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2. On the Trail of Authentic Collaboration over Extended Time in Inquiry Classrooms: Following the Footprints of Role Diversification as Indicators That Inquiry Occurred

Author

Walker, Cheryl L., Shore, Bruce M., and Tabatabai, Diana

Abstract

Role diversification, the different roles participants adopt within collaborative or inquiry-based teaching and learning environments, is insufficiently understood. We observed two inquiry classroom groups, two teachers and eight students, in weekly visits over three months. Qualitative analysis of audiorecorded interactions, interviews, journals, and fieldnotes generated frequencies, nature, and adaptability of student and teacher roles across the extended instructional units, and contextual variables including classroom context, teacher and student differences, and group-work dynamics. Just one role of the many was shared between teachers and students in the situations examined. Role diversification was supported as an indicator of collaborative-inquiry engagement having occurred.

Published
2022
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4. Eye of the Beholder: Investigating the Interplay between Inquiry Role Diversification and Social Perspective Taking

Author

Walker, Cheryl L., Shore, Bruce M., and Tabatabai, Diana

Abstract

Students and teachers engage in specific roles in classrooms, and within inquiry classrooms, these roles tend to be more varied compared to traditional settings. Teachers may take on traditional student roles including the role of learner, and students, for example, take on the additional role of question asker, traditionally reserved for the role of a teacher. Several of these roles are specific to perspective taking, in particular, social perspective taking (SPT). SPT is critical to successful social interactions and, because group work occurs frequently within inquiry-based teaching and learning environments, a better understanding of SPT roles is required. SPT roles within two different inquiry classrooms were closely examined through audio-recorded group interactions. Additional data were collected in the form of questionnaires, interviews, student and teacher log responses, and field notes. Two teachers and eight students participated. Social perspective-taking roles were dynamic and susceptible to influences including the nature of the classroom activities and instructional choices, student personality differences, and group-work dynamics. All participants adopted SPT roles, however, students who played an active role in choosing their work partners and who were assigned a task that required a consideration of the audience's understanding tended to adopt more Imagine Other roles as opposed to Imagine Self roles and also adopted more emotionally-based SPT roles compared to students in teacher-formed groups who were assigned more cognitively-based assignments. Implications for researchers, consultants, and students and teachers were discussed.

Published
2013

5. The Maternal and Infant Environmental Health Riskscape study of perinatal disparities in greater Houston: rationale, study design and participant profiles.

Author

Symanski, Elaine, Whitworth, Kristina W., Mendez-Figueroa, Hector, Aagaard, Kjersti M., Moussa, Iman, Alvarez, Juan, Fabian, Adrien Chardon, Kannan, Kurunthachalam, Walker, Cheryl L., Coarfa, Cristian, Suter, Melissa A., and Salihu, Hamisu M.

Subjects
ENVIRONMENTAL health, MATERNAL health services, AFRICAN Americans, RESEARCH funding, PREGNANT women, DESCRIPTIVE statistics, LONGITUDINAL method, ENVIRONMENTAL exposure, METROPOLITAN areas, PSYCHOLOGICAL stress, ELECTRONIC health records, WOMEN'S health, HEALTH equity, SOCIODEMOGRAPHIC factors, SOCIAL support, DATA analysis software
Abstract

Introduction: The Maternal and Infant Environmental Health Riskscape (MIEHR) Center was established to address the interplay among chemical and non-chemical stressors in the biological, physical, social, and built environments that disproportionately impact perinatal health among Black pregnant people in a large and diverse urban area with documented disparities in the U.S. Methods: The MIEHR cohort is recruiting non-Hispanic Black and non-Hispanic white pregnant people who deliver their infants at major obstetric hospitals in Houston, Texas. At enrollment, all participants are asked to provide urine samples for chemical [metals, cotinine, and polycyclic aromatic hydrocarbons (PAHs)] analyses and blood samples. A subset of the cohort is asked to provide oral and vaginal swabs, and fecal samples. Questionnaire and electronic health record data gather information about residential address history during pregnancy, pregnancy history and prenatal care, sociodemographic and lifestyle factors, experiences of discrimination and stress, and sources of social support. Using information on where a participant lived during their pregnancy, features of their neighborhood environment are characterized. We provide summaries of key individual- and neighborhood-level features of the entire cohort, as well as for Black and white participants separately. Results: Between April 2021 and February 2023, 1,244 pregnant people were recruited. Nearly all participants provided urine samples and slightly less than half provided blood samples. PAH exposure patterns as assessed on 47% of participants thus far showed varying levels depending on metabolite as compared to previous studies. Additionally, analyses suggest differences between Black and white pregnant people in experiences of discrimination, stress, and levels of social support, as well as in neighborhood characteristics. Discussion: Our findings to date highlight racial differences in experiences of discrimination, stress, and levels of support, as well as neighborhood characteristics. Recruitment of the cohort is ongoing and additional neighborhood metrics are being constructed. Biospecimens will be analyzed for metals and PAH metabolites (urine samples), miRNAs (plasma samples) and the microbiome (oral swabs). Once enrollment ends, formal assessments are planned to elucidate individual- and neighborhood-level features in the environmental riskscape that contribute to Black-White disparities in perinatal health. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Contributors

Author

Allard, Patrick, primary, Angrish, Michelle M., additional, Baccarelli, Andrea A., additional, Bollati, Valentina, additional, Bommarito, Paige A., additional, Bowers, Emma C., additional, Camacho, Jessica A., additional, Cavalcante, Raymond G., additional, Cheng, Robert Y.S., additional, Chorley, Brian N., additional, Cote, Ila, additional, Cui, Julia Yue, additional, Davis, Ian J., additional, Dempsey, Joseph, additional, Deyssenroth, Maya A., additional, Dioni, Laura, additional, Druwe, Ingrid L., additional, Faulk, Christopher, additional, Fry, Rebecca C., additional, Fu, Zidong Donna, additional, Goodrich, Jaclyn M., additional, Grant, Patrick A., additional, Katz, Tiffany A., additional, Lee, Christina Y., additional, Machtinger, Ronit, additional, Martin, Elizabeth M., additional, McCullough, Shaun D., additional, On, Doan M., additional, Pattenden, Samantha G., additional, Pulczinski, Jairus, additional, Qin, Tingting, additional, Sant, Karilyn E., additional, Sartor, Maureen A., additional, Tang, Wan-yee, additional, Vandenberg, John J., additional, Walker, Cheryl L., additional, Woolard, Emily, additional, Wright, Robert O., additional, Wu, Qian, additional, and Yeung, Bonnie H.Y., additional

Published
2019
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14. SMARCB1 regulates the hypoxic stress response in sickle cell trait

Author

Soeung, Melinda, primary, Perelli, Luigi, additional, Chen, Ziheng, additional, Dondossola, Eleonora, additional, Ho, I-Lin, additional, Carbone, Federica, additional, Zhang, Li, additional, Khan, Hania, additional, Le, Courtney N., additional, Zhu, Cihui, additional, Peoples, Michael D., additional, Feng, Ningping, additional, Jiang, Shan, additional, Zacharias, Niki Millward, additional, Minelli, Rosalba, additional, Shapiro, Daniel D., additional, Deem, Angela K., additional, Gao, Sisi, additional, Cheng, Emily H., additional, Lucchetti, Donatella, additional, Walker, Cheryl L., additional, Carugo, Alessandro, additional, Giuliani, Virginia, additional, Heffernan, Timothy P., additional, Viale, Andrea, additional, Tannir, Nizar M., additional, Draetta, Giulio F., additional, Msaouel, Pavlos, additional, and Genovese, Giannicola, additional

Published
2023
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15. Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy

Author

Shapiro, Daniel D., primary, Zacharias, Niki Millward, additional, Tripathi, Durga N., additional, Karki, Menuka, additional, Bertocchio, Jean‐Philippe, additional, Soeung, Melinda, additional, He, Rong, additional, Westerman, Mary E., additional, Gao, Jianjun, additional, Rao, Priya, additional, Lam, Truong N. A., additional, Jonasch, Eric, additional, Perelli, Luigi, additional, Cheng, Emily H., additional, Carugo, Alessandro, additional, Heffernan, Timothy P., additional, Walker, Cheryl L., additional, Genovese, Giannicola, additional, Tannir, Nizar M., additional, Karam, Jose A., additional, and Msaouel, Pavlos, additional

Published
2023
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23. Supplementary Fig. 6 from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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24. Supplementary Fig. 3 from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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25. Data from SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma

Author

Chiang, Yun-Chen, primary, Park, In-Young, primary, Terzo, Esteban A., primary, Tripathi, Durga Nand, primary, Mason, Frank M., primary, Fahey, Catherine C., primary, Karki, Menuka, primary, Shuster, Charles B., primary, Sohn, Bo-Hwa, primary, Chowdhury, Pratim, primary, Powell, Reid T., primary, Ohi, Ryoma, primary, Tsai, Yihsuan S., primary, de Cubas, Aguirre A., primary, Khan, Abid, primary, Davis, Ian J., primary, Strahl, Brian D., primary, Parker, Joel S., primary, Dere, Ruhee, primary, Walker, Cheryl L., primary, and Rathmell, W. Kimryn, primary

Published
2023
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26. Figure S5 from SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma

Author

Chiang, Yun-Chen, primary, Park, In-Young, primary, Terzo, Esteban A., primary, Tripathi, Durga Nand, primary, Mason, Frank M., primary, Fahey, Catherine C., primary, Karki, Menuka, primary, Shuster, Charles B., primary, Sohn, Bo-Hwa, primary, Chowdhury, Pratim, primary, Powell, Reid T., primary, Ohi, Ryoma, primary, Tsai, Yihsuan S., primary, de Cubas, Aguirre A., primary, Khan, Abid, primary, Davis, Ian J., primary, Strahl, Brian D., primary, Parker, Joel S., primary, Dere, Ruhee, primary, Walker, Cheryl L., primary, and Rathmell, W. Kimryn, primary

Published
2023
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27. Supplementary Fig Legends from SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma

Author

Chiang, Yun-Chen, primary, Park, In-Young, primary, Terzo, Esteban A., primary, Tripathi, Durga Nand, primary, Mason, Frank M., primary, Fahey, Catherine C., primary, Karki, Menuka, primary, Shuster, Charles B., primary, Sohn, Bo-Hwa, primary, Chowdhury, Pratim, primary, Powell, Reid T., primary, Ohi, Ryoma, primary, Tsai, Yihsuan S., primary, de Cubas, Aguirre A., primary, Khan, Abid, primary, Davis, Ian J., primary, Strahl, Brian D., primary, Parker, Joel S., primary, Dere, Ruhee, primary, Walker, Cheryl L., primary, and Rathmell, W. Kimryn, primary

Published
2023
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28. Supplementary Fig. 2 from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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29. Supplementary Fig. 1 from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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30. Supplementary Fig. 4. from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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31. Supplementary Fig. 5 from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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32. Data from HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

Author

Sun, Mianen, primary, Tong, Pan, primary, Kong, Wen, primary, Dong, Baijun, primary, Huang, Yiran, primary, Park, In Young, primary, Zhou, Lijun, primary, Liu, Xian-De, primary, Ding, Zhiyong, primary, Zhang, Xuesong, primary, Bai, Shanshan, primary, German, Peter, primary, Powell, Reid, primary, Wang, Quan, primary, Tong, Xuefei, primary, Tannir, Nizar M., primary, Matin, Surena F., primary, Rathmell, W. Kimryn, primary, Fuller, Gregory N., primary, McCutcheon, Ian E., primary, Walker, Cheryl L., primary, Wang, Jing, primary, and Jonasch, Eric, primary

Published
2023
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33. Supplementary Table 2 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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34. Supplementary Methods from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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35. Supplementary Table 1 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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36. Data from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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37. Supplementary Table 4 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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38. Supplementary Table 3 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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39. Supplementary Figures 1-3 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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40. Supplementary Figure Legends 1-3 from Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

Author

Crabtree, Judy S., primary, Jelinsky, Scott A., primary, Harris, Heather A., primary, Choe, Sung E., primary, Cotreau, Monette M., primary, Kimberland, Michelle L., primary, Wilson, Ewa, primary, Saraf, Kathryn A., primary, Liu, Wei, primary, McCampbell, Adrienne S., primary, Dave, Bhuvanesh, primary, Broaddus, Russell R., primary, Brown, Eugene L., primary, Kao, Wenling, primary, Skotnicki, Jerauld S., primary, Abou-Gharbia, Magid, primary, Winneker, Richard C., primary, and Walker, Cheryl L., primary

Published
2023
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41. SMARCB1 regulates the hypoxic stress response in sickle cell trait

Author

Soeung, Melinda, Perelli, Luigi, Chen, Ziheng, Dondossola, Eleonora, Ho, I-Lin, Carbone, Federica, Zhang, Li, Khan, Hania, Le, Courtney N, Zhu, Cihui, Peoples, Michael D, Feng, Ningping, Jiang, Shan, Zacharias, Niki Millward, Minelli, Rosalba, Shapiro, Daniel D, Deem, Angela K, Gao, Sisi, Cheng, Emily H, Lucchetti, Donatella, Walker, Cheryl L, Carugo, Alessandro, Giuliani, Virginia, Heffernan, Timothy P, Viale, Andrea, Tannir, Nizar M, Draetta, Giulio F, Msaouel, Pavlo, Genovese, Giannicola, Lucchetti, Donatella (ORCID:0000-0001-8147-0079), Soeung, Melinda, Perelli, Luigi, Chen, Ziheng, Dondossola, Eleonora, Ho, I-Lin, Carbone, Federica, Zhang, Li, Khan, Hania, Le, Courtney N, Zhu, Cihui, Peoples, Michael D, Feng, Ningping, Jiang, Shan, Zacharias, Niki Millward, Minelli, Rosalba, Shapiro, Daniel D, Deem, Angela K, Gao, Sisi, Cheng, Emily H, Lucchetti, Donatella, Walker, Cheryl L, Carugo, Alessandro, Giuliani, Virginia, Heffernan, Timothy P, Viale, Andrea, Tannir, Nizar M, Draetta, Giulio F, Msaouel, Pavlo, Genovese, Giannicola, and Lucchetti, Donatella (ORCID:0000-0001-8147-0079)

Abstract

Renal medullary carcinoma (RMC) is an aggressive kidney cancer that almost exclusively develops in individuals with sickle cell trait (SCT) and is always characterized by loss of the tumor suppressor SMARCB1. Because renal ischemia induced by red blood cell sickling exacerbates chronic renal medullary hypoxia in vivo, we investigated whether the loss of SMARCB1 confers a survival advantage under the setting of SCT. Hypoxic stress, which naturally occurs within the renal medulla, is elevated under the setting of SCT. Our findings showed that hypoxia-induced SMARCB1 degradation protected renal cells from hypoxic stress. SMARCB1 wild-type renal tumors exhibited lower levels of SMARCB1 and more aggressive growth in mice harboring the SCT mutation in human hemoglobin A (HbA) than in control mice harboring wild-type human HbA. Consistent with established clinical observations, SMARCB1-null renal tumors were refractory to hypoxia-inducing therapeutic inhibition of angiogenesis. Further, reconstitution of SMARCB1 restored renal tumor sensitivity to hypoxic stress in vitro and in vivo. Together, our results demonstrate a physiological role for SMARCB1 degradation in response to hypoxic stress, connect the renal medullary hypoxia induced by SCT with an increased risk of SMARCB1-negative RMC, and shed light into the mechanisms mediating the resistance of SMARCB1-null renal tumors against angiogenesis inhibition therapies.

Published
2023

42. Understanding Classroom Roles in Inquiry Education: Linking Role Theory and Social Constructivism to the Concept of Role Diversification

Author

Walker, Cheryl L. and Shore, Bruce M.

Abstract

Inquiry-based teaching and learning are rooted in social constructivism and are central to curricular reform. Role theory and social constructivism provided insight into a commonly observed but insufficiently understood phenomenon in inquiry. Within inquiry, role shifts have been described as the switching of roles between students and teachers; however, the process may be better conceptualized as role diversification because students and teachers may undertake multiple roles simultaneously in inquiry. This article expands on existing research and proposes a framework potentially applicable to both learners and teachers, but here focused on learners. Beyond exploration, engagement, and stabilization of roles, diversification was added and described. This framework expanded on current education theory, adding new insight to a minimally explored topic, with implications for students, teachers, consultants, and researchers.

Published
2015
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43. Myth Busting: Do High-Performance Students Prefer Working Alone?

Author

Walker, Cheryl L. and Shore, Bruce M.

Abstract

There has been a longstanding assumption that gifted, high-ability, or high-performing students prefer working alone; however, this may not be true in every case. The current study expanded on this assumption to reveal more nuanced learning preferences of these students. Sixty-nine high-performing and community-school students in Grades 5 and 6 participated. A 26-item questionnaire addressed students' learning preferences. Nine students were interviewed after completing the questionnaire to further explore their answers. Substantial evidence supported high-performing students' preferences for working with others. These preferences were complex and varied depending on the learning situation. Implications for future research were discussed.

Published
2015
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48. SETD2 safeguards the genome against isochromosome formation

Author

Mason, Frank M., primary, Kounlavong, Emily S., additional, Tebeje, Anteneh T., additional, Dahiya, Rashmi, additional, Guess, Tiffany, additional, Vlach, Logan, additional, Norris, Stephen R., additional, Lovejoy, Courtney A., additional, Dere, Ruhee, additional, Ohi, Ryoma, additional, Ly, Peter, additional, Walker, Cheryl L., additional, and Rathmell, W. Kimryn, additional

Published
2022
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50. How Do Parents and Teachers of Gifted Students Perceive Group Work in Classrooms?

Author

Saunders-Stewart, Katie S., Walker, Cheryl L., and Shore, Bruce M.

Abstract

Although an abundance of information exists concerning advantages and disadvantages of certain grouping arrangements with highly able students in classroom settings, little research has focused on gifted children's parents' and teachers' opinions of group work. The present study explored potential differences between these opinions. Parents (n= 15), teachers (n = 11), and a group who were both parents and teachers (n = 5) of gifted children responded to a researcher-designed telephone interview. Teachers were move favorable to group work, reported their opinions as driven by their pedagogical knowledge regarding its advantages, and perceived parents as competitive and grade-oriented. Parents were less favorable and their opinions were based on their children's negative experiences. Both groups were aware of each other's perspective. Reform-based pedagogy, extensively endorsed in gifted education, supports classroom group work. Educators seeking parental support for group work should ensure, beyond learning benefits, a positive experience for gifted students.

Published
2013
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