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4. Correction: Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Author

Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Leal, Lucía, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Ørntoft, Torben F., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Vander Heiden, Matthew G., Albar, Juan Pablo, and Esteller, Manel

Published
2016
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7. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Author

Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Vander Heiden, Matthew G., Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Albar, Juan Pablo, Esteller, Manel, Leal, Lucia, Orntoft, Torben F., Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Vander Heiden, Matthew G., Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., Bramsem, Jesper B., Andersen, Claus L., Tabernero, Josep, McDermott, Ultan, Boxer, Matthew B., Albar, Juan Pablo, Esteller, Manel, Leal, Lucia, and Orntoft, Torben F.

Abstract

Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation. Here we demonstrate the presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3), a key gene in the endoplasmic reticulum-associated protein degradation pathway, in human tumours. The restoration of in vitro and in vivo DERL3 activity highlights the tumour suppressor features of the gene. Using the stable isotopic labelling of amino acids in cell culture workflow for differential proteome analysis, we identify SLC2A1 (glucose transporter 1, GLUT1) as a downstream target of DERL3. Most importantly, SLC2A1 overexpression mediated by DERL3 epigenetic loss contributes to the Warburg effect in the studied cells and pinpoints a subset of human tumours with greater vulnerability to drugs targeting glycolysis., Seventh Framework Programme (European Commission) (Grant HEALTH-F5-2010-258236-SYSCOL), Seventh Framework Programme (European Commission) (Grant HEALTH-F2-2011-259015-COLTHERES), Cellex Foundation, Olga Torres Foundation, European Research Council (EPINORC Project Grant Agreement 268626), Spain. Ministerio de Economia y Competividad (MINECO Project SAF2011-22803), Institute of Health Carlos III (RTICC Grant RD12/0036/0039)

Published
2015

8. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Author

Lopez-Serra, Paula, primary, Marcilla, Miguel, additional, Villanueva, Alberto, additional, Ramos-Fernandez, Antonio, additional, Palau, Anna, additional, Leal, Lucía, additional, Wahi, Jessica E., additional, Setien-Baranda, Fernando, additional, Szczesna, Karolina, additional, Moutinho, Catia, additional, Martinez-Cardus, Anna, additional, Heyn, Holger, additional, Sandoval, Juan, additional, Puertas, Sara, additional, Vidal, August, additional, Sanjuan, Xavier, additional, Martinez-Balibrea, Eva, additional, Viñals, Francesc, additional, Perales, Jose C., additional, Bramsem, Jesper B., additional, Ørntoft, Torben F., additional, Andersen, Claus L., additional, Tabernero, Josep, additional, McDermott, Ultan, additional, Boxer, Matthew B., additional, Heiden, Matthew G. Vander, additional, Albar, Juan Pablo, additional, and Esteller, Manel, additional

Published
2014
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10. Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.

Author

Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Ramos-Fernandez, Antonio, Palau, Anna, Leal, Lucía, Wahi, Jessica E., Setien-Baranda, Fernando, Szczesna, Karolina, Moutinho, Catia, Martinez-Cardus, Anna, Heyn, Holger, Sandoval, Juan, Puertas, Sara, Vidal, August, Sanjuan, Xavier, Martinez-Balibrea, Eva, Viñals, Francesc, Perales, Jose C., and Bramsem, Jesper B.

Published
2016
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