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1. Learnings from implementing a surgical training program

Author

Obermair, Andreas, primary, Gebski, Val, additional, Hanna, George B., additional, Coleman, Mark G., additional, Graves, Nicholas, additional, Tang, Amy, additional, Garrett, Andrea, additional, Walker, Graeme, additional, Larwood, Kelvin, additional, and Janda, Monika, additional

Published
2024
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4. Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial

Author

Janda, Monika, Robledo, Kristy P., Gebski, Val, Armes, Jane E., Alizart, Michelle, Cummings, Margaret, Chen, Chen, Leung, Yee, Sykes, Peter, McNally, Orla, Oehler, Martin K., Walker, Graeme, Garrett, Andrea, Tang, Amy, Land, Russell, Nicklin, James L., Chetty, Naven, Perrin, Lewis C., Hoet, Greet, Sowden, Katherine, Eva, Lois, Tristram, Amanda, and Obermair, Andreas

Published
2021
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7. Ultra high densities of cold atoms in a holographically controlled dark SPOT trap

Author

Radwell, Neal, Walker, Graeme, and Franke-Arnold, Sonja

Subjects
Physics - Atomic Physics
Abstract

We demonstrate an atom trap geometry for 87Rb which is capable of producing ultra high atom densities. Reradiation forces, which usually limit high densities, can be avoided in dark spontaneous-force optical traps (dark SPOTs) by sheltering atoms from intense trapping light. Here we demonstrate a dynamic implementation of a dark SPOT, resulting in an increase in atom density by almost two orders of magnitude up to 1.3x10^12cm-3. Holographic control of the trapping beams and dynamic switching between MOT and dark SPOT configuration allows us to optimise the trapping geometry. We have identified the ideal size of the dark core to be six times larger than the MOT. Our method also avoids unwanted heating so that we reach a record phase-space density for a MOT., Comment: 5 pages, 4 figures

Published
2013

11. Trans-spectral transfer of orbital angular momentum and creation of an ultra high density cold atom trap

Author

Walker, Graeme

Subjects
539.7, QC Physics
Abstract

In recent years there has been great interest in the applications of the interaction of the phase and intensity of laser light in atomic vapours. The generation of light beams with arbitrary phase and intensity patterns can now be easily achieved by using Spatial Light Modulators (SLMs). The transformation of quantized units of phase information to atomic vapours has implications in the fields of quantum optics for the realisation of sources of entangled photons, optical switching, and quantum information storage. Spatially shaped beams with non-trivial intensity geometries have found use in single atom quantum well traps and for the enhancement of density of standard Magneto Optical Traps. The work in this thesis is focussed around two main pro jects, involving the interaction of holographically shaped light beams with cold trapped atoms and with a hot atomic vapour respectively. An enhancement to the previously investigated technique of a SPontaneous force Optical Trap SPOT of 87 Rb is presented here which aims to solve various issues which naturally arise from compressing cold atoms in a Magneto Optical Trap (MOT) such as unavoidable heating during the compression. High density/high atom number traps are highly sought after in many experiments for more efficient transfer of atoms to Bose Einstein Condensates and for improved quantum storage capabilities in cold atom traps. The highest density achieved in our SPOT was 2.5 × 10^12 atoms cm−3 for 2 × 10^8 atoms at a temperature of approximately 100µK. This represents almost 2 orders of magnitude increase in density from the standard MOT setup with no adverse heating of the trap while maintaining 75% of the atoms. In the second part of this work hot atomic vapours are utilized for the efficient transfer of orbital angular momentum information from near infra-red pump fields, driving from 5S_1/2 to 5D_5/2 on a two-photon transition, to a cascade from 5D_5/2 to 6P_3/2 to 5S_1/2 generating 5230nm light and a coherent blue, 420nm, beam respecitively. This generation is performed using four wave mixing in 85 Rb. We observe the complete conversion of all input quantum information, the Orbital Angular Momentum (OAM) from the pump fields to the blue. In addition we show the additional phase coherence effects of this experiment through the use of simple superpositions of Laguerre-Gaussian (LG) modes showing that the process is indeed quantum in nature. A theoretical basis for the transfer of all OAM information to only the 420nm beam is also discussed here.

Published
2013
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14. A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors

Author

St-Gallay, Stephen A., Bennett, Neil, Critchlow, Susan E., Curtis, Nicola, Davies, Gareth, Debreczeni, Judit, Evans, Nicola, Hardern, Ian, Holdgate, Geoff, Jones, Neil P., Leach, Lindsey, Maman, Sarita, McLoughlin, Sheila, Preston, Marian, Rigoreau, Laurent, Thomas, Andrew, Turnbull, Andrew P., Walker, Graeme, Walsh, Jarrod, Ward, Richard A., Wheatley, Ed, and Winter-Holt, Jon

Published
2018
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15. Early endovascular retrieval of a migrated Implanon NXT from a branch of the right pulmonary artery.

Author

Borg, Michelle, Swaminathan, Mathusi, Cheuk, Johnson, Michael, Joanne, and Walker, Graeme

Abstract

A woman in her 20s was referred to a tertiary hospital emergency department for management of a migrating Implanon NXT. The Implanon was inserted 1 week prior by the patient’s general practitioner who was unable to palpate the Implanon after insertion and hence, ordered an ultrasound scan which showed an actively migrating Implanon in the left basilic vein. She had mild chest pain, and her physical examination, ECG and blood tests were unremarkable. A CT chest showed a 31 mm foreign body within the right lower lobar artery. The foreign body was removed by interventional radiology by accessing the right internal jugular vein under ultrasound guidance and inserting a 6 FR pig catheter into the pulmonary trunk. The position was confirmed with angiogram and the foreign body was removed using a goose neck snare. The patient was discharged the same day with no complications, and fell pregnant a few months afterwards. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Supplementary Figure Legends from AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Author

Loddick, Sarah A., primary, Ross, Sarah J., primary, Thomason, Andrew G., primary, Robinson, David M., primary, Walker, Graeme E., primary, Dunkley, Tom P.J., primary, Brave, Sandra R., primary, Broadbent, Nicola, primary, Stratton, Natalie C., primary, Trueman, Dawn, primary, Mouchet, Elizabeth, primary, Shaheen, Fadhel S., primary, Jacobs, Vivien N., primary, Cumberbatch, Marie, primary, Wilson, Joanne, primary, Jones, Rhys D.O., primary, Bradbury, Robert H., primary, Rabow, Alfred, primary, Gaughan, Luke, primary, Womack, Chris, primary, Barry, Simon T., primary, Robson, Craig N., primary, Critchlow, Susan E., primary, Wedge, Stephen R., primary, and Brooks, A. Nigel, primary

Published
2023
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21. Supplementary Figures 1-5 from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

Author

Rhyasen, Garrett W., primary, Hattersley, Maureen M., primary, Yao, Yi, primary, Dulak, Austin, primary, Wang, Wenxian, primary, Petteruti, Philip, primary, Dale, Ian L., primary, Boiko, Scott, primary, Cheung, Tony, primary, Zhang, Jingwen, primary, Wen, Shenghua, primary, Castriotta, Lillian, primary, Lawson, Deborah, primary, Collins, Michael, primary, Bao, Larry, primary, Ahdesmaki, Miika J., primary, Walker, Graeme, primary, O'Connor, Greg, primary, Yeh, Tammie C., primary, Rabow, Alfred A., primary, Dry, Jonathan R., primary, Reimer, Corinne, primary, Lyne, Paul, primary, Mills, Gordon B., primary, Fawell, Stephen E., primary, Waring, Michael J., primary, Zinda, Michael, primary, Clark, Edwin, primary, and Chen, Huawei, primary

Published
2023
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22. Supplementary Table 2 from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

Author

Rhyasen, Garrett W., primary, Hattersley, Maureen M., primary, Yao, Yi, primary, Dulak, Austin, primary, Wang, Wenxian, primary, Petteruti, Philip, primary, Dale, Ian L., primary, Boiko, Scott, primary, Cheung, Tony, primary, Zhang, Jingwen, primary, Wen, Shenghua, primary, Castriotta, Lillian, primary, Lawson, Deborah, primary, Collins, Michael, primary, Bao, Larry, primary, Ahdesmaki, Miika J., primary, Walker, Graeme, primary, O'Connor, Greg, primary, Yeh, Tammie C., primary, Rabow, Alfred A., primary, Dry, Jonathan R., primary, Reimer, Corinne, primary, Lyne, Paul, primary, Mills, Gordon B., primary, Fawell, Stephen E., primary, Waring, Michael J., primary, Zinda, Michael, primary, Clark, Edwin, primary, and Chen, Huawei, primary

Published
2023
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23. Supplementary Materials and Methods from AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Author

Loddick, Sarah A., primary, Ross, Sarah J., primary, Thomason, Andrew G., primary, Robinson, David M., primary, Walker, Graeme E., primary, Dunkley, Tom P.J., primary, Brave, Sandra R., primary, Broadbent, Nicola, primary, Stratton, Natalie C., primary, Trueman, Dawn, primary, Mouchet, Elizabeth, primary, Shaheen, Fadhel S., primary, Jacobs, Vivien N., primary, Cumberbatch, Marie, primary, Wilson, Joanne, primary, Jones, Rhys D.O., primary, Bradbury, Robert H., primary, Rabow, Alfred, primary, Gaughan, Luke, primary, Womack, Chris, primary, Barry, Simon T., primary, Robson, Craig N., primary, Critchlow, Susan E., primary, Wedge, Stephen R., primary, and Brooks, A. Nigel, primary

Published
2023
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24. Data from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

Author

Rhyasen, Garrett W., primary, Hattersley, Maureen M., primary, Yao, Yi, primary, Dulak, Austin, primary, Wang, Wenxian, primary, Petteruti, Philip, primary, Dale, Ian L., primary, Boiko, Scott, primary, Cheung, Tony, primary, Zhang, Jingwen, primary, Wen, Shenghua, primary, Castriotta, Lillian, primary, Lawson, Deborah, primary, Collins, Michael, primary, Bao, Larry, primary, Ahdesmaki, Miika J., primary, Walker, Graeme, primary, O'Connor, Greg, primary, Yeh, Tammie C., primary, Rabow, Alfred A., primary, Dry, Jonathan R., primary, Reimer, Corinne, primary, Lyne, Paul, primary, Mills, Gordon B., primary, Fawell, Stephen E., primary, Waring, Michael J., primary, Zinda, Michael, primary, Clark, Edwin, primary, and Chen, Huawei, primary

Published
2023
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25. Supplementary Figures 1 -7 from AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Author

Loddick, Sarah A., primary, Ross, Sarah J., primary, Thomason, Andrew G., primary, Robinson, David M., primary, Walker, Graeme E., primary, Dunkley, Tom P.J., primary, Brave, Sandra R., primary, Broadbent, Nicola, primary, Stratton, Natalie C., primary, Trueman, Dawn, primary, Mouchet, Elizabeth, primary, Shaheen, Fadhel S., primary, Jacobs, Vivien N., primary, Cumberbatch, Marie, primary, Wilson, Joanne, primary, Jones, Rhys D.O., primary, Bradbury, Robert H., primary, Rabow, Alfred, primary, Gaughan, Luke, primary, Womack, Chris, primary, Barry, Simon T., primary, Robson, Craig N., primary, Critchlow, Susan E., primary, Wedge, Stephen R., primary, and Brooks, A. Nigel, primary

Published
2023
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26. Supplementary Table 3 from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

Author

Rhyasen, Garrett W., primary, Hattersley, Maureen M., primary, Yao, Yi, primary, Dulak, Austin, primary, Wang, Wenxian, primary, Petteruti, Philip, primary, Dale, Ian L., primary, Boiko, Scott, primary, Cheung, Tony, primary, Zhang, Jingwen, primary, Wen, Shenghua, primary, Castriotta, Lillian, primary, Lawson, Deborah, primary, Collins, Michael, primary, Bao, Larry, primary, Ahdesmaki, Miika J., primary, Walker, Graeme, primary, O'Connor, Greg, primary, Yeh, Tammie C., primary, Rabow, Alfred A., primary, Dry, Jonathan R., primary, Reimer, Corinne, primary, Lyne, Paul, primary, Mills, Gordon B., primary, Fawell, Stephen E., primary, Waring, Michael J., primary, Zinda, Michael, primary, Clark, Edwin, primary, and Chen, Huawei, primary

Published
2023
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27. Data from AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Author

Loddick, Sarah A., primary, Ross, Sarah J., primary, Thomason, Andrew G., primary, Robinson, David M., primary, Walker, Graeme E., primary, Dunkley, Tom P.J., primary, Brave, Sandra R., primary, Broadbent, Nicola, primary, Stratton, Natalie C., primary, Trueman, Dawn, primary, Mouchet, Elizabeth, primary, Shaheen, Fadhel S., primary, Jacobs, Vivien N., primary, Cumberbatch, Marie, primary, Wilson, Joanne, primary, Jones, Rhys D.O., primary, Bradbury, Robert H., primary, Rabow, Alfred, primary, Gaughan, Luke, primary, Womack, Chris, primary, Barry, Simon T., primary, Robson, Craig N., primary, Critchlow, Susan E., primary, Wedge, Stephen R., primary, and Brooks, A. Nigel, primary

Published
2023
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28. Supplementary Tables 1-4 from AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Author

Loddick, Sarah A., primary, Ross, Sarah J., primary, Thomason, Andrew G., primary, Robinson, David M., primary, Walker, Graeme E., primary, Dunkley, Tom P.J., primary, Brave, Sandra R., primary, Broadbent, Nicola, primary, Stratton, Natalie C., primary, Trueman, Dawn, primary, Mouchet, Elizabeth, primary, Shaheen, Fadhel S., primary, Jacobs, Vivien N., primary, Cumberbatch, Marie, primary, Wilson, Joanne, primary, Jones, Rhys D.O., primary, Bradbury, Robert H., primary, Rabow, Alfred, primary, Gaughan, Luke, primary, Womack, Chris, primary, Barry, Simon T., primary, Robson, Craig N., primary, Critchlow, Susan E., primary, Wedge, Stephen R., primary, and Brooks, A. Nigel, primary

Published
2023
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29. Supplementary Table 1 from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

Author

Rhyasen, Garrett W., primary, Hattersley, Maureen M., primary, Yao, Yi, primary, Dulak, Austin, primary, Wang, Wenxian, primary, Petteruti, Philip, primary, Dale, Ian L., primary, Boiko, Scott, primary, Cheung, Tony, primary, Zhang, Jingwen, primary, Wen, Shenghua, primary, Castriotta, Lillian, primary, Lawson, Deborah, primary, Collins, Michael, primary, Bao, Larry, primary, Ahdesmaki, Miika J., primary, Walker, Graeme, primary, O'Connor, Greg, primary, Yeh, Tammie C., primary, Rabow, Alfred A., primary, Dry, Jonathan R., primary, Reimer, Corinne, primary, Lyne, Paul, primary, Mills, Gordon B., primary, Fawell, Stephen E., primary, Waring, Michael J., primary, Zinda, Michael, primary, Clark, Edwin, primary, and Chen, Huawei, primary

Published
2023
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32. Supplementary Table from AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Author

Zabludoff, Sonya D., primary, Deng, Chun, primary, Grondine, Michael R., primary, Sheehy, Adam M., primary, Ashwell, Susan, primary, Caleb, Benjamin L., primary, Green, Stephen, primary, Haye, Heather R., primary, Horn, Candice L., primary, Janetka, James W., primary, Liu, Dongfang, primary, Mouchet, Elizabeth, primary, Ready, Shannon, primary, Rosenthal, Judith L., primary, Queva, Christophe, primary, Schwartz, Gary K., primary, Taylor, Karen J., primary, Tse, Archie N., primary, Walker, Graeme E., primary, and White, Anne M., primary

Published
2023
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33. Supplementary Tables and Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Author

Weir, Hazel M., primary, Bradbury, Robert H., primary, Lawson, Mandy, primary, Rabow, Alfred A., primary, Buttar, David, primary, Callis, Rowena J., primary, Curwen, Jon O., primary, de Almeida, Camila, primary, Ballard, Peter, primary, Hulse, Michael, primary, Donald, Craig S., primary, Feron, Lyman J.L., primary, Karoutchi, Galith, primary, MacFaul, Philip, primary, Moss, Thomas, primary, Norman, Richard A., primary, Pearson, Stuart E., primary, Tonge, Michael, primary, Davies, Gareth, primary, Walker, Graeme E., primary, Wilson, Zena, primary, Rowlinson, Rachel, primary, Powell, Steve, primary, Sadler, Claire, primary, Richmond, Graham, primary, Ladd, Brendon, primary, Pazolli, Ermira, primary, Mazzola, Anne Marie, primary, D'Cruz, Celina, primary, and De Savi, Chris, primary

Published
2023
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35. Supplementary Methods from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Author

Weir, Hazel M., primary, Bradbury, Robert H., primary, Lawson, Mandy, primary, Rabow, Alfred A., primary, Buttar, David, primary, Callis, Rowena J., primary, Curwen, Jon O., primary, de Almeida, Camila, primary, Ballard, Peter, primary, Hulse, Michael, primary, Donald, Craig S., primary, Feron, Lyman J.L., primary, Karoutchi, Galith, primary, MacFaul, Philip, primary, Moss, Thomas, primary, Norman, Richard A., primary, Pearson, Stuart E., primary, Tonge, Michael, primary, Davies, Gareth, primary, Walker, Graeme E., primary, Wilson, Zena, primary, Rowlinson, Rachel, primary, Powell, Steve, primary, Sadler, Claire, primary, Richmond, Graham, primary, Ladd, Brendon, primary, Pazolli, Ermira, primary, Mazzola, Anne Marie, primary, D'Cruz, Celina, primary, and De Savi, Chris, primary

Published
2023
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36. Supplementary Figure Legends from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Author

Weir, Hazel M., primary, Bradbury, Robert H., primary, Lawson, Mandy, primary, Rabow, Alfred A., primary, Buttar, David, primary, Callis, Rowena J., primary, Curwen, Jon O., primary, de Almeida, Camila, primary, Ballard, Peter, primary, Hulse, Michael, primary, Donald, Craig S., primary, Feron, Lyman J.L., primary, Karoutchi, Galith, primary, MacFaul, Philip, primary, Moss, Thomas, primary, Norman, Richard A., primary, Pearson, Stuart E., primary, Tonge, Michael, primary, Davies, Gareth, primary, Walker, Graeme E., primary, Wilson, Zena, primary, Rowlinson, Rachel, primary, Powell, Steve, primary, Sadler, Claire, primary, Richmond, Graham, primary, Ladd, Brendon, primary, Pazolli, Ermira, primary, Mazzola, Anne Marie, primary, D'Cruz, Celina, primary, and De Savi, Chris, primary

Published
2023
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37. Supplementary Figures from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Author

Weir, Hazel M., primary, Bradbury, Robert H., primary, Lawson, Mandy, primary, Rabow, Alfred A., primary, Buttar, David, primary, Callis, Rowena J., primary, Curwen, Jon O., primary, de Almeida, Camila, primary, Ballard, Peter, primary, Hulse, Michael, primary, Donald, Craig S., primary, Feron, Lyman J.L., primary, Karoutchi, Galith, primary, MacFaul, Philip, primary, Moss, Thomas, primary, Norman, Richard A., primary, Pearson, Stuart E., primary, Tonge, Michael, primary, Davies, Gareth, primary, Walker, Graeme E., primary, Wilson, Zena, primary, Rowlinson, Rachel, primary, Powell, Steve, primary, Sadler, Claire, primary, Richmond, Graham, primary, Ladd, Brendon, primary, Pazolli, Ermira, primary, Mazzola, Anne Marie, primary, D'Cruz, Celina, primary, and De Savi, Chris, primary

Published
2023
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38. Data from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

Author

Weir, Hazel M., primary, Bradbury, Robert H., primary, Lawson, Mandy, primary, Rabow, Alfred A., primary, Buttar, David, primary, Callis, Rowena J., primary, Curwen, Jon O., primary, de Almeida, Camila, primary, Ballard, Peter, primary, Hulse, Michael, primary, Donald, Craig S., primary, Feron, Lyman J.L., primary, Karoutchi, Galith, primary, MacFaul, Philip, primary, Moss, Thomas, primary, Norman, Richard A., primary, Pearson, Stuart E., primary, Tonge, Michael, primary, Davies, Gareth, primary, Walker, Graeme E., primary, Wilson, Zena, primary, Rowlinson, Rachel, primary, Powell, Steve, primary, Sadler, Claire, primary, Richmond, Graham, primary, Ladd, Brendon, primary, Pazolli, Ermira, primary, Mazzola, Anne Marie, primary, D'Cruz, Celina, primary, and De Savi, Chris, primary

Published
2023
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45. Studies of the genes and enzymes of the shikimate pathway in Streptomyces coelicolor

Author

Walker, Graeme Edward

Subjects
572
Abstract

Aromatic compounds are synthesized via the shikimate pathway. The first activity, DAHP synthase, has been implicated in the regulation of the pathway in a number of organisms. This activity was investigated in the organism S. coelicolor and an assessment made of its regulatory importance.

Published
1991

50. Potent and selective bivalent inhibitors of BET bromodomains

Author

Waring, Michael J, Chen, Huawei, Rabow, Alfred A, Walker, Graeme, Bobby, Romel, Boiko, Scott, Bradbury, Rob H, Callis, Rowena, Clark, Edwin, Dale, Ian, Daniels, Danette L, Dulak, Austin, Flavell, Liz, Holdgate, Geoff, Jowitt, Thomas A, Kikhney, Alexey, McAlister, Mark, Méndez, Jacqui, Ogg, Derek, Patel, Joe, Petteruti, Philip, Robb, Graeme R, Robers, Matthew B, Saif, Sakina, Stratton, Natalie, Svergun, Dmitri I, Wang, Wenxian, Whittaker, David, Wilson, David M, and Yao, Yi

Published
2016
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