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3. Humoral and cellular immune response in Wistar Han RCC rats fed two genetically modified maize MON810 varieties for 90 days (EU 7th Framework Programme project GRACE)

Author

Tulinská, Jana, Adel-Patient, Karine, Bernard, Hervé, Líšková, Aurélia, Kuricová, Miroslava, Ilavská, Silvia, Horváthová, Mira, Kebis, Anton, Rollerová, Eva, Babincová, Júlia, Aláčová, Radka, Wal, Jean-Michel, Schmidt, Kerstin, Schmidtke, Jörg, Schmidt, Paul, Kohl, Christian, Wilhelm, Ralf, Schiemann, Joachim, and Steinberg, Pablo

Published
2018
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5. Modifying the infantʼs diet to prevent food allergy

Author

Grimshaw, Kate, Logan, Kirsty, OʼDonovan, Sinead, Kiely, Mairead, Patient, Karine, van Bilsen, Jolanda, Beyer, Kirsten, Campbell, Dianne E, Garcia-Larsen, Vanessa, Grabenhenrich, Linus, Lack, Gideon, Mills, Clare, Wal, Jean-Michel, and Roberts, Graham

Published
2017
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7. Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)

Author

Zeljenková, Dagmar, Ambrušová, Katarína, Bartušová, Mária, Kebis, Anton, Kovrižnych, Jevgenij, Krivošíková, Zora, Kuricová, Miroslava, Líšková, Aurélia, Rollerová, Eva, Spustová, Viera, Szabová, Elena, Tulinská, Jana, Wimmerová, Soňa, Levkut, Mikuláš, Révajová, Viera, Ševčíková, Zuzana, Schmidt, Kerstin, Schmidtke, Jörg, La Paz, Jose Luis, Corujo, Maria, Pla, Maria, Kleter, Gijs A., Kok, Esther J., Sharbati, Jutta, Hanisch, Carlos, Einspanier, Ralf, Adel-Patient, Karine, Wal, Jean-Michel, Spök, Armin, Pöting, Annette, Kohl, Christian, Wilhelm, Ralf, Schiemann, Joachim, and Steinberg, Pablo

Published
2014
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9. List of Contributors

Author

Alldrick, Anton, primary, Asero, Ricardo, additional, Ballmer-Weber, Barbara K., additional, Baranowsky, Susan A., additional, Baumert, Joseph L., additional, Botjes, Erna, additional, Burney, Peter, additional, Cochrane, Stella, additional, Crevel, René W.R., additional, Critenden, Ross, additional, Dubois, Anthony E.J., additional, Dunaif, George E., additional, DunnGalvin, Audrey, additional, Fernández-Rivas, Montserrat, additional, Flokstra-de Blok, B.M.J., additional, Gendel, Steven M., additional, Grabenhenrich, Linus, additional, Grinter, Kirsten, additional, Hattersley, Sue, additional, Houben, Geert, additional, Husby, Steffen, additional, Ivarsson, Anneli, additional, Johnson, Phil E., additional, Keil, Thomas, additional, King, Rita, additional, Knulst, André C., additional, Leitch, I.S., additional, Madsen, Charlotte Bernhard, additional, McIntosh, J., additional, Mills, Clare, additional, Nørhede, Pia, additional, O’B. Hourihane, Jonathan, additional, Olsson, Cecilia, additional, Pfaff, Sylvia, additional, Reading, David, additional, Remington, Ben C., additional, Sherlock, Robin, additional, Skrypec, Dan, additional, Taylor, Steven L., additional, van Ravenhorst, Marjan, additional, Wal, Jean-Michel, additional, Ward, Rachel, additional, Wong, Gary, additional, and Zuidmeer-Jongejan, Laurian, additional

Published
2014
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19. Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity

Author

Blanc, Fany, Vissers, Yvonne M., Adel-Patient, Karine, Rigby, Neil M., Mackie, Alan R., Gunning, Patrick A., Wellner, Nikolaus K., Skov, Per S., Przybylski-Nicaise, Laetitia, Ballmer-Weber, Barbara, Zuidmeer-Jongejan, Laurian, Szépfalusi, Zsolt, Ruinemans-Koerts, Janneke, Jansen, Ad P. H., Bernard, Hervé, Wal, Jean-Michel, Savelkoul, Huub F. J., Wichers, Harry J., and Mills, Clare E. N.

Published
2011
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21. Assessment of genetically modified maize 1507 × NK603 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐008)

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Ruiz Gómez, José Ángel, Lanzoni, Anna, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Unité de Recherche Génomique Info (URGI), Institut National de la Recherche Agronomique (INRA), Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité Impacts Ecologiques des Innovations en Production Végétale (ECO-INNOV), Biologie du fruit et pathologie (BFP), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1, Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Naegeli, Hanspeter, Birch, Andrew Nichola, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nil, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean-Michel, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Ruiz Gómez, José Ángel, Lanzoni, Anna, Papadopoulou, Nikoletta, and Paraskevopoulos, Konstantinos

Subjects
0301 basic medicine, Veterinary (miscellaneous), [SDV]Life Sciences [q-bio], Plant Science, 010501 environmental sciences, 01 natural sciences, Microbiology, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 1507 × NK603, [SDV.IDA]Life Sciences [q-bio]/Food engineering, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, 0105 earth and related environmental sciences, 2. Zero hunger, renewal, Gmo, Regulation (EC) No 1829/2003, Maize, 030104 developmental biology, Scientific Opinion, [SDE]Environmental Sciences, 1507 x NK603, Parasitology, Animal Science and Zoology, Articles 11 and 23, Food Science
Abstract

International audience; Following the submission of application EFSA-GMO-RX-008 under Regulation (EC) No 1829/2003 from Pioneer Hi-Bred International, Inc. and Dow AgroSciences LLC, the Panel on Genetically Modified Organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the insect-resistant, herbicide-tolerant genetically modified maize 1507 x NK603, for food and feed uses, import and processing, excluding cultivation within the EU. The data received in the context of this renewal application contained a systematic search and evaluation of literature, updated bioinformatic analyses and additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. In conclusion, under the assumption that the DNA sequence of the events in maize 1507 x NK603 considered for renewal are identical to the newly reported 1507 sequence and the NK603 sequence of the originally assessed two-event stack maize, the GMO Panel concludes that there is no evidence in the renewal application EFSA-GMO-RX-008 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on maize 1507 x NK603 (EFSA, 2006). (C) 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Published
2018
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23. IgE-Mediated food allergy diagnosis: Current status and new perspectives

Author

Asero, Riccardo, Ballmer-Weber, Barbara K., Beyer, Kirsten, Conti, Amedeo, Dubakiene, Ruta, Fernandez-Rivas, Montserrat, Hoffmann-Sommergruber, Karin, Lidholm, Jonas, Mustakov, Tihomir, Elberink, Joanne N. G. Oude, Pumphrey, Richard S. H., Skov, Per Stahl, Ree, Ronald van, Boerstra, Berber J. Vlieg-, Hiller, Reinhard, Hourihane, Jonathan O., Kowalski, Marek, Papadopoulos, Nikos G., Wal, Jean-Michel, Mills, Clare E. N., and Vieths, Stefan

Published
2007
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28. Scientific Opinion on application EFSA‐GMO‐BE‐2013‐117 for authorisation of genetically modified maize MON 87427 × MON 89034 × NK603 and subcombinations independently of their origin, for food and feed uses, import and processing submitted under Regulation (EC) No 1829/2003 by Monsanto Company

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐michel, Gennaro, Andrea, Neri, Franco Maria, Paraskevopoulos, Konstantinos, Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris-Saclay, Naegeli, Hanspeter, Birch, Andrew Nichola, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nil, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Gennaro, Andrea, Neri, Franco Maria, and Paraskevopoulos, Konstantinos

Subjects
0106 biological sciences, Cry1A, herbicide tolerance, maïs, Veterinary (miscellaneous), gmo, [SDV]Life Sciences [q-bio], MON87427xMON89034xNK603, ogm, Plant Science, 010501 environmental sciences, maize, CP4EPSPS, 01 natural sciences, Microbiology, zea mays, MON 87427 × MON 89034 × NK603, Cry2Ab2, CP4 EPSPS, 0105 earth and related environmental sciences, 2. Zero hunger, Cry1A.105, indian corn, Regulation (EC) No 1829/2003, GMO, insect resistance, MON 87427 x MON 89034 x NK603, MON 87427 9 MON 89034 9 NK603, Scientific Opinion, Regulation (EC) No1829/2003, Animal Science and Zoology, Parasitology, 010606 plant biology & botany, Food Science
Abstract

Scientific opinionRequestor: Competent Authority of BelgiumQuestion number: EFSA-Q-2013-00765; In this opinion, the EFSA Panel on Genetically Modified Organisms (GMO Panel) assessed the three-event stack maize MON 87427 9 MON 89034 9 NK603 and its three subcombinations, independently of their origin. The GMO Panel has previously assessed the three single events combined to produce this three-event stack maize and did not identify safety concerns. No new data on the single events, leading to modification of the original conclusions on their safety, were identified. Based on the molecular, agronomic, phenotypic and compositional characteristics, the combination of the single maize events and of the newly expressed proteins in the three-event stack maize did not give rise to issues regarding food and feed safety or nutrition. In the case of accidental release of viable grains of maize MON 87427 9 MON 89034 9 NK603 into the environment, the three-event stack maize would not raise environmental safety concerns. The GMO Panel concludes that the threeevent stack maize is as safe and as nutritious as the non-GM comparator and the tested non-GM reference varieties in the context of its scope. The GMO Panel considered that its previous conclusions on the two-event stack maize MON 89034 9 NK603 remain valid. For the two maize subcombinations for which no experimental data were provided the GMO Panel assessed the likelihood of interactions among the single events, and concluded that their combination would not raise safety concerns. These two subcombinations are therefore expected to be as safe as the single events, the previously assessed maize MON 89034 9 NK603 and maize MON 87427 9 MON 89034 9 NK603. Since the post-market environmental monitoring plan for the three-event stack maize does not include any provisions for the two subcombinations not previously assessed, the GMO Panel recommended the applicant to revise the plan accordingly.

Published
2017
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29. Assessment of genetically modified sugar beet H7‐1 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐006)

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Fernandez‐Dumont, Antonio, Gennaro, Andrea, Ramon, Matthew, University of Zurich, Institut Jean-Pierre Bourgin (IJPB), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris-Saclay, Naegeli, Hanspeter, Birch, Andrew Nichola, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nil, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Fernandez‐Dumont, Antonio, Gennaro, Andrea, and Ramon, Matthew

Subjects
040301 veterinary sciences, Veterinary (miscellaneous), gmo, [SDV]Life Sciences [q-bio], sugarbeet, ogm, Plant Science, 010501 environmental sciences, sugar beet, H7-1, renewal, articles 11 and 23, regulation (EC) No 1829/2003, CP4 EPSPS, 01 natural sciences, Microbiology, 0403 veterinary science, 0105 earth and related environmental sciences, fungi, 04 agricultural and veterinary sciences, 10079 Institute of Veterinary Pharmacology and Toxicology, betterave sucrière, H7‐1, Scientific Opinion, 570 Life sciences, biology, Animal Science and Zoology, Parasitology, Food Science
Abstract

Efsa Panel On Genetically Modified Organisms (gmo)Scientific opinionRequestor: European Commission (DG SANTE)Question number: EFSA-Q-2017-00026; Following the submission of application EFSA-GMO-RX-006 under Regulation (EC) No 1829/2003 fromKWS SAAT SE and Monsanto Company, the Panel on Genetically Modified Organisms of the EuropeanFood Safety Authority (GMO Panel) was asked to deliver a scientific risk assessment on the datasubmitted in the context of the renewal of authorisation application for the herbicide-tolerantgenetically modified sugar beet H7-1. The data received in the context of this renewal applicationcontained a systematic search and evaluation of literature, updated bioinformatics analyses andadditional documents or studies performed by or on behalf of the applicant. The GMO Panel assessedthese data for possible new hazards, modified exposure or new scientific uncertainties identified duringthe authorisation period and not previously assessed in the context of the original application. Underthe assumption that the DNA sequence of the event in sugar beet H7-1 considered for renewal isidentical to the originally assessed event, the GMO Panel concludes that there is no evidence in thecontext of this renewal application for new hazards, modified exposure or scientific uncertainties thatwould change the conclusions of the original risk assessment on sugar beet H7-1.

Published
2017
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30. Assessment of genetically modified soybean MON 87751 for food and feed uses under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2014‐121)

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, Fernandez Dumont, Antonio, Gómez Ruiz, José Ángel, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, and University of Zurich

Subjects
3401 Veterinary (miscellaneous), 2404 Microbiology, 1110 Plant Science, 2405 Parasitology, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology, 1103 Animal Science and Zoology, 1106 Food Science
Published
2018
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31. Assessment of genetically modified cotton GHB614 × LLCotton25 × MON 15985 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2011‐94)

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, huw jones, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Cristoph, Visioli, Francesco, Wal, Jean-Michel, Broll, Hermann, Gennaro, Andrea, Neri, Franco Maria, Paraskevopoulos, Konstantinos, and University of Zurich

Subjects
3401 Veterinary (miscellaneous), 2404 Microbiology, 1110 Plant Science, 2405 Parasitology, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology, 1103 Animal Science and Zoology, 1106 Food Science
Published
2018

32. Assessment of genetically modified maize MON 87403 for food and feed uses, import and processing, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐BE‐2015‐125)

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Devos, Yann, Broll, Hermann, Ramon, Matthew, and University of Zurich

Subjects
3401 Veterinary (miscellaneous), 2404 Microbiology, 1110 Plant Science, 2405 Parasitology, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology, 1103 Animal Science and Zoology, 1106 Food Science
Published
2018

33. Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin

Author

Bossios Apostolos, Theodoropoulou Maria, Mondoulet Lucie, Rigby Neil M, Papadopoulos Nikolaos G, Bernard Hervé, Adel-Patient Karine, Wal Jean-Michel, Mills Clare EN, and Papageorgiou Photini

Subjects
in vitro digestion, cow's milk allergy, β-lactoglobulin, flow cytometry, Basophil activation, skin prick test, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Cow's milk (CM) allergy affects about 2% of infants. The allergenicity of dietary proteins, including those from CM, has been related to their digestibility although the generality of the link and its causality remains to be demonstrated. In this study we use an in vitro digestion system, to investigate the digestibility of β-lactoglobulin (blg) during gastrointestinal transit and to assess the impact of this process on blg allergenic reactivity in CM allergic children. Methods Blg digesta were prepared using an in vitro digestion protocol simulating either gastric digestion alone or followed by duodenal digestion with or without phosphatidylcholine (PC). Biochemical analysis of blg digesta was performed by SDS-PAGE and their concentration was measured by a sandwich ELISA. Assessment of their allergenic reactivity was done in vitro by EAST inhibition, specific basophil activation (basotest) and lymphocyte proliferation (PCNA-flow cytometry) assays using sera and cells from patients allergic to blg and in vivo by skin prick testing (SPT) of these patients. Results Blg was only broken down to smaller peptides after gastro-duodenal digestion although a sizeable amount of intact protein still remained. Digestion did not modify the IgE binding capacity of blg except for gastro-duodenal digestion performed in the absence of PC. These results are consistent with the quantity of intact blg remaining in the digesta. Overall both gastric and gastroduodenal digestion enhanced activation of sensitized basophils and proliferation of sensitized lymphocytes by blg. However, there was a tendency towards reduction in mean diameter of SPT following digestion, the PC alone during phase 1 digestion causing a significant increase in mean diameter. Conclusions Digestion did not reduce the allergenic reactivity of blg to a clinically insignificant extent, PC inhibiting digestion and thereby protecting blg allergenic reactivity. SPT reactivity was reduced compared to blg immunoreactivity in in vitro tests.

Published
2011
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34. Efficient production and secretion of bovine β-lactoglobulin by Lactobacillus casei

Author

Wal Jean-Michel, Corthier Gérard, Azevedo Vasco, Pothelune Laetitia, Hazebrouck Stéphane, and Langella Philippe

Subjects
Microbiology, QR1-502
Abstract

Abstract Background Lactic acid bacteria (LAB) are attractive tools to deliver therapeutic molecules at the mucosal level. The model LAB Lactococcus lactis has been intensively used to produce and deliver such heterologous proteins. However, compared to recombinant lactococci, lactobacilli offer some advantages such as better survival in the digestive tract and immunomodulatory properties. Here, we compared different strategies to optimize the production of bovine β-lactoglobulin (BLG), a major cow's milk allergen, in the probiotic strain Lactobacillus casei BL23. Results Using a nisin-inducible plasmid system, we first showed that L. casei BL23 strain could efficiently secrete a reporter protein, the staphylococcal nuclease (Nuc), with the lactococcal signal peptide SPUsp45 fused to its N-terminus. The fusion of SPUsp45 failed to drive BLG secretion but led to a 10-fold increase of intracellular BLG production. Secretion was significantly improved when the synthetic propeptide LEISSTCDA (hereafter called LEISS) was added to the N-terminus of the mature moiety of BLG. Secretion rate of LEISS-BLG was 6-fold higher than that of BLG alone while intracellular production reached then about 1 mg/L of culture. The highest yield of secretion was obtained by using Nuc as carrier protein. Insertion of Nuc between LEISS and BLG resulted in a 20-fold increase in BLG secretion, up to 27 μg/L of culture. Furthermore, the lactococcal nisRK regulatory genes were integrated into the BL23 chromosome. The nisRK insertion allowed a decrease of BLG synthesis in uninduced cultures while BLG production increased by 50% after nisin induction. Moreover, modification of the induction protocol led to increase the proportion of soluble BLG to around 74% of the total BLG production. Conclusion BLG production and secretion in L. casei were significantly improved by fusions to a propeptide enhancer and a carrier protein. The resulting recombinant strains will be further tested for their ability to modulate the immune response against BLG via mucosal delivery in a cow's milk allergy model in mice.

Published
2007
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35. Statement complementing the EFSA Scientific Opinion on application (EFSA‐GMO‐DE‐2011‐95) for the placing on the market of genetically modified maize 5307 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Syngenta Crop Protection AG taking into consideration an additional toxicological study

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Paraskevopoulos, Konstantinos, Lanzoni, Anna, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Paraskevopoulos, Konstantinos, and Lanzoni, Anna

Published
2018

36. Assessment of genetically modified cotton GHB614 × LLCotton25 × MON 15985 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2011‐94)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Broll, Hermann, Gennaro, Andrea, Neri, Franco Maria, Paraskevopoulos, Konstantinos, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Broll, Hermann, Gennaro, Andrea, Neri, Franco Maria, and Paraskevopoulos, Konstantinos

Published
2018

37. Assessment of genetically modified maize MON 87411 for food and feed uses, import and processing, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2015‐124)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Angel, Lanzoni, Anna, Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Ramon, Matthew, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Angel, Lanzoni, Anna, Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, and Ramon, Matthew

Abstract

Maize MON 87411 was developed to confer resistance to corn rootworms (Diabrotica spp.) by the expression of a modified version of the Bacillus thuringiensis cry3Bb1 gene and a DvSnf7 dsRNA expression cassette, and tolerance to glyphosate-containing herbicides by the expression of a CP4 5-enolpyruvylshikimate-3-phosphate synthase (cp4 epsps) gene. The molecular characterisation data and bioinformatics analyses did not identify issues requiring assessment for food and feed safety. No statistically significant differences in the agronomic and phenotypic characteristics tested between maize MON 87411 and its conventional counterpart were identified. The compositional analysis of maize MON 87411 did not identify differences that required further assessment except for palmitic acid levels in grains from not treated maize MON 87411. The GMO Panel did not identify safety concerns regarding the toxicity and allergenicity of the Cry3Bb1 and CP4 EPSPS proteins, as expressed in maize MON 87411 and found no evidence that the genetic modification might significantly change the overall allergenicity of maize MON 87411. The nutritional impact of maize MON 87411-derived food and feed is expected to be the same as those derived from the conventional counterpart and non-GM commercial reference varieties. The GMO Panel concludes that maize MON 87411, as described in this application, is nutritionally equivalent to and as safe as the conventional counterpart and the non-GM maize reference varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize MON 87411 grains into the environment, maize MON 87411 would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 87411. The GMO Panel concludes that maize MON 87411, as described in this application, is as safe as its conventional counterpart and the tested non-GM

Published
2018

38. Assessment of genetically modified maize 4114 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2014‐123)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Àlvarez, Fernando, Ardizzone, Michele, Paraskevopoulos, Konstantinos, Broll, Hermann, Devos, Yann, Fernandez Dumont, Antonio, Gómez Ruiz, Jose Ángel, Lanzoni, Anna, Neri, Franco Maria, Olaru, Irina, Papadopoulou, Nikoletta, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Àlvarez, Fernando, Ardizzone, Michele, Paraskevopoulos, Konstantinos, Broll, Hermann, Devos, Yann, Fernandez Dumont, Antonio, Gómez Ruiz, Jose Ángel, Lanzoni, Anna, Neri, Franco Maria, Olaru, Irina, and Papadopoulou, Nikoletta

Published
2018

39. Assessment of genetically modified maize NK603 x MON810 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐007)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Broll, Hermann, Fernandez Dumont, Antonio, Olaru, Irina, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Broll, Hermann, Fernandez Dumont, Antonio, and Olaru, Irina

Published
2018

40. Assessment of genetically modified maize 1507 × NK603 for renewal of authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐008)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Ruiz Gómez, José Ángel, Lanzoni, Anna, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Ruiz Gómez, José Ángel, Lanzoni, Anna, Papadopoulou, Nikoletta, and Paraskevopoulos, Konstantinos

Abstract

Following the submission of application EFSA-GMO-RX-008 under Regulation (EC) No 1829/2003 from Pioneer Hi-Bred International, Inc. and Dow AgroSciences LLC, the Panel on Genetically Modified Organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the insect-resistant, herbicide-tolerant genetically modified maize 1507 x NK603, for food and feed uses, import and processing, excluding cultivation within the EU. The data received in the context of this renewal application contained a systematic search and evaluation of literature, updated bioinformatic analyses and additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. In conclusion, under the assumption that the DNA sequence of the events in maize 1507 x NK603 considered for renewal are identical to the newly reported 1507 sequence and the NK603 sequence of the originally assessed two-event stack maize, the GMO Panel concludes that there is no evidence in the renewal application EFSA-GMO-RX-008 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on maize 1507 x NK603 (EFSA, 2006). (C) 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Published
2018

41. Assessment of genetically modified soybean MON 87751 for food and feed uses under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2014‐121)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, Fernandez Dumont, Antonio, Gómez Ruiz, José Ángel, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, Fernandez Dumont, Antonio, Gómez Ruiz, José Ángel, Papadopoulou, Nikoletta, and Paraskevopoulos, Konstantinos

Published
2018

42. Technical Note on the quality of DNA sequencing for the molecular characterisation of genetically modified plants

Author

Casacuberta, Josep, Nogué, Fabien, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Moxon, Simon, Schneeberger, Korbinian, Federici, Silvia, Ramon, Matthew, Papadopoulou, Nikoletta, Jones, Huw, Casacuberta, Josep, Nogué, Fabien, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Moxon, Simon, Schneeberger, Korbinian, Federici, Silvia, Ramon, Matthew, Papadopoulou, Nikoletta, and Jones, Huw

Published
2018

43. Assessment of genetically modified cotton GHB614 × T304‐40 × GHB119 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2014‐122)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Ardizzone, Michele, Fernandez‐Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Lanzoni, Anna, Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Ardizzone, Michele, Fernandez‐Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Lanzoni, Anna, Neri, Franco Maria, Papadopoulou, Nikoletta, and Paraskevopoulos, Konstantinos

Published
2018

44. Assessment of genetically modified maize MON 87403 for food and feed uses, import and processing, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐BE‐2015‐125)

Author

Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Devos, Yann, Broll, Hermann, Ramon, Matthew, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Devos, Yann, Broll, Hermann, and Ramon, Matthew

Published
2018

45. Annual post‐market environmental monitoring (PMEM) report on the cultivation of genetically modified maize MON 810 in 2015 from Monsanto Europe S.A

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, Devos, Yann, Fernández‐Dumont, Antonio, and University of Zurich

Subjects
fungi, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology
Published
2017

46. Scientific Opinion on application EFSA‐GMO‐NL‐2013‐119 for authorisation of genetically modified glufosinate‐ammonium‐ and glyphosate‐tolerant oilseed rape MON 88302 × MS8 × RF3 and subcombinations independently of their origin, for food and feed uses, import and processing submitted in accordance with Regulation (EC) No 1829/2003 by Monsanto Company and Bayer CropScience

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Devos, Yann, Lanzoni, Anna, Olaru, Irina, and University of Zurich

Subjects
570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology
Published
2017

47. Risk assessment of information on the subcombination Bt11 × MIR162, related to the application of Syngenta (EFSA‐GMO‐DE‐2009‐66) for authorisation of food and feed containing, consisting and produced from genetically modified maize Bt11 × MIR162 × MIR604 × GA21

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikolaj Antoni, Guerche, Philippe, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Neri, Franco Maria, and Paraskevopoulos, Konstantinos

Subjects
maïs, 040301 veterinary sciences, Veterinary (miscellaneous), ogm, TP1-1185, Plant Science, 010501 environmental sciences, Biology, 01 natural sciences, Microbiology, zea mays, 0403 veterinary science, four‐event maize stack Bt11 × MIR162 × MIR604 × GA21, GMO, maize (Zea mays), four-event maize stack, Regulation (EC) No 1829/2003, subcombination Bt11 x MIR162, Bt11 x MIR162 x MIR604 x GA21, TX341-641, European commission, 0105 earth and related environmental sciences, 2. Zero hunger, Genetically modified maize, Animal health, Nutrition. Foods and food supply, business.industry, Chemical technology, Authorization, subcombination Bt11 × MIR162, 04 agricultural and veterinary sciences, Zea mays, Biotechnology, Genetically modified organism, Animal Science and Zoology, Parasitology, Statement, Risk assessment, business, Food Science
Abstract

The EFSA Panel on Genetically Modified Organisms (GMO) has previously assessed the single events Bt11, MIR162, MIR604 and GA21 as well as different stacked events corresponding to combinations of these events. These maize events were found to be as safe as their conventional counterparts and other appropriate comparators with respect to potential effects on human and animal health and the environment. In its assessment of the four‐event maize stack Bt11 × MIR162 × MIR604 × GA21, the GMO Panel also assessed all the subcombinations of these events not previously assessed, including some for which little or no experimental data were provided, including the two‐stack maize event Bt11 × MIR162 (application EFSA‐GMO‐DE‐2009‐66). On 8 November 2016, the European Commission received from Syngenta information on the subcombination Bt11 × MIR162. On 14 December 2016, the European Commission tasked EFSA to analyse these data and to indicate whether they have an impact on the previously issued opinion on the four‐event stack Bt11 × MIR162 × MIR604 × GA21 and its subcombinations. The GMO Panel used the appropriate principles described in its guidelines for the risk assessment of genetically modified (GM) plants to analyse the provided data. The levels of the newly expressed proteins Cry1Ab, PAT, Vip3Aa20 and PMI are similar between the two‐event stack Bt11 × MIR162 and the corresponding single events Bt11 and MIR162. Based on this analysis, there is no indication of an interaction between the events combined in maize Bt11 × MIR162 that would affect the levels of the newly expressed proteins. Thus, the GMO Panel considers that the new information for maize Bt11 × MIR162 does not alter the conclusions of the scientific opinion on application EFSA‐GMO‐DE‐2009‐66.

Published
2017
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48. Scientific opinion on an application by Monsanto (EFSA‐GMO‐NL‐2013‐114) for the placing on the market of a herbicide‐tolerant genetically modified cotton MON 88701 for food and feed uses, import and processing under Regulation (EC) No 1829/2003

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Poeting, Annette, Álvarez, Fernando, Broll, Hermann, Ramon, Matthew, and University of Zurich

Subjects
fungi, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology
Published
2017

49. Scientific opinion on an application by Dow AgroSciences LLC (EFSA‐GMO‐NL‐2012‐106) for the placing on the market of genetically modified herbicide‐tolerant soybean DAS‐44406‐6 for food and feed uses, import and processing under Regulation (EC) No 1829/2003

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Álvarez, Fernando, Ardizzone, Michele, Liu, Yi, Neri, Franco Maria, Ramon, Matthew, EFSA Panel on Genetically Modified Organisms, GMO, and University of Zurich

Subjects
fungi, food and beverages, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology
Published
2017

50. Scientific Opinion on an application by Dow AgroSciences LLC (EFSA‐GMO‐NL‐2011‐91) for the placing on the market of genetically modified herbicide‐tolerant soybean DAS‐68416‐4 for food and feed uses, import and processing under Regulation (EC) No 1829/2003

Author

Naegeli, Hanspeter, Birch, Andrew Nicholas, Casacuberta, Josep, De Schrijver, Adinda, Gralak, Mikołaj Antoni, Jones, Huw, Manachini, Barbara, Messéan, Antoine, Nielsen, Elsa Ebbesen, Nogué, Fabien, Robaglia, Christophe, Rostoks, Nils, Sweet, Jeremy, Tebbe, Christoph, Visioli, Francesco, Wal, Jean‐Michel, Ardizzone, Michele, Devos, Yann, Gomes, Ana, Liu, Yi, Neri, Franco Maria, Olaru, Irina, and University of Zurich

Subjects
fungi, food and beverages, 570 Life sciences, biology, 10079 Institute of Veterinary Pharmacology and Toxicology
Published
2017

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