Search

Your search keyword '"Waiswa, Charles"' showing total 219 results
Start Over Author "Waiswa, Charles"
219 results on '"Waiswa, Charles"'

12. Scaling up of tsetse control to eliminate Gambian sleeping sickness in northern Uganda

Author

Hope, Andrew, primary, Mugenyi, Albert, additional, Esterhuizen, Johan, additional, Tirados, Inaki, additional, Cunningham, Lucas, additional, Garrod, Gala, additional, Lehane, Mike J., additional, Longbottom, Joshua, additional, Mangwiro, TN Clement, additional, Opiyo, Mercy, additional, Stanton, Michelle, additional, Torr, Steve J., additional, Vale, Glyn A., additional, Waiswa, Charles, additional, and Selby, Richard, additional

Published
2022
Full Text
View/download PDF

13. Seasonal Monitoring of Glossina Species Occurrence, Infection Rates, and Trypanosoma Species Infections in Pigs in West Nile Region, Uganda

Author

Maxamhud, Sadiya, Lindahl, Johanna F., Mugenyi, Albert, Echodu, Richard, Waiswa, Charles, Roesel, Kristina, Maxamhud, Sadiya, Lindahl, Johanna F., Mugenyi, Albert, Echodu, Richard, Waiswa, Charles, and Roesel, Kristina

Abstract

Introduction: Trypanosomiasis is a parasitic infection caused by the protozoa Trypanosoma. It is exclusively associated with Glossina species habitats and, therefore, restricted to specific geographical settings. It affects a wide range of hosts, including humans. Animals may carry different Trypanosoma spp. while being asymptomatic. They are, therefore, potentially important in unpremeditated disease transmission. Aim: The aim of this study was to study the potential impact of the government tsetse fly control program, and to elucidate the role of pigs in the Trypanosoma epidemiology in the West Nile region in Uganda. Methods: A historically important human African trypanosomiasis (HAT) hotspot was selected, with sampling in sites with and without a government tsetse fly control program. Pigs were screened for infection with Trypanosoma and tsetse traps were deployed to monitor vector occurrence, followed by tsetse fly dissection and microscopy to establish infection rates with Trypanosoma. Pig blood samples were further analyzed to identify possible Trypanosoma infections using internal transcribed spacer (ITS)-PCR. Results: Using microscopy, Trypanosoma was detected in 0.56% (7/1262) of the sampled pigs. Using ITS-PCR, 114 of 341 (33.4%) pig samples were shown to be Trypanosoma vivax positive. Of the 360 dissected tsetse flies, 13 (3.8%) were positive for Trypanosoma under the microscope. The difference in captured tsetse flies in the government intervention sites in comparison with the control sites was significant (p<0.05). Seasonality did not play a substantial role in the tsetse fly density (p>0.05). Conclusion: This study illustrated the impact of a government control program with low vector abundance in a historical HAT hotspot in Uganda. The study could not verify that pigs in the area were carriers for the causative agent for HAT, but showed a high prevalence of the animal infectious agent T. vivax.

Published
2022
Full Text
View/download PDF

18. Controlling tsetse flies and ticks using insecticide treatment of cattle in Tororo district Uganda: cost benefit analysis 

Author

Okello, Walter O, MacLeod, Ewan T, Muhanguzi, Dennis, Waiswa, Charles, and Welburn, Susan C

Subjects
trypanosomiasis, parasitic diseases, Uganda, cost–benefit analysis, gross margin analysis, tick control
Abstract

BackgroundThe endemic vector-borne diseases transmitted by tsetse and ticks impose heavy burdens on Africa’s livestock. Cattle offers the possibility of mitigating these losses at a cost affordable to livestock keepers, by applying deltamethrin just to the belly, legs and ears of cattle. Although studies have quantified the impacts of individual diseases on livestock productivity, little is known about the dual economic benefits of controlling both tsetse and ticks, nor about the number of cattle who need to be treated to confer these benefits. Alongside an epidemiological study in south-east Uganda, a farm level assessment was done to investigate the benefits and costs of spraying different proportions of the village cattle population using this restricted application protocol. MethodsA study comprising 1,902 semi-structured interviews was undertaken over a period of 18 months. Financial data on household income from and expenditure on cattle was collected and cost benefit analysis done, pre and post intervention and for different spraying regimes. The total cost of the intervention was obtained from the epidemiological study’s implementation costs and from expenses incurred by participating farmers enabling examination of benefit-cost ratios and incremental benefit-cost ratios for each treatment regime. ResultsThe benefit-cost analysis of spraying 25%, 50% and 75% of the cattle population yielded average benefit-cost ratios of 1.55, 3.85, 4.51 and 4.46. The incremental benefit-cost ratios from spraying each additional 25% of the cattle population were 11.38, 3.89 and 0.79 respectively, showing a very high return on investment for spraying 50% of the population, with returns reducing thereafter. ConclusionComparing the gross margins per bovine, the study found that increasing the proportion of cattle sprayed yielded increasing benefits to farmers, but that these benefits were subject to diminishing returns. From a practical viewpoint this study recommends spraying only draft cattle to control trypanosomiasis and tick-borne diseases in this area as they make 38.62% of the cattle population, approaching the 50% threshold. In areas with a lower proportion of draft males, farmers could be advised to also include cows.

Published
2021
Full Text
View/download PDF

19. Additional file 2 of Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus

Author

Bessell, Paul R., Esterhuizen, Johan, Lehane, Michael J., Longbottom, Joshua, Mugenyi, Albert, Selby, Richard, Tirados, Inaki, Torr, Steve J., Waiswa, Charles, Wamboga, Charles, and Hope, Andrew

Abstract

Additional file 2: Figures S9–S17. Maps showing the vector control intervention in each year from 2012 to 2019 with cases overlain. The first figure shows just the baseline cases (2000–2020). Watersheds were derived from HydroSHEDS created from the NASA SRTM1 DEM using ESRI ArcGIS 10.5.

Published
2021
Full Text
View/download PDF

20. Additional file 1 of Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus

Author

Bessell, Paul R., Esterhuizen, Johan, Lehane, Michael J., Longbottom, Joshua, Mugenyi, Albert, Selby, Richard, Tirados, Inaki, Torr, Steve J., Waiswa, Charles, Wamboga, Charles, and Hope, Andrew

Abstract

Additional file 1: Figures S1–S8. Maps showing the vector control intervention in each year from 2012 to 2019. Watersheds were derived from HydroSHEDS created from the NASA SRTM1 DEM using ESRI ArcGIS 10.5.

Published
2021
Full Text
View/download PDF

26. Agricultural Impact of Porcine Cyisticercosis in Africa: A Review

Author

A., Helena, primary, Mukaratirwa, Samson, additional, P., Faustin, additional, Maingi, Ndichu, additional, Waiswa, Charles, additional, Sikasunge, Chummy, additional, Afonso, Sonia, additional, Sumbu, Julienne, additional, Ramiandrasoa, Sylvia, additional, Louise, Mary, additional, and Lee, Arve, additional

Published
2013
Full Text
View/download PDF

27. Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies

Author

Ndung’u, Joseph Mathu, primary, Boulangé, Alain, additional, Picado, Albert, additional, Mugenyi, Albert, additional, Mortensen, Allan, additional, Hope, Andrew, additional, Mollo, Brahim Guihini, additional, Bucheton, Bruno, additional, Wamboga, Charles, additional, Waiswa, Charles, additional, Kaba, Dramane, additional, Matovu, Enock, additional, Courtin, Fabrice, additional, Garrod, Gala, additional, Gimonneau, Geoffrey, additional, Bingham, Georgina V., additional, Hassane, Hassane Mahamat, additional, Tirados, Inaki, additional, Saldanha, Isabel, additional, Kabore, Jacques, additional, Rayaisse, Jean-Baptiste, additional, Bart, Jean-Mathieu, additional, Lingley, Jessica, additional, Esterhuizen, Johan, additional, Longbottom, Joshua, additional, Pulford, Justin, additional, Kouakou, Lingue, additional, Sanogo, Lassina, additional, Cunningham, Lucas, additional, Camara, Mamadou, additional, Koffi, Mathurin, additional, Stanton, Michelle, additional, Lehane, Mike, additional, Kagbadouno, Moise Saa, additional, Camara, Oumou, additional, Bessell, Paul, additional, Mallaye, Peka, additional, Solano, Philippe, additional, Selby, Richard, additional, Dunkley, Sophie, additional, Torr, Steve, additional, Biéler, Sylvain, additional, Lejon, Veerle, additional, Jamonneau, Vincent, additional, Yoni, Wilfried, additional, and Katz, Zachary, additional

Published
2020
Full Text
View/download PDF

29. Harnessing technology and portability to conduct molecular epidemiology of endemic pathogens in resource-limited settings

Author

Faust, Christina L, primary, Brunker, Kirstyn, additional, Ajambo, Diana, additional, Ryan, Mary, additional, Moses, Arinaitwe, additional, Rowel, Candia, additional, Wangoola, Robert Mandela, additional, Wampande, Eddie M, additional, Guma, Andrew, additional, Adriko, Moses, additional, Lamberton, Poppy H L, additional, Tukahebwa, Edridah M, additional, Mugenyi, Albert, additional, and Waiswa, Charles, additional

Published
2020
Full Text
View/download PDF

31. Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with 'screen, diagnose and treat' using innovative tools and strategies

Author

Ndung'u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Guihini Mollo, Brahim, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Mahamat Hassane, Hassane, Tirados, Inaki, Saldanha, Isabel, Kaboré, Jacques, et al., Ndung'u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Guihini Mollo, Brahim, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Mahamat Hassane, Hassane, Tirados, Inaki, Saldanha, Isabel, Kaboré, Jacques, and et al.

Published
2020

34. Spatial epidemiology of hospital-diagnosed brucellosis in Kampala, Uganda

Author

Welburn Susan C, Waiswa Charles, Kaboyo Winyi, Eisler Mark C, Fèvre Eric M, and Makita Kohei

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background A retrospective case-control study was undertaken to examine the spatial risk factors for human brucellosis in Kampala, Uganda. Methods Information on age, sex and month of diagnosis was derived from records from plate agglutination tests undertaken at Mulago Hospital, Kampala. Information on Parishes (LC2s) where patients reside was sourced from the outpatient registration book. In-patient fracture cases were selected for use as controls using 1:1 matching based on the age, sex and month of diagnosis. The locations of cases and controls were obtained by calculating Cartesian coordinates of the centroids of Parish level (LC2) polygons and a spatial scan statistic was applied to test for disease clustering. Parishes were classified according to the level of urbanization as urban, peri-urban or rural. Results Significantly more females than males were found to show sero-positivity for brucellosis when compared with the sex ratio of total outpatients, in addition female brucellosis patients were found to be significantly older than the male patients. Spatial clustering of brucellosis cases was observed including around Mulago Hospital (radius = 6.8 km, p = 0.001). The influence of proximity to the hospital that was observed for brucellosis cases was not significantly different from that observed in the controls. The disease cluster was confounded by the different catchment areas between cases and controls. The level of urbanization was not associated with the incidence of brucellosis but living in a slum area was a significant risk factor among urban dwellers (odds ratio 1.97, 95% CI: 1.10-3.61). Conclusions Being female was observed to be a risk factor for brucellosis sero-positvity and among urban dwellers, living in slum areas was also a risk factor although the overall risk was not different among urban, peri-urban and rural areas of the Kampala economic zone.

Published
2011
Full Text
View/download PDF

35. Herd prevalence of bovine brucellosis and analysis of risk factors in cattle in urban and peri-urban areas of the Kampala economic zone, Uganda

Author

Eisler Mark C, Waiswa Charles, Fèvre Eric M, Makita Kohei, Thrusfield Michael, and Welburn Susan C

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Background Human brucellosis has been found to be prevalent in the urban areas of Kampala, the capital city of Uganda. A cross-sectional study was designed to generate precise information on the prevalence of brucellosis in cattle and risk factors for the disease in its urban and peri-urban dairy farming systems. Results The adjusted herd prevalence of brucellosis was 6.5% (11/177, 95% CI: 3.6%-10.0%) and the adjusted individual animal prevalence was 5.0% (21/423, 95% CI: 2.7% - 9.3%) based on diagnosis using commercial kits of the competitive enzyme-linked immunosorbent assay (CELISA) for Brucella abortus antibodies. Mean within-herd prevalence was found to be 25.9% (95% CI: 9.7% - 53.1%) and brucellosis prevalence in an infected herd ranged from 9.1% to 50%. A risk factor could not be identified at the animal level but two risk factors were identified at the herd level: large herd size and history of abortion. The mean number of milking cows in a free-grazing herd (5.0) was significantly larger than a herd with a movement restricted (1.7, p < 0.001). Conclusions Vaccination should be targeted at commercial large-scale farms with free-grazing farming to control brucellosis in cattle in and around Kampala city.

Published
2011
Full Text
View/download PDF

36. Prevalence of and factors associated with Brucella sero-positivity in cattle in urban and peri-urban Gulu and Soroti towns of Uganda

Author

MUGIZI, Denis Rwabiita, BOQVIST, Sofia, NASINYAMA, George William, WAISWA, Charles, IKWAP, Kokas, ROCK, Kim, LINDAHL, Elisabeth, MAGNUSSON, Ulf, and ERUME, Joseph

Subjects
Full Paper, urban and peri-urban cattle, Brucella abortus, Bacteriology, Brucellosis, Bovine, Cross-Sectional Studies, risk factor, Risk Factors, Seroepidemiologic Studies, brucellosis, parasitic diseases, Prevalence, Animals, Uganda, Cattle, Animal Husbandry, Cities, sero-positivity
Abstract

Brucellosis is a key zoonosis of major public health, animal welfare and economic significance, and is endemic in livestock in Uganda. A cross-sectional epidemiological study was carried out to estimate the sero-prevalence of brucellosis and identify factors associated with sero-positivity in cattle in urban and peri-urban Gulu and Soroti towns of Northern and Eastern Uganda, respectively. A total of 1007 sera and data on biologically plausible risk factors from 166 herds and their spatial locations, were collected from cattle reared in urban and peri-urban Gulu and Soroti towns of Uganda. The sera were analyzed using indirect ELISA and sero-positive reactors confirmed by competitive ELISA. Multivariable models were used to investigate for risk factors. The overall animal-level and herd-level sero-prevalence was 7.5% (76/1007, 95% Confidence Interval (CI): 6.15–9.4%) and 27.1% (45/166, 95% CI: 20.9–34.3%), respectively. Herd-level sero-prevalence was significantly (P

Published
2015

37. Tsetse Control and the Elimination of Gambian Sleeping Sickness

Author

Bates, Paul Andrew, Lehane, Mike, Alfaroukh, Idriss, Bucheton, Bruno, Camara, Mamadou, Harris, Angi, Kaba, Dramane, Lumbala, Crispin, Peka, Mallaye, Rayaisse, Jean-Baptiste, Waiswa, Charles, Solano, Philippe, and Torr, Steve

Subjects
wc_705, qx_70, qx_505, wa_110
Published
2016

39. Prevalence of and factors associated with Brucella sero-positivity in cattle in urban and peri-urban Gulu and Soroti towns of Uganda

Author

Rwabiita Mugizi, Denis, Boqvist, Sofia, Nasinyama, George, Waiswa, Charles, Ikwap, Kokas, Rock, Kim, Lindahl, Elisabeth, Magnusson, Ulf, and Erume, Joseph

Subjects
parasitic diseases, Medical Bioscience, Clinical Science
Abstract

Brucellosis is a key zoonosis of major public health, animal welfare and economic significance, and is endemic in livestock in Uganda. A cross-sectional epidemiological study was carried out to estimate the sero-prevalence of brucellosis and identify factors associated with sero-positivity in cattle in urban and pen-urban Gulu and Soroti towns of Northern and Eastern Uganda, respectively. A total of 1007 sera and data on biologically plausible risk factors from 166 herds and their spatial locations, were collected from cattle reared in urban and pen-urban Gulu and Soroti towns of Uganda. The sera were analyzed using indirect ELISA and sero-positive reactors confirmed by competitive ELISA. Multivariable models were used to investigate for risk factors. The overall animal-level and herd-level sero-prevalence was 7.5% (76/1007, 95% Confidence Interval (CI): 6.15-9.4%) and 27.1% (45/166, 95% CI: 20.9-34.3%), respectively. Herd-level sero-prevalence was significantly (P

Published
2015

41. Evaluating the impact of targeting livestock for the prevention of human and animal trypanosomiasis, at village level, in districts newly affected with T. b. rhodesiense in Uganda

Author

Hamill, Louise, primary, Picozzi, Kim, additional, Fyfe, Jenna, additional, von Wissmann, Beatrix, additional, Wastling, Sally, additional, Wardrop, Nicola, additional, Selby, Richard, additional, Acup, Christine Amongi, additional, Bardosh, Kevin L., additional, Muhanguzi, Dennis, additional, Kabasa, John D., additional, Waiswa, Charles, additional, and Welburn, Susan C., additional

Published
2017
Full Text
View/download PDF

43. Tsetse Control and the Elimination of Gambian Sleeping Sickness

Author

Lehane, Mike, primary, Alfaroukh, Idriss, additional, Bucheton, Bruno, additional, Camara, Mamadou, additional, Harris, Angi, additional, Kaba, Dramane, additional, Lumbala, Crispin, additional, Peka, Mallaye, additional, Rayaisse, Jean-Baptiste, additional, Waiswa, Charles, additional, Solano, Philippe, additional, and Torr, Steve, additional

Published
2016
Full Text
View/download PDF

44. Harnessing technology and portability to conduct molecular epidemiology of endemic pathogens in resource-limited settings.

Author

Faust, Christina L, Brunker, Kirstyn, Ajambo, Diana, Ryan, Mary, Moses, Arinaitwe, Rowel, Candia, Wangoola, Robert Mandela, Wampande, Eddie M, Guma, Andrew, Adriko, Moses, Lamberton, Poppy H L, Tukahebwa, Edridah M, Mugenyi, Albert, and Waiswa, Charles

Subjects
MOLECULAR epidemiology, LOW-income countries, ENDEMIC diseases, MIDDLE-income countries, COMMUNICABLE diseases
Abstract

Improvements in genetic and genomic technology have enabled field-deployable molecular laboratories and these have been deployed in a variety of epidemics that capture headlines. In this editorial, we highlight the importance of building physical and personnel capacity in low and middle income countries to deploy these technologies to improve diagnostics, understand transmission dynamics and provide feedback to endemic communities on actionable timelines. We describe our experiences with molecular field research on schistosomiasis, trypanosomiasis and rabies and urge the wider tropical medicine community to embrace these methods and help build capacity to benefit communities affected by endemic infectious diseases. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

47. Isolation and Molecular Characterization of Brucella Isolates in Cattle Milk in Uganda

Author

Mugizi, Denis Rwabiita, Muradrasoli, Shaman, Boqvist, Sofia, Erume, Joseph, Nasinyama, George William, Waiswa, Charles, Mboowa, Gerald, Klint, Markus, Magnusson, Ulf, Mugizi, Denis Rwabiita, Muradrasoli, Shaman, Boqvist, Sofia, Erume, Joseph, Nasinyama, George William, Waiswa, Charles, Mboowa, Gerald, Klint, Markus, and Magnusson, Ulf

Abstract

Brucellosis is endemic in livestock and humans in Uganda and its transmission involves amultitude of risk factors like consumption of milk from infected cattle. To shed new light on the epidemiology of brucellosis in Uganda the present study used phenotypic and molecular approaches to delineate the Brucella species, biovars, and genotypes shed in cattle milk. Brucella abortus without a biovar designation was isolated from eleven out of 207 milk samples from cattle in Uganda. These isolates had a genomic monomorphism at 16 variable number tandem repeat (VNTR) loci and showed in turn high levels of genetic variation when compared with other African strains or other B. abortus biovars from other parts of the world. This study further highlights the usefulness of MLVA as an epidemiological tool for investigation of Brucella infections.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results