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2. A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function

Author

Heerspink, Hiddo J.L., Wheeler, David C., Chertow, Glenn, Correa-Rotter, Ricardo, Greene, Tom, Hou, Fan Fan, McMurray, John, Rossing, Peter, Toto, Robert, Stefansson, Bergur, Langkilde, Anna Maria, Maffei, L.E., Raffaele, P., Solis, S.E., Arias, C.A., Aizenberg, D., Luquez, C., Zaidman, C., Cluigt, N., Mayer, M., Alvarisqueta, A., Wassermann, A., Maldonado, R., Bittar, J., Maurich, M., Gaite, L.E., Garcia, N., Sivak, L., Ramallo, P.O., Santos, J.C., Garcia Duran, R., Oddino, J.A., Maranon, A., Maia, L.N., Avila, D.D., Barros, E.J.G., Vidotti, M.H., Panarotto, D., Noronha, I.D.L., Turatti, L.A.A., Deboni, L., Canziani, M.E., Riella, M.C., Bacci, M.R., Paschoalin, R.P., Franco, R.J., Goldani, J.C., St-Amour, E., Steele, A.W., Goldenberg, R., Pandeya, S., Bajaj, H., Cherney, D., Kaiser, S.M., Conway, J.R., Chow, S.S., Bailey, G., Lafrance, J., Winterstein, J., Cournoyer, S., Gaudet, D., Madore, F., Houlden, R.L., Dowell, A., Langlois, M., Muirhead, N., Khandwala, H., Levin, A., Hou, F., Xue, Y., Zuo, L., Hao, C., Ni, Z., Xing, C., Chen, N., Dong, Y., Zhou, R., Xiao, X., Zou, Y., Wang, C., Liu, B., Chen, Q., Lin, M., Luo, Q., Zhang, D., Wang, J., Chen, M., Wang, X., Zhong, A., Dong, J., Zhu, C., Yan, T., Luo, P., Ren, Y., Pai, P., Li, D., Zhang, R., Zhang, J., Xu, M., Zhuang, Y., Kong, Y., Yao, X., Peng, X., Persson, F.I., Hansen, T.K., Borg, R., Pedersen Bjergaard, U., Hansen, D., Hornum, M., Haller, H., Klausmann, G., Tschope, D., Kruger, T., Gross, P., Hugo, C., Obermuller, N., Rose, L., Mertens, P., Zeller-Stefan, H., Fritsche, A., Renders, L., Muller, J., Budde, K., Schroppel, B., Wittmann, I., Voros, P., Dudas, M., Tabak, G.A., Kirschner, R., Letoha, A., Balku, I., Hermanyi, Z., Zakar, G., Mezei, I., Nagy, G.G., Lippai, J., Nemeth, A., Khullar, D., Gowdaiah, P.K., Fernando Mervin, E., Rao, V.A., Dewan, D., Goplani, K., Maddi, V.S.K., Vyawahare, M.S., Pulichikkat, R.K., Pandey, R., Sonkar, S.K., Gupta, V.K., Agarwal, S., Asirvatham, A.J., Ignatius, A., Chaubey, S., Melemadathil, S., Alva, H., Kadam, Y., Shimizu, H., Sueyoshi, A., Takeoka, H., Abe, Y., Imai, T., Onishi, Y., Fujita, Y., Tokita, Y., Oura, M., Makita, Y., Idogaki, A., Koyama, R., Kikuchi, H., Kashihara, N., Hayashi, T., Ando, Y., Tanaka, T., Shimizu, M., Hidaka, S., Gohda, T., Tamura, K., Abe, M., Kamijo, Y., Imasawa, T., Takahashi, Y., Nakayama, M., Tomita, M., Hirano, F., Fukushima, Y., Kiyosue, A., Kurioka, S., Imai, E., Kitagawa, K., Waki, M., Wada, J., Uehara, K., Iwatani, H., Ota, K., Shibazaki, S., Katayama, K., Narita, I., Iinuma, M., Matsueda, S., Sasaki, S., Yokochi, A., Tsukamoto, T., Yoshimura, T., Kang, S., Lee, S., Lim, C.S., Chin, H., Joo, K.W., Han, S.Y., Chang, T.I., Park, S., Park, H., Park, C.W., Han, B.G., Cha, D.R., Yoon, S.A., Kim, W., Kim, S.W., Ryu, D., Correa Rotter, R., Irizar Santana, S.S., Hernandez Llamas, G., Valdez Ortiz, R., Secchi Nicolas, N.C., Gonzalez Galvez, G., Lazcano Soto, J.R., Bochicchio Riccardelli, T., Bayram Llamas, E.A., Ramos Ibarra, D.R., Melo, M.G.S., Gonzalez Gonzalez, J.G., Sanchez Mijangos, J.H., Madero Robalo, M., Garcia Castillo, A., Manrique, H.A., Farfan, J.C., Vargas, R., Valdivia, A., Dextre, A., Escudero, E., Calderon Ticona, J.R., Gonzales, L., Villena, J., Leon, L., Molina, G., Saavedra, A., Garrido, E., Arbanil, H., Vargas Marquez, S., Rodriguez, J., Isidto, R., Villaflor, A.J., Gumba, M.A., Tirador, L., Comia, R.S., Sy, R.A., Guanzon, M.L.V.V., Aquitania, G., De Asis, N.C., Silva, A.A., Romero, C.M., Lim, M.E., Danguilan, R.A., Nowicki, M., Rudzki, H., Landa, K., Kucharczyk-Bauman, I., Gogola-Migdal, B., Golski, M., Olech-Cudzik, A., Stompor, T., Szczepanik, T., Miklaszewicz, B., Sciborski, R., Kuzniewski, M., Ciechanowski, K., Wronska, D., Klatko, W., Mazur, S., Popenda, G., Myslicki, M., Bolieva, L.Z., Berns, S., Galyavich, A., Abissova, T., Karpova, I., Platonov, D., Koziolova, N., Kvitkova, L., Nilk, R., Medina, T., Rebrov, A., Rossovskaya, M., Sinitsina, I., Vishneva, E., Zagidullin, N., Novikova, T., Krasnopeeva, N., Magnitskaya, O., Antropenko, N., Batiushin, M., Escudero Quesada, V., Barrios Barrea, C., Espinel Garauz, E., Cruzado Garrit, J.M., Morales Portillo, C., Gorriz Teruel, J.L., Cigarran Guldris, S., Praga Terente, M., Robles Perez-Monteoliva, N.R., Tinahones Madueno, F.J., Soto Gonzalez, A., Diaz Rodriguez, C., Furuland, H., Saeed, A., Dreja, K., Spaak, J., Bruchfeld, A., Kolesnyk, M., Levchenko, O., Pyvovarova, N., Stus, V., Doretskyy, V., Korobova, N., Horoshko, O., Katerenchuk, I., Mostovoy, Y.M., Orynchak, M., Legun, O., Dudar, I., Bilchenko, O., Andreychyn, S., Levchenko, A., Zub, L., Tereshchenko, N., Topchii, I., Ostapenko, T., Bezuglova, S., Kopytsya, M., Turenko, O., Mark, P., Barratt, J., Bhandari, S., Fraser, D., Kalra, P., Kon, S.P., Mccafferty, K., Mikhail, A., Alvarado, O.P., Anderson, R., Andrawis, N.S., Arif, A., Benjamin, S.A., Bueso, G., Busch, R.S., Carr, K.W., Crawford, P., Daboul, N., De La Calle, G.M., Delgado, B., Earl, J., El-Shahawy, M.A., Graf, R.J., Greenwood, G., Guevara, A., Wendland, E.M., Mayfield, R.K., Montero, M., Morin, D.J., Narayan, P., Numrungroad, V., Reddy, A.C., Reddy, R., Samson, M.B., Trejo, R., Butcher, M.B., Wise, J.K., Zemel, L.R., Raikhel, M., Weinstein, D., Hernandez, P., Wynne, A., Khan, B.V., Sterba, G.A., Jamal, A., Ross, D., Rovner, S.F., Tan, A., Ovalle, F., Patel, R.J., Talano, J., Patel, D.R., Burgner, A., Aslam, N., Elliott, M., Goral, S., Jovanovich, A., Manley, J.A., Umanath, K., Waguespack, D., Weiner, D., Yu, M., Schneider, L., Jalal, D., Le, T., Nguyen, N., Nguyen, H., Nguyen, D., Nguyen, V., Do, T., Chu, P., Ta, D., Tran, N., Pham, B., Pfeffer, Marc A., Pocock, Stuart, Swedberg, Karl, Rouleau, Jean L., Chaturvedi, Nishi, Ivanovich, Peter, Levey, Andrew S., Christ-Schmidt, Heidi, Held, Claes, Christersson, Christina, Mann, Johannes, Varenhorst, Christoph, Cherney, David, Postmus, Douwe, Stefánsson, Bergur V., Chertow, Glenn M., Dwyer, Jamie P., Kosiborod, Mikhail, McMurray, John J.V., Sjöström, C. David, and Toto, Robert D.

Published
2022
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14. Estimation of nitrogen removal from swine wastewater in activated sludge systems using activated sludge model simulation

Author

Waki, M., Yasuda, T., Fukumoto, Y., Béline, Fabrice, Magri, A., NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION INSTITUTE OF LIVESTOCK AND GRASSLAND SCIENCE ANIMAL WASTE MANAGEMENT AND ENVIRONMENT RESEARCH DIVISION IBARAKI JPN, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and Irstea Publications, Migration

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences
Abstract

International audience; Livestock waste has a lot of influence on nitrogen contamination in public water body, in Japan, because it is produced as much as 20% of the total amount of industrial waste generated in the country. Commonly, liquid fractions that was produced by solid-liquid fraction of livestock waste, is treated by activated sludge process and then discharged to public water body. According to government sources, 61% of such swine wastewater is aerobically treated. An activated sludge model (ASM)-type model considering BOD and N removal was implemented including nitrite as intermediate, free ammonia and free nitrous acid as potential inhibitors and temperature as process parameter during swine wastewater treatment. Aeration condition is a key factor on nitrogen removal in the activated sludge process. Therefore, simulations were performed with focusing on aeration conditions: continuous and intermittent aeration with various aeration intensity; influent swine wastewater BOD/N ratio of 2, 3 and 4. In the continuous aeration condition, when DO was low, N was mainly removed through the nitrite short cut in simultaneous nitrification-denitrification. In intermittent aeration condition, N was removed at broader DO conditions during aeration than previously assessed for continuous aeration. However, electrical energy consumption to achieve satisfactory N removal was almost same between two aeration conditions. When the BOD/N ratio was set at 4, achieving satisfactory N removal was easier than BOD/N ratio of 3, and 2, at both conditions. When the BOD/N ratio was set at 2, critical DO control was required to achieve satisfactory N removal, therefore in such case, adding post-treatment for nitrogen removal like anammox process, after the activated sludge process would be practical.

Published
2018

15. Nitrogen Removal from Swine Wastewater in Activated Sludge Systems Using an ASM for Continuous and Intermittent Aeration

Author

Waki, M., Yasuda, T, Fukumoto, Y., Béline, Fabrice, Magri, A., NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION INSTITUTE OF LIVESTOCK AND GRASSLAND SCIENCE ANIMAL WASTE MANAGEMENT AND ENVIRONMENT RESEARCH DIVISION IBARAKI JPN, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and Irstea Publications, Migration

Subjects
[SDE] Environmental Sciences, Nitrificació, Simultaneous nitrification and denitrification, Ammonia, [SDE]Environmental Sciences, DO control, Enginyeria agroalimentària::Impacte ambiental [Àrees temàtiques de la UPC], Nitrite short-cut
Abstract

International audience; An ASM-type model considering BOD and N removal was implemented including nitrite as intermediate, free ammonia and free nitrous acid as potential inhibitors and temperature as process parameter during swine wastewater treatment. Simulations were performed at various conditions: continuous and intermittent aeration; influent swine wastewater BOD/N ratio of 2, 3 and 4. Under continuous aeration and low DO, N was mainly removed through the nitrite short cut in simultaneous nitrification-denitrification. Under intermittent aeration, N was removed at broader DO conditions during aeration than previously assessed for continuous aeration. In both aeration conditions, critical DO control was required to achieve satisfactory N removal, particularly when the BOD/N ratio of the wastewater was set at 2. This study assesses those conditions needed to meet the N effluent standards in AS swine wastewater treatment plants, and to identify those cases when post-treatment will be needed.

Published
2018

20. Nitrogen removal from swine wastewater in activated sludge systems evaluated using simulation -comparison between continuous and intermittent aeration

Author

Waki, M., Yasuda, T., Fukumoto, Y., Béline, Fabrice, Magri, A., Irstea Publications, Migration, INSTITUTE OF LIVESTOCK AND GRASSLAND SCIENCE NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION TSUKUBA JPN, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences, education
Abstract

International audience; Nitrogen removal from swine wastewater in activated sludge systems evaluated using simulation -comparison between continuous and intermittent aeration.

Published
2017

22. Appendix

Author

Basov, N. G., Krokhin, O. N., Kriukov, P. G., Zakharov, S. D., Senatsky, Yu. V., Tchekalin, S. V., Linlor, William L., Papoular, Renaud, Alcock, A. J., Siller, G., Büchl, K., Hora, H., Dawson, John M., Mulser, Peter, Wilhelm, Hannelore, DuBois, Donald F., Lindl, John D., Kaw, Predhiman K., Chen, Francis F., Nuckolls, John H., Lengyel, L. L., Clarke, J. S., Fisher, H. N., Mason, R. J., Floux, F., Cognard, D., Denoeud, L-G., Piar, G., Parisot, D., Bobin, J. L., Delobeau, F., Fauquignon, C., Sklizkov, G. V., Ivanov, Yu. S., Mikhailov, Yu. A., Fedotov, S. I., Yamanaka, C., Yamanaka, T., Sasaki, T., Yoshida, K., Waki, M., Kang, H. B., McCall, G. H., Young, F., Ehler, A. W., Kephart, J. F., Godwin, R. P., Goldman, L. M., Soures, J., Lubin, M. J., Shearer, J. W., Garrison, J., Wong, J., Swain, J. E., Hora, Heinrich, and Ksander, Yuri, editor

Published
1975
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23. Effect of DO concentration on nitrogen removal of swine wastewater activated sludge treatment -estimation using mathematical model

Author

Waki, M., Yasuda, T., Fukumoto, Y., Béline, Fabrice, Magri, A., INSTITUTE OF LIVESTOCK AND GRASSLAND SCIENCE NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION TSUKUBA JPN, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Optimisation des procédés en Agriculture, Agroalimentaire et Environnement (UR OPAALE), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), and Irstea Publications, Migration

Subjects
[SDE] Environmental Sciences, [SDE]Environmental Sciences
Abstract

National audience; Effect of DO concentration on nitrogen removal of swine wastewater activated sludge treatment -estimation using mathematical model

Published
2016

32. Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism

Author

Horiuchi, S, Koyanagi, Y, Tanaka, Y, Waki, M, Matsumoto, A, Zhou, Y W, Yamamoto, M, and Yamamoto, N

Subjects
Adult, Leukemia, T-Cell, Base Sequence, Blotting, Western, Molecular Sequence Data, Gene Expression, Receptors, Interleukin-2, HTLV-I Infections, Polymerase Chain Reaction, Alternative Splicing, Leukocytes, Mononuclear, Tumor Cells, Cultured, Humans, Amino Acid Sequence, RNA, Messenger, Research Article
Abstract

A polymerase chain reaction (PCR) method was used to detect the interleukin-2 receptor alpha-chain (IL-2R alpha) chain which lacks the conventional transmembrane (TM) domain in mRNA from human T-cell leukaemia virus type-I (HTLV-I)-infected cell lines or peripheral blood mononuclear cells (PBMC) isolated from adult T-cell leukaemia (ATL) patients. Primer pairs encompassing the TM domain were selected to generate a 357-base pair (bp) fragment. A 146-bp PCR product was observed consistently in addition to the target 357-bp PCR product in mRNA from HTLV-I-infected cell lines, such as MT-1, MT-2, MT-4 and in PBMC isolated from ATL patients. However, this 146-bp PCR product was undetectable in HTLV-I-negative cell lines. The product was also detected in PBMC from normal individuals if activated in vitro with phytohaemagglutinin but not without stimulation. DNA sequence analyses revealed that exons from 5 to 7, which define a 211-bp region containing the conventional TM domain, were deleted in the 146-bp PCR product. The C-terminal amino acid sequence starting from Gly174 of the 211-bp-deleted molecule was distinct from that of conventional IL-2R alpha as a result of an altered reading frame. We identified a 45000 MW peptide generated from IL-2R alpha mRNA through this exon skip in cell lysate of MT-1 and MT-2 by Western blot analyses using an antibody raised against the peptides specific to an altered IL-2R alpha. Our results indicate that an altered IL-2R alpha chain is expressed in HTLV-I-infected T lymphocytic cell lines and in ATL patients.

Published
1997

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