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2. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Author

Mokry, Michal, Boltjes, Arjan, Slenders, Lotte, Bel-Bordes, Gemma, Cui, Kai, Brouwer, Eli, Mekke, Joost M., Depuydt, Marie A. C., Timmerman, Nathalie, Waissi, Farahnaz, Verwer, Maarten C., Turner, Adam W., Khan, Mohammad Daud, Hodonsky, Chani J., Diez Benavente, Ernest, Hartman, Robin J. G., van den Dungen, Noortje A. M., Lansu, Nico, Nagyova, Emilia, Prange, Koen H. M., Kovacic, Jason C., Björkegren, Johan L. M., Pavlos, Eleftherios, Andreakos, Evangelos, Schunkert, Heribert, Owens, Gary K., Monaco, Claudia, Finn, Aloke V., Virmani, Renu, Leeper, Nicholas J., de Winther, Menno P. J., Kuiper, Johan, de Borst, Gert J., Stroes, Erik S. G., Civelek, Mete, de Kleijn, Dominique P. V., den Ruijter, Hester M., Asselbergs, Folkert W., van der Laan, Sander W., Miller, Clint L., and Pasterkamp, Gerard

Published
2022
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3. Atherogenic Lipoprotein(A) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation

Author

Schnitzler, Johan G, Hoogeveen, Renate M, Ali, Lubna, Prange, Koen HM, Waissi, Farahnaz, van Weeghel, Michel, Bachmann, Julian C, Versloot, Miranda, Borrelli, Matthew J, Yeang, Calvin, De Kleijn, Dominique PV, Houtkooper, Riekelt H, Koschinsky, Marlys L, de Winther, Menno PJ, Groen, Albert K, Witztum, Joseph L, Tsimikas, Sotirios, Stroes, Erik SG, and Kroon, Jeffrey

Subjects
Cardiovascular, Atherosclerosis, 2.1 Biological and endogenous factors, Aetiology, Aged, Aged, 80 and over, Animals, Apolipoprotein B-100, Apolipoproteins A, Cells, Cultured, Coculture Techniques, Disease Models, Animal, Endothelial Cells, Female, Glycolysis, Humans, Inflammation Mediators, Intercellular Adhesion Molecule-1, Leukocytes, Lipoprotein(a), Male, Mice, Transgenic, Middle Aged, Mutation, Oligonucleotides, Antisense, Phosphofructokinase-2, Receptors, LDL, Transendothelial and Transepithelial Migration, endothelial cell, glycolysis, inflammation, lipoprotein(a), metabolism, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
Abstract

RationalePatients with elevated levels of lipoprotein(a) [Lp(a)] are hallmarked by increased metabolic activity in the arterial wall on positron emission tomography/computed tomography, indicative of a proinflammatory state.ObjectiveWe hypothesized that Lp(a) induces endothelial cell inflammation by rewiring endothelial metabolism.Methods and resultsWe evaluated the impact of Lp(a) on the endothelium and describe that Lp(a), through its oxidized phospholipid content, activates arterial endothelial cells, facilitating increased transendothelial migration of monocytes. Transcriptome analysis of Lp(a)-stimulated human arterial endothelial cells revealed upregulation of inflammatory pathways comprising monocyte adhesion and migration, coinciding with increased 6-phophofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB)-3-mediated glycolysis. ICAM (intercellular adhesion molecule)-1 and PFKFB3 were also found to be upregulated in carotid plaques of patients with elevated levels of Lp(a). Inhibition of PFKFB3 abolished the inflammatory signature with concomitant attenuation of transendothelial migration.ConclusionsCollectively, our findings show that Lp(a) activates the endothelium by enhancing PFKFB3-mediated glycolysis, leading to a proadhesive state, which can be reversed by inhibition of glycolysis. These findings pave the way for therapeutic agents targeting metabolism aimed at reducing inflammation in patients with cardiovascular disease.

Published
2020

11. Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients

Author

Zorgeenheid Vaatchirurgie Medisch, CDL Cluster Onderzoek en Onderwijs, Centraal Diagnostisch Laboratorium, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Verwer, Maarten C., Mekke, Joost, Timmerman, Nathalie, Waissi, Farahnaz, Boltjes, Arjan, Pasterkamp, Gerard, de Borst, Gert J., de Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, CDL Cluster Onderzoek en Onderwijs, Centraal Diagnostisch Laboratorium, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Verwer, Maarten C., Mekke, Joost, Timmerman, Nathalie, Waissi, Farahnaz, Boltjes, Arjan, Pasterkamp, Gerard, de Borst, Gert J., and de Kleijn, Dominique P.V.

Published
2023

12. Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

Author

Dekker, Mirthe, Waissi, Farahnaz, van Bennekom, Joelle, Silvis, Max J. M., Timmerman, Nathalie, Bank, Ingrid E. M., Walter, Joan E., Mueller, Christian, Schoneveld, A. H., Schiffelers, Raymond M., Pasterkamp, Gerard, Grobbee, Diederick E., de Winter, Robbert J., Mosterd, A., de Kleijn, Dominique P. V., and Timmers, Leo

Published
2020
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14. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Author

CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, Onderzoek Precision medicine, Zorgeenheid Vaatchirurgie Medisch, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Centraal Diagnostisch Laboratorium, Mokry, Michal, Boltjes, Arjan, Slenders, Lotte, Bel-Bordes, Gemma, Cui, Kai, Brouwer, Eli, Mekke, Joost M., Depuydt, Marie A. C., Timmerman, Nathalie, Waissi, Farahnaz, Verwer, Maarten C., Turner, Adam W., Khan, Mohammad Daud, Hodonsky, Chani J., Diez Benavente, Ernest, Hartman, Robin J. G., van den Dungen, Noortje A. M., Lansu, Nico, Nagyova, Emilia, Prange, Koen H. M., Kovacic, Jason C., Björkegren, Johan L. M., Pavlos, Eleftherios, Andreakos, Evangelos, Schunkert, Heribert, Owens, Gary K., Monaco, Claudia, Finn, Aloke V., Virmani, Renu, Leeper, Nicholas J., de Winther, Menno P. J., Kuiper, Johan, de Borst, Gert J., Stroes, Erik S. G., Civelek, Mete, de Kleijn, Dominique P. V., den Ruijter, Hester M., Asselbergs, Folkert W., van der Laan, Sander W., Miller, Clint L., Pasterkamp, Gerard, CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, Onderzoek Precision medicine, Zorgeenheid Vaatchirurgie Medisch, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Centraal Diagnostisch Laboratorium, Mokry, Michal, Boltjes, Arjan, Slenders, Lotte, Bel-Bordes, Gemma, Cui, Kai, Brouwer, Eli, Mekke, Joost M., Depuydt, Marie A. C., Timmerman, Nathalie, Waissi, Farahnaz, Verwer, Maarten C., Turner, Adam W., Khan, Mohammad Daud, Hodonsky, Chani J., Diez Benavente, Ernest, Hartman, Robin J. G., van den Dungen, Noortje A. M., Lansu, Nico, Nagyova, Emilia, Prange, Koen H. M., Kovacic, Jason C., Björkegren, Johan L. M., Pavlos, Eleftherios, Andreakos, Evangelos, Schunkert, Heribert, Owens, Gary K., Monaco, Claudia, Finn, Aloke V., Virmani, Renu, Leeper, Nicholas J., de Winther, Menno P. J., Kuiper, Johan, de Borst, Gert J., Stroes, Erik S. G., Civelek, Mete, de Kleijn, Dominique P. V., den Ruijter, Hester M., Asselbergs, Folkert W., van der Laan, Sander W., Miller, Clint L., and Pasterkamp, Gerard

Published
2022

15. Targeted proteomics improves cardiovascular risk prediction in secondary prevention

Author

Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Circulatory Health, Infection & Immunity, Interne Geneeskunde Vasculaire, Nurmohamed, Nick S., Belo Pereira, João P., Hoogeveen, Renate M., Kroon, Jeffrey, Kraaijenhof, Jordan M., Waissi, Farahnaz, Timmerman, Nathalie, Bom, Michiel J., Hoefer, Imo E., Knaapen, Paul, Catapano, Alberico L., Koenig, Wolfgang, de Kleijn, Dominique, Visseren, Frank L.J., Levin, Evgeni, Stroes, Erik S.G., Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Circulatory Health, Infection & Immunity, Interne Geneeskunde Vasculaire, Nurmohamed, Nick S., Belo Pereira, João P., Hoogeveen, Renate M., Kroon, Jeffrey, Kraaijenhof, Jordan M., Waissi, Farahnaz, Timmerman, Nathalie, Bom, Michiel J., Hoefer, Imo E., Knaapen, Paul, Catapano, Alberico L., Koenig, Wolfgang, de Kleijn, Dominique, Visseren, Frank L.J., Levin, Evgeni, and Stroes, Erik S.G.

Published
2022

16. Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Infection & Immunity, Timmerman, Nathalie, Waissi, Farahnaz, Dekker, Mirthe, de Borst, Gert J., van Bennekom, Joelle, de Winter, Robbert J., Hilvo, Mika, Jylhä, Antti, Pasterkamp, Gerard, de Kleijn, Dominique P.V., Laaksonen, Reijo, Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Centraal Diagnostisch Laboratorium, Infection & Immunity, Timmerman, Nathalie, Waissi, Farahnaz, Dekker, Mirthe, de Borst, Gert J., van Bennekom, Joelle, de Winter, Robbert J., Hilvo, Mika, Jylhä, Antti, Pasterkamp, Gerard, de Kleijn, Dominique P.V., and Laaksonen, Reijo

Published
2022

17. High lipoprotein(a) is associated with major adverse limb events after femoral artery endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Verwer, Maarten C., Waissi, Farahnaz, Mekke, Joost M., Dekker, Mirthe, Stroes, Erik S.G., de Borst, Gert J., Kroon, Jeffrey, Hazenberg, Constantijn E.V.B., de Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Infection & Immunity, Verwer, Maarten C., Waissi, Farahnaz, Mekke, Joost M., Dekker, Mirthe, Stroes, Erik S.G., de Borst, Gert J., Kroon, Jeffrey, Hazenberg, Constantijn E.V.B., and de Kleijn, Dominique P.V.

Published
2022

18. TARGETED PROTEOMICS IMPROVES CARDIOVASCULAR RISK PREDICTION IN SECONDARY PREVENTION PATIENTS

Author

Nurmohamed, Nick S., primary, Pereira, Joao P. Belo, additional, Hoogeveen, Renate M., additional, Kroon, Jeffrey, additional, Kraaijenhof, Jordan M., additional, Waissi, Farahnaz, additional, Timmerman, Nathalie, additional, Bom, Michiel, additional, Hoefer, Imo, additional, Knaapen, Paul, additional, Catapano, Alberico L., additional, Koenig, Wolfgang, additional, de Kleijn, Dominique, additional, Visseren, Frank, additional, Levin, Evgeni, additional, and Stroes, Erik S.G., additional

Published
2022
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19. Targeted proteomics improves cardiovascular risk prediction in secondary prevention

Author

Nurmohamed, Nick S., primary, Belo Pereira, João P., additional, Hoogeveen, Renate M., additional, Kroon, Jeffrey, additional, Kraaijenhof, Jordan M., additional, Waissi, Farahnaz, additional, Timmerman, Nathalie, additional, Bom, Michiel J., additional, Hoefer, Imo E., additional, Knaapen, Paul, additional, Catapano, Alberico L., additional, Koenig, Wolfgang, additional, de Kleijn, Dominique, additional, Visseren, Frank L.J., additional, Levin, Evgeni, additional, and Stroes, Erik S.G., additional

Published
2022
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20. Transcriptomic-based clustering of advanced atherosclerotic plaques identifies subgroups of plaques with differential underlying biology that associate with clinical presentation

Author

Mokry, Michal, primary, Boltjes, Arjan, additional, Cui, Kai, additional, Slenders, Lotte, additional, Mekke, Joost M., additional, depuydt, Marie A.C., additional, Timmerman, Nathalie M., additional, Waissi, Farahnaz, additional, Verwer, Maarten C., additional, Turner, Adam W., additional, Khan, Mohammad D., additional, Hodonsky, Chani J., additional, Diez Benavente, Ernest, additional, Hartman, Robin J. G., additional, van den Dungen, Noortje A. M., additional, Lansu, Nico, additional, Nagyova, Emilia, additional, Prange, Koen H. M., additional, Pavlos, Eleftherios, additional, Andreakos, Evangelos, additional, Schunkert, Heribert, additional, Owens, Gary K., additional, Monaco, Claudia, additional, Finn, Aloke V., additional, Virmani, Renu, additional, Leeper, Nicholas J., additional, de Winther, Menno P. J., additional, Kuiper, Johan, additional, de Borst, Gert J., additional, Stroes, Erik S. G., additional, Civelek, Mete, additional, de Kleijn, Dominique P. V., additional, den Ruijter, Hester M., additional, Asselbergs, Folkert W., additional, van der Laan, Sander W., additional, Miller, Clint L., additional, and Pasterkamp, Gerard, additional

Published
2021
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21. Pre-Operative Plasma Extracellular Vesicle Proteins are Associated with a High Risk of Long Term Secondary Major Cardiovascular Events in Patients Undergoing Carotid Endarterectomy

Author

Timmerman, Nathalie, primary, Waissi, Farahnaz, additional, Dekker, Mirthe, additional, van de Pol, Qiu Ying, additional, van Bennekom, Joelle, additional, Schoneveld, Arjan, additional, klein Avink, Marjet J.M., additional, de Winter, Robbert J., additional, Pasterkamp, Gerard, additional, de Borst, Gert J., additional, and de Kleijn, Dominique P.V., additional

Published
2021
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23. Mast Cell Distribution in Human Carotid Atherosclerotic Plaque Differs Significantly by Histological Segment

Author

Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Circulatory Health, Brain, Regenerative Medicine and Stem Cells, Infection & Immunity, Mekke, Joost M, Egberts, Daan H J, Waissi, Farahnaz, Timmerman, Nathalie, Bot, Ilze, Kuiper, Johan, Pasterkamp, Gerard, de Borst, Gert J, de Kleijn, Dominique P V, Zorgeenheid Vaatchirurgie Medisch, Centraal Diagnostisch Laboratorium, Circulatory Health, Brain, Regenerative Medicine and Stem Cells, Infection & Immunity, Mekke, Joost M, Egberts, Daan H J, Waissi, Farahnaz, Timmerman, Nathalie, Bot, Ilze, Kuiper, Johan, Pasterkamp, Gerard, de Borst, Gert J, and de Kleijn, Dominique P V

Published
2021

24. Pre-Operative Plasma Extracellular Vesicle Proteins are Associated with a High Risk of Long Term Secondary Major Cardiovascular Events in Patients Undergoing Carotid Endarterectomy

Author

Zorgeenheid Vaatchirurgie Medisch, CDL Arcadia, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Onderzoek Pasterkamp, Brain, Regenerative Medicine and Stem Cells, Infection & Immunity, Timmerman, Nathalie, Waissi, Farahnaz, Dekker, Mirthe, van de Pol, Qiu Ying, van Bennekom, Joelle, Schoneveld, Arjan, klein Avink, Marjet J.M., de Winter, Robbert J., Pasterkamp, Gerard, de Borst, Gert J., de Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, CDL Arcadia, Centraal Diagnostisch Laboratorium, Circulatory Health, CDL Onderzoek Pasterkamp, Brain, Regenerative Medicine and Stem Cells, Infection & Immunity, Timmerman, Nathalie, Waissi, Farahnaz, Dekker, Mirthe, van de Pol, Qiu Ying, van Bennekom, Joelle, Schoneveld, Arjan, klein Avink, Marjet J.M., de Winter, Robbert J., Pasterkamp, Gerard, de Borst, Gert J., and de Kleijn, Dominique P.V.

Published
2021

25. High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

Author

Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Researchgr. Hart-brein as., Brain, Circulatory Health, Centraal Diagnostisch Laboratorium, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Silvis, Max J.M., Bennekom, Joelle V., Schoneveld, Arjan H., de Winter, Robbert J., Isgum, Ivana, Lessmann, Nikolas, Velthuis, Birgitta K., Pasterkamp, Gerard, Mosterd, Arend, Timmers, Leo, de Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Researchgr. Hart-brein as., Brain, Circulatory Health, Centraal Diagnostisch Laboratorium, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Silvis, Max J.M., Bennekom, Joelle V., Schoneveld, Arjan H., de Winter, Robbert J., Isgum, Ivana, Lessmann, Nikolas, Velthuis, Birgitta K., Pasterkamp, Gerard, Mosterd, Arend, Timmers, Leo, and de Kleijn, Dominique P.V.

Published
2021

26. Plasma Testosterone Levels and Atherosclerotic Plaque Gene Expression in Men With Advanced Atherosclerosis

Author

CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Infection & Immunity, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Cardiovasculaire Epi Team 3, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Centraal Diagnostisch Laboratorium, Onderzoek Vrouw Hart & Vaatziekten, Groepenhoff, Floor, Diez Benavente, Ernest, Boltjes, Arjan, Timmerman, Nathalie, Waissi, Farahnaz, Hartman, Robin J G, Onland-Moret, N C, Pasterkamp, Gerard, Den Ruijter, Hester, CDL Onderzoek Pasterkamp, Experimentele Afd. Cardiologie 1, Child Health, Infection & Immunity, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Cardiovasculaire Epi Team 3, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Centraal Diagnostisch Laboratorium, Onderzoek Vrouw Hart & Vaatziekten, Groepenhoff, Floor, Diez Benavente, Ernest, Boltjes, Arjan, Timmerman, Nathalie, Waissi, Farahnaz, Hartman, Robin J G, Onland-Moret, N C, Pasterkamp, Gerard, and Den Ruijter, Hester

Published
2021

27. The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from 82Rb-PET/CT myocardial perfusion imaging

Author

Zorgeenheid Vaatchirurgie Medisch, Beeldverwerking ISI, Brain, Cancer, Researchgr. Hart-brein as., Circulatory Health, CDL Onderzoek Pasterkamp, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Bank, Ingrid E M, Isgum, Ivana, Scholtens, Asbjørn M, Velthuis, Birgitta K, Pasterkamp, Gerard, de Winter, Robbert J, Mosterd, Arend, Timmers, Leo, de Kleijn, Dominique P V, Zorgeenheid Vaatchirurgie Medisch, Beeldverwerking ISI, Brain, Cancer, Researchgr. Hart-brein as., Circulatory Health, CDL Onderzoek Pasterkamp, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Bank, Ingrid E M, Isgum, Ivana, Scholtens, Asbjørn M, Velthuis, Birgitta K, Pasterkamp, Gerard, de Winter, Robbert J, Mosterd, Arend, Timmers, Leo, and de Kleijn, Dominique P V

Published
2021

28. Improving risk stratification in atherosclerotic disease: Circulating biomarkers: The holy grail or a mythic battle?

Author

Waissi, Farahnaz, de Winter, R.J., de Kleijn, D.P.V., Timmers, L., Faculteit der Geneeskunde, de Winter, Robbert J., de Kleijn, D. P. V., Cardiology, ACS - Heart failure & arrhythmias, and Graduate School

Abstract

Risk prediction in cardiovascular disease is an ongoing work in progress: researchers continue to seek new risk factors that can predict cardiovascular events or that can be incorporated into risk assessment algorithms. In the current era of risk-tailored and personalized cardiovascular care, assessment of cardiovascular risk in individuals is an integral part of clinical decision making. Risk prediction can be applied in various clinical domains. The overall aim of this thesis is to improve risk stratification of patients with atherosclerotic disease focusing on carotid artery disease and coronary artery disease (CAD). Part I describes biomarkers in plasma and in plasma extracellular vesicles that are associated with major adverse cardiovascular events (MACE) in patients following carotid endarterectomy (CEA). Due to the considerably high residual risk of MACE after CEA, intensified secondary prevention therapy is recommended in this population. In order to balance the health-related costs and associated benefits of intensified secondary prevention in CEA patients, detailed risk stratification using blood based biomarkers is of key importance. Part II assesses the value of extracellular vesicle proteins as diagnostic biomarkers for CAD (Chronic Coronary Syndrome and Unstable Angina). Early recognition of CAD is important as lifestyle adjustments, pharmacological therapies and invasive interventions can modify the risk for progression to Acute Coronary Syndrome. However, currently a large number of patients is unnecessary referred for additional diagnostic testing. EV-associated markers could improve the risk stratification before referral and decrease the burden for patients and the health care system.

Published
2021

29. Letter to the editor: Response by Waissi et al Regarding Article, 'Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients following Carotid Endarterectomy'

Author

Waissi, Farahnaz, de Kleijn, Dominique P. V., Kroon, Jeffrey, Graduate School, ACS - Heart failure & arrhythmias, Experimental Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, and Amsterdam Gastroenterology Endocrinology Metabolism

Published
2021

31. The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from 82Rb-PET/CT myocardial perfusion imaging

Author

Dekker, Mirthe, primary, Waissi, Farahnaz, additional, Bank, Ingrid E.M., additional, Isgum, Ivana, additional, Scholtens, Asbjørn M., additional, Velthuis, Birgitta K., additional, Pasterkamp, Gerard, additional, de Winter, Robbert J., additional, Mosterd, Arend, additional, Timmers, Leo, additional, and de Kleijn, Dominique P.V., additional

Published
2021
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32. Automated calcium scores collected during myocardial perfusion imaging improve identification of obstructive coronary artery disease

Author

Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Immunologie, Experimentele Afd. Cardiologie 1, Strategische Impuls RvB ISI, Circulatory Health, Beeldverwerking ISI, Cancer, Brain, Researchgr. Hart-brein as., Team Medisch, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Infection & Immunity, Divisieleiding, Dekker, Mirthe, Waissi, Farahnaz, Bank, Ingrid E.M., Lessmann, Nikolas, Išgum, Ivana, Velthuis, Birgitta K., Scholtens, Asbjørn M., Leenders, Geert E., Pasterkamp, Gerard, de Kleijn, Dominique P.V., Timmers, Leo, Mosterd, Arend, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Immunologie, Experimentele Afd. Cardiologie 1, Strategische Impuls RvB ISI, Circulatory Health, Beeldverwerking ISI, Cancer, Brain, Researchgr. Hart-brein as., Team Medisch, CDL Onderzoek Pasterkamp, dLAB Afdelingen, Infection & Immunity, Divisieleiding, Dekker, Mirthe, Waissi, Farahnaz, Bank, Ingrid E.M., Lessmann, Nikolas, Išgum, Ivana, Velthuis, Birgitta K., Scholtens, Asbjørn M., Leenders, Geert E., Pasterkamp, Gerard, de Kleijn, Dominique P.V., Timmers, Leo, and Mosterd, Arend

Published
2020

33. Extracellular vesicles in diagnosing chronic coronary syndromes: the bumpy road to clinical implementation

Author

Zorgeenheid Vaatchirurgie Medisch, Arts Assistenten Cardiologie, Cardiologie, Team Onderzoek, Circulatory Health, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Timmerman, Nathalie, Silvis, Max J.M., Timmers, Leo, de Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, Arts Assistenten Cardiologie, Cardiologie, Team Onderzoek, Circulatory Health, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Timmerman, Nathalie, Silvis, Max J.M., Timmers, Leo, and de Kleijn, Dominique P.V.

Published
2020

34. Extracellular vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain

Author

Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Van Bennekom, Joelle, Silvis, Max J.M., Timmerman, Nathalie, Schoneveld, Arjan H., Grobbee, Diederick E., De Winter, Robbert J., Mosterd, Arend, Timmers, Leo, De Kleijn, Dominique P.V., Zorgeenheid Vaatchirurgie Medisch, Onderzoek Vrouw Hart & Vaatziekten, Team Onderzoek, CDL Arcadia, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Dekker, Mirthe, Waissi, Farahnaz, Van Bennekom, Joelle, Silvis, Max J.M., Timmerman, Nathalie, Schoneveld, Arjan H., Grobbee, Diederick E., De Winter, Robbert J., Mosterd, Arend, Timmers, Leo, and De Kleijn, Dominique P.V.

Published
2020

35. Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy

Author

DHS-Bedrijfsvoering, Utrecht Palliatie Centrum, Zorgeenheid Vaatchirurgie Medisch, Staf strategisch beleid, CDL Onderzoek Pasterkamp, Circulatory Health, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Brain, Regenerative Medicine and Stem Cells, Infection & Immunity, Waissi, Farahnaz, Dekker, Mirthe, Timmerman, Nathalie, Hoogeveen, Renate M, van Bennekom, Joelle, Dzobo, Kim E, Schnitzler, Johan G, Pasterkamp, Gerard, Grobbee, Diederick E, de Borst, Gert J, Stroes, Erik S G, de Kleijn, Dominique P V, Kroon, Jeffrey, DHS-Bedrijfsvoering, Utrecht Palliatie Centrum, Zorgeenheid Vaatchirurgie Medisch, Staf strategisch beleid, CDL Onderzoek Pasterkamp, Circulatory Health, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Brain, Regenerative Medicine and Stem Cells, Infection & Immunity, Waissi, Farahnaz, Dekker, Mirthe, Timmerman, Nathalie, Hoogeveen, Renate M, van Bennekom, Joelle, Dzobo, Kim E, Schnitzler, Johan G, Pasterkamp, Gerard, Grobbee, Diederick E, de Borst, Gert J, Stroes, Erik S G, de Kleijn, Dominique P V, and Kroon, Jeffrey

Published
2020

36. Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

Author

Zorgeenheid Vaatchirurgie Medisch, Planningssecretariaat HCK, Team Onderzoek, Experimentele Afd. Cardiologie 1, CDL Arcadia, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Cancer, CDL Onderzoek Pasterkamp, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Team Medisch, Dekker, Mirthe, Waissi, Farahnaz, van Bennekom, Joelle, Silvis, Max J M, Timmerman, Nathalie, Bank, Ingrid E M, Walter, Joan E, Mueller, Christian, Schoneveld, A H, Schiffelers, Raymond M, Pasterkamp, Gerard, Grobbee, Diederick E, de Winter, Robbert J, Mosterd, A, de Kleijn, Dominique P V, Timmers, Leo, Zorgeenheid Vaatchirurgie Medisch, Planningssecretariaat HCK, Team Onderzoek, Experimentele Afd. Cardiologie 1, CDL Arcadia, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Cancer, CDL Onderzoek Pasterkamp, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Team Medisch, Dekker, Mirthe, Waissi, Farahnaz, van Bennekom, Joelle, Silvis, Max J M, Timmerman, Nathalie, Bank, Ingrid E M, Walter, Joan E, Mueller, Christian, Schoneveld, A H, Schiffelers, Raymond M, Pasterkamp, Gerard, Grobbee, Diederick E, de Winter, Robbert J, Mosterd, A, de Kleijn, Dominique P V, and Timmers, Leo

Published
2020

37. Sex differences in flow cytometry-based platelet reactivity in stable outpatients suspected of myocardial ischemia

Author

Zorgeenheid Vaatchirurgie Medisch, Experimentele Afd. Cardiologie 1, Circulatory Health, Poli Van Creveldkliniek Medisch, Brain, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Team Medisch, Waissi, Farahnaz, Dekker, Mirthe, Bank, Ingrid E M, Korporaal, Suzanne J A, Urbanus, Rolf T, de Borst, Gert J, Pasterkamp, Gerard, Scholtens, Asbjorn M, Grobbee, Diederick E, Mosterd, Arend, de Kleijn, Dominique P V, Timmers, Leo, Zorgeenheid Vaatchirurgie Medisch, Experimentele Afd. Cardiologie 1, Circulatory Health, Poli Van Creveldkliniek Medisch, Brain, Regenerative Medicine and Stem Cells, CDL Onderzoek Pasterkamp, Global Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Infection & Immunity, Team Medisch, Waissi, Farahnaz, Dekker, Mirthe, Bank, Ingrid E M, Korporaal, Suzanne J A, Urbanus, Rolf T, de Borst, Gert J, Pasterkamp, Gerard, Scholtens, Asbjorn M, Grobbee, Diederick E, Mosterd, Arend, de Kleijn, Dominique P V, and Timmers, Leo

Published
2020

39. Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability

Author

Poels, Kikkie, primary, Schnitzler, Johan G., additional, Waissi, Farahnaz, additional, Levels, Johannes H. M., additional, Stroes, Erik S. G., additional, Daemen, Mat J. A. P., additional, Lutgens, Esther, additional, Pennekamp, Anne-Marije, additional, De Kleijn, Dominique P. V., additional, Seijkens, Tom T. P., additional, and Kroon, Jeffrey, additional

Published
2020
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40. Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain

Author

Dekker, Mirthe, primary, Waissi, Farahnaz, additional, van Bennekom, Joelle, additional, Silvis, Max J. M., additional, Timmerman, Nathalie, additional, Schoneveld, Arjan H., additional, Grobbee, Diederick E., additional, de Winter, Robbert J., additional, Mosterd, Arend, additional, Timmers, Leo, additional, and de Kleijn, Dominique P. V., additional

Published
2020
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41. Fast-track Radioiodine Ablation Therapy After Thyroidectomy Reduces Sick Leave in Patients With Differentiated Thyroid Cancer (FASTHYNA Trial)

Author

Zorgeenheid Vaatchirurgie Medisch, Arts-assistenten Radiologie, MS CGO, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, MS Radiologie, Cancer, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, Waissi, Farahnaz, Kist, Jakob W, Lodewijk, Lutske, de Wit, Ardine G, van der Hage, Jos A, van Dalen, Thijs, de Keizer, Bart, Valk, Gerlof D, Borel Rinkes, Inne H M, Vriens, Menno R, Zorgeenheid Vaatchirurgie Medisch, Arts-assistenten Radiologie, MS CGO, HEE, Circulatory Health, JC onderzoeksprogramma Methodologie, MS Radiologie, Cancer, MS Endocriene Oncologie, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, Waissi, Farahnaz, Kist, Jakob W, Lodewijk, Lutske, de Wit, Ardine G, van der Hage, Jos A, van Dalen, Thijs, de Keizer, Bart, Valk, Gerlof D, Borel Rinkes, Inne H M, and Vriens, Menno R

Published
2019

43. The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from 82 Rb-PET/CT myocardial perfusion imaging.

Author

Dekker M, Waissi F, Bank IEM, Isgum I, Scholtens AM, Velthuis BK, Pasterkamp G, de Winter RJ, Mosterd A, Timmers L, and de Kleijn DPV

Subjects
Calcium, Coronary Angiography, Humans, Positron Emission Tomography Computed Tomography, Predictive Value of Tests, Prognosis, Risk Factors, Coronary Artery Disease diagnostic imaging, Deep Learning, Myocardial Perfusion Imaging
Abstract

Background: Assessment of both coronary artery calcium(CAC) scores and myocardial perfusion imaging(MPI) in patients suspected of coronary artery disease(CAD) provides incremental prognostic information. We used an automated method to determine CAC scores on low-dose attenuation correction CT(LDACT) images gathered during MPI in one single assessment. The prognostic value of this automated CAC score is unknown, we therefore investigated the association of this automated CAC scores and major adverse cardiovascular events(MACE) in a large chest-pain cohort., Method: We analyzed 747 symptomatic patients referred for 82 RubidiumPET/CT, without a history of coronary revascularization. Ischemia was defined as a summed difference score≥2. We used a validated deep learning(DL) method to determine CAC scores. For survival analysis CAC scores were dichotomized as low(<400) and high(≥400). MACE was defined as all cause death, late revascularization (>90 days after scanning) or nonfatal myocardial infarction. Cox proportional hazard analysis were performed to identify predictors of MACE., Results: During 4 years follow-up, 115 MACEs were observed. High CAC scores showed higher cumulative event rates, irrespective of ischemia (nonischemic: 25.8% vs 11.9% and ischemic: 57.6% vs 23.4%, P-values <0.001). Multivariable cox regression revealed both high CAC scores (HR 2.19 95%CI 1.43-3.35) and ischemia (HR 2.56 95%CI 1.71-3.35) as independent predictors of MACE. Addition of automated CAC scores showed a net reclassification improvement of 0.13(0.022-0.245)., Conclusion: Automatically derived CAC scores determined during a single imaging session are independently associated with MACE. This validated DL method could improve risk stratification and subsequently lead to more personalized treatment in patients suspected of CAD., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2021
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44. Automated calcium scores collected during myocardial perfusion imaging improve identification of obstructive coronary artery disease.

Author

Dekker M, Waissi F, Bank IEM, Lessmann N, Išgum I, Velthuis BK, Scholtens AM, Leenders GE, Pasterkamp G, de Kleijn DPV, Timmers L, and Mosterd A

Abstract

Background: Myocardial perfusion imaging (MPI) is an accurate noninvasive test for patients with suspected obstructive coronary artery disease (CAD) and coronary artery calcium (CAC) score is known to be a powerful predictor of cardiovascular events. Collection of CAC scores simultaneously with MPI is unexplored., Aim: We aimed to investigate whether automatically derived CAC scores during myocardial perfusion imaging would further improve the diagnostic accuracy of MPI to detect obstructive CAD., Methods: We analyzed 150 consecutive patients without a history of coronary revascularization with suspected obstructive CAD who were referred for 82Rb PET/CT and available coronary angiographic data. Myocardial perfusion was evaluated both semi quantitatively as well as quantitatively according to the European guidelines. CAC scores were automatically derived from the low-dose attenuation correction CT scans using previously developed software based on deep learning. Obstructive CAD was defined as stenosis >70% (or >50% in the left main coronary artery) and/or fractional flow reserve (FFR) ≤0.80., Results: In total 58% of patients had obstructive CAD of which seventy-four percent were male. Addition of CAC scores to MPI and clinical predictors significantly improved the diagnostic accuracy of MPI to detect obstructive CAD. The area under the curve (AUC) increased from 0.87 to 0.91 (p: 0.025). Sensitivity and specificity analysis showed an incremental decrease in false negative tests with our MPI + CAC approach (n = 14 to n = 4), as a consequence an increase in false positive tests was seen (n = 11 to n = 28)., Conclusion: CAC scores collected simultaneously with MPI improve the detection of obstructive coronary artery disease in patients without a history of coronary revascularization., (© 2019 Published by Elsevier B.V.)

Published
2019
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