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1. Immunological imprinting of humoral immunity to SARS-CoV-2 in children

Author

Dowell, Alexander C., Lancaster, Tara, Bruton, Rachel, Ireland, Georgina, Bentley, Christopher, Sylla, Panagiota, Zuo, Jianmin, Scott, Sam, Jadir, Azar, Begum, Jusnara, Roberts, Thomas, Stephens, Christine, Ditta, Shabana, Shepherdson, Rebecca, Powell, Annabel A., Brent, Andrew J., Brent, Bernadette, Baawuah, Frances, Okike, Ifeanyichukwu, Beckmann, Joanne, Ahmad, Shazaad, Aiano, Felicity, Garstang, Joanna, Ramsay, Mary E., Azad, Rafaq, Waiblinger, Dagmar, Willett, Brian, Wright, John, Ladhani, Shamez N., and Moss, Paul

Published
2023
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3. Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Author

Dowell, Alexander C., Butler, Megan S., Jinks, Elizabeth, Tut, Gokhan, Lancaster, Tara, Sylla, Panagiota, Begum, Jusnara, Bruton, Rachel, Pearce, Hayden, Verma, Kriti, Logan, Nicola, Tyson, Grace, Spalkova, Eliska, Margielewska-Davies, Sandra, Taylor, Graham S., Syrimi, Eleni, Baawuah, Frances, Beckmann, Joanne, Okike, Ifeanyichukwu O., Ahmad, Shazaad, Garstang, Joanna, Brent, Andrew J., Brent, Bernadette, Ireland, Georgina, Aiano, Felicity, Amin-Chowdhury, Zahin, Jones, Samuel, Borrow, Ray, Linley, Ezra, Wright, John, Azad, Rafaq, Waiblinger, Dagmar, Davis, Chris, Thomson, Emma C., Palmarini, Massimo, Willett, Brian J., Barclay, Wendy S., Poh, John, Amirthalingam, Gayatri, Brown, Kevin E., Ramsay, Mary E., Zuo, Jianmin, Moss, Paul, and Ladhani, Shamez

Published
2022
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4. Cohort Profile Update: Born in Bradford

Author

McEachan, Rosemary R C, primary, Santorelli, Gillian, additional, Watmuff, Aidan, additional, Mason, Dan, additional, Barber, Sally E, additional, Bingham, Daniel D, additional, Bird, Philippa K, additional, Lennon, Laura, additional, Lewer, Dan, additional, Mon-Williams, Mark, additional, Shire, Katy A, additional, Waiblinger, Dagmar, additional, West, Jane, additional, Yang, Tiffany C, additional, Lawlor, Deborah A, additional, Pickett, Kate E, additional, and Wright, John, additional

Published
2024
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5. Understanding the patterns and health impact of indoor air pollutant exposures in Bradford, UK: a study protocol

Author

Ikeda, Erika, primary, Hamilton, Jacqueline, additional, Wood, Chantelle, additional, Chatzidiakou, Lia, additional, Warburton, Thomas, additional, Ruangkanit, Athina, additional, Shao, Yunqi, additional, Genes, Denisa, additional, Waiblinger, Dagmar, additional, Yang, Tiffany C, additional, Giorio, Chiara, additional, McFiggans, Gordon, additional, O'Meara, Simon P, additional, Edwards, Pete, additional, Bates, Elizabeth, additional, Shaw, David R, additional, Jones, Roderic L, additional, Carslaw, Nicola, additional, and McEachan, Rosemary, additional

Published
2023
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6. Born in Bradford’s Better Start (BiBBS) interventional birth cohort study: Interim cohort profile

Author

Dickerson, Josie, primary, Bridges, Sally, additional, Willan, Kathryn, additional, Kelly, Brian, additional, Moss, Rachael H., additional, Lister, Jennie, additional, Netkitsing, Chandani, additional, Atkinson, Amy L., additional, Bird, Philippa K., additional, Uphoff, Eleanora P., additional, Mason, Dan, additional, Newsham, Alex, additional, Waiblinger, Dagmar, additional, Razaq, Rifat, additional, Ahern, Sara, additional, Bryant, Maria, additional, Blower, Sarah L., additional, Pickett, Kate E., additional, McEachan, Rosemary M., additional, and Wright, John, additional

Published
2023
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8. Maternal iodine status in a multi-ethnic UK birth cohort: associations with autism spectrum disorder

Author

Cromie, Kirsten Jade, Threapleton, Diane Erin, Snart, Charles Jonathan Peter, Taylor, Elizabeth, Mason, Dan, Wright, Barry, Kelly, Brian, Reid, Stephen, Azad, Rafaq, Keeble, Claire, Waterman, Amanda H., Meadows, Sarah, McKillion, Amanda, Alwan, Nisreen A., Cade, Janet Elizabeth, Simpson, Nigel A. B., Stewart, Paul M., Zimmermann, Michael, Wright, John, Waiblinger, Dagmar, Mon-Williams, Mark, Hardie, Laura J., and Greenwood, Darren Charles

Published
2020
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10. Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort

Author

Snart, Charles Jonathan Peter, Threapleton, Diane Erin, Keeble, Claire, Taylor, Elizabeth, Waiblinger, Dagmar, Reid, Stephen, Alwan, Nisreen A., Mason, Dan, Azad, Rafaq, Cade, Janet Elizabeth, Simpson, Nigel A. B., Meadows, Sarah, McKillion, Amanda, Santorelli, Gillian, Waterman, Amanda H., Zimmermann, Michael, Stewart, Paul M., Wright, John, Mon-Williams, Mark, Greenwood, Darren Charles, and Hardie, Laura J.

Published
2020
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11. A molecular sensitization map of European children reveals exposome‐ and climate‐dependent sensitization profiles

Author

Kiewiet, M. B. Gea, primary, Lupinek, Christian, additional, Vrtala, Susanne, additional, Wieser, Sandra, additional, Baar, Alexandra, additional, Kiss, Renata, additional, Kull, Inger, additional, Melén, Erik, additional, Wickman, Magnus, additional, Porta, Daniela, additional, Gori, Davide, additional, Gehring, Ulrike, additional, Aalberse, Rob, additional, Sunyer, Jordi, additional, Standl, Marie, additional, Heinrich, Joachim, additional, Waiblinger, Dagmar, additional, Wright, John, additional, Antó, Josep M., additional, Bousquet, Jean, additional, van Hage, Marianne, additional, and Valenta, Rudolf, additional

Published
2023
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12. A molecular sensitization map of European children reveals exposome- and climate-dependent sensitization profiles

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Kiewiet, M B Gea, Lupinek, Christian, Vrtala, Susanne, Wieser, Sandra, Baar, Alexandra, Kiss, Renata, Kull, Inger, Melén, Erik, Wickman, Magnus, Porta, Daniela, Gori, Davide, Gehring, Ulrike, Aalberse, Rob, Sunyer, Jordi, Standl, Marie, Heinrich, Joachim, Waiblinger, Dagmar, Wright, John, Antó, Josep M, Bousquet, Jean, van Hage, Marianne, Valenta, Rudolf, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Kiewiet, M B Gea, Lupinek, Christian, Vrtala, Susanne, Wieser, Sandra, Baar, Alexandra, Kiss, Renata, Kull, Inger, Melén, Erik, Wickman, Magnus, Porta, Daniela, Gori, Davide, Gehring, Ulrike, Aalberse, Rob, Sunyer, Jordi, Standl, Marie, Heinrich, Joachim, Waiblinger, Dagmar, Wright, John, Antó, Josep M, Bousquet, Jean, van Hage, Marianne, and Valenta, Rudolf

Published
2023

14. Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model

Author

Deepika, Deepika, primary, Sharma, Raju Prasad, additional, Schuhmacher, Marta, additional, Sakhi, Amrit Kaur, additional, Thomsen, Cathrine, additional, Chatzi, Leda, additional, Vafeiadi, Marina, additional, Quentin, Joane, additional, Slama, Remy, additional, Grazuleviciene, Regina, additional, Andrušaitytė, Sandra, additional, Waiblinger, Dagmar, additional, Wright, John, additional, Yang, Tiffany C., additional, Urquiza, Jose, additional, Vrijheid, Martine, additional, Casas, Maribel, additional, Domingo, José L., additional, and Kumar, Vikas, additional

Published
2022
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15. Born in Bradford’s Better Start (BiBBS) interventional birth cohort study: Interim cohort profile

Author

Dickerson, Josie, primary, Bridges, Sally, additional, Willan, Kathryn, additional, Kelly, Brian, additional, Moss, Rachael H., additional, Lister, Jennie, additional, Netkitsing, Chandani, additional, Atkinson, Amy L., additional, Bird, Philippa K., additional, Uphoff, Eleanora P., additional, Mason, Dan, additional, Newsham, Alex, additional, Waiblinger, Dagmar, additional, Razaq, Rifat, additional, Ahern, Sara, additional, Bryant, Maria, additional, Blower, Sarah L., additional, Pickett, Kate E., additional, McEachan, Rosemary M., additional, and Wright, John, additional

Published
2022
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16. Immunological imprinting of humoral immunity to SARS-CoV-2 in children

Author

Dowell, Alexander C., primary, Lancaster, Tara, additional, Bruton, Rachel, additional, Ireland, Georgina, additional, Bentley, Christopher, additional, Sylla, Panagiota, additional, Zuo, Jianmin, additional, Scott, Sam, additional, Jadir, Azar, additional, Begum, Jusnara, additional, Roberts, Thomas, additional, Stephens, Christine, additional, Ditta, Shabana, additional, Shepherdson, Rebecca, additional, Powell, Annabel A., additional, Brent, Andrew J., additional, Brent, Bernadette, additional, Baawuah, Frances, additional, Okike, Ifeanyichukwu, additional, Beckmann, Joanne, additional, Ahmad, Shazaad, additional, Aiano, Felicity, additional, Garstang, Joanna, additional, Ramsay, Mary E., additional, Azad, Rafaq, additional, Waiblinger, Dagmar, additional, Willett, Brian, additional, Wright, John, additional, Ladhani, Shamez N., additional, and Moss, Paul, additional

Published
2022
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17. mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273

Author

Dowell, Alexander C., primary, Powell, Annabel A., additional, Davis, Chris, additional, Scott, Sam, additional, Logan, Nicola, additional, Willett, Brian J., additional, Bruton, Rachel, additional, Ayodele, Morenike, additional, Jinks, Elizabeth, additional, Gunn, Juliet, additional, Spalkova, Eliska, additional, Sylla, Panagiota, additional, Nicol, Samantha M., additional, Zuo, Jianmin, additional, Ireland, Georgina, additional, Okike, Ifeanyichukwu, additional, Baawuah, Frances, additional, Beckmann, Joanne, additional, Ahmad, Shazaad, additional, Garstang, Joanna, additional, Brent, Andrew J., additional, Brent, Bernadette, additional, White, Marie, additional, Collins, Aedin, additional, Davis, Francesca, additional, Lim, Ming, additional, Cohen, Jonathan, additional, Kenny, Julia, additional, Linley, Ezra, additional, Poh, John, additional, Amirthalingam, Gayatri, additional, Brown, Kevin, additional, Ramsay, Mary E., additional, Azad, Rafaq, additional, Wright, John, additional, Waiblinger, Dagmar, additional, Moss, Paul, additional, and Ladhani, Shamez N., additional

Published
2022
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18. Ethnic differences in kidney function in childhood: the Born in Bradford Cohort Renal Study [version 1; peer review: awaiting peer review]

Author

Ziauddeen, Nida, Jeffrey, Robin F, Waiblinger, Dagmar, Fraser, Simon, Alwan, Nisreen, Yuen, Ho, Azad, Rafaq, Mason, Dan, Wright, John, Coward, Richard J.M., and Roderick, Paul

Abstract

Background: Endstage kidney failure rates are higher in South Asians than in White Europeans. Low birth weight is associated with adult chronic kidney disease and is more common in South Asians. Foetal kidney size was smaller in South Asians in the Born in Bradford (BiB) birth cohort. As part of BiB follow up, we aimed to investigate if there were ethnic differences in kidney function and blood pressure in early childhood and whether this was mediated by foetal kidney size. Methods: Serum creatinine, cystatin C, urea, and urinary albumin to creatinine ratio (ACR), protein to creatinine ratio (PCR) and retinol binding protein (RBP) were analysed in blood and urine samples from those who participated in the BiB follow-up at 7-11 years. Ethnicity was categorised by parental self-report as White European and South Asian. Estimated glomerular filtration rate (eGFR) was calculated using Schwartz, and cystatin C Zappitelli and Filler equations. Linear regression was used to examine the association between ethnicity and eGFR, PCR and blood pressure. Results: 1591 children provided blood (n=1403) or urine (n=625) samples. Mean eGFR was 92 ml/min/1.73m2 (standard deviation (SD) 9) using Schwartz (n=1156) and 94 (SD 11) using Zappitelli (n=1257). CKD prevalence was rare (1 with eGFR 2.5 mg/mmol in boys/3.5 mg/mmol in girls). Diastolic blood pressure was higher in South Asian children (difference 2.04 mmHg, 95% CI 0.99 to 3.10) but was not significant in adjusted analysis. There was no evidence of association in adjusted models between ethnicity and any eGFR or urinary measure at this age. Conclusions: There was no evidence of significant ethnic differences in kidney function at pre-pubertal age despite differences in kidney volume at birth. Longitudinal follow-up is required to track ethnic patterns in kidney function and blood pressure as children develop through puberty.

Published
2022

19. Born in Bradford’s Better Start (BiBBS) interventional birth cohort study: Interim cohort profile

Author

Dickerson, Josie, Bridges, Sally, Willan, Kathryn, Kelly, Brian, Moss, Rachael H, Lister, Jennie, Netkitsing, Chandani, Atkinson, Amy, Bird, Philippa K, Uphoff, Eleanora P, Mason, Dan, Newsham, Alex, Waiblinger, Dagmar, Razaq, Rifat, Ahern, Sara, Bryant, Maria, Blower, Sarah L, Pickett, Kate E, McEachan, Rosemary M, Wright, John, Dickerson, Josie, Bridges, Sally, Willan, Kathryn, Kelly, Brian, Moss, Rachael H, Lister, Jennie, Netkitsing, Chandani, Atkinson, Amy, Bird, Philippa K, Uphoff, Eleanora P, Mason, Dan, Newsham, Alex, Waiblinger, Dagmar, Razaq, Rifat, Ahern, Sara, Bryant, Maria, Blower, Sarah L, Pickett, Kate E, McEachan, Rosemary M, and Wright, John

Abstract

Background: The Born in Bradford’s Better Start (BiBBS) interventional birth cohort study was designed as an innovative cohort platform for efficient evaluation of early life interventions delivered through the Better Start Bradford programme. There are a growing number of interventional cohorts being implemented internationally. This paper provides an interim analysis of BiBBS in order to share learning about the feasibility and value of this method. Methods: Recruitment began in January 2016 and will complete in December 2023 with a target sample of 5,000 pregnancies. An interim data cut was completed for all pregnancies recruited between January 2016 and November 2019 with an expected due date between 1st April 2016 and 8th March 2020. Descriptive statistics were completed on the data. Results: Of 4,823 eligible pregnancies, 2,626 (54%) pregnancies were recruited, resulting in 2,392 mothers and 2,501 children. The sample are representative of the pregnant population (61% Pakistani heritage; 12% White British; 8% other South Asian and 6% Central and Eastern European ethnicity). The majority of participants (84%) live in the lowest decile of the Index of Multiple Deprivation, and many live in vulnerable circumstances. A high proportion (85%) of BiBBS families have engaged in one or more of the Better Start Bradford interventions. Levels of participation varied by the characteristics of the interventions, such as the requirement for active participation and the length of commitment to a programme. Conclusions: We have demonstrated the feasibility of recruiting an interventional cohort that includes seldom heard families from ethnic minority and deprived backgrounds. The high level of uptake of interventions is encouraging for the goal of evaluating the process and outcomes of multiple early life interventions using the innovative interventional cohort approach. BiBBS covers a period before, during and after the coronavirus disease 2019 (COVID-19) pandemic which adds

Published
2022

21. Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Author

Dowell, Alexander C., primary, Butler, Megan S., additional, Jinks, Elizabeth, additional, Tut, Gokhan, additional, Lancaster, Tara, additional, Sylla, Panagiota, additional, Begum, Jusnara, additional, Bruton, Rachel, additional, Pearce, Hayden, additional, Verma, Kriti, additional, Logan, Nicola, additional, Tyson, Grace, additional, Spalkova, Eliska, additional, Margielewska-Davies, Sandra, additional, Taylor, Graham S., additional, Syrimi, Eleni, additional, Baawuah, Frances, additional, Beckmann, Joanne, additional, Okike, Ifeanyichukwu O., additional, Ahmad, Shazaad, additional, Garstang, Joanna, additional, Brent, Andrew J., additional, Brent, Bernadette, additional, Ireland, Georgina, additional, Aiano, Felicity, additional, Amin-Chowdhury, Zahin, additional, Jones, Samuel, additional, Borrow, Ray, additional, Linley, Ezra, additional, Wright, John, additional, Azad, Rafaq, additional, Waiblinger, Dagmar, additional, Davis, Chris, additional, Thomson, Emma C., additional, Palmarini, Massimo, additional, Willett, Brian J., additional, Barclay, Wendy S., additional, Poh, John, additional, Amirthalingam, Gayatri, additional, Brown, Kevin E., additional, Ramsay, Mary E., additional, Zuo, Jianmin, additional, Moss, Paul, additional, and Ladhani, Shamez, additional

Published
2021
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22. mRNA COVID-19 vaccines induce enhanced antibody and cellular responses compared to ChAdOx1 or natural infection in children

Author

Dowell, Alexander, primary, Powell, Annable, additional, Davis, Chris, additional, Willett, Brian, additional, Bruton, Rachel, additional, Ayodele, Morenike, additional, Jinks, Elizabeth, additional, Sylla, Panagiota, additional, Spalkova, Eliska, additional, Nicol, Samantha, additional, Zuo, Jianmin, additional, Ireland, Georgina, additional, OKIKE, Ifeanyichukwu, additional, Baawuah, Frances, additional, BECKMANN, Joanne, additional, Ahmad, Shazaad, additional, GARSTANG, Joanna, additional, Brent, Andrew, additional, Brent, Bernadette, additional, white, marie, additional, Collins, Aedin, additional, Davis, Fracesca, additional, lim, ming, additional, Kenny, Julia, additional, Cohen, Jonathan, additional, Ramsay, Mary, additional, Linley, Ezra, additional, Poe, John, additional, Amirthalingam, Gayatri, additional, Brown, Kevin, additional, Azad, Rafaq, additional, Waiblinger, Dagmar, additional, Wright, John, additional, Moss, Paul, additional, and Ladhani, Shamez, additional

Published
2021
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23. Children develop robust and sustained cross-reactive spike-specific immune responses following SARS-CoV-2 infection

Author

Dowell, Alexander C., primary, Butler, Megan S., additional, Jinks, Elizabeth, additional, Tut, Gokhan, additional, Lancaster, Tara, additional, Sylla, Panagiota, additional, Begum, Jusnara, additional, Bruton, Rachel, additional, Pearce, Hayden, additional, Verma, Kriti, additional, Logan, Nicola, additional, Tyson, Grace, additional, Spalkova, Eliska, additional, Margielewska-Davies, Sandra, additional, Taylor, Graham S., additional, Syrimi, Eleni, additional, Baawuah, Frances, additional, Beckmann, Joanne, additional, Okike, Ifeanyichukwu, additional, Ahmad, Shazaad, additional, Garstang, Joanna, additional, Brent, Andrew J, additional, Brent, Bernadette, additional, Ireland, Georgina, additional, Aiano, Felicity, additional, Amin-Chowdhury, Zahin, additional, Jones, Samuel, additional, Borrow, Ray, additional, Linley, Ezra, additional, Wright, John, additional, Azad, Rafaq, additional, Waiblinger, Dagmar, additional, Davis, Chris, additional, Thomson, Emma, additional, Palmarini, Massimo, additional, Willett, Brian J., additional, Barclay, Wendy S., additional, Poh, John, additional, Saliba, Vanessa, additional, Amirthalingam, Gayatri, additional, Brown, Kevin E, additional, Ramsay, Mary E, additional, Zuo, Jianmin, additional, Moss, Paul, additional, and Ladhani, Shamez, additional

Published
2021
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24. Additional file 1 of Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort

Author

Snart, Charles Jonathan Peter, Threapleton, Diane Erin, Keeble, Claire, Taylor, Elizabeth, Waiblinger, Dagmar, Reid, Stephen, Nisreen A. Alwan, Mason, Dan, Rafaq Azad, Cade, Janet Elizabeth, Simpson, Nigel A. B., Meadows, Sarah, McKillion, Amanda, Santorelli, Gillian, Waterman, Amanda H., Zimmermann, Michael, Stewart, Paul M., Wright, John, Mon-Williams, Mark, Greenwood, Darren Charles, and Hardie, Laura J.

Abstract

Additional file 1: Table S1. Details of socioeconomic position categories and maternal education levels. Table S2. Details of model covariates, sample exclusions, sensitivity analyses and subgroup analyses for each of the different outcomes. Table S3. Pairwise correlations between each of the growth measures. Table S4. Predicted estimates (continuous outcomes) and percent at the threshold (binary outcomes) (99% CIs) at the 25th, 50th and 75th centiles of iodine concentration and p-overall* for ‘average’ participants†. Figure S1. A directed acyclic graph used to identify confounders and competing exposures in the association between maternal iodine concentration and birth or pregnancy outcomes. Figure S2. Flow chart of participant inclusions and exclusions. Figure S3. Estimated APGAR score at 1 minute and percent with congenital anomalies, using imputed datasets for the full sample. Figure S4. Estimated biparietal diameter, femur length and abdominal circumference, from ultrasound scans at 34 weeks’ gestation, across the range of maternal I:Cr concentrations using imputed datasets for the full sample. Figure S5. Estimated birthweight centile in all participants, sensitivity analysis and subgroups. Figure S6. Estimated birthweight in grams in all participants, sensitivity analysis and subgroups. Figure S7. Probability of being small for gestational age in all participants, sensitivity analysis and subgroups. Figure S8. Probability of low birthweight in all participants, sensitivity analysis and subgroups. Figure S9. Apgar score at 5 minutes after birth in all participants, sensitivity analysis and subgroups. Figure S10. Estimated head circumference at birth in all participants, sensitivity analysis and subgroups. Figure S11. Estimated head circumference from 34 week ultrasound scan in all participants, sensitivity analysis and subgroups. Figure S12. Estimated weight from 34 week ultrasound scan in all participants, sensitivity analysis and subgroups. Figure S13. Probability of preterm birth in all participants, sensitivity analysis and subgroups. Figure S14. Probability of congenital anomalies in all participants, sensitivity analysis and subgroups.

Published
2020
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25. Prenatal and Postpartum Maternal Iodide Intake from Diet and Supplements, Urinary Iodine and Thyroid Hormone Concentrations in a Region of the United Kingdom with Mild-to-Moderate Iodine Deficiency

Author

Threapleton, Diane E., primary, Waiblinger, Dagmar, additional, Snart, Charles J.P., additional, Taylor, Elizabeth, additional, Keeble, Claire, additional, Ashraf, Samina, additional, Bi, Shazia, additional, Ajjan, Ramzi, additional, Azad, Rafaq, additional, Hancock, Neil, additional, Mason, Dan, additional, Reid, Stephen, additional, Cromie, Kirsten J., additional, Alwan, Nisreen A., additional, Zimmermann, Michael, additional, Stewart, Paul M., additional, Simpson, Nigel A.B., additional, Wright, John, additional, Cade, Janet E., additional, Hardie, Laura J., additional, and Greenwood, Darren C., additional

Published
2021
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30. Maternal iodine status in a multi‐ethnic UK birth cohort: Associations with child cognitive and educational development

Author

Threapleton, Diane E., primary, Snart, Charles J. P., additional, Keeble, Claire, additional, Waterman, Amanda H., additional, Taylor, Elizabeth, additional, Mason, Dan, additional, Reid, Stephen, additional, Azad, Rafaq, additional, Hill, Liam J. B., additional, Meadows, Sarah, additional, McKillion, Amanda, additional, Alwan, Nisreen A., additional, Cade, Janet E., additional, Simpson, Nigel A. B., additional, Stewart, Paul M., additional, Zimmermann, Michael, additional, Wright, John, additional, Waiblinger, Dagmar, additional, Mon‐Williams, Mark, additional, Hardie, Laura J., additional, and Greenwood, Darren C., additional

Published
2020
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31. Maternal Iodine Status in a Multi-Ethnic UK Birth Cohort: Associations with Autism Spectrum Disorder

Author

Cromie, Kirsten Jade, primary, Threapleton, Diane Erin, additional, Snart, Charles Jonathan Peter, additional, Taylor, Elizabeth, additional, Mason, Dan, additional, Wright, Barry John Debenham, additional, Kelly, Brian, additional, Reid, Stephen, additional, Azad, Rafaq, additional, Keeble, Claire, additional, Waterman, Amanda H, additional, Meadows, Sarah, additional, McKillion, Amanda, additional, Alwan, Nisreen A., additional, Cade, Janet Elizabeth, additional, Simpson, Nigel AB, additional, Stewart, Paul, additional, Zimmermann, Michael, additional, Wright, John, additional, Waiblinger, Dagmar, additional, Mon-Williams, Mark, additional, Hardie, Laura, additional, and Greenwood, Darren C., additional

Published
2020
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32. Age at cytomegalovirus, Epstein Barr virus and varicella zoster virus infection and risk of atopy: The Born in Bradford cohort, UK

Author

Pembrey, Lucy, Waiblinger, Dagmar, Griffiths, Paul, and Wright, John

Subjects
virus diseases
Abstract

BACKGROUND: The prevalence of allergic diseases has increased in recent decades, but the causes remain unclear. Changes in the epidemiology of childhood infections could have contributed, but the current evidence is inconclusive. This study aims to investigate whether age at cytomegalovirus (CMV), Epstein-Barr virus (EBV) or varicella zoster virus (VZV) infection is associated with the development of atopy. METHODS: A total of 2559 children were enrolled in the Born in Bradford Allergy and Infection Study. Serum samples collected at 12 and 24 months were tested for CMV-IgG, EBV-IgG and VZV-IgG for 1000 children to establish age at infection. Skin prick testing (SPT) was conducted at age 4 years. RESULTS: Serology and SPT results were available for 740 children. Of these, 135 (18%) were atopic. In girls, there was a strong association of CMV infection in the second year with increased odds of atopy (adjusted OR 4.38, 95% CI 1.87-10.29) but this was not observed in boys. Age at EBV or VZV infection was not associated with risk of atopy in unadjusted analysis, but there was effect modification by sex; girls infected with VZV in the second year of life had increased odds of atopy (adjusted OR 2.85, 95% CI 1.29-6.30). CONCLUSIONS: Our results highlight potential sex-specific effects of age at CMV infection and age at VZV infection on risk of atopy, which provide insight into the mechanisms involved in the development of atopy.

Published
2019

33. Additional File 3

Author

Bird, Philippa, McEachan, Rosemary, Mon-Williams, Mark, Small, Neil, West, Jane, Whincup, Peter, Wright, John, Andrews, Elizabeth, Barber, Sally, Hill, Liam, Lennon, Laura, Mason, Dan, Shire, Katy, Waiblinger, Dagmar, Waterman, Amanda, Lawlor, Deborah, and Pickett, Kate

Subjects
body regions, nervous system, fungi
Abstract

Procedures for child and adult measurements and samples. Table summarising procedures for child and adult measurements and samples (PDF 193 kb)

Published
2019
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34. Additional File 5

Author

Bird, Philippa, McEachan, Rosemary, Mon-Williams, Mark, Small, Neil, West, Jane, Whincup, Peter, Wright, John, Andrews, Elizabeth, Barber, Sally, Hill, Liam, Lennon, Laura, Mason, Dan, Shire, Katy, Waiblinger, Dagmar, Waterman, Amanda, Lawlor, Deborah, and Pickett, Kate

Subjects
fungi, technology, industry, and agriculture, cardiovascular system, lipids (amino acids, peptides, and proteins), cardiovascular diseases
Abstract

Child feedback leaflet. Child Participant feedback leaflet (PDF 6015 kb)

Published
2019
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35. Additional File 2

Author

Bird, Philippa, McEachan, Rosemary, Mon-Williams, Mark, Small, Neil, West, Jane, Whincup, Peter, Wright, John, Andrews, Elizabeth, Barber, Sally, Hill, Liam, Lennon, Laura, Mason, Dan, Shire, Katy, Waiblinger, Dagmar, Waterman, Amanda, Lawlor, Deborah, and Pickett, Kate

Abstract

Overview of questionnaire domains and sources. Three tables summarising questionnaire domains and sources using in the Born in Bradford age 7â 11 assessments (PDF 336 kb)

Published
2019
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36. Additional File 4

Author

Bird, Philippa, McEachan, Rosemary, Mon-Williams, Mark, Small, Neil, West, Jane, Whincup, Peter, Wright, John, Andrews, Elizabeth, Barber, Sally, Hill, Liam, Lennon, Laura, Mason, Dan, Shire, Katy, Waiblinger, Dagmar, Waterman, Amanda, Lawlor, Deborah, and Pickett, Kate

Subjects
fungi, technology, industry, and agriculture, cardiovascular system, lipids (amino acids, peptides, and proteins), cardiovascular diseases
Abstract

Adult feedback leaflet. Adult Participant feedback leaflet (PDF 1431 kb)

Published
2019
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37. Additional File 1

Author

Bird, Philippa, McEachan, Rosemary, Mon-Williams, Mark, Small, Neil, West, Jane, Whincup, Peter, Wright, John, Andrews, Elizabeth, Barber, Sally, Hill, Liam, Lennon, Laura, Mason, Dan, Shire, Katy, Waiblinger, Dagmar, Waterman, Amanda, Lawlor, Deborah, and Pickett, Kate

Abstract

Summary of existing data by participant group. Table summarising existing data available for the Born in Bradford cohort (PDF 283 kb)

Published
2019
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38. Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

Author

Maitre, Léa, De Bont, Jeroen, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferrán, Basagaña, Xavier, Borrás, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Angel, De Castro, Montserrat, Dedele, Audrius, Donaire González, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis Allemand, Lise, Granum, Berit, Grazuleviciene, Regina, Gützkow, Kristine Bjerve, Småstuen Haug, Line, Hernández Ferrer, Carles, Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C, Hjertager Krog, Norun, Lau, Chung-Ho E., Leventakou, Vasiliki, Lyon Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre-Jean, Siskos, Alexandros P, Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, Vrijheid, Martine, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Norwegian Institute of Public Health [Oslo] (NIPH), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Universitat de València (UV), Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne] (FISABIO), Centre for Genomic Regulation [Barcelona] (CRG), Universitat Pompeu Fabra [Barcelona] (UPF)-Centro Nacional de Analisis Genomico [Barcelona] (CNAG), Institut National de l'Environnement Industriel et des Risques (INERIS), Universidade de Santiago de Compostela [Spain] (USC ), CIBER de Enfermedades Raras (CIBERER), Sidra Medicine [Doha, Qatar], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), BIODonostia Research Institute, Public Health Division of Gipuzkoa, University of Crete [Heraklion] (UOC), Imperial College London, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard University [Cambridge], Keck School of Medicine [Los Angeles], University of Southern California (USC), Maastricht University [Maastricht], Veiligheids-en Gezondheidsregio Gelderland Midden [Arnhem, the Netherlands] (VGGM), Civs, Gestionnaire, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commission of the European Communities, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Universidade de Santiago de Compostela. Instituto de Ciencias Forenses 'Luis Concheiro'(INCIFOR), RS: NUTRIM - R3 - Respiratory & Age-related Health, and Complexe Genetica

Subjects
Male, Urban Population, Epidemiology, Blood Pressure, 01 natural sciences, 0302 clinical medicine, USE REGRESSION-MODELS, Prospective Studies, profile, education.field_of_study, Anthropometry, public health, birth cohort, General Medicine, 3. Good health, MOTHER, Child, Preschool, Prenatal Exposure Delayed Effects, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Cohort, Body Composition, HEALTH, Food Hypersensitivity, Birth cohort, medicine.medical_specialty, Exposome, exposome, 03 medical and health sciences, land-use, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Humans, education, Psychological Tests, child cohort, Public health, areas, Infant, Environmental Exposure, AIR-POLLUTION, DNA Methylation, Omics, medicine.disease, CHILD COHORT, exposure, Attention Deficit Disorder with Hyperactivity, Biomarkers, Proteome, Salut Pública, Neurodevelopment, use regression-models, 010501 environmental sciences, AREAS, 11. Sustainability, 030212 general & internal medicine, Prospective cohort study, mother, Smoking, Community child health, health, omics, Respiratory Function Tests, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Europe, PREGNANCY, Exposoma, Blood pressure, Metabolome, epidemiology, Female, pregnancy, community child health, Adult, Population, Mothers, PROFILE, Childhood obesity, Hazardous Substances, Young Adult, Environmental health, medicine, air-pollution, Body Weights and Measures, EXPOSURE, 0105 earth and related environmental sciences, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, LAND-USE, business.industry, Respiratory health, Infant, Newborn, HELIX, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Gene-Environment Interaction, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, European population, business, Transcriptome
Abstract

Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333-the HELIX project. Dr Maribel Casas and Dr Jordi Julvez received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128, MS14/00108). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, the Conselleria de Sanitat, Generalitat Valenciana, Department of Health of the Basque Government; the Provincial Government of Gipuzkoa, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother and Child Cohort Study (MoBa) is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no. N01-ES-75558), and NIH/NINDS (grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011-2014; 'Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-2015). The work was also supported by MICINN (MTM2015-68140-R) and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII. CW received funding from the Fondation de France.

Published
2018

39. Personal assessment of the external exposome during pregnancy and childhood in Europe.

Author

Donaire-Gonzalez, David, primary, Curto, Ariadna, additional, Valentín, Antònia, additional, Andrusaityte, Sandra, additional, Basagaña, Xavier, additional, Casas, Maribel, additional, Chatzi, Leda, additional, de Bont, Jeroen, additional, de Castro, Montserrat, additional, Dedele, Audrius, additional, Granum, Berit, additional, Grazuleviciene, Regina, additional, Kampouri, Mariza, additional, Lyon-Caen, Sarah, additional, Manzano-Salgado, Cyntia B., additional, Aasvang, Gunn Marit, additional, McEachan, Rosemary, additional, Meinhard-Kjellstad, Carin Helena, additional, Michalaki, Eirini, additional, Pañella, Pau, additional, Petraviciene, Inga, additional, Schwarze, Per E., additional, Slama, Rémy, additional, Robinson, Oliver, additional, Tamayo-Uria, Ibon, additional, Vafeiadi, Marina, additional, Waiblinger, Dagmar, additional, Wright, John, additional, Vrijheid, Martine, additional, and Nieuwenhuijsen, Mark J., additional

Published
2019
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41. The early-life exposome: Description and patterns in six European countries

Author

Tamayo-Uria, Ibon, primary, Maitre, Léa, additional, Thomsen, Cathrine, additional, Nieuwenhuijsen, Mark J., additional, Chatzi, Leda, additional, Siroux, Valérie, additional, Aasvang, Gunn Marit, additional, Agier, Lydiane, additional, Andrusaityte, Sandra, additional, Casas, Maribel, additional, de Castro, Montserrat, additional, Dedele, Audrius, additional, Haug, Line S., additional, Heude, Barbara, additional, Grazuleviciene, Regina, additional, Gutzkow, Kristine B., additional, Krog, Norun H., additional, Mason, Dan, additional, McEachan, Rosemary R.C., additional, Meltzer, Helle M., additional, Petraviciene, Inga, additional, Robinson, Oliver, additional, Roumeliotaki, Theano, additional, Sakhi, Amrit K., additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Waiblinger, Dagmar, additional, Warembourg, Charline, additional, Wright, John, additional, Slama, Rémy, additional, Vrijheid, Martine, additional, and Basagaña, Xavier, additional

Published
2019
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42. Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children

Author

Casas, Maribel, primary, Basagaña, Xavier, additional, Sakhi, Amrit K., additional, Haug, Line S., additional, Philippat, Claire, additional, Granum, Berit, additional, Manzano-Salgado, Cyntia B., additional, Brochot, Céline, additional, Zeman, Florence, additional, de Bont, Jeroen, additional, Andrusaityte, Sandra, additional, Chatzi, Leda, additional, Donaire-Gonzalez, David, additional, Giorgis-Allemand, Lise, additional, Gonzalez, Juan R., additional, Gracia-Lavedan, Esther, additional, Grazuleviciene, Regina, additional, Kampouri, Mariza, additional, Lyon-Caen, Sarah, additional, Pañella, Pau, additional, Petraviciene, Inga, additional, Robinson, Oliver, additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Vernet, Céline, additional, Waiblinger, Dagmar, additional, Wright, John, additional, Thomsen, Cathrine, additional, Slama, Rémy, additional, and Vrijheid, Martine, additional

Published
2018
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43. Maternal iodine status in a multi‐ethnic UK birth cohort: Associations with child cognitive and educational development.

Author

Threapleton, Diane E., Snart, Charles J. P., Keeble, Claire, Waterman, Amanda H., Taylor, Elizabeth, Mason, Dan, Reid, Stephen, Azad, Rafaq, Hill, Liam J. B., Meadows, Sarah, McKillion, Amanda, Alwan, Nisreen A., Cade, Janet E., Simpson, Nigel A. B., Stewart, Paul M., Zimmermann, Michael, Wright, John, Waiblinger, Dagmar, Mon‐Williams, Mark, and Hardie, Laura J.

Subjects
CHILD development, COGNITION, IODINE deficiency, PREGNANCY, NUTRITION in pregnancy
Abstract

Background: Maternal iodine requirements increase during pregnancy to supply thyroid hormones critical for fetal neurodevelopment. Iodine insufficiency may result in poorer cognitive or child educational outcomes but current evidence is sparse and inconsistent. Objectives: To quantify the association between maternal iodine status and child educational outcomes. Methods: Urinary iodine concentrations (UIC) and iodine/creatinine ratios (I:Cr) were measured in 6971 mothers at 26‐28 weeks' gestation participating in the Born in Bradford cohort. Maternal iodine status was examined in relation to child school achievement (early years foundation stage (EYFS), phonics, and Key Stage 1 (KS1)), other learning outcomes, social and behavioural difficulties, and sensorimotor control in 5745 children aged 4‐7 years. Results: Median (interquartile range) UIC was 76 µg/L (46, 120), and I:Cr was 83 µg/g (59, 121). Overall, there was no strong or consistent evidence to support associations between UIC or I:Cr and neurodevelopmental outcomes. For instance, predicted EYFS and phonics scores (primary outcomes) at the 25th vs 75th I:Cr percentiles (99% confidence intervals) were similar, with no evidence of associations: EYFS scores were 32 (99% CI 31, 33) and 33 (99% CI 32, 34), and phonics scores were 34 (99% CI 33, 35) and 35 (99% CI 34, 36), respectively. Conclusions: In the largest single study of its kind, there was little evidence of detrimental neurodevelopmental outcomes in children born to pregnant women with iodine insufficiency as defined by World Health Organization–outlined thresholds. Alternative functional biomarkers for iodine status in pregnancy and focused assessment of other health outcomes may provide additional insight. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

Author

Procesos psicológicos básicos y su desarrollo, Oinarrizko psikologia prozesuak eta haien garapena, Maitre, Léa, De Bont, Jeroen, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferrán, Basagaña, Xavier, Borrás, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Angel, De Castro, Montserrat, Dedele, Audrius, Donaire González, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis Allemand, Lise, Granum, Berit, Grazuleviciene, Regina, Gützkow, Kristine Bjerve, Småstuen Haug, Line, Hernández Ferrer, Carles, Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C, Hjertager Krog, Norun, Lau, Chung-Ho E., Leventakou, Vasiliki, Lyon Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre-Jean, Siskos, Alexandros P, Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, Vrijheid, Martine, Procesos psicológicos básicos y su desarrollo, Oinarrizko psikologia prozesuak eta haien garapena, Maitre, Léa, De Bont, Jeroen, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferrán, Basagaña, Xavier, Borrás, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Angel, De Castro, Montserrat, Dedele, Audrius, Donaire González, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis Allemand, Lise, Granum, Berit, Grazuleviciene, Regina, Gützkow, Kristine Bjerve, Småstuen Haug, Line, Hernández Ferrer, Carles, Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C, Hjertager Krog, Norun, Lau, Chung-Ho E., Leventakou, Vasiliki, Lyon Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre-Jean, Siskos, Alexandros P, Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, and Vrijheid, Martine

Abstract

Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatur

Published
2018

45. Human early life exposome (HELIX) study: a European population-based exposome cohort

Author

Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Universidade de Santiago de Compostela. Instituto de Ciencias Forenses “Luis Concheiro”(INCIFOR), Maitre, Léa, Bont, Jeroen de, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferran, Basagaña, Xavier, Borràs, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Ángel, Castro, Montserrat de, Dedele, Audrius, Donaire Gonzalez, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis-Allemand, Lise, González, Juan R., Granum, Berit, Grazuleviciene, Regina, Bjerve Gützkow, Kristine, Småstuen Haug, Line, Hernandez Ferrer, Carles, Heude, Barbara, Ibarluzea, Jesús, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C., Hjertager Krog, Norun, Lau, Chung-Ho E, Leventakou, Vasiliki, Lyon-Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre Jean, Siskos, Alexandros P., Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives-Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, Vrijheid, Martine, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Universidade de Santiago de Compostela. Instituto de Ciencias Forenses “Luis Concheiro”(INCIFOR), Maitre, Léa, Bont, Jeroen de, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferran, Basagaña, Xavier, Borràs, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Ángel, Castro, Montserrat de, Dedele, Audrius, Donaire Gonzalez, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis-Allemand, Lise, González, Juan R., Granum, Berit, Grazuleviciene, Regina, Bjerve Gützkow, Kristine, Småstuen Haug, Line, Hernandez Ferrer, Carles, Heude, Barbara, Ibarluzea, Jesús, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C., Hjertager Krog, Norun, Lau, Chung-Ho E, Leventakou, Vasiliki, Lyon-Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre Jean, Siskos, Alexandros P., Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives-Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, and Vrijheid, Martine

Abstract

Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations

Published
2018

46. Additional file 3: of Cytomegalovirus, Epstein-Barr virus and varicella zoster virus infection in the first two years of life: a cohort study in Bradford, UK

Author

Pembrey, Lucy, Waiblinger, Dagmar, Griffiths, Paul, Mauli Patel, Rafaq Azad, and Wright, John

Subjects
integumentary system, hemic and lymphatic diseases, viruses, virus diseases, biochemical phenomena, metabolism, and nutrition, 3. Good health
Abstract

CMV, EBV and VZV incidence data for Figure 2; table showing the CMV, EBV and VZV incidence data presented in Figure 2. (DOCX 13 kb)

Published
2017
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47. Additional file 1: of Born in Bradfordâ s Better Start: an experimental birth cohort study to evaluate the impact of early life interventions

Author

Dickerson, Josie, Bird, Philippa, McEachan, Rosemary, Pickett, Kate, Waiblinger, Dagmar, Uphoff, Eleonora, Mason, Dan, Bryant, Maria, Bywater, Tracey, Bowyer-Crane, Claudine, Pinki Sahota, Small, Neil, Howell, Michaela, Thornton, Gill, Astin, Melanie, Lawlor, Debbie, and Wright, John

Abstract

Additional information on study methods and management. (DOC 1533 kb)

Published
2016
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49. The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies

Author

Hohmann, Cynthia, Pinart, Mariona, Tischer, Christina, Gehring, Ulrike, Heinrich, Joachim, Kull, Inger, Melén, Eric, Smit, Henriette A., Torrent, Maties, Wijga, Alet H., Wickman, Magnus, Bachert, Claus, Carlsen, Karin C Lødrup, Carlsen, Kai Håkon, Bindslev-Jensen, Carsten, Eller, Esben, Esplugues, Ana, Fantini, Maria Pia, Annesi-Maesano, Isabella, Momas, Isabelle, Porta, Daniela, Vassilaki, Maria, Waiblinger, Dagmar, Sunyer, Jordi, Antó, Josep M., Bousquet, Jean, Keil, Thomas, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Cynthia Hohmann, Mariona Pinart, Christina Tischer, Ulrike Gehring, Joachim Heinrich, Inger Kull, Eric Melén, Henriette A. Smit, Maties Torrent, Alet H. Wijga, Magnus Wickman, Claus Bachert, Karin C. Lødrup Carlsen, Kai-Håkon Carlsen, Carsten Bindslev-Jensen, Esben Eller, Ana Esplugue, Maria Pia Fantini, Isabella Annesi-Maesano, Isabelle Moma, Daniela Porta, Maria Vassilaki, Dagmar Waiblinger, Jordi Sunyer, Josep M. Antó, Jean Bousquet, Thomas Keil, and T. NIL

Subjects
Male, Parents, Questionnaires, Pediatrics, Allergy, SYMPTOMS, Asthma Allergy, humanos, CHILDHOOD, adolescente, CHILDREN, estudios de seguimiento, Cohort Studies, Surveys and Questionnaires, MeDALL, Allergies, Medicine and Health Sciences, Medicine, Immunology and Allergy, hipersensibilidad, estudios de cohortes, Child, ATOPIC DISEASES, Incidence (epidemiology), Incidence, General Medicine, 3. Good health, asma, Europe, Child, Preschool, Questionnaire assessment, GA(2)LEN, Cohort, Female, Birth cohort, POSITION PAPER, Cohort study, medicine.medical_specialty, Adolescent, European birth cohorts, Immunology, Harmonization, padres, VALIDATION, incidencia, Hypersensitivity, Humans, ddc:610, Asthma, business.industry, Asma -- Epidemiologia, CONSUMPTION, medicine.disease, Family medicine, Epidemiologia -- Europa, Position paper, business, Follow-Up Studies
Abstract

Background: Numerous birth cohorts have been initiated in the world over the past 30 years using heterogeneous methods to assess the incidence, course and risk factors of asthma and allergies. The aim of the present work is to provide the stepwise proceedings of the development and current version of the harmonized MeDALL-Core Questionnaire (MeDALL-CQ) used prospectively in 11 European birth cohorts. Methods: The harmonization of questions was accomplished in 4 steps: (i) collection of variables from 14 birth cohorts, (ii) consensus on questionnaire items, (iii) translation and back-translation of the harmonized English MeDALL-CQ into 8 other languages and (iv) implementation of the harmonized follow-up. Results: Three harmonized MeDALL-CQs (2 for parents of children aged 4-9 and 14-18,1 for adolescents aged 14-18) were developed and used for a harmonized follow-up assessment of 11 European birth cohorts on asthma and allergies with over 13,000 children. Condusions:The harmonized MeDALL follow-up produced more comparable data across different cohorts and countries in Europe and will offer the possibility to verify results of former cohort analyses. Thus, MeDALL can become the starting point to stringently plan, conduct and support future common asthma and allergy research initiatives in Europe., Mechanisms of the Development of Allergy (MeDALL) is funded by the European Union in the 7th Framework program, grant agreement No. 261357.

Published
2014

50. Born in Bradford’s Better Start: an experimental birth cohort study to evaluate the impact of early life interventions

Author

Dickerson, Josie, primary, Bird, Philippa K., additional, McEachan, Rosemary R. C., additional, Pickett, Kate E., additional, Waiblinger, Dagmar, additional, Uphoff, Eleonora, additional, Mason, Dan, additional, Bryant, Maria, additional, Bywater, Tracey, additional, Bowyer-Crane, Claudine, additional, Sahota, Pinki, additional, Small, Neil, additional, Howell, Michaela, additional, Thornton, Gill, additional, Astin, Melanie, additional, Lawlor, Debbie A., additional, and Wright, John, additional

Published
2016
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