, García, Federico, Garsia, Roger, Gershy-Damet, Guy Michel, Glynn, Judith R, Goodall, Ruth, Grossman, Zehava, Lindenmeyer-Guimarães, Monick, Hahn, Beatrice, Hamers, Raph L, Hamouda, Osamah, Handema, Ray, He, Xiang, Herbeck, Joshua, Ho, David D, Holguin, Africa, Hosseinipour, Mina, Hunt, Gillian, Ito, Masahiko, Bel Hadj Kacem, Mohamed Ali, Kahle, Erin, Kaleebu, Pontiano Kaleebu, Kalish, Marcia, Kamarulzaman, Adeeba, Kang, Chun, Kanki, Phyllis, Karamov, Edward, Karasi, Jean-Claude, Kayitenkore, Kayitesi, Kelleher, Tony, Kitayaporn, Dwip, Kostrikis, Leondios G, Kucherer, Claudia, Lara, Claudia, Leitner, Thomas, Liitsola, Kirsi, Lingappa, Jai, Linka, Marek, Lorenzana de Rivera, Ivette, Lukashov, Vladimir, Maayan, Shlomo, Mayr, Luzia, McCutchan, Francine, Meda, Nicolas, Menu, Elisabeth, Mhalu, Fred, Mloka, Doreen, Mokili, John L, Montes, Brigitte, Mor, Orna, Morgado, Mariza, Mosha, Fausta, Moussi, Awatef, Mullins, James, Najera, Rafael, Nasr, Mejda, Ndembi, Nicaise, Neilson, Joel R, Nerurkar, Vivek R, Neuhann, Florian, Nolte, Claudine, Novitsky, Vlad, Nyambi, Philippe, Ofner, Marianna, Paladin, Fem J, Papa, Anna, Pape, Jean, Parkin, Neil, Parry, Chris, Peeters, Martine, Pelletier, Alexandra, Pérez-Álvarez, Lucía, Pillay, Deenan, Pinto, Angie, Quang, Trinh Duy, Rademeyer, Cecilia, Raikanikoda, Filimone, Rayfield, Mark A, Reynes, Jean-Marc, Rinke de Wit, Tobias, Robbins, Kenneth E, Rolland, Morgane, Rousseau, Christine, Salazar-Gonzales, Jesus, Salem, Hanan, Salminen, Mika, Salomon, Horacio, Sandstrom, Paul, Santiago, Mario L, Sarr, Abdoulaye D, Schroeder, Bryan, Segondy, Michel, Selhorst, Philippe, Sempala, Sylvester, Servais, Jean, Shaik, Ansari, Shao, Yiming, Slim, Amine, Soares, Marcelo A, Songok, Elijah, Stewart, Debbie, Stokes, Julie, Subbarao, Shambavi, Sutthent, Ruengpung, Takehisa, Jun, Tanuri, Amilcar, Tee, Kok Keng, Thapa, Kiran, Thomson, Michael, Tran, Tyna, Urassa, Willy, Ushijima, Hiroshi, van de Perre, Philippe, van der Groen, Guido, van Laethem, Kristel, van Oosterhout, Joep, van Sighem, Ard, van Wijngaerden, Eric, Vandamme, Anne-Mieke, Vercauteren, Jurgen, Vidal, Nicole, Wallace, Lesley, Williamson, Carolyn, Wolday, Dawit, Xu, Jianqing, Yang, Chunfu, Zhang, Linqi, Zhang, Rong, John Radcliffe Hospital [Oxford University Hospital], Centre for Statistics in Medicine, University of Oxford [Oxford], Stellenbosch University, UNAIDS [Genève, Suisse] (ONUSIDA), Institut Pasteur [Paris], Noguchi Memorial Institute for Medical Research [Accra, Ghana] (NMIMR), University of Ghana, Institute of Tropical Medicine [Antwerp] (ITM), State Key Laboratory of Silkworm Genome Biology, Southwest University, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Georg-Speyer-Haus, The University of Sydney, National AIDS Centre, Istituto Superiore di Sanita [Rome], Harvard School of Public Health, Digital Enterprise Research Institute (DERI-NUIG), National University of Ireland [Galway] (NUI Galway), Microbiologie cellulaire et moléculaire et pathogénicité (MCMP), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Virologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Departments of Medicine and Microbiology, University of Alabama at Birmingham [ Birmingham] (UAB), Robert Koch Institute [Berlin] (RKI), Beihang University (BUAA), Statens Serum Institut [Copenhagen], Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), SANTE/SIDA [Bobo-Dioulasso, Burkina Faso], Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz, Department of Microbiology, University of Washington School of Medicine, Department of Microbiology, Medical School, University of Thessaly [Volos] (UTH), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Africa Centre for Health and Population Studies, University of KwaZulu-Natal (UKZN)-Medical Research Council of South Africa, Lab-STICC_UBO_CID_IHSEV, Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (Lab-STICC), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Laboratory of Virology, CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Universidade Federal do Rio de Janeiro (UFRJ), Departements of Medicine and Microbiology, University of Alabama [Tuscaloosa] (UA), Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), Département Génétique Internal Médecine, Hôpital Universitaire Leuven, Department of Chemical and Biomolecular Engineering [Baltimore], Johns Hopkins University (JHU), Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, China Academy of Chinese Medical Sciences, Chatzidimitriou, Dimitrios [0000-0001-9656-5898], University of Oxford, Institut Pasteur [Paris] (IP), Istituto Superiore di Sanità (ISS), Microbiologie Fondamentale et Pathogénicité (MFP), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of KwaZulu-Natal [Durban, Afrique du Sud] (UKZN)-Medical Research Council of South Africa, Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Université européenne de Bretagne - European University of Brittany (UEB)-École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Télécom Bretagne-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), UNAIDS, Noguchi Memorial Institute for Medical Research, University of Ghana, Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Université Grenoble Alpes (UGA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Beihang University, Recherches Translationnelles sur le VIH et les maladies infectieuses (TransVIHMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Universtié Yaoundé 1 [Cameroun]-Université de Montpellier (UM), Universidade Federal do Rio de Janeiro [Rio de Janeiro] (UFRJ), Nuffield Department of Women's and Reproductive Health (NDWRH), University of Oxford- John Radcliffe Hospital [Oxford University Hospital], South African Centre for Epidemiological Modelling and Analysis, JH is supported by the Oxford University Clinical Academic Graduate School (Oxford, UK) and Linacre College, Oxford University (Oxford, UK)., WHO–UNAIDS Network for HIV Isolation Characterisation : Alash'le G Abimiku, Simon Agwale, Chris Archibald, Boaz Avidor, María Gabriela Barbás, Francoise Barre-Sinoussi, Banson Barugahare, El Hadj Belabbes, Silvia Bertagnolio, Deborah Birx, Aleksei F Bobkov, James Brandful, Helba Bredell, Catherine A Brennan, James Brooks, Marie Bruckova, Luigi Buonaguro, Franco Buonaguro, Stefano Buttò, Anne Buve, Mary Campbell, Jean Carr, Alex Carrera, Manuel Gómez Carrillo, Connie Celum, Beth Chaplin, Macarthur Charles, Dimitrios Chatzidimitriou, Zhiwei Chen, Katsumi Chijiwa, David Cooper, Philip Cunningham, Anoumou Dagnra, Cillian F de Gascun, Julia Del Amo, Elena Delgado, Ursula Dietrich, Dominic Dwyer, Dennis Ellenberger, Barbara Ensoli, Max Essex, Feng Gao, Herve Fleury, Peter N Fonjungo, Vincent Foulongne, Deepak A Gadkari, Federico García, Roger Garsia, Guy Michel Gershy-Damet, Judith R Glynn, Ruth Goodall, Zehava Grossman, Monick Lindenmeyer-Guimarães, Beatrice Hahn, Raph L Hamers, Osamah Hamouda, Ray Handema, Xiang He, Joshua Herbeck, David D Ho, Africa Holguin, Mina Hosseinipour, Gillian Hunt, Masahiko Ito, Mohamed Ali Bel Hadj Kacem, Erin Kahle, Pontiano Kaleebu Kaleebu, Marcia Kalish, Adeeba Kamarulzaman, Chun Kang, Phyllis Kanki, Edward Karamov, Jean-Claude Karasi, Kayitesi Kayitenkore, Tony Kelleher, Dwip Kitayaporn, Leondios G Kostrikis, Claudia Kucherer, Claudia Lara, Thomas Leitner, Kirsi Liitsola, Jai Lingappa, Marek Linka, Ivette Lorenzana de Rivera, Vladimir Lukashov, Shlomo Maayan, Luzia Mayr, Francine McCutchan, Nicolas Meda, Elisabeth Menu, Fred Mhalu, Doreen Mloka, John L Mokili, Brigitte Montes, Orna Mor, Mariza Morgado, Fausta Mosha, Awatef Moussi, James Mullins, Rafael Najera, Mejda Nasr, Nicaise Ndembi, Joel R Neilson, Vivek R Nerurkar, Florian Neuhann, Claudine Nolte, Vlad Novitsky, Philippe Nyambi, Marianna Ofner, Fem J Paladin, Anna Papa, Jean Pape, Neil Parkin, Chris Parry, Martine Peeters, Alexandra Pelletier, Lucía Pérez-Álvarez, Deenan Pillay, Angie Pinto, Trinh Duy Quang, Cecilia Rademeyer, Filimone Raikanikoda, Mark A Rayfield, Jean-Marc Reynes, Tobias Rinke de Wit, Kenneth E Robbins, Morgane Rolland, Christine Rousseau, Jesus Salazar-Gonzales, Hanan Salem, Mika Salminen, Horacio Salomon, Paul Sandstrom, Mario L Santiago, Abdoulaye D Sarr, Bryan Schroeder, Michel Segondy, Philippe Selhorst, Sylvester Sempala, Jean Servais, Ansari Shaik, Yiming Shao, Amine Slim, Marcelo A Soares, Elijah Songok, Debbie Stewart, Julie Stokes, Shambavi Subbarao, Ruengpung Sutthent, Jun Takehisa, Amilcar Tanuri, Kok Keng Tee, Kiran Thapa, Michael Thomson, Tyna Tran, Willy Urassa, Hiroshi Ushijima, Philippevan de Perre, Guidovan der Groen, Kristel van Laethem, Joep van Oosterhout, Ard van Sighem, Eric van Wijngaerden, Anne-Mieke Vandamme, Jurgen Vercauteren, Nicole Vidal, Lesley Wallace, Carolyn Williamson, Dawit Wolday, Jianqing Xu, Chunfu Yang, Linqi Zhang, and Rong Zhang

Subjects
0301 basic medicine, Serotype, Genotype, Genotyping Techniques, 030106 microbiology, DIVERSITY, MULTICENTER, VACCINE, HIV Infections, Genome, Viral, Biology, Global Health, Serogroup, SUBTYPES, 03 medical and health sciences, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Surveys and Questionnaires, INFECTION, Genetic variation, Global health, Humans, HIV vaccine, Serotyping, AIDS Vaccines, Science & Technology, Molecular epidemiology, Genetic Variation, Subtyping, 3. Good health, Trend analysis, 030104 developmental biology, Infectious Diseases, 13. Climate action, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HIV-1, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Life Sciences & Biomedicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography
Abstract

BACKGROUND: Global genetic diversity of HIV-1 is a major challenge to the development of HIV vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and recombinants during 1990-2015. METHODS: We searched PubMed, EMBASE (Ovid), CINAHL (Ebscohost), and Global Health (Ovid) for HIV-1 subtyping studies published between Jan 1, 1990, and Dec 31, 2015. We collected additional unpublished HIV-1 subtyping data through a global survey. We included prevalence studies with HIV-1 subtyping data collected during 1990-2015. We grouped countries into 14 regions and analysed data for four time periods (1990-99, 2000-04, 2005-09, and 2010-15). The distribution of HIV-1 subtypes, circulating recombinant forms (CRFs), and unique recombinant forms (URFs) in individual countries was weighted according to the UNAIDS estimates of the number of people living with HIV (PLHIV) in each country to generate regional and global estimates of HIV-1 diversity in each time period. The primary outcome was the number of samples designated as HIV-1 subtypes A, B, C, D, F, G, H, J, K, CRFs, and URFs. The systematic review is registered with PROSPERO, number CRD42017067164. FINDINGS: This systematic review and global survey yielded 2203 datasets with 383 519 samples from 116 countries in 1990-2015. Globally, subtype C accounted for 46·6% (16 280 897/34 921 639 of PLHIV) of all HIV-1 infections in 2010-15. Subtype B was responsible for 12·1% (4 235 299/34 921 639) of infections, followed by subtype A (10·3%; 3 587 003/34 921 639), CRF02_AG (7·7%; 2 705 110/34 921 639), CRF01_AE (5·3%; 1 840 982/34 921 639), subtype G (4·6%; 1 591 276/34 921 639), and subtype D (2·7%; 926 255/34 921 639). Subtypes F, H, J, and K combined accounted for 0·9% (311 332/34 921 639) of infections. Other CRFs accounted for 3·7% (1 309 082/34 921 639), bringing the proportion of all CRFs to 16·7% (5 844 113/34 921 639). URFs constituted 6·1% (2 134 405/34 921 639), resulting in recombinants accounting for 22·8% (7 978 517/34 921 639) of all global HIV-1 infections. The distribution of HIV-1 subtypes and recombinants changed over time in countries, regions, and globally. At a global level during 2005-15, subtype B increased, subtypes A and D were stable, and subtypes C and G and CRF02_AG decreased. CRF01_AE, other CRFs, and URFs increased, leading to a consistent increase in the global proportion of recombinants over time. INTERPRETATION: Global and regional HIV diversity is complex and evolving, and is a major challenge to HIV vaccine development. Surveillance of the global molecular epidemiology of HIV-1 remains crucial for the design, testing, and implementation of HIV vaccines. FUNDING: None. ispartof: LANCET INFECTIOUS DISEASES vol:19 issue:2 pages:143-155 ispartof: location:United States status: published

Published
2018
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30. Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis

Author

Hemelaar, Joris, primary, Elangovan, Ramyiadarsini, additional, Yun, Jason, additional, Dickson-Tetteh, Leslie, additional, Fleminger, Isabella, additional, Kirtley, Shona, additional, Williams, Brian, additional, Gouws-Williams, Eleanor, additional, Ghys, Peter D, additional, Abimiku, Alash'le G, additional, Agwale, Simon, additional, Archibald, Chris, additional, Avidor, Boaz, additional, Barbás, María Gabriela, additional, Barre-Sinoussi, Francoise, additional, Barugahare, Banson, additional, Belabbes, El Hadj, additional, Bertagnolio, Silvia, additional, Birx, Deborah, additional, Bobkov, Aleksei F, additional, Brandful, James, additional, Bredell, Helba, additional, Brennan, Catherine A, additional, Brooks, James, additional, Bruckova, Marie, additional, Buonaguro, Luigi, additional, Buonaguro, Franco, additional, Buttò, Stefano, additional, Buve, Anne, additional, Campbell, Mary, additional, Carr, Jean, additional, Carrera, Alex, additional, Carrillo, Manuel Gómez, additional, Celum, Connie, additional, Chaplin, Beth, additional, Charles, Macarthur, additional, Chatzidimitriou, Dimitrios, additional, Chen, Zhiwei, additional, Chijiwa, Katsumi, additional, Cooper, David, additional, Cunningham, Philip, additional, Dagnra, Anoumou, additional, de Gascun, Cillian F, additional, Del Amo, Julia, additional, Delgado, Elena, additional, Dietrich, Ursula, additional, Dwyer, Dominic, additional, Ellenberger, Dennis, additional, Ensoli, Barbara, additional, Essex, Max, additional, Gao, Feng, additional, Fleury, Herve, additional, Fonjungo, Peter N, additional, Foulongne, Vincent, additional, Gadkari, Deepak A, additional, García, Federico, additional, Garsia, Roger, additional, Gershy-Damet, Guy Michel, additional, Glynn, Judith R, additional, Goodall, Ruth, additional, Grossman, Zehava, additional, Lindenmeyer-Guimarães, Monick, additional, Hahn, Beatrice, additional, Hamers, Raph L, additional, Hamouda, Osamah, additional, Handema, Ray, additional, He, Xiang, additional, Herbeck, Joshua, additional, Ho, David D, additional, Holguin, Africa, additional, Hosseinipour, Mina, additional, Hunt, Gillian, additional, Ito, Masahiko, additional, Bel Hadj Kacem, Mohamed Ali, additional, Kahle, Erin, additional, Kaleebu, Pontiano Kaleebu, additional, Kalish, Marcia, additional, Kamarulzaman, Adeeba, additional, Kang, Chun, additional, Kanki, Phyllis, additional, Karamov, Edward, additional, Karasi, Jean-Claude, additional, Kayitenkore, Kayitesi, additional, Kelleher, Tony, additional, Kitayaporn, Dwip, additional, Kostrikis, Leondios G, additional, Kucherer, Claudia, additional, Lara, Claudia, additional, Leitner, Thomas, additional, Liitsola, Kirsi, additional, Lingappa, Jai, additional, Linka, Marek, additional, Lorenzana de Rivera, Ivette, additional, Lukashov, Vladimir, additional, Maayan, Shlomo, additional, Mayr, Luzia, additional, McCutchan, Francine, additional, Meda, Nicolas, additional, Menu, Elisabeth, additional, Mhalu, Fred, additional, Mloka, Doreen, additional, Mokili, John L, additional, Montes, Brigitte, additional, Mor, Orna, additional, Morgado, Mariza, additional, Mosha, Fausta, additional, Moussi, Awatef, additional, Mullins, James, additional, Najera, Rafael, additional, Nasr, Mejda, additional, Ndembi, Nicaise, additional, Neilson, Joel R, additional, Nerurkar, Vivek R, additional, Neuhann, Florian, additional, Nolte, Claudine, additional, Novitsky, Vlad, additional, Nyambi, Philippe, additional, Ofner, Marianna, additional, Paladin, Fem J, additional, Papa, Anna, additional, Pape, Jean, additional, Parkin, Neil, additional, Parry, Chris, additional, Peeters, Martine, additional, Pelletier, Alexandra, additional, Pérez-Álvarez, Lucía, additional, Pillay, Deenan, additional, Pinto, Angie, additional, Quang, Trinh Duy, additional, Rademeyer, Cecilia, additional, Raikanikoda, Filimone, additional, Rayfield, Mark A, additional, Reynes, Jean-Marc, additional, Rinke de Wit, Tobias, additional, Robbins, Kenneth E, additional, Rolland, Morgane, additional, Rousseau, Christine, additional, Salazar-Gonzales, Jesus, additional, Salem, Hanan, additional, Salminen, Mika, additional, Salomon, Horacio, additional, Sandstrom, Paul, additional, Santiago, Mario L, additional, Sarr, Abdoulaye D, additional, Schroeder, Bryan, additional, Segondy, Michel, additional, Selhorst, Philippe, additional, Sempala, Sylvester, additional, Servais, Jean, additional, Shaik, Ansari, additional, Shao, Yiming, additional, Slim, Amine, additional, Soares, Marcelo A, additional, Songok, Elijah, additional, Stewart, Debbie, additional, Stokes, Julie, additional, Subbarao, Shambavi, additional, Sutthent, Ruengpung, additional, Takehisa, Jun, additional, Tanuri, Amilcar, additional, Tee, Kok Keng, additional, Thapa, Kiran, additional, Thomson, Michael, additional, Tran, Tyna, additional, Urassa, Willy, additional, Ushijima, Hiroshi, additional, van de Perre, Philippe, additional, van der Groen, Guido, additional, van Laethem, Kristel, additional, van Oosterhout, Joep, additional, van Sighem, Ard, additional, van Wijngaerden, Eric, additional, Vandamme, Anne-Mieke, additional, Vercauteren, Jurgen, additional, Vidal, Nicole, additional, Wallace, Lesley, additional, Williamson, Carolyn, additional, Wolday, Dawit, additional, Xu, Jianqing, additional, Yang, Chunfu, additional, Zhang, Linqi, additional, and Zhang, Rong, additional

Published
2019
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31. Results from a national treatment database – does it matter which ART combination is prescribed in the real world?

Author

Scott, Gordon and Wallace, Lesley

Subjects
Drugs -- Prescribing, Antiviral agents -- Dosage and administration -- Patient outcomes, Viremia -- Measurement, Market trend/market analysis, Health
Abstract

Introduction: Clinical trials frequently show differences in viral load (VL) response between antiretroviral therapy (ART) regimes. Patterns of prescribing vary from country to country (Mocroft et al. Infection 2014 Jun 6 [epub ahead of print]), and are likely to vary between individual clinics. Scotland has a national database that records VL results and specific ART regimes for every patient under care, thus allowing different prescribing patterns between clinical centres to be monitored. Does this reveal any difference in achievement of undetectable VL? Materials and Methods: We interrogated the database held by Health Protection Scotland (HPS) that contains a record of every VL result matched against prescribed ART. Results were censored at the end of December 2013 and are based on the latest attendance of patients who have been under monitoring for at least six months. For simplicity, we have broken the results into class of drug rather than individual drugs for example, nucleoside reverse transcriptase inhibitor (NRTI) rather than lamivudine, abacavir etc. The data were analyzed using univariate Poisson regression. Results: The anonymized records of 3302 individual patients who attended in 11 separate regions were scrutinized. Sixty‐eight different combinations of antiretroviral regimes were identified. The prescribing patterns for the five most frequently prescribed regimes in the four largest clinics are shown in Table 1, along with the overall percentage of patients with undetectable VL. A higher proportion of patients in Scotland who are prescribed regimes of NRTI×2 or NRTI/NtRTI plus PI have detectable VL but this is not statistically significant. Although the percentage of patients with VL Conclusions: Overall, a high proportion of Scottish patients on ART have undetectable VL. Patterns of ART prescribing in Scotland do vary by region but there are no significant differences in outcome with regard to undetectable VL. There is a non‐significant trend which may be accounted for by differing levels of PI prescribing., Table 1: Regional patterns of prescribing NRTI×2 +PI (%) NRTI×2 +NNRTI (%) NRTI/NtRTI/PI (%) NRTI/NtRTI/NNRTI (%) NRTI/NtRTI/II (%) % VL < 50 Region 1 7 6 16 61 1 91 [...]

Published
2014
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35. 100 years of STIs in the UK: a review of national surveillance data

Author

Mohammed, Hamish, primary, Blomquist, Paula, additional, Ogaz, Dana, additional, Duffell, Stephen, additional, Furegato, Martina, additional, Checchi, Marta, additional, Irvine, Neil, additional, Wallace, Lesley A, additional, Thomas, Daniel Rhys, additional, Nardone, Anthony, additional, Dunbar, J Kevin, additional, and Hughes, Gwenda, additional

Published
2018
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38. HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population

Author

Campos-Lima, Pedro-Otavio de, Gavioli, Riccardo, Zhang, Qian-Jim, Wallace, Lesley E., Dolcetti, Riccardo, Rowe, Martin, Rickinson, Alan B., and Masucci, Maria G.

Subjects
Antigenic determinants -- Research, Epstein-Barr virus -- Research, Science and technology, Research
Abstract

Cytotoxic T lymphocytes (CTLs) control viral infections by recognizing viral peptides presented by major histocompatibility complex (MHC) class I molecules. Human leukocyte antigen (HLA)-A11-restricted CTLs that recognize peptide residues 416 to 424 of the Epstein-Barr virus (EBV) nuclear antigen-4 frequently dominate EBV-induced responses in [A11.sup.+] Caucasian donors. This epitope is conservved in type A EBV strains from Caucasians and central African populations, where A11 relatively infrequent. However, strains from highly [A11.sup.+] populations in New Guinea carry a lysine-to-threonine mutation at residue 24 that abrogates CTL recognition and binding of the peptide to nascent A11 molecules. The results suggest that evolution of a widespread and genetically stable virus such as EBV is influenced by pressure from MHC-restricted CTL responses., EBV-specific CTL memory can be demonstrated in virtually all healthy virus-carrying individuals [1, 2]. The identity of the EBV target antigens and the influence of host HLA class I type [...]

Published
1993

39. Association between universal hepatitis B prison vaccination, vaccine uptake and hepatitis B infection among people who inject drugs

Author

Palmateer, Norah E., primary, Goldberg, David J., additional, Munro, Alison, additional, Taylor, Avril, additional, Yeung, Alan, additional, Wallace, Lesley A., additional, Mitchell, Alan, additional, Shepherd, Samantha J., additional, Gunson, Rory N., additional, Aitken, Celia, additional, and Hutchinson, Sharon J., additional

Published
2017
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40. HIV prevalence and undiagnosed infection among a\ud community sample of gay and bisexual men in Scotland, 2005-2011: implications for HIV testing policy and prevention

Author

Wallace, Lesley A., Li, Jessica, and McDaid, Lisa M.

Abstract

Objective\ud \ud To examine HIV prevalence, HIV testing behaviour, undiagnosed infection and risk factors for HIV positivity among a community sample of gay men in Scotland.\ud \ud Methods\ud \ud Cross-sectional survey of gay and bisexual men attending commercial gay venues in Glasgow and Edinburgh, Scotland with voluntary anonymous HIV testing of oral fluid samples in 2011. A response rate of 65.2% was achieved (1515 participants).\ud \ud Results\ud \ud HIV prevalence (4.8%, 95% confidence interval, CI 3.8% to 6.2%) remained stable compared to previous survey years (2005 and 2008) and the proportion of undiagnosed infection among HIV-positive men (25.4%) remained similar to that recorded in 2008. Half of the participants who provided an oral fluid sample stated that they had had an HIV test in the previous 12 months; this proportion is significantly higher when compared to previous study years (50.7% versus 33.8% in 2005, p25 years) was associated with HIV positivity (1.8% in those \ud \ud Conclusion\ud \ud HIV transmission continues to occur among gay and bisexual men in Scotland. Despite evidence of recent testing within the previous six months, suggesting a willingness to test, the current opt-out policy may have reached its limit with regards to maximising HIV test uptake. Novel strategies are required to improve regular testing opportunities and more frequent testing as there are implications for the use of other biomedical HIV interventions.

Published
2014

45. Rapid virological surveillance of community influenza infection in general practice

Author

Carman, William F, Wallace, Lesley A, Walker, Jacqueline, McIntyre, Sheena, Noone, Ahilya, Christie, Peter, Millar, James, and Douglas, James D

Subjects
Influenza -- Diagnosis, Polymerase chain reaction
Abstract

The annual outbreak of influenza in Scotland is monitored by sentinel general practices, which report influenza-like illness. We piloted real time virological surveillance to investigate whether polymerase chain reaction (PCR)[12] […]

Published
2000

49. What's in a name - was John Curtin 'Vigilant'? Analysing style to determine authorship.

Author

Wallace, Lesley, Antonia, A., Craig, H., Wallace, Lesley, Antonia, A., and Craig, H.

Abstract

Curtin researcher Tom Fitzgerald amassed a wealth of evidence that John Curtin wrote under the pen name "Vigilant" in the early years of his editorship of the Westralian Worker. If true, the personal and literary columns penned by "Vigilant" provide new insights into the inner temperament of Australia's war time Prime Minister. Fitzgerald's evidence for Curtin as "Vigilant" is presented in this paper and the attribution is further explored by applying stylistic tests developed at the Centre for Literary and Linguistic Computing at the University of Newcastle (NSW).

Published
2009

50. Politics, Literature, Folklore and Circumnavigating the World: The What, Why and How of Digital Collections at Curtin University Library

Author

Haddow, Gaby, Wallace, Lesley, Haddow, Gaby, and Wallace, Lesley

Abstract

This paper explores the journey Curtin University Library has taken in providing digital access to recently acquired collections. It discusses the collections, outlines important criteria and processes, and presents the challenges and benefits of digitising collections.Building on the expertise gained in establishing the digital archive of the John Curtin Prime Ministerial Library, Curtin University Library has since developed a number of digital collections with themes as varied as politics, literature, folklore and circumnavigating the world.In order to consider collections of vastly different subject matter, formats and information types for acceptance, the Library developed ?Archival Collections Principles? and a selection checklist for donations. These documents ensure decisions are made in a consistent and defensible manner, and take into account available resources. The range of formats (e.g. print, audio, video, images, objects) and information types (e.g. speeches, scrapbooks, journal articles, plays, sail plans, echo sound charts, questionnaires, interviews) across the collections has required an individual and creative approach to organising and providing digital access to each collection.The benefits resulting from these activities include utilising and developing staff expertise, making valuable collections widely available where they otherwise would have remained largely inaccessible, and enhancing the reputation of Curtin University.For libraries considering developing a digital collection, this paper outlines some useful principles and guidelines with which to proceed.

Published
2008

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