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1. Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial

Author

Belle-Isle, Jasmin, Nadeau, Jerome, Killorn, William, Francoeur, Bruno, Millaire, Emilie, Pek, Bonavuth, Ferguson, Murdo, Maltais, Francois, Killian, Kieran, Mazza, Giuseppe, Melenka, Lyle, Walker, Brandie, Bergeron, Celine, FitzGerald, John, Weinreich, Ulla Møller, Bendstrup, Elisabeth, Porsbjerg, Celeste, Ulrik, Charlotte, Titlestad, Ingrid, Meyer, Christian, Hilberg, Ole, Couturaud, Francis, Andrejak, Claire, Bourdin, Arnaud, Devouassoux, Gilles, Pepin, Jean-Louis, Chanez, Pascal, Cavailles, Arnaud, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Schultz, Thomas, Bar-Shai, Amir, Wand, Ori, Adir, Yochai, Berkman, Neville, Fink, Gershon, Shitrit, David, Izbicki, Gabriel, Raviv, Yael, Wielders, Pascal, Goosens, Martijn, Heller-Baan, Roxane, in't Veen, Johannes, Custers, Frank, Oh, Yeon-Mok, Lee, YongChul, Kim, Jaeyeol, Yoo, Kwang-Ha, Park, Jung-Won, Lee, Sang Haak, Ahn, Joong Hyun, Lee, Sook Young, Kim, Jin Woo, Lee, Kwan Ho, Caballero, Luis Mateos, Naval Sendra, Elsa, Ramos Barbón, David, Velasco Garrido, José Luis, Alcázar Navarrete, Bernardino, Saralaya, Dinesh, Crooks, Michael, Shah, Pallav, Chaudhuri, Rekha, de Soyza, Anthony, Nordstrom, Monica, Dwarakanath, Akshay, Weinstein, Steven, Pham, David, Mitchell, John, Spangenthal, Selwyn, Surdulescu, Sever, Denenberg, Michael, Alpizar, Sady, Maybee, David, Moriarty, Timothy, Fakih, Faisal, Beasley, Richard, Heuer, Marvin, Patel, Amit, Dorf, Jeffrey, Martinez, Rafael, Kureishy, Shahrukh, Klein, Ryan, Hewitt, Mitzie, Cole, Jeremy, Robinette, Emory, Cordasco, Edward, Garver, Robert, Criner, Gerard, Sciurba, Frank, Kerwin, Edward, Lucksinger, Gregg, Delgado, John, Russian, David, Chupp, Geoffrey, Singh, Dave, Brightling, Christopher E, Rabe, Klaus F, Han, MeiLan K, Christenson, Stephanie A, Drummond, M Bradley, Papi, Alberto, Pavord, Ian D, Molfino, Nestor A, Almqvist, Gun, Kotalik, Ales, Hellqvist, Åsa, Gołąbek, Monika, Sindhwani, Navreet S, and Ponnarambil, Sandhia S

Published
2025
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2. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, and Lewthwaite, Hayley

Published
2024
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3. Identifying Abnormal Exertional Breathlessness in COPD: Comparing Modified Medical Research Council and COPD Assessment Test With Cardiopulmonary Exercise Testing

Author

FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, Lewthwaite, Hayley, Bourbeau, Jean, and Tan, Wan C.

Published
2024
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5. Impaired Sleep Quality in COPD Is Associated With Exacerbations The CanCOLD Cohort Study

Author

Shorofsky, Matthew, Bourbeau, Jean, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Tan, Wan C, Aaron, Shawn D, Sin, Don D, Road, Jeremy, Chapman, Kenneth R, O’Donnell, Denis E, Maltais, François, Hernandez, Paul, Walker, Brandie L, Marciniuk, Darcy, Kaminska, Marta, FitzGerald, J Mark, Sin, DD, Marciniuk, DD, O'Donnell, DE, Cowie, Robert, Aaron, Shawn, Maltais, F, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C, Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, and Clemens, Ron

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Prevention, Chronic Obstructive Pulmonary Disease, Lung, Sleep Research, Clinical Research, 6.1 Pharmaceuticals, Respiratory, Aged, Cohort Studies, Disease Progression, Dyspnea, Female, Health Services, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Sleep, Sleep Wake Disorders, Sputum, Time Factors, acute exacerbation of chronic bronchitis, COPD, sleep medicine, Canadian Respiratory Research Network, CanCOLD Collaborative Research group, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundCOPD increases susceptibility to sleep disturbances, which may in turn predispose to increased respiratory symptoms. The objective of this study was to evaluate, in a population-based sample, the relationship between subjective sleep quality and risk of COPD exacerbations.MethodsData were obtained from the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Participants with COPD who had completed 18 months of follow-up were included. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a three-factor analysis. Symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) exacerbations were assessed. Association of PSQI with exacerbation rate was assessed by using negative binomial regression. Exacerbation-free survival was also assessed.ResultsA total of 480 participants with COPD were studied, including 185 with one or more exacerbations during follow-up and 203 with poor baseline sleep quality (PSQI score > 5). Participants with subsequent symptom-based exacerbations had higher median baseline PSQI scores than those without (6.0 [interquartile range, 3.0-8.0] vs 5.0 [interquartile range, 2.0-7.0]; P = .01), and they were more likely to have baseline PSQI scores > 5 (50.3% vs 37.3%; P = .01). Higher PSQI scores were associated with increased symptom-based exacerbation risk (adjusted rate ratio, 1.09; 95% CI, 1.01-1.18; P = .02) and event-based exacerbation risk (adjusted rate ratio, 1.10; 95% CI, 1.00-1.21; P = .048). The association occurred mainly in those with undiagnosed COPD. Strongest associations were with Factor 3 (sleep disturbances and daytime dysfunction). Time to symptom-based exacerbation was shorter in participants with poor sleep quality (adjusted hazard ratio, 1.49; 95% CI, 1.09-2.03).ConclusionsHigher baseline PSQI scores were associated with increased risk of COPD exacerbation over 18 months' prospective follow-up.

Published
2019

7. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study

Author

FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Bourbeau, Jean, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candace, Krishnan, Suurya, Tan, Wan C., Farias, Raquel, and Aaron, Shawn D.

Published
2023
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8. Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Author

Pohl, Wolfgang, Doberer, Daniel, Martinot, Jean Benoit, Deschampheleire, Maud, Himpe, Ulrike, Chapman, Kenneth, Cheema, Amarjit, Dorscheid, Delbert, Ramsey, Clare, Rolf, Jeffrey, Walker, Brandie, Olivenstein, Ronald, Poirier, Claude, Larivee, Pierre, Bjerrum, Anne Sofie, Titlestad, Ingrid, Hilberg, Ole, Kilpeläinen, Maritta, Bonniaud, Philippe, Taillé, Camille, Tiotiu, Iuliana-Angelica, Girodet, Pierre-Olivier, Blanc, François-Xavier, Pradelli, Johana, Didier, Alain, Nocent Ejnaini, Cecilia, Deslee, Gaetan, Pison, Christophe, Douadi, Youcef, Mahay, Guillaume, Devouassoux, Gilles, Melloni, Boris, Roux, Pauline-Marie, Bourdin, Arnaud, Fry, Stephanie, Schaum, Thomas, Schulz, Christian, Skowasch, Dirk, Taube, Christian, Welte, Tobias, Gleiber, Wolfgang, Brehler, Randolf, Schreiber, Jens, Schuette, Wolfgang, Kronsbein, Juliane, Bonnet, Reiner, Beck, Ekkehard, Lacedonia, Donato, Senna, Gianenrico, Caruso, Cristiano, Crimi, Nunzio, Blasi, Francesco, Santus, Pierachille, Canonica, Giorgio Walter, Guarnieri, Gabriella, Pelaia, Girolamo, Milanese, Manlio, Micheletto, Claudio, Corsico, Angelo Guido, Scichilone, Nicola, Spadaro, Giuseppe, Langeveld, Bas, Holters, Jurgen, Willem van den Berg, Jan, Smit, Arthur, Conemans, Lennart, van Veen, Helena, Staaks, Gerald, Lehmann, Sverre, Echave-Sustaeta, Jose Maria, Ribas, Christian Domingo, de Luiz Martinez, Gustavo, Gonzalez Perez, Ruperto, Garcia Rivero, Juan Luis, Gall, Xavier Muñoz, Soto Campos, Jose Gregorio, Mozo, Paloma Campo, Pan, Carmen Vidal, Fernandez, Ana Gomez-Bastero, Tellez, Sergio Campos, Rivera, Carlos Martinez, Bobolea, Irina Diana, Guerrero, Raquel Morillo, Garcia, Ismael Ali, Rodriguez Hermosa, Juan Luis, Stenfors, Nikolai, Tunsäter, Alf, Curiac, Dan, von Garnier, Christophe, Leuppi, Joerg, Schmid-Grendelmeier, Peter, Nasser, Shuaib, Chaudhuri, Rekha, Nordstrom, Monica, Saralaya, Dinesh, Pfeffer, Paul, Mansur, Adel, Short, Philip, Wenzel, Sally, Cherry, William Brett, Zafra, Heidi, Gonzalez, Erika, Soong, Weily, Davis, Benjamin, Kao, Neil, Hussain, Iftikhar, Maselli Caceres, Diego Jose, Harris, James, Calhoun, William, Rodicio, Ileana, Kaufman, David, Moss, Mark, Sztejman, Eric, DeLeon, Samuel, Sumino, Kaharu, Kashyap, Ravindra, Leflein, Jeffrey, Hajal, Rizan, Fakih, Faisal, Hill, David, Lin, Robert, Jarratt, Mikell, Subramaniam, Vijay, Sussman, Robert, Mumneh, Nayla, Reibman, Joan, Darveaux, Jared, Tan, Ricardo, Tanus, Tonny, Sikand, Vinay, Marshall, Gailen, Mehta, Hemalini, Cole, Jeremy, Goodman, Brad, Goss, Deborah, Bardelas, Jose, Milstone, Aaron, Mehta, Vinay, Clore, Lee, Millard, Mark, Palumbo, Michael, Puppala, Dileep, Leong, Mila, Prenner, Bruce, Robinette, Emory, Heidarian Raissy, Hengameh, Fost, David, Pleskow, Warren, Marcus, Michael, Ilowite, Jonathan, Moore, Wendy, Steven, Gary, De la Cruz, Luis, Chupp, Geoffrey, Berger, William, Randolph, Christopher, Holguin, Fernando, Kureishy, Shahrukh, Campbell, Edward, Peche, Rudi, Pini, Laura, Papi, Alberto, Beghé, Bianca, Peveri, Silvia, Henriquez Santa, Aythamy, Ramos Gonzalez, Jacinto, Vinge, Ines, St. John, Roy, Louis, Renaud, Harrison, Tim W., Chanez, Pascal, Menzella, Francesco, Philteos, George, Cosio, Borja G., Lugogo, Njira L., de Luiz, Gustavo, Burden, Annie, Adlington, Timothy, Keeling, Nanna, Kwiatek, Justin, and Garcia Gil, Esther

Published
2023
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9. Short-Acting Beta-2-Agonist Exposure and Severe Asthma Exacerbations: SABINA Findings From Europe and North America

Author

Fong, Andrew, Qian, Christina, Fabry-Vendrand, Caroline, Touboul, Chantal, Brzostek, Dorota, Maslova, Ekaterina, Surmont, Filip, Goike, Helena, Gandhi, Hitesh, Korevaar, J.C., Tkacz, Joseph, Johnston, Karissa, Peres da Costa, Keith, van Dijk, L., Vervloet, M., Pollack, Michael, Hernandez, Paul, Boarino, Silvia, Noorduyn, Stephen G., Beekman-Hendricks, Wendy, Weesie, Y.M., Quint, Jennifer K., Arnetorp, Sofie, Kocks, Janwillem W.H., Kupczyk, Maciej, Nuevo, Javier, Plaza, Vicente, Cabrera, Claudia, Raherison-Semjen, Chantal, Walker, Brandie, Penz, Erika, Gilbert, Ileen, Lugogo, Njira Lucia, and van der Valk, Ralf J.P.

Published
2022
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10. Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care Coordinator: A Randomized Clinical Trial

Author

Atwood, Chantal E., Bhutani, Mohit, Ospina, Maria B., Rowe, Brian H., Leigh, Richard, Deuchar, Lesly, Faris, Peter, Michas, Marta, Mrklas, Kelly J., Graham, Jim, Aceron, Raymond, Damant, Ron, Green, Lee, Hirani, Naushad, Longard, Kelly, Meyer, Virginia, Mitchell, Patrick, Tsai, Willis, Walker, Brandie, and Stickland, Michael K.

Published
2022
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11. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Junior, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Shorofsky, Matthew, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Aaron, Shawn D., Sin, Don D., O’Donnell, Denis E., Maltais, François, Walker, Brandie L., and Kaminska, Marta

Published
2019
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12. Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial

Author

Singh, Dave, Brightling, Christopher E, Rabe, Klaus F, Han, MeiLan K, Christenson, Stephanie A, Drummond, M Bradley, Papi, Alberto, Pavord, Ian D, Molfino, Nestor A, Almqvist, Gun, Kotalik, Ales, Hellqvist, Åsa, Gołąbek, Monika, Sindhwani, Navreet S, Ponnarambil, Sandhia S, Belle-Isle, Jasmin, Nadeau, Jerome, Killorn, William, Francoeur, Bruno, Millaire, Emilie, Pek, Bonavuth, Ferguson, Murdo, Maltais, Francois, Killian, Kieran, Mazza, Giuseppe, Melenka, Lyle, Walker, Brandie, Bergeron, Celine, FitzGerald, John, Weinreich, Ulla Møller, Bendstrup, Elisabeth, Porsbjerg, Celeste, Ulrik, Charlotte, Titlestad, Ingrid, Meyer, Christian, Hilberg, Ole, Couturaud, Francis, Andrejak, Claire, Bourdin, Arnaud, Devouassoux, Gilles, Pepin, Jean-Louis, Chanez, Pascal, Cavailles, Arnaud, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Schultz, Thomas, Bar-Shai, Amir, Wand, Ori, Adir, Yochai, Berkman, Neville, Fink, Gershon, Shitrit, David, Izbicki, Gabriel, Raviv, Yael, Wielders, Pascal, Goosens, Martijn, Heller-Baan, Roxane, in't Veen, Johannes, Custers, Frank, Oh, Yeon-Mok, Lee, YongChul, Kim, Jaeyeol, Yoo, Kwang-Ha, Park, Jung-Won, Lee, Sang Haak, Ahn, Joong Hyun, Lee, Sook Young, Kim, Jin Woo, Lee, Kwan Ho, Caballero, Luis Mateos, Naval Sendra, Elsa, Ramos Barbón, David, Velasco Garrido, José Luis, Alcázar Navarrete, Bernardino, Saralaya, Dinesh, Crooks, Michael, Shah, Pallav, Chaudhuri, Rekha, de Soyza, Anthony, Nordstrom, Monica, Dwarakanath, Akshay, Weinstein, Steven, Pham, David, Mitchell, John, Spangenthal, Selwyn, Surdulescu, Sever, Denenberg, Michael, Alpizar, Sady, Maybee, David, Moriarty, Timothy, Fakih, Faisal, Beasley, Richard, Heuer, Marvin, Patel, Amit, Dorf, Jeffrey, Martinez, Rafael, Kureishy, Shahrukh, Klein, Ryan, Hewitt, Mitzie, Cole, Jeremy, Robinette, Emory, Cordasco, Edward, Garver, Robert, Criner, Gerard, Sciurba, Frank, Kerwin, Edward, Lucksinger, Gregg, Delgado, John, Russian, David, and Chupp, Geoffrey

Abstract

Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, which has shown increased expression in patients with chronic obstructive pulmonary disease (COPD) compared with healthy individuals. We aimed to assess the efficacy and safety of tezepelumab in patients with moderate to very severe COPD despite receiving triple inhaled therapy.

Published
2025
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13. Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial

Author

Pohl, Wolfgang, Voves, Robert, Deschampheleire, Maud, Louis, Renaud, Martinot, Jean-Benoit, Peché, Rudi, Chapman, Kenneth, Cheema, Amarjit, Dorscheid, Delbert, FitzGerald, J. Mark, Gagnon, Remi, Killorn, William Patrick, Olivenstein, Ronald, Philteos, George, Ramsey, Clare, Rolf, J. Douglass, Walker, Brandie, Hilberg, Ole, Skjold, Tina, Titlestad, Ingrid, Hakulinen, Auli, Kilpeläinen, Maritta, Ben Hayoun, Michèle, Bonniaud, Philippe, Bourdin, Arnaud, Chanez, Pascal, De Blay, Frédéric, Deslee, Gaëtan, Devouassoux, Gilles, Didier, Alain, Douadi, Youcef, Fry, Stéphanie, Garcia, Gilles, Girodet, Pierre-Olivier, Leroyer, Christophe, Magnan, Antoine, Mahay, Guillaume, Nocent, Cécilia, Pison, Christophe, Roux, Pauline-Marie, Taillé, Camille, Tiotiu, Juliana-Angelica, Beck, Ekkehard, Jandl, Margret, Kaehler, Christian, Kässner, Frank, Koesters, Frank, Kronsbein, Juliane, Schaum, Thomas, Schulz, Christian, Skowasch, Dirk, Taube, Christian, Welte, Tobias, de Roux, Andrés, Beghé, Bianca, Blasi, Francesco, Canonica, Giorgio Walter, Carpagnano, Giovanna, Caruso, Cristiano, Corsico, Angelo Guido, Constantino, Elio, Crimi, Nunzio, Maestrelli, Piero, Menzella, Francesco, Milanese, Manlio, Papi, Alberto, Pelaia, Girolamo, Pini, Laura, Santus, Pierachille, Savi, Eleonora, Scichilone, Nicola, Senna, Gianenrico, Spadaro, Giuseppe, Vaghi, Adriano, Gans, Steven, Hölters, Jurgen, Langeveld, B., Pieters, Willem, Staaks, G.H.A., van Veen, Ilonka, van den Berg, J.W.K., Einvik, Gunnar, Lehmann, Sverre, Ali García, Ismael, Almonacid, Carlos, Bobolea, Irina, Campo Mozo, Paloma, de Luiz, Gustavo, Domingo Ribas, Christian, Echave-Sustaeta María-Tomé, José María, García Rivero, Juan Luis, García-Cosío Piqueras, Borja, Gómez-Bastero Fernández, Ana, González Pérez, Ruperto, Henríquez Santa, Aythamy, Martínez Rivera, Carlos, Muñoz Gall, Xavier, Ramos, Jacinto, Gregorio Soto Campos, Jose, Vidal Pan, Carmen, Stenfors, Nikolai, Tunsäter, Alf, Vinge, Ines, Chaudhuri, Rekha, Harrison, Timothy, Mansur, Adel, Nasser, Shuaib, Nordstrom, Monica, Pfeffer, Paul, Saralaya, Dinesh, Short, Philip, Adlakha, Arun, Alpan, Oral, Averill, Francis, Badhwar, Anil, Bardelas, Jose, Baxter, Barbara, Bensch, George, Berger, William, Bernstein, Jonathan, Bridges, Tracy, Brimeyer, Ryan, Calhoun, William, Campbell, Edward, Cherry, William Brett, Chupp, Geoffrey, Clore, Lee, Cohn, John, Cole, Jeremy, Condemi, John, Cury, James, Davis, Benjamin, DeLeon, Samuel, Delacruz, Luis, Diaz, Joseph, Erb, David, Eziri, Emeka, Fakih, Faisal, Fiedler, Douglas, Fost, David, Fritz, Stephen, Gonzalez, Erika, Goodman, Brad, Gottlieb, Peter, Gottschlich, Gregory, Gower, Richard, Hajal, Rizan, Harris, James, Heidarian-Raissy, Hengameh, Heyder, Albrecht, Hill, David, Holguin, Fernando, Hussain, Iftikhar, Illowite, Jonathan, Jacobs, Joshua, Jarratt, Mikell, Kaiser, Harold, Kao, Neil, Kashyap, Ravindra, Kaufman, David, Kent, Edward, Kim, Kenneth, Klein, Ryan, Kraft, Monica, Kono, Ritsu, Kureishy, Shahrukh, Leflein, Jeffrey, Leong, Mila, Li, Huamin, Lin, Robert, Lugogo, Njira, Marcus, Michael, Maselli Caceres, Diego Jose, Mehta, Vinay, Mello, Curtis, Millard, Mark, Milstone, Aaron, Mohan, Arjun, Moore, Wendy, Moss, Mark, Mumneh, Nayla, O'Brien, Thomas, Ostransky, David, Palumbo, Michael, Parikh, Purvi, Parikh, Sudhir, Patel, Amit, Perez, Guido, Pleskow, Warren, Prenner, Bruce, Puppala, Dileep, Ramey, John, Reibman, Joan, Reyes, Ramon, Robinette, Emory, Rodicio, Ileana, Ryan, Stephen, Sekhsaria, Sudhir, Sigal, Barry, Sikand, Vinay, Soong, Weily, Spangenthal, Selwyn, St. John, Roy, Steven, Gary, Subramaniam, Vijay, Sumino, Kaharu, Sztejman, Eric, Tan, Ricardo A., Tanus, Tonny, Thompson, Charles, Thornblade, Carl, Villareal, Manuel, Wenzel, Sally, Zafra, Heidi, Ziedalski, Tomasz, Harrison, Tim W, Cosio, Borja G, Lugogo, Njira L, Burden, Annie, McDermott, Lawrence, Garcia Gil, Esther, and Zangrilli, James G

Published
2021
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14. Early response to benralizumab in Canadian patients with severe eosinophilic asthma: Interim results from a prospective observational cohort

Author

Noorduyn, Stephen G., primary, Kayaniyil, Sheena, additional, Lancaster, Brett, additional, Dorscheid, Delbert, additional, Tourin, Olga, additional, Walker, Brandie, additional, Thawer, Amin, additional, Ramesh, Warren, additional, Khan, Irfan, additional, Kim, Harold, additional, Sussman, Gordon, additional, Mbuagbaw, Lawrence, additional, and Penz, Erika, additional

Published
2024
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15. Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing

Author

Ekström, Magnus, primary, Li, Pei Zhi, additional, Lewthwaite, Hayley, additional, Bourbeau, Jean, additional, Tan, Wan C., additional, Schiöler, Linus, additional, Brotto, Andrew, additional, Stickland, Michael K., additional, Jensen, Dennis, additional, FitzGerald, J. Mark, additional, Sin, Don D., additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Aaron, Shawn, additional, Maltais, François, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Doiron, Dany, additional, Mancino, Palmina, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Benedetti, Andrea, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2024
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19. EFFECTIVENESS OF BENRALIZUMAB AFTER 12 MONTHS OF TREATMENT IN CANADIANS WITH SEVERE ASTHMA

Author

PENZ, ERIKA D, primary, KAYANIYIL, SHEENA, additional, LANCASTER, BRETT, additional, LEE, JASON, additional, TOURIN, OLGA, additional, RAMESH, WARREN, additional, WALKER, BRANDIE L, additional, KHAN HAZARATOOLA, IRFAN I, additional, SUSSMAN, GORDON, additional, FRANCOEUR, BRUNO, additional, THAWER, AMIN, additional, FERA, THARWAT A, additional, BELAK, ZENON A, additional, SEBASTIAN, JUSTIN C, additional, DHAWAN, VIVEK, additional, and MBUAGBAW, LAWRENCE, additional

Published
2023
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20. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Haynes, Nancy, Chuang, Junior, Zheng, Liyun, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Gupta, Nisha, Pinto, Lancelot, Li, Pei Zhi, Aaron, Shawn D., Marciniuk, Darcy D., Maltais, François, O'Donnell, Denis E., and Walker, Brandie L.

Published
2016
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21. Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort

Author

Ross, Bryan A, primary, Doiron, Dany, additional, Benedetti, Andrea, additional, Aaron, Shawn D, additional, Chapman, Kenneth, additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy, additional, O'Donnell, Denis E, additional, Sin, Don D, additional, Walker, Brandie L, additional, Tan, Wan, additional, and Bourbeau, Jean, additional

Published
2023
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22. Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Author

Louis, Renaud, primary, Harrison, Tim W., additional, Chanez, Pascal, additional, Menzella, Francesco, additional, Philteos, George, additional, Cosio, Borja G., additional, Lugogo, Njira L., additional, de Luiz, Gustavo, additional, Burden, Annie, additional, Adlington, Timothy, additional, Keeling, Nanna, additional, Kwiatek, Justin, additional, Garcia Gil, Esther, additional, Pohl, Wolfgang, additional, Doberer, Daniel, additional, Martinot, Jean Benoit, additional, Deschampheleire, Maud, additional, Himpe, Ulrike, additional, Chapman, Kenneth, additional, Cheema, Amarjit, additional, Dorscheid, Delbert, additional, Ramsey, Clare, additional, Rolf, Jeffrey, additional, Walker, Brandie, additional, Olivenstein, Ronald, additional, Poirier, Claude, additional, Larivee, Pierre, additional, Bjerrum, Anne Sofie, additional, Titlestad, Ingrid, additional, Hilberg, Ole, additional, Kilpeläinen, Maritta, additional, Bonniaud, Philippe, additional, Taillé, Camille, additional, Tiotiu, Iuliana-Angelica, additional, Girodet, Pierre-Olivier, additional, Blanc, François-Xavier, additional, Pradelli, Johana, additional, Didier, Alain, additional, Nocent Ejnaini, Cecilia, additional, Deslee, Gaetan, additional, Pison, Christophe, additional, Douadi, Youcef, additional, Mahay, Guillaume, additional, Devouassoux, Gilles, additional, Melloni, Boris, additional, Roux, Pauline-Marie, additional, Bourdin, Arnaud, additional, Fry, Stephanie, additional, Schaum, Thomas, additional, Schulz, Christian, additional, Skowasch, Dirk, additional, Taube, Christian, additional, Welte, Tobias, additional, Gleiber, Wolfgang, additional, Brehler, Randolf, additional, Schreiber, Jens, additional, Schuette, Wolfgang, additional, Kronsbein, Juliane, additional, Bonnet, Reiner, additional, Beck, Ekkehard, additional, Lacedonia, Donato, additional, Senna, Gianenrico, additional, Caruso, Cristiano, additional, Crimi, Nunzio, additional, Blasi, Francesco, additional, Santus, Pierachille, additional, Canonica, Giorgio Walter, additional, Guarnieri, Gabriella, additional, Pelaia, Girolamo, additional, Milanese, Manlio, additional, Micheletto, Claudio, additional, Corsico, Angelo Guido, additional, Scichilone, Nicola, additional, Spadaro, Giuseppe, additional, Langeveld, Bas, additional, Holters, Jurgen, additional, Willem van den Berg, Jan, additional, Smit, Arthur, additional, Conemans, Lennart, additional, van Veen, Helena, additional, Staaks, Gerald, additional, Lehmann, Sverre, additional, Echave-Sustaeta, Jose Maria, additional, Ribas, Christian Domingo, additional, de Luiz Martinez, Gustavo, additional, Gonzalez Perez, Ruperto, additional, Garcia Rivero, Juan Luis, additional, Gall, Xavier Muñoz, additional, Soto Campos, Jose Gregorio, additional, Mozo, Paloma Campo, additional, Pan, Carmen Vidal, additional, Fernandez, Ana Gomez-Bastero, additional, Tellez, Sergio Campos, additional, Rivera, Carlos Martinez, additional, Bobolea, Irina Diana, additional, Guerrero, Raquel Morillo, additional, Garcia, Ismael Ali, additional, Rodriguez Hermosa, Juan Luis, additional, Stenfors, Nikolai, additional, Tunsäter, Alf, additional, Curiac, Dan, additional, von Garnier, Christophe, additional, Leuppi, Joerg, additional, Schmid-Grendelmeier, Peter, additional, Nasser, Shuaib, additional, Chaudhuri, Rekha, additional, Nordstrom, Monica, additional, Saralaya, Dinesh, additional, Pfeffer, Paul, additional, Mansur, Adel, additional, Short, Philip, additional, Wenzel, Sally, additional, Cherry, William Brett, additional, Zafra, Heidi, additional, Gonzalez, Erika, additional, Soong, Weily, additional, Davis, Benjamin, additional, Kao, Neil, additional, Hussain, Iftikhar, additional, Maselli Caceres, Diego Jose, additional, Harris, James, additional, Calhoun, William, additional, Rodicio, Ileana, additional, Kaufman, David, additional, Moss, Mark, additional, Sztejman, Eric, additional, DeLeon, Samuel, additional, Sumino, Kaharu, additional, Kashyap, Ravindra, additional, Leflein, Jeffrey, additional, Hajal, Rizan, additional, Fakih, Faisal, additional, Hill, David, additional, Lin, Robert, additional, Jarratt, Mikell, additional, Subramaniam, Vijay, additional, Sussman, Robert, additional, Mumneh, Nayla, additional, Reibman, Joan, additional, Darveaux, Jared, additional, Tan, Ricardo, additional, Tanus, Tonny, additional, Sikand, Vinay, additional, Marshall, Gailen, additional, Mehta, Hemalini, additional, Cole, Jeremy, additional, Goodman, Brad, additional, Goss, Deborah, additional, Bardelas, Jose, additional, Milstone, Aaron, additional, Mehta, Vinay, additional, Clore, Lee, additional, Millard, Mark, additional, Palumbo, Michael, additional, Puppala, Dileep, additional, Leong, Mila, additional, Prenner, Bruce, additional, Robinette, Emory, additional, Heidarian Raissy, Hengameh, additional, Fost, David, additional, Pleskow, Warren, additional, Marcus, Michael, additional, Ilowite, Jonathan, additional, Moore, Wendy, additional, Steven, Gary, additional, De la Cruz, Luis, additional, Chupp, Geoffrey, additional, Berger, William, additional, Randolph, Christopher, additional, Holguin, Fernando, additional, Kureishy, Shahrukh, additional, and Campbell, Edward, additional

Published
2023
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23. Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease

Author

Krishnan, Suurya, primary, Tan, Wan C., additional, Farias, Raquel, additional, Aaron, Shawn D., additional, Benedetti, Andrea, additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Sin, Don D., additional, Walker, Brandie, additional, Bourbeau, Jean, additional, FitzGerald, J. Mark, additional, Aaron, Shawn, additional, Doiron, Dany, additional, Mancino, Palmina, additional, Li, Pei Zhi, additional, Jensen, Dennis, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Sin, Don, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Song, Zhi, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, O’Donnell, Denis, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candace, additional

Published
2023
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24. Physical Activity and Symptom Burden in COPD: The Canadian Obstructive Lung Disease Study

Author

Oostrik, Loes, primary, Bourbeau, Jean, additional, Doiron, Dany, additional, Ross, Bryan, additional, Zhi-Li, Pei, additional, Aaron, Shawn D., additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis, additional, Tan, Wan C., additional, Sin, Don D., additional, Walker, Brandie, additional, and Janaudis-Ferreira, Tania, additional

Published
2023
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25. Factors Associated with Attrition in a Longitudinal Cohort of Older Adults in the Community

Author

Katsuno, Noah, primary, Li, Pei Z., additional, Bourbeau, Jean, additional, Aaron, Shawn, additional, Maltais, Francois, additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Marciniuk, Darcy D., additional, ODonnell, Denis D., additional, Sin, Don D., additional, Hogg, James C., additional, Cheng, Michael, additional, Road, Jeremy, additional, and Tan, Wan C., additional

Published
2023
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27. Short-Acting Beta-2-Agonist Exposure and Severe Asthma Exacerbations: SABINA Findings From Europe and North America

Author

Quint, Jennifer K., primary, Arnetorp, Sofie, additional, Kocks, Janwillem W.H., additional, Kupczyk, Maciej, additional, Nuevo, Javier, additional, Plaza, Vicente, additional, Cabrera, Claudia, additional, Raherison-Semjen, Chantal, additional, Walker, Brandie, additional, Penz, Erika, additional, Gilbert, Ileen, additional, Lugogo, Njira Lucia, additional, van der Valk, Ralf J.P., additional, Fong, Andrew, additional, Qian, Christina, additional, Fabry-Vendrand, Caroline, additional, Touboul, Chantal, additional, Brzostek, Dorota, additional, Maslova, Ekaterina, additional, Surmont, Filip, additional, Goike, Helena, additional, Gandhi, Hitesh, additional, Korevaar, J.C., additional, Tkacz, Joseph, additional, Johnston, Karissa, additional, Peres da Costa, Keith, additional, van Dijk, L., additional, Vervloet, M., additional, Pollack, Michael, additional, Hernandez, Paul, additional, Boarino, Silvia, additional, Noorduyn, Stephen G., additional, Beekman-Hendricks, Wendy, additional, and Weesie, Y.M., additional

Published
2022
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28. Ambient Air Pollution and Dysanapsis: Associations with Lung Function and Chronic Obstructive Pulmonary Disease in the Canadian Cohort Obstructive Lung Disease Study

Author

Bourbeau, Jean, primary, Doiron, Dany, additional, Biswas, Sharmistha, additional, Smith, Benjamin M., additional, Benedetti, Andrea, additional, Brook, Jeffrey R., additional, Aaron, Shawn D., additional, Chapman, Kenneth R., additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy D., additional, O’Donnell, Denis, additional, Sin, Don D., additional, Walker, Brandie, additional, Dsilva, Liesel, additional, Nadeau, Gilbert, additional, Coats, Valérie, additional, Compton, Chris, additional, Miller, Bruce E., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, FitzGerald, J. Mark, additional, O’Donnell, Denis E., additional, Aaron, Shawn, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Mancino, Palmina, additional, Li, Pei Zhi, additional, Jensen, Dennis, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Kirby, Miranda, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonté, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, Vincent, Sandra, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2022
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29. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study

Author

Phillips, Devin B., primary, Elbehairy, Amany F., additional, James, Matthew D., additional, Vincent, Sandra G., additional, Milne, Kathryn M., additional, de-Torres, Juan P., additional, Neder, J. Alberto, additional, Kirby, Miranda, additional, Jensen, Dennis, additional, Stickland, Michael K., additional, Guenette, Jordan A., additional, Smith, Benjamin M., additional, Aaron, Shawn D., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, O’Donnell, Denis E., additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hogg, James C., additional, Hamid, Qutayba, additional, Doiron, Dany, additional, Mancino, Palmina, additional, Li, Pei-Zhi, additional, Song, Zhi, additional, Fortier, Yvan, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Duke, Jane, additional, Gershon, Andrea S., additional, Toh, Teresa, additional, Sadatsafavi, Mohsen, additional, Sin, Don, additional, Fitzgerald, J. Mark, additional, Road, Jeremy, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Cheng, Michael, additional, Fung, Cynthia, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Choi, Rena, additional, Comeau, Joe, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Walker, Brandie, additional, Dumonceaux, Curtis, additional, Hernandez, Paul, additional, Fulton, Scott, additional, Vandemheen, Kathy, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Maltais, Francois, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, and Baran, Janet, additional

Published
2022
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31. The population risk attribution associated with chronic airway obstruction from the results of the Canadian Obstructive Lung Disease study

Author

Tan, Wan Cheng, primary, Li, Pei, additional, Choi, Rena, additional, Bourbeau, Jean, additional, Aaron, Shawn, additional, Leung, Clarus, additional, Maltais, Francois, additional, Hernandez, Paul, additional, Chapman, Kenneth, additional, Walker, Brandie, additional, Marciniuk, Darcy, additional, O'Donnell, Denis, additional, Hogg, James, additional, Road, Jeremy, additional, Fitzgerald, Mark, additional, Amaral, Andre, additional, Vollmer, William, additional, Burney, Peter, additional, Buist, Sonia, additional, and Sin, Don, additional

Published
2021
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32. Late Breaking Abstract - Cardiovascular risk and COPD in a population-based study

Author

Krishnan, Suurya, primary, Tan, Wan, additional, Farias, Raquel, additional, Aaron, Shawn, additional, Benedetti, Andrea, additional, Chapman, Kenneth, additional, Hernandez, Paul, additional, Maltais, Francois, additional, Marciniuk, Darcy, additional, O'Donnell, Denis, additional, Sin, Don, additional, Walker, Brandie, additional, and Bourbeau, Jean, additional

Published
2021
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33. Pan-Canadian standards for severe asthma in electronic medical records

Author

Lougheed, M. Diane, primary, Morra, Alison, additional, Bullock, Emma, additional, Tregobov, Noah, additional, Barber, Dave, additional, Boulet, Louis-Philippe, additional, Dell, Sharon, additional, Ducharme, Francine M., additional, Ferrone, Madonna, additional, FitzGerald, J. Mark, additional, Gupta, Samir, additional, Licskai, Christopher, additional, Podgers, Delanya, additional, Nair, Parameswaran, additional, Radhakrishnan, Dhenuka, additional, Sadatsafavi, Mohsen, additional, Tamari, Itamar E., additional, To, Teresa, additional, Walker, Brandie, additional, Yang, Connie L., additional, and Lemiere, Catherine, additional

Published
2021
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34. The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the Heterogeneity of Risk Factors in the Canadian Population: Results from the Canadian Obstructive Lung Disease (COLD) Study

Author

Leung,Clarus, Bourbeau,Jean, Sin,Don D, Aaron,Shawn D, FitzGerald,J Mark, Maltais,François, Marciniuk,Darcy D, O'Donnell,Denis, Hernandez,Paul, Chapman,Kenneth R, Walker,Brandie, Road,Jeremy D, Zheng,Liyun, Zou,Carl, Hogg,James C, Tan,Wan C, Leung,Clarus, Bourbeau,Jean, Sin,Don D, Aaron,Shawn D, FitzGerald,J Mark, Maltais,François, Marciniuk,Darcy D, O'Donnell,Denis, Hernandez,Paul, Chapman,Kenneth R, Walker,Brandie, Road,Jeremy D, Zheng,Liyun, Zou,Carl, Hogg,James C, and Tan,Wan C

Abstract

Clarus Leung,1 Jean Bourbeau,2 Don D Sin,1 Shawn D Aaron,3 J Mark FitzGerald,4 François Maltais,5 Darcy D Marciniuk,6 Denis O’Donnell,7 Paul Hernandez,8 Kenneth R Chapman,9 Brandie Walker,10 Jeremy D Road,4 Liyun Zheng,1 Carl Zou,1 James C Hogg,1 Wan C Tan1 On behalf of the CanCOLD Collaborative Research Group1Centre for Heart Lung Innovation, St Pauls Hospital, The University of British Columbia, Vancouver, BC, Canada; 2Research Institute McGill University Health Centre, McGill University, Montreal, Quebec, Canada; 3The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada; 4Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada; 5Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Quebec, Canada; 6Respiratory Research Centre, University of Saskatchewan, Saskatoon, Canada; 7Department of Medicine, Queen’s University, Kingston, Canada; 8Department of Medicine, Dalhousie University, Halifax, Canada; 9Toronto General Hospital Research Institute, University of Toronto, Toronto, Canada; 10Department of Medicine, University of Calgary (BW), Alberta, CanadaCorrespondence: Wan C TanCentre for Heart Lung Innovation, St. Paul’s Hospital, University of British Columbia, Rm 166, 1081 Burrard Street, Vancouver, B.C, V6Z 1Y6, CanadaTel +1-604-682-2344 ext 62749Fax +1-604-806-9274Email wan.tan@hli.ubc.caPurpose: To determine the spirometric-based prevalence of COPD across different regions in Canada and to evaluate the site heterogeneity of risk factors.Patients and Methods: In this cross-sectional, population-based study, random samples of non-institutionalized adults aged ≥ 40 years were generated by random digit dialling. Participants answered an interviewer-administered questionnaire and performed spirometry before and after bronchodilator administration. COPD was defined as post-bronchodilator FE

Published
2021

36. Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial

Author

Harrison, Tim W, primary, Chanez, Pascal, additional, Menzella, Francesco, additional, Canonica, Giorgio Walter, additional, Louis, Renaud, additional, Cosio, Borja G, additional, Lugogo, Njira L, additional, Mohan, Arjun, additional, Burden, Annie, additional, McDermott, Lawrence, additional, Garcia Gil, Esther, additional, Zangrilli, James G, additional, Pohl, Wolfgang, additional, Voves, Robert, additional, Deschampheleire, Maud, additional, Martinot, Jean-Benoit, additional, Peché, Rudi, additional, Chapman, Kenneth, additional, Cheema, Amarjit, additional, Dorscheid, Delbert, additional, FitzGerald, J. Mark, additional, Gagnon, Remi, additional, Killorn, William Patrick, additional, Olivenstein, Ronald, additional, Philteos, George, additional, Ramsey, Clare, additional, Rolf, J. Douglass, additional, Walker, Brandie, additional, Hilberg, Ole, additional, Skjold, Tina, additional, Titlestad, Ingrid, additional, Hakulinen, Auli, additional, Kilpeläinen, Maritta, additional, Ben Hayoun, Michèle, additional, Bonniaud, Philippe, additional, Bourdin, Arnaud, additional, De Blay, Frédéric, additional, Deslee, Gaëtan, additional, Devouassoux, Gilles, additional, Didier, Alain, additional, Douadi, Youcef, additional, Fry, Stéphanie, additional, Garcia, Gilles, additional, Girodet, Pierre-Olivier, additional, Leroyer, Christophe, additional, Magnan, Antoine, additional, Mahay, Guillaume, additional, Nocent, Cécilia, additional, Pison, Christophe, additional, Roux, Pauline-Marie, additional, Taillé, Camille, additional, Tiotiu, Juliana-Angelica, additional, Beck, Ekkehard, additional, Jandl, Margret, additional, Kaehler, Christian, additional, Kässner, Frank, additional, Koesters, Frank, additional, Kronsbein, Juliane, additional, Schaum, Thomas, additional, Schulz, Christian, additional, Skowasch, Dirk, additional, Taube, Christian, additional, Welte, Tobias, additional, de Roux, Andrés, additional, Beghé, Bianca, additional, Blasi, Francesco, additional, Carpagnano, Giovanna, additional, Caruso, Cristiano, additional, Corsico, Angelo Guido, additional, Constantino, Elio, additional, Crimi, Nunzio, additional, Maestrelli, Piero, additional, Milanese, Manlio, additional, Papi, Alberto, additional, Pelaia, Girolamo, additional, Pini, Laura, additional, Santus, Pierachille, additional, Savi, Eleonora, additional, Scichilone, Nicola, additional, Senna, Gianenrico, additional, Spadaro, Giuseppe, additional, Vaghi, Adriano, additional, Gans, Steven, additional, Hölters, Jurgen, additional, Langeveld, B., additional, Pieters, Willem, additional, Staaks, G.H.A., additional, van Veen, Ilonka, additional, van den Berg, J.W.K., additional, Einvik, Gunnar, additional, Lehmann, Sverre, additional, Ali García, Ismael, additional, Almonacid, Carlos, additional, Bobolea, Irina, additional, Campo Mozo, Paloma, additional, de Luiz, Gustavo, additional, Domingo Ribas, Christian, additional, Echave-Sustaeta María-Tomé, José María, additional, García Rivero, Juan Luis, additional, García-Cosío Piqueras, Borja, additional, Gómez-Bastero Fernández, Ana, additional, González Pérez, Ruperto, additional, Henríquez Santa, Aythamy, additional, Martínez Rivera, Carlos, additional, Muñoz Gall, Xavier, additional, Ramos, Jacinto, additional, Gregorio Soto Campos, Jose, additional, Vidal Pan, Carmen, additional, Stenfors, Nikolai, additional, Tunsäter, Alf, additional, Vinge, Ines, additional, Chaudhuri, Rekha, additional, Harrison, Timothy, additional, Mansur, Adel, additional, Nasser, Shuaib, additional, Nordstrom, Monica, additional, Pfeffer, Paul, additional, Saralaya, Dinesh, additional, Short, Philip, additional, Adlakha, Arun, additional, Alpan, Oral, additional, Averill, Francis, additional, Badhwar, Anil, additional, Bardelas, Jose, additional, Baxter, Barbara, additional, Bensch, George, additional, Berger, William, additional, Bernstein, Jonathan, additional, Bridges, Tracy, additional, Brimeyer, Ryan, additional, Calhoun, William, additional, Campbell, Edward, additional, Cherry, William Brett, additional, Chupp, Geoffrey, additional, Clore, Lee, additional, Cohn, John, additional, Cole, Jeremy, additional, Condemi, John, additional, Cury, James, additional, Davis, Benjamin, additional, DeLeon, Samuel, additional, Delacruz, Luis, additional, Diaz, Joseph, additional, Erb, David, additional, Eziri, Emeka, additional, Fakih, Faisal, additional, Fiedler, Douglas, additional, Fost, David, additional, Fritz, Stephen, additional, Gonzalez, Erika, additional, Goodman, Brad, additional, Gottlieb, Peter, additional, Gottschlich, Gregory, additional, Gower, Richard, additional, Hajal, Rizan, additional, Harris, James, additional, Heidarian-Raissy, Hengameh, additional, Heyder, Albrecht, additional, Hill, David, additional, Holguin, Fernando, additional, Hussain, Iftikhar, additional, Illowite, Jonathan, additional, Jacobs, Joshua, additional, Jarratt, Mikell, additional, Kaiser, Harold, additional, Kao, Neil, additional, Kashyap, Ravindra, additional, Kaufman, David, additional, Kent, Edward, additional, Kim, Kenneth, additional, Klein, Ryan, additional, Kraft, Monica, additional, Kono, Ritsu, additional, Kureishy, Shahrukh, additional, Leflein, Jeffrey, additional, Leong, Mila, additional, Li, Huamin, additional, Lin, Robert, additional, Lugogo, Njira, additional, Marcus, Michael, additional, Maselli Caceres, Diego Jose, additional, Mehta, Vinay, additional, Mello, Curtis, additional, Millard, Mark, additional, Milstone, Aaron, additional, Moore, Wendy, additional, Moss, Mark, additional, Mumneh, Nayla, additional, O'Brien, Thomas, additional, Ostransky, David, additional, Palumbo, Michael, additional, Parikh, Purvi, additional, Parikh, Sudhir, additional, Patel, Amit, additional, Perez, Guido, additional, Pleskow, Warren, additional, Prenner, Bruce, additional, Puppala, Dileep, additional, Ramey, John, additional, Reibman, Joan, additional, Reyes, Ramon, additional, Robinette, Emory, additional, Rodicio, Ileana, additional, Ryan, Stephen, additional, Sekhsaria, Sudhir, additional, Sigal, Barry, additional, Sikand, Vinay, additional, Soong, Weily, additional, Spangenthal, Selwyn, additional, St. John, Roy, additional, Steven, Gary, additional, Subramaniam, Vijay, additional, Sumino, Kaharu, additional, Sztejman, Eric, additional, Tan, Ricardo A., additional, Tanus, Tonny, additional, Thompson, Charles, additional, Thornblade, Carl, additional, Villareal, Manuel, additional, Wenzel, Sally, additional, Zafra, Heidi, additional, and Ziedalski, Tomasz, additional

Published
2021
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37. On Recommending Specific Lung Ultrasound Protocols in the Assessment of Medical Inpatients with Known or Suspected Coronavirus Disease‐19 Reply

Author

Ma, Irene W. Y., primary, Noble, Vicki E., additional, Mints, Gregory, additional, Wong, Tanping, additional, Tonelli, Ana Claudia, additional, Hussain, Arif, additional, Liu, Rachel B., additional, Hergott, Christopher A., additional, Dumoulin, Elaine, additional, Chee, Alex, additional, Miller, Daniel J., additional, Walker, Brandie, additional, Buchanan, Brian, additional, Wagner, Michael, additional, Arishenkoff, Shane, additional, and Liteplo, Andrew S., additional

Published
2021
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38. The Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and the Heterogeneity of Risk Factors in the Canadian Population: Results from the Canadian Obstructive Lung Disease (COLD) Study

Author

Leung, Clarus, primary, Bourbeau, Jean, additional, Sin, Don D, additional, Aaron, Shawn D, additional, FitzGerald, J Mark, additional, Maltais, François, additional, Marciniuk, Darcy D, additional, O'Donnell, Denis, additional, Hernandez, Paul, additional, Chapman, Kenneth R, additional, Walker, Brandie, additional, Road, Jeremy D, additional, Zheng, Liyun, additional, Zou, Carl, additional, Hogg, James C, additional, and Tan, Wan C, additional

Published
2021
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39. Dyspnoea and symptom burden in mild–moderate COPD: the Canadian Cohort Obstructive Lung Disease Study

Author

Cherian, Mathew, primary, Jensen, Dennis, additional, Tan, Wan C., additional, Mursleen, Sara, additional, Goodall, Emma C., additional, Nadeau, Gilbert A., additional, Awan, Amnah M., additional, Marciniuk, Darcy D., additional, Walker, Brandie L., additional, Aaron, Shawn D., additional, O'Donnell, Denis E., additional, Chapman, Kenneth R., additional, Maltais, François, additional, Hernandez, Paul, additional, Sin, Don D., additional, Benedetti, Andrea, additional, and Bourbeau, Jean, additional

Published
2021
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40. Canadian Internal Medicine Ultrasound (CIMUS) Expert Consensus Statement on the Use of Lung Ultrasound for the Assessment of Medical Inpatients With Known or Suspected Coronavirus Disease 2019

Author

Ma, Irene W. Y., primary, Hussain, Arif, additional, Wagner, Michael, additional, Walker, Brandie, additional, Chee, Alex, additional, Arishenkoff, Shane, additional, Buchanan, Brian, additional, Liu, Rachel B., additional, Mints, Gregory, additional, Wong, Tanping, additional, Noble, Vicki, additional, Tonelli, Ana Claudia, additional, Dumoulin, Elaine, additional, Miller, Daniel J., additional, Hergott, Christopher A., additional, and Liteplo, Andrew S., additional

Published
2020
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44. Canadian Internal Medicine Ultrasound (CIMUS) Expert Consensus Statement on the Use of Lung Ultrasound for the Assessment of Medical Inpatients With Known or Suspected Coronavirus Disease 2019.

Author

Ma, Irene W. Y., Hussain, Arif, Wagner, Michael, Walker, Brandie, Chee, Alex, Arishenkoff, Shane, Buchanan, Brian, Liu, Rachel B., Mints, Gregory, Wong, Tanping, Noble, Vicki, Tonelli, Ana Claudia, Dumoulin, Elaine, Miller, Daniel J., Hergott, Christopher A., and Liteplo, Andrew S.

Subjects
COVID-19, ULTRASONIC imaging, INTERNAL medicine, LUNGS
Abstract

Objectives: To develop a consensus statement on the use of lung ultrasound (LUS) in the assessment of symptomatic general medical inpatients with known or suspected coronavirus disease 2019 (COVID‐19). Methods: Our LUS expert panel consisted of 14 multidisciplinary international experts. Experts voted in 3 rounds on the strength of 26 recommendations as "strong," "weak," or "do not recommend." For recommendations that reached consensus for do not recommend, a fourth round was conducted to determine the strength of those recommendations, with 2 additional recommendations considered. Results: Of the 26 recommendations, experts reached consensus on 6 in the first round, 13 in the second, and 7 in the third. Four recommendations were removed because of redundancy. In the fourth round, experts considered 4 recommendations that reached consensus for do not recommend and 2 additional scenarios; consensus was reached for 4 of these. Our final recommendations consist of 24 consensus statements; for 2 of these, the strength of the recommendations did not reach consensus. Conclusions: In symptomatic medical inpatients with known or suspected COVID‐19, we recommend the use of LUS to: (1) support the diagnosis of pneumonitis but not diagnose COVID‐19, (2) rule out concerning ultrasound features, (3) monitor patients with a change in the clinical status, and (4) avoid unnecessary additional imaging for patients whose pretest probability of an alternative or superimposed diagnosis is low. We do not recommend the use of LUS to guide admission and discharge decisions. We do not recommend routine serial LUS in patients without a change in their clinical condition. [ABSTRACT FROM AUTHOR]

Published
2021
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46. The effects of marijuana smoking on lung function in older people

Author

Tan, Wan C., primary, Bourbeau, Jean, additional, Aaron, Shawn D., additional, Hogg, James C., additional, Maltais, François, additional, Hernandez, Paul, additional, Marciniuk, Darcy D., additional, Chapman, Kenneth R., additional, To, Teresa, additional, FitzGerald, J. Mark, additional, Walker, Brandie L., additional, Road, Jeremy, additional, Zheng, Liyun, additional, Zhou, Guohai, additional, Yau, Trevor, additional, Benedetti, Andrea, additional, O'Donnell, Denis, additional, and Sin, Don D., additional

Published
2019
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48. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study.

Author

Ayas, Najib, Ayas, Najib, Tan, Wan, Aaron, Shawn, Sin, Don, Road, Jeremy, Chapman, Kenneth, ODonnell, Denis, Maltais, François, Hernandez, Paul, Walker, Brandie, Marciniuk, Darcy, Kaminska, Marta, Shorofsky, Matthew, Bourbeau, Jean, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Ayas, Najib, Tan, Wan, Aaron, Shawn, Sin, Don, Road, Jeremy, Chapman, Kenneth, ODonnell, Denis, Maltais, François, Hernandez, Paul, Walker, Brandie, Marciniuk, Darcy, Kaminska, Marta, Shorofsky, Matthew, Bourbeau, Jean, Kimoff, John, Jen, Rachel, and Malhotra, Atul

Abstract

BACKGROUND: COPD increases susceptibility to sleep disturbances, which may in turn predispose to increased respiratory symptoms. The objective of this study was to evaluate, in a population-based sample, the relationship between subjective sleep quality and risk of COPD exacerbations. METHODS: Data were obtained from the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Participants with COPD who had completed 18 months of follow-up were included. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a three-factor analysis. Symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) exacerbations were assessed. Association of PSQI with exacerbation rate was assessed by using negative binomial regression. Exacerbation-free survival was also assessed. RESULTS: A total of 480 participants with COPD were studied, including 185 with one or more exacerbations during follow-up and 203 with poor baseline sleep quality (PSQI score > 5). Participants with subsequent symptom-based exacerbations had higher median baseline PSQI scores than those without (6.0 [interquartile range, 3.0-8.0] vs 5.0 [interquartile range, 2.0-7.0]; P = .01), and they were more likely to have baseline PSQI scores > 5 (50.3% vs 37.3%; P = .01). Higher PSQI scores were associated with increased symptom-based exacerbation risk (adjusted rate ratio, 1.09; 95% CI, 1.01-1.18; P = .02) and event-based exacerbation risk (adjusted rate ratio, 1.10; 95% CI, 1.00-1.21; P = .048). The association occurred mainly in those with undiagnosed COPD. Strongest associations were with Factor 3 (sleep disturbances and daytime dysfunction). Time to symptom-based exacerbation was shorter in participants with poor sleep quality (adjusted hazard ratio, 1.49; 95% CI, 1.09-2.03). CONCLUSIONS: Higher baseline PSQI scores were associated with increased risk of COPD exacerba

Published
2019

49. Identification and definition of asthma–COPD overlap: The CanCOLD study.

Author

Barrecheguren, Miriam, Pinto, Lancelot, Mostafavi‐Pour‐Manshadi, Seyed‐Mohammad‐Yousof, Tan, Wan C., Li, Pei Z., Aaron, Shawn D., Benedetti, Andrea, Chapman, Kenneth R., Walker, Brandie, Fitzgerald, J. Mark, Hernandez, Paul, Maltais, François, Marciniuk, Darcy D., O'Donnell, Denis E., Sin, Don D., and Bourbeau, Jean

Subjects
DEFINITIONS, ATOPY, OBSTRUCTIVE lung diseases, QUALITY of life, SYMPTOMS
Abstract

Background and objective: Lack of consensus on diagnosis of ACO limits our understanding of the impact, management and outcomes of ACO. The present observational study aims to describe the prevalence, clinical characteristics and course of individuals with ACO based on various definitions used in clinical practice. Methods: We included individuals with COPD from the prospective, multisite CanCOLD study and defined subjects with ACO using seven definitions commonly used in the literature. Results: Data including questionnaires, lung function and CT scans were analysed from 522 individuals with COPD who were randomly recruited from the population. Among them, 264 fulfilled at least one of the seven definitions of ACO. Prevalence of ACO varied from 3.8% to 31%. Regardless of the definition, individuals with ACO had worse outcomes (lung function and higher percentage of fast decliners, symptoms and exacerbations, health‐related quality of life and comorbidities) than the remaining patients with COPD. Conversely, patients with non‐ACO had higher emphysema and bronchiolitis scores. The three definitions that included atopy and/or physician diagnosis of asthma identified subjects who differed significantly from patients with COPD. The two ACO definitions with post‐bronchodilator reversibility were concordant with COPD and were the least stable, with less than 50% of the patients from each group maintaining reversibility over visits. Conclusion: Atopy and physician‐diagnosed asthma are more distinguishing characteristics to identify ACO. This finding needs to be validated using measures of airway inflammation and other specific biomarkers. [ABSTRACT FROM AUTHOR]

Published
2020
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