638 results on '"Walkinshaw, Malcolm D."'
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2. Peripheral blood immune cell profiling of acute corneal transplant rejection
3. Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice
4. Crystal Structure of Dihydrofolate Reductase from Plasmodium vivax: Pyrimethamine Displacement Linked with Mutation-Induced Resistance
5. Protein Recognition of Macrocycles: Binding of Anti-HIV Metallocyclams to Lysozyme
6. Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design
7. Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation
8. Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes
9. Allosteric effects in cyclophilin mutants may be explained by changes in nano-microsecond time scale motions
10. M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
11. Targeting FKBP isoforms with small-molecule ligands
12. X-Ray Structure of a Cyclophilin B/Cyclosporin Complex: Comparison with Cyclophilin A and Delineation of its Calcineurin-Binding Domain
13. Three-Dimensional Structure of the ``Long'' Neurotoxin from Cobra Venom
14. Biochemical and transcript level differences between the three human phosphofructokinases show 3 optimisation of each isoform for specific metabolic niches
15. Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis
16. Molecular Architecture of the Mos1 Paired-End Complex: The Structural Basis of DNA Transposition in a Eukaryote
17. Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening
18. Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches
19. Pyruvate kinase from Plasmodium falciparum: Structural and kinetic insights into the allosteric mechanism
20. Learning Binding Affinity from Augmented High Throughput Screening Data
21. The role of Thr268 and Phe393 in cytochrome P450 BM3
22. Engineering water to act as an active site acid catalyst in a soluble fumarate reductase
23. Role of His505 in the soluble fumarate reductase from Shewanella frigidimarina
24. Cyclosporins: Recent Developments in Biosynthesis, Pharmacology and Biology, and Clinical Applications
25. Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3
26. Kinetic and crystallographic analysis of the key active site acid/base arginine in a soluble fumarate reductase
27. EDULISS: a small-molecule database with data-mining and pharmacophore searching capabilities
28. Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase
29. Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis
30. Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A
31. Identification of the active site acid-base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study
32. Identification of protein binding surfaces using surface triplet propensities
33. Crystallographic and solution studies of oligosaccharide conformation
34. Location of a cytochrome c binding site on the surface of flavocytochrome b 2
35. Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance
36. Structures of Leishmania Fructose-1,6-Bisphosphatase Reveal Species-Specific Differences in the Mechanism of Allosteric Inhibition
37. A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A
38. Biological Ligands
39. Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach
40. Oligopeptide signaling through TbGPR89 drives trypanosome quorum sensing
41. Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
42. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
43. Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
44. Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
45. An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
46. Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis
47. The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction
48. A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors
49. Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing
50. Dynamic design: manipulation of millisecond timescale motions on the energy landscape of Cyclophilin A
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