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38 results on '"Waldmann, T.A."'

1. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

Author

DePaolo, R.W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J.A., Wang, W., Marietta, E.V., Kasarda, D.D., Waldmann, T.A., Murray, J.A., Semrad, C., Kupfer, S.S., Belkaid, Y., Guandalini, S., and Jabri, B.

Subjects
Tretinoin -- Health aspects -- Physiological aspects, Immune response -- Research, Antigens -- Health aspects -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Under physiological conditions the gut-associated lymphoid tissues not only prevent the induction of a local inflammatory immune response, but also induce systemic tolerance to fed antigens (1,2). A notable exception is coeliac disease, where genetically susceptible individuals expressing human leukocyte antigen (HLA) HLA-DQ2 or HLA-DQ8 molecules develop inflammatory T-cell and antibody responses against dietary gluten, a protein present in wheat (3). The mechanisms underlying this dysregulated mucosal immune response to a soluble antigen have not been identified. Retinoic acid, a metabolite of vitamin A, has been shown to have a critical role in the induction of intestinal regulatory responses (4-6). Here we find in mice that in conjunction with IL-15, a cytokine greatly upregulated in the gut of coeliac disease patients (3,7), retinoic acid rapidly activates dendritic cells to induce JNK (also known as MAPK8) phosphorylation and release the proinflammatory cytokines IL-12p70 and IL-23. As a result, in a stressed intestinal environment, retinoic acid acted as an adjuvant that promoted rather than prevented inflammatory cellular and humoral responses to fed antigen. Altogether, these findings reveal an unexpected role for retinoic acid and IL-15 in the abrogation of tolerance to dietary antigens., Induction of regulatory intestinal responses to oral antigens prevents the subsequent development of systemic T-helper type-1 ([T.sub.H]1) responses to those antigens, a phenomenon referred to as oral tolerance (2). An [...]

Published
2011
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2. Dynamic, yet structured: the cell membrane three decades after the Singer-Nicolson model

Author

Vereb, G., Szollosi, J., Matko, J., Nagy, P., Farkas, T., Vigh, L., Matyus, L., Waldmann, T.A., and Damjanovich, S.

Subjects
Cell membranes -- Analysis, Science and technology
Abstract

The fluid mosaic membrane model proved to be a very useful hypothesis in explaining many, but certainly not all, phenomena taking place in biological membranes. New experimental data show that the compartmentalization of membrane components can be as important for effective signal transduction as is the fluidity of the membrane. In this work, we pay tribute to the Singer-Nicolson model, which is near its 30th anniversary, honoring its basic features, 'mosaicism' and 'diffusion,' which predict the interspersion of proteins and lipids and their ability to undergo dynamic rearrangement via Brownian motion. At the same time, modifications based on quantitative data are proposed, highlighting the often genetically predestined, yet flexible, multilevel structure implementing a vast complexity of cellular functions. This new 'dynamically structured mosaic model' bears the following characteristics: emphasis is shifted from fluidity to mosaicism, which, in our interpretation, means nonrandom codistribution patterns of specific kinds of membrane proteins forming small-scale clusters at the molecular level and large-scale clusters (groups of clusters, islands) at the submicrometer level. The cohesive forces, which maintain these assemblies as principal elements of the membranes, originate from within a microdomain structure, where lipid-lipid, protein-protein, and protein-lipid interactions, as well as sub- and supramembrane (cytoskeletal, extracellular matrix, other cell) effectors, many of them genetically predestined, play equally important roles. The concept of fluidity in the original model now is interpreted as permissiveness of the architecture to continuous, dynamic restructuring of the molecular- and higher-level clusters according to the needs of the cell and as evoked by the environment.

Published
2003

3. Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes

Author

Panyi, G., Bagdany, M., Bodnar, A., Vamosi, G., Szentesi, G., Jenei, A., Matyus, L., Varga, S., Waldmann, T.A., Gaspar, R., and Damjanovich, S.

Subjects
Potassium channels -- Physiological aspects, Electron microscopy -- Usage, Fluorescence -- Physiological aspects, T cells -- Genetic aspects, T cells -- Physiological aspects, Lymphomas -- Causes of, Poisson distribution -- Analysis, Cell membranes -- Physiological aspects, Cell membranes -- Genetic aspects, Science and technology
Abstract

Distribution and lateral organization of Kv1.3 potassium channels and CD3 molecules were studied by using electron microscopy, confocal laser scanning microscopy, and fluorescence resonance energy transfer. Immunogold labeling and electron microscopy showed that the distribution of FLAG epitope-tagged Kv1.3 channels (Kv1.3/FLAG) significantly differs from the stochastic Poisson distribution in the plasma membrane of human T lymphoma cells. Confocal laser scanning microscopy images showed that Kv1.3/FLAG channels and CD3 molecules accumulated in largely overlapping membrane areas. The numerical analysis of cross-correlation of the spatial intensity distributions yielded a high correlation coefficient (C = 0.64). A different hierarchical level of molecular proximity between Kv1.3/FLAG and CD3 proteins was reported by a high fluorescence resonance energy transfer efficiency (E = 51%). These findings implicate that reciprocal regulation of ion-channel activity, membrane potential, and the function of receptor complexes may contribute to the proper functioning of the immunological synapse.

Published
2003

5. Impact of antigenemia on the bioactivity of infused anti-Tac antibody: implications for dose selection in antibody immunotherapies

Author

Junghans, R.P., Carrasquillo, J.A., and Waldmann, T.A.

Subjects
Antibodies -- Research, Immunotherapy -- Research, Immunologic diseases -- Research, Interleukin-2 -- Receptors, Science and technology
Abstract

In patients with malignancies and immune disorders expressing Tac ([Alpha] chain of the interleukin 2 receptor; CD25), physiologic shedding of this receptor may lead to high blood levels of the soluble form (sTac). This system was used to model the interaction of soluble antigen with antibody in therapeutic settings and to develop rational principles to optimize the delivery of antibody to tumor target cells. First, we confirmed that sTac in vivo can block anti-Tac binding sites and diminish antibody binding to Tac+ cells. Second, the bioactivity of antibody in vivo correlated directly with the amount of antibody infused and inversely with the sTac concentration. Third, bindability of antibody declined in the hours and days after anti-Tac infusion in patients. Finally, tumor targeting was achieved even in the presence of excess sTac, demonstrating a partition of antibody between soluble and cell-bound antigen. A role is proposed for the Brambell receptor (FcRB) to delay saturation of human or chimeric antibodies via differential catabolism of antigen-antibody complexes. Principles are developed for predicting activity of administered antibody in the presence of soluble antigen to assist in dose selection in passive, radioimmuno and immunotoxin therapies.

Published
1998

6. Multiple sclerosis, retroviruses, and PCR

Author

Ehrlich, G.D., Glaser, J.B., Bryz-Gornia, V., Maese, J., Waldmann, T.A., Poiesz, B.J., and Greenberg, S.J.

Subjects
Polymerase chain reaction -- Evaluation, HTLV (Viruses) -- Genetic aspects, HTLV-I (Virus), Multiple sclerosis -- Causes of, Health, Psychology and mental health
Abstract

For many years, some researchers have suspected that multiple sclerosis results from infection with an as-yet unidentified virus. This suspicion emerges both from some pathological features of the disease itself and from epidemiological observations on the geographical distribution of MS. It is only reasonable, therefore, that when the laboratory technique known as polymerase chain reaction (PCR) was developed, it would be applied to the search for viruses in patients with multiple sclerosis. The PCR method utilizes repetitive cycles of DNA synthesis to amplify extremely small quantities of DNA to a large enough concentration to use for more conventional laboratory tests. One of the primary difficulties of the method, however, is that its sensitivity is so great that false-positive results may indicate the presence of viral gene sequences when, in fact, only random 'noise' and not the viral genes are present. This problem with PCR is illustrated by reports in recent years linking multiple sclerosis to the human T-cell leukemia virus (HTLV). Since this virus is associated with a neurological disease called tropical spastic paraparesis, it did not seem unreasonable when researchers reported its association with multiple sclerosis. However, concerns about the possibility of false-positive results using the PCR method prompted other researchers to conduct a careful large-scale study to determine if HTLV gene sequences are indeed associated with multiple sclerosis. A total of 202 multiple sclerosis patients were tested, as were 803 control subjects, which included MS family members, patients with other neurological diseases, and random blood donors. Initial testing found indications of HTLV in 19 MS patients and 47 other subjects. On further testing, HTLV could be confirmed in only one MS patient and in none of the control subjects. The results confirm that false positives are likely when using the PCR method, and that most of the positive results will not be confirmed on further testing. Furthermore, the results of the present study provide no reason to believe that HTLV plays an important role in the etiology of multiple sclerosis. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

7. The promiscuous IL-2/IL-15 receptor: a target for immunotherapy of HTLV-I-associated disorders

Author

Waldmann, T.A.

Subjects
Interleukin-2 -- Receptors, Adult T-cell leukemia-lymphoma -- Care and treatment, Immunotherapy -- Evaluation, Health
Abstract

The use of humanized monoclonal antibodies to the Tac peptide of the interleukin-2 receptor (IL-2R) may be effective in treating adult T-cell leukemia (ATL). ATL is caused by the human T-cell lymphotropic virus type I (HTLV-I). When T cells become infected with HTLV-I, they express IL-2R. However, normal T cells do not express IL-2R. Nine of 18 ATL patients who received humanized monoclonal antibodies against the Tac peptide of IL-2R went into partial or complete remission. In some cases, the antibody contained a radioactive substance to destroy the cancerous T cells.

Published
1996

10. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia

Author

Pancewicz, J., Taylor, J.M., Datta, A., Baydoun, H.H., Waldmann, T.A., Hermine, O., Nicot, C., Cytokines, hématopoïèse et réponse immune (CHRI), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2010

12. LIST OF CONTRIBUTORS

Author

ABELL, C.W., primary, ALFORD, ROBERT H., additional, ALTER, B.J., additional, ANDERSON, A.O., additional, ANDERSON, DEBORAH J., additional, ANDERSON, SUSAN M., additional, ANDRON, L.A., additional, ANTON, ELIZABETH, additional, ARALA-CHAVES, M.P., additional, ARNON, R., additional, ASCHER, M.S., additional, BACH, F.H., additional, BAIRD, LYNN G., additional, BARCINSKI, MARCELLO A., additional, BARKER, BARBARA E., additional, BARTH, ROLF F., additional, BATTISTO, JACK R., additional, BELL, CLARA, additional, BEN-SASSON, SHMUEL A., additional, BERKE, GIDEON, additional, BERNHEIM, JAN L., additional, BESSLER, WOLFGANG G., additional, BETEL, IDO, additional, BETZ, SALLY J., additional, BEYER, C.F., additional, BLAESE, R. MICHAEL, additional, BLANKWATER, M.J., additional, BOCHERT, G., additional, BOCKMAN, D.E., additional, BOLDT, DAVID H., additional, BONA, CONSTANTIN, additional, BONAVIDA, BENJAMIN, additional, BONNARD, GUY D., additional, BOREL, J.F., additional, BOWERS, W.E., additional, BRAATZ, J.A., additional, BRADLEY, B., additional, BRADLEY, B.A., additional, BRAUNSTEINER, HERBERT, additional, BRODER, S., additional, BROWN, JOHN M., additional, BUNDY, BONITA M., additional, BURGER, D.R., additional, CAMBELL, D.A., additional, CARPENTER, C.B., additional, CASTAGNOLA, JAN, additional, CAVILES, ALENDRY P., additional, CHAKRAVARTY, A.K., additional, CHAPLIN, D.D., additional, CHARMOT, D., additional, CHISARI, F.V., additional, CLARK, W.R., additional, CLEMENTS, PHILIP J., additional, COHEN, I.R., additional, COOPER, HERBERT L., additional, COOPER, M.D., additional, COOPER, R.A., additional, CORLEY, RONALD B., additional, CROSIER, P., additional, CUNNINGHAM-RUNDLES, S., additional, CURTISS, LINDA K., additional, DANIELE, RONALD P., additional, DARAI, G., additional, DAUSSET, J., additional, DAVID, JOHN R., additional, DAYNES, RAYMOND A., additional, DEAN, JACK H., additional, DEBATES, MARY JO, additional, DECKER, JEAN M., additional, DE GOEDE, R.E.Y, additional, DEHEER, DAVID H., additional, DELFRAISSY, J.F., additional, DEWOLF, W.C., additional, DOOLEY, N.D., additional, DOOLEY, NANCY J., additional, DORIAN, RANDEL, additional, DORMONT, J., additional, DOUGLAS, GARY N., additional, DRAY, SHELDON, additional, DUPONT, B., additional, DURM, M., additional, DWYER, JOHN M., additional, EDGINGTON, THOMAS S., additional, ELFERINK, DIENNE, additional, ENDRES, ROBERT O., additional, ESSELMAN, WALTER J., additional, FAGAN, G., additional, FARNES, PATRICIA, additional, FAUCI, ANTHONY S., additional, FERGUSON, RONALD M., additional, FERRARINI, M., additional, FLETCHER, MARK P., additional, FRELINGER, JEFFREY A., additional, FORSDYKE, D.R., additional, FROST, A.F., additional, FUDENBERG, H. HUGH, additional, GALANAUD, P., additional, GAROVOY, M.R., additional, GARRIDO, F., additional, GEHA, RAIF S., additional, GEMSA, DIETHARD, additional, GEORGE, K., additional, GERSHWIN, M. ERIC, additional, GLICKMAN, E., additional, GOLDBLUM, R.M., additional, GOLDMAN, C., additional, GOLDSTEIN, ALLAN L., additional, GOOD, R.A., additional, GORDON, DAVID S., additional, GORDON, G., additional, GORDON, IAN L., additional, GORDON, JULIUS, additional, GORENBERG, DAVID J., additional, GORSKA, R., additional, GORSKI, A.J., additional, GOTTLIEB, M.N., additional, GRANBERG, CHRISTER, additional, GRANGER, GALE A., additional, GRAYBILL, J. RICHARD, additional, GREY, HOWARD M., additional, GRILLOT-COURVALIN, C., additional, GRIMM, ELIZABETH ANN, additional, GRINWICH, KAZIMIERA, additional, GROSSI, C.E., additional, GüNTHER, EBERHARD, additional, GUERRY, D., additional, HAMILL, BARBARA, additional, HANSEN, J.A., additional, HANTKE, KLAUS, additional, HAYWARD, A.R., additional, HEININGER, D., additional, HELDERMAN, J. HAROLD, additional, HENKART, PIERRE A., additional, HENNEY, CHRISTOPHER H., additional, HERBERMAN, R.B., additional, HESTER, RAYMOND B., additional, HIRSCHBERG, HENRY, additional, HISERODT, JOHN C., additional, HOETTE, M., additional, HOLIMAN, B.J., additional, HORSMANHEIMO, A., additional, HORSMANHEIMO, M., additional, SUNY, MICHAEL L. HOWE, additional, HUBER, CHRISTOPH, additional, HURTUBISE, P.E., additional, IKEDA, RICHARD, additional, ITZCHAKI, M., additional, JACOBS, DIANE M., additional, JANICKI, BERNARD W., additional, JARRETT-TOTH, E., additional, JENSEN, PAMELA, additional, JERRY, L. MARTIN, additional, JONES, THOMAS B., additional, JONGENEEL, C. VICTOR, additional, JUNGFER, H., additional, KACENA, AMELIA, additional, KALDANY, A., additional, KAPLAN, ALAN M., additional, KAPLAN, J.G., additional, KASHKET, EVA R., additional, KAY, H. DAVID, additional, KAZURA, J., additional, KEARNEY, J.K., additional, KERMANI-ARAB, V., additional, KIERSZENBAUM, F., additional, KEYSSNER, K., additional, KIRCHNER, H., additional, KIRKPATRICK, CHARLES H., additional, KLEIN, J., additional, KLIMPEL, GARY, additional, KOLB, W.P., additional, KORN, J., additional, KOSKI, L.J., additional, KRAKAUER, R., additional, KRUISBEEK, ADA M., additional, KRUITHOF, E.K.O., additional, KUBO, RALPH T., additional, LANOTTE, M., additional, LAUGHTER, ARLINE H., additional, LAUGHTER, BARBARA J., additional, LA VIA, D.S., additional, LA VIA, M.F., additional, LAWRENCE, E.C., additional, LAWTON, A.R., additional, LEGRAND, L., additional, LEON, MYRON A., additional, LESLIE, G.A., additional, UCLA, JOSHUA LEVY, additional, LICHTMAN, M.A., additional, LIFTON, J., additional, LIGHTBODY, JAMES J., additional, LINKER-ISRAELI, M., additional, LOPATIN, DENNIS E., additional, LORARCHER, ALOIS, additional, LORD, EDITH M., additional, LUCAS, DAVID O., additional, LUCAS, KEES, additional, LUNDIN, A.P., additional, LYDYARD, P.M., additional, MCCALMON, ROBERT T., additional, MACDERMOTT, RICHARD P., additional, MCDOUGAL, J.S., additional, MCINTIRE, K.R., additional, MACKLER, BRUCE F., additional, MADYASTHA, K.R., additional, MADYASTHA, P.R., additional, MÄHLER, BERND, additional, MAKI, TAKASHI, additional, MANNINEN, KIMMO, additional, MARTIJNSE, JOKE, additional, MAWAS, C., additional, MAYER, EUGENE P., additional, MEADE, B., additional, MENDELSOHN, JOHN, additional, MENZEL, J., additional, MERGENHAGEN, S.E., additional, METZGER, JOACHIM, additional, MILLER, GINGER W., additional, MILLER, HAROLD C., additional, MILLER, J., additional, MILLS, G., additional, MINGARI, M.C., additional, MOERMAN, C., additional, MOLDOW, C.F., additional, MONAHAN, T.M., additional, MORETTA, A., additional, MORETTA, L., additional, MORRISON, DAVID C., additional, MOTICKA, EDWARD J., additional, MUCHMORE, ANDREW V., additional, MULLER-EBERHARD, H.J., additional, MUNK, K., additional, MUUL, L., additional, NASH, GEOFFREY S., additional, NEGENDANK, W., additional, NELSON, DAVID L., additional, NELSON, J.A., additional, NETA, R., additional, NEWELL, LAURIE, additional, NG, A.K., additional, O'BRIEN, RICHARD L., additional, OEHLER, J.R., additional, O'NEILL, PEGGY A., additional, OPPENHEIM, JOOST J., additional, ORTALDO, J.R., additional, PAHWA, S., additional, PANIJEL, J., additional, PAPE, GERD R., additional, PARADYSZ, J., additional, PARKER, C.W., additional, PARKER, JOHN W., additional, PARRILLO, JOSEPH E., additional, PAWELEC, G.P., additional, PEARSON, CARL M., additional, PERLMANN, PETER, additional, PILARSKI, LINDA M., additional, PLATA, FERNANDO, additional, PLESCIA, ANNE M., additional, PLESCIA, OTTO J., additional, PONZIO, N.M., additional, POPLACK, D.G., additional, PRATT, KAREN R., additional, PUNTIS, M.C.A, additional, RANNEY, DAVID F., additional, RASMUSSEN, HOWARD, additional, REDELMAN, DOUG, additional, RESCH, KLAUS, additional, RICH, ROBERT R., additional, RICH, SUSAN SOLLIDAY, additional, ROBERTS, R.L., additional, RODE, HAROLD N., additional, ROSENSTREICH, DAVID L., additional, ROSENTHAL, ALAN S., additional, ROSSIO, JEFFREY L., additional, ROWDEN, GEOFFREY, additional, ROWLAND, GEORGE, additional, RUBIN, ARNOLD S., additional, RüDE, ERWIN, additional, RüHL, H., additional, RüHL, U., additional, RYAN, JOHN L., additional, SALVIN, S.B., additional, SASPORTES, M., additional, SCHIRRMACHER, V., additional, SCHMALSTIEG, F.C., additional, SCHMIDTKE, JON R., additional, SCHOLLE, H., additional, SCHRIEBER, A.D., additional, SCHUBERT, RICHARD D., additional, SEGEL, G.B., additional, SELL, STEWART, additional, SHALLER, C., additional, SHARON, N., additional, SHEA, MARY, additional, SHEEHAN, JAMES M., additional, SHEPPARD, HAYNES W., additional, SHEPPARD, J.R., additional, SHERIDAN, JOHN, additional, SHEVACH, ETHAN M., additional, SHIFRINE, M., additional, SHIFTAN, THOMAS A., additional, SHORE, STEVEN L., additional, SIMMONS, RICHARD L., additional, SMITH, ALAN, additional, SMITH, TERRILL K., additional, SOULILLOU, J.P., additional, SPECKART, STEPHEN F., additional, SPELLMAN, CRAIG W., additional, STEGGEMANN, LUDWIG, additional, STEINMAN, L., additional, STEJSKAL, VERA, additional, STEWART, CARLETON C., additional, STITES, DANIEL P., additional, ST. LOUIS, G., additional, STOBO, J.D., additional, STOECK, MICHAEL, additional, STRAUSS, PHYLLIS R., additional, STROBER, W., additional, STROM, TERRY B., additional, SULLIVAN, ARTHUR K., additional, SUNDSMO, J.S., additional, SUTCLIFFE, MARILYN C., additional, SUTHANTHIRAN, M., additional, SWART, A.C.W., additional, TAYLOR, CLIVE R., additional, TEITELBAUM, D., additional, TEODORESCU, MARIUS, additional, TERMIJTELEN, A., additional, THESTRUP-PEDERSEN, KRISTIAN, additional, LE THI, HIEN, additional, THOMAS, DAVID W., additional, THORBECKE, G.J., additional, THORSBY, ERIK, additional, THURMAN, GARY B., additional, TILL, GERD, additional, TILNEY, N.L., additional, TOIVANEN, PAAVO, additional, TOMASI, THOMAS B., additional, TOUTON, M., additional, TRAININ, N., additional, TREFTS, PARK E., additional, TROWBRIDGE, SIDNEYE, additional, TRUFFA-BACHI, PAULO, additional, UBELS-POSTMA, JOSÉ, additional, UMIEL, T., additional, VAN BEKKUM, D.W., additional, VAN DE BERG, TINEKE, additional, VAN DEN TWEEL, JAN G., additional, VAN DEN WESTEN, GERARD, additional, VAN HEES, MARITA, additional, VAN OERS, M.H.J., additional, VAN ROOD, J.J., additional, VOGT, W., additional, WAKSMAN, B.H., additional, WALDMANN, T.A., additional, WALKER, WILLIAM S., additional, WALLON, CH., additional, WARE, CARL F., additional, WEBB, S.R., additional, WEBER, W.T., additional, WEDNER, H.J., additional, WERNET, P., additional, WEST, WILLIAM H., additional, WHISLER, R.L., additional, WIESINGER, DOROTHEE, additional, WIGZELL, HANS, additional, WILCOX, C., additional, WILSON, F.D., additional, WINKELSTEIN, A., additional, WOOD, DAVID D., additional, WOODWARD, JEROLD G., additional, WRIGHT, S.C., additional, YEN, BELINDA, additional, YOSHIDA, TAKESHI, additional, YU, DAVID TAK YAN, additional, ZEIJLEMAKER, W.P., additional, ZICCA, A., additional, ZIER, KAREN, additional, and ZIMMERMANN, RITA, additional

Published
1977
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17. The GREGOR telescope control system

Author

Halbgewachs, C., primary, Caligari, P., additional, Glogowski, K., additional, Heidecke, F., additional, Knobloch, M., additional, Mustedanagic, M., additional, Volkmer, R., additional, and Waldmann, T.A., additional

Published
2012
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18. The 1.5 meter solar telescope GREGOR

Author

Schmidt, W., primary, von der Lühe, O., additional, Volkmer, R., additional, Denker, C., additional, Solanki, S.K., additional, Balthasar, H., additional, Bello González, N., additional, Berkefeld, Th., additional, Collados, M., additional, Fischer, A., additional, Halbgewachs, C., additional, Heidecke, F., additional, Hofmann, A., additional, Kneer, F., additional, Lagg, A., additional, Nicklas, H., additional, Popow, E., additional, Puschmann, K.G., additional, Schmidt, D., additional, Sigwarth, M., additional, Sobotka, M., additional, Soltau, D., additional, Staude, J., additional, Strassmeier, K.G., additional, and Waldmann, T.A., additional

Published
2012
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20. Preparation and in vivo evaluation of linkers for 211 At labeling of humanized anti-Tac

Author

Yordanov, A.T., primary, Garmestani, K., additional, Zhang, M., additional, Zhang, Z., additional, Yao, Z., additional, Phillips, K.E., additional, Herring, B., additional, Horak, E., additional, Beitzel, M.P., additional, Schwarz, U.P., additional, Gansow, O.A., additional, Plascjak, P.S., additional, Eckelman, W.C., additional, Waldmann, T.A., additional, and Brechbiel, M.W., additional

Published
2001
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25. Intrathecal effects of daclizumab treatment of multiple sclerosis

Author

Bielekova, B., Richert, N., Herman, M.L., Ohayon, J., Waldmann, T.A., McFarland, H., Martin, R., and Blevins, G.

Abstract

We previously reported that daclizumab, a humanized monoclonal antibody against CD25, reduced contrast-enhancing lesions (CEL) in patients with multiple sclerosis (MS) who were suboptimal responders to interferon- and that this response correlated with expansion of CD56brightNK cells. These data have been reproduced in a placebo-controlled multicenter trial (CHOICE study). The current study investigates whether daclizumab monotherapy reduces CEL in untreated patients with relapsing-remitting MS (RRMS) and the effects of daclizumab on the intrathecal immune system.

Published
2011
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26. Monoclonal antibodies in diagnosis and therapy.

Author

Waldmann, T.A.

Subjects
*IMMUNITY
Abstract

Summarizes information on in vivo use of monoclonal antibodies for diagnosis and therapy. Cell surface antigenic targets; Genetically engineered antibodies; Human monoclonal antibodies; Bifunctional antibodies; Monoclonal antibody-cytotoxic agent conjugates; Radiolabeled monoclonal antibodies.

Published
1991
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28. Preparation and in vivoevaluation of linkers for 211At labeling of humanized anti-Tac

Author

Yordanov, A.T., Garmestani, K., Zhang, M., Zhang, Z., Yao, Z., Phillips, K.E., Herring, B., Horak, E., Beitzel, M.P., Schwarz, U.P., Gansow, O.A., Plascjak, P.S., Eckelman, W.C., Waldmann, T.A., and Brechbiel, M.W.

Abstract

The syntheses, radiolabeling, antibody conjugation, and in vivoevaluation of new linkers for 211At labeling of humanized anti-Tac (Hu-anti-Tac), an antibody to the α-chain of the IL-2 receptor (IL-2Rα) shown to be a useful target for radioimmunotherapy are described. Synthesis of the organometallic linker precursors is accomplished by reaction of the corresponding bromo- or iodoaryl esters with bis(tributyltin) in the presence of a palladium catalyst. Subsequent conversion to the corresponding N-succinimidyl ester and labeling with 211At of two new linkers, N-succinimidyl 4-[211At]astato-3-methylbenzoate and N-succinimidyl N-(4-[211At]astatophenethyl)succinamate (SAPS), together with the previously reported N-succinimidyl 4-[211At]astatobenzoate and N-succinimidyl 3-[211At]astato-4-methylbenzoate, are each conjugated to Hu-anti-Tac. The plasma survival times of these conjugates are compared to those of directly iodinated (125I) Hu-anti-Tac. The N-succinimidyl N-(4-[211At]astatophenethyl)succinamate compound (SAPS) emerged from this assay as the most viable candidate for 211At-labeling of Hu-anti-Tac. SAPS, along with the directly analogous radio-iodinated reagent, N-succinimidyl N-(4-[125I]astatophenethyl)succinamate (SIPS), are evaluated in a biodistribution study along with directly iodinated (125I) Hu-anti-Tac. Blood clearance and biological accretion results indicate that SAPS is a viable candidate for further evaluation for radioimmunotherapy of cancer.

Published
2001
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29. The Role of Alphafetoprotein and Human Chorionic Gonadotropin in Seminoma

Author

Javadpour, N., Mcintire, K.R., Waldmann, T.A., and Bergman, S.M.

Abstract

In a prospective study of 60 patients with pure seminoma we have measured the levels of serum human chorionic gonadotropin and alpha-fetoprotein by specific double antibody immunoassays developed originally at the National Cancer Institute, These markers also were localized in different cells using the techniques of immunoperoxidase and immunofluorescence on serial sections of the tumors. Of 60 patients 4 had elevated serum human chorionic gonadotropin, with a range of 2.8 to 428ng./ml. and an average of 109ng./ml. In serial sectioning of the tumor specimens 1 of 4 patients had an element of choriocarcinoma and underwent retroperitoneal lymph node dissection and chemotherapy. The serum human chorionic gonadotropin decreased to normal. Normal levels of alpha-fetoprotein were seen in 59 patients. However, in 1 patient the serum alpha-fetoprotein was 152ng./ml. In serial sectioning an element of embryonal carcinoma was found. This patient has been proved to have metastatic involvement of aortocaval nodes and underwent retroperitoneal lymphadenectomy. Histopathological examination showed an element of embryonal carcinoma.

Published
1978
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34. CLINICAL USE OF A.F.P. AND H.C.G. IN TESTICULAR TUMOURS OF GERM-CELL ORIGIN

Author

Nørgaard-Pedersen, Bent, primary, Albrechtsen, R., additional, Bagshawe, K.D., additional, Buffe, D., additional, Endo, Y., additional, Heyderman, E., additional, Hirai, H., additional, Horne, C.H., additional, Hägerstrand, I., additional, Javadpour, N., additional, Knudsen, J.B., additional, Kohn, J., additional, Lamerz, R., additional, Lange, P.H., additional, Mcintire, K.R., additional, Munro Neville, A., additional, Nustad, K., additional, Peckham, M.J., additional, Ratcliffe, J.G., additional, Rimbaut, C., additional, Rosen, S., additional, Sakashita, S., additional, Scardino, P.T., additional, Schultz, H., additional, Seppäla, M., additional, Sizaret, PH., additional, Talerman, A., additional, Thompson, D.K., additional, Tsuchida, J., additional, Vaitukaitis, J., additional, Wahren, B., additional, and Waldmann, T.A., additional

Published
1978
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35. Primary immunodeficiency diseases

Author

Rosen, F.S., primary, Wedgwood, R.J., additional, Aiuti, F., additional, Cooper, M.D., additional, Good, R.A., additional, Hanson, L.A., additional, Hitzig, W.H., additional, Matsumoto, S., additional, Seligmann, M., additional, Soothill, J.F., additional, and Waldmann, T.A., additional

Published
1983
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36. Primary immunodeficiency diseases

Author

Rosen, F.S., primary, Wedgwood, R.J., additional, Eibl, M., additional, Aiuti, F., additional, Cooper, M.D., additional, Good, R.A., additional, Griscelli, C., additional, Hanson, L.A., additional, Hitzig, W.H., additional, Matsumoto, S., additional, Seligmann, M., additional, Soothill, J.F., additional, and Waldmann, T.A., additional

Published
1986
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