3,239 results on '"Waldmann, Herbert"'
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2. A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds
3. Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype
4. Programming inactive RNA-binding small molecules into bioactive degraders
5. Phenotypic profiling enables the targeted design of a novel pseudo-natural product class
6. Morphological subprofile analysis for bioactivity annotation of small molecules
7. Chemical evolution of natural product structure for drug discovery
8. Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds
9. Asymmetric catalysis with chiral cyclopentadienyl complexes to access privileged scaffolds
10. Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
11. Tafbromin selectively targets the TAF1 bromodomain
12. Illuminating Dark Chemical Matter Using the Cell Painting Assay
13. Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling
14. Identification of Readily Available Pseudo-Natural Products
15. Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
16. A dataset of compound-target pairs to analyse differences between drugs, clinical candidates and other bioactive compounds
17. Restriction of Glycolysis Increases Serial Killing Capacity of Natural Killer Cells
18. Progress and Opportunities of Pseudo-Natural Product Design in Molecular Discovery
19. Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
20. Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones
21. Morphological profiling of small molecules
22. A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation
23. Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay.
24. The Pseudo‐Natural Product Tafbromin Selectively Targets the TAF1 Bromodomain 2.
25. Identification of readily available pseudo-natural products.
26. Identification of lysosomotropism using explainable machine learning and morphological profiling cell painting data.
27. Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery
28. Identification of Lysosomotropism using Explainable Machine Learning and Morphological Profiling Cell Painting Data
29. Identification of Lysosomotropism using Explainable Machine Learning and Morphological Profiling Cell Painting Data
30. Natural product fragment combination to performance-diverse pseudo-natural products
31. Principle and design of pseudo-natural products
32. Voices of chemical biology.
33. IMI European Lead Factory — democratizing access to high-throughput screening
34. Hot-spot guided design of macrocyclic inhibitors of the LSD1-CoREST1 interaction
35. Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
36. The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery
37. Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells
38. The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype
39. Discovery of a novel pseudo-natural product Aurora kinase inhibitor chemotype through morphological profiling
40. Discovery of the sEH Inhibitor Epoxykynin as Potent Kynurenine Pathway Modulator
41. Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay
42. Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair
43. Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space
44. Collective Synthesis of Sarpagine and Macroline Alkaloid‐Inspired Compounds
45. Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways
46. Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors
47. Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion
48. Identification of novel PDEδ interacting proteins
49. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein
50. Bioactive Compound Collections: From Design to Target Identification
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