Search

Abstract The impact of environmental pollutants has been a focus of investigation in recent years. Studies assessing the effects of these pollutants are essential for understanding the challenges faced by non-target species. Among the many substances used for agricultural purposes, the herbicide glyphosate is one of the most widely marketed in recent years. This broad-spectrum herbicide is commonly used to protect a variety of crops. In this study, we evaluated the effects of chronic glyphosate exposure on a native amphibian species, Physalaemus gracilis. Amphibians, which develop in aquatic environments, are highly sensitive to pesticides. Because of this, we investigated morphological, physiological, behavioral, and biochemical parameters in the early stages of development. The animals were exposed to environmentally relevant concentrations of a glyphosate-based herbicide (0, 100, 350, and 700 µg L⁻¹) during their first seven days of life. As a result, we observed impairments in anti-predatory behavior, reduced body mass index, and scaled mass index, malformations of the mouth and intestine, increased acetylcholinesterase activity, cardiotoxicity, and oxidative stress. These findings underscore the importance of studying native non-target species and highlight the need to evaluate the effects of environmentally relevant concentrations, as well as to review legislation regarding permissible levels of glyphosate in surface water and public water supplies.

The rapid advancements in nanotechnology have spurred the search for more efficient materials across various advanced applications. To this end, this study aimed to synthesize and investigate the structural properties of copper ferrite and mixed copper-silver ferrite anchored onto reduced graphene oxide (rGO) sheets. Samples were synthesized via the hydrothermal method at four different temperature ranges for 6 h at pH 11. The systems were analyzed using Raman spectroscopy, X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM). XRD analysis revealed changes in the structural parameters of the ferrite, the presence of Fe2O3 and Ag, and confirmed the anchorage of submicron particles onto rGO, along with diversified morphologies. Both Raman spectroscopy and XRD confirmed the reduction of graphene oxide (GO) to rGO.

The plant adaptation response to a changing environment depends on the genetic diversity level it possesses. Genetic diversity and a thorough understanding of population indices are pivotal for decoding plant adaptation to dynamic environmental stressors. The development of polymerase chain reaction (PCR)-based molecular markers enables comprehensive population analyses and the precise detection of individuals and groups with unique genetic variations. Various molecular markers have been employed to assess genetic diversity, examine population structure, and delineate cluster patterns within and among populations. DNA markers revolutionize plant diversity studies by allowing detailed analyses of genetic variations, including economically significant trait-influencing genes. Despite their simplicity, they offer high reproducibility, ensuring accurate estimations of plant variation. Integrating multiple marker systems with advanced high-throughput sequencing techniques is poised to enhance the understanding and management of depleting plant genetic resources by providing a comprehensive picture of diversity at the genome-wide level. This review explores diverse molecular markers, elucidating their advantages and limitations, and highlights their impact on evaluating the genetic diversity and population structure of plants.

Successful participation in Proficiency Testing/Interlaboratory Comparison (PT/ILC) schemes is a method to ensure validity of results for any laboratory. It is also a component of a complex of means for demonstrating technical competence of a laboratory as an organization. The new accreditation standard ISO 17043 for PT providers together with the newly updated ILAC Policy of PT participation introduce a different perspective on the activity of PT provider in regard to quality assurance.

The objective of the present study was to evaluate the performance of broiler chickens fed a diet containing deactivated soy supplemented with the enzyme β-mannanase. A total of 1,152 broiler chickens, one day old and from the COOB 500 lineage, were used in a completely randomized design with a 4x2 factorial scheme. Four levels of β-mannanase (0, 80, 160, and 240 g ton-1) and the presence or absence of deactivated soy were tested, with eight repetitions, each with 18 birds per experimental unit. On the 1st, 7th, 14th, 21st, 28th, 35th, and 42nd days of life, the birds were weighed, and the feed leftovers were measured to obtain performance variables. From days 1 to 21, weight gain, feed conversion, and average weight were significantly affected by the addition of β-mannanase to the diet. The use of deactivated soy in combination with enzyme levels in mg kg-1 of metabolizable energy resulted in greater gains than did the use of soybean meal combined with the same levels of metabolizable energy. The use of deactivated soy along with 240 mg of β-mannanase enzyme supplementation in broiler diets from 1--42 days of age is recommended, as this supplementation improves bird performance.

This study evaluated the prevalence of temporomandibular disorders (TMD) in dental students and its association with psychosocial factors (general health, quality of life and anxiety). Sixty students were initially selected and analyzed for TMD presence by the Diagnostic Criteria for TMD (DC/TMD). The participants answered self-administered questionnaires to assess general health (General Health Questionnaire – GHQ), quality of life (World Health Organization Quality of Life – WHOQOL-brief), and anxiety (State-Trait Anxiety Inventory – STAI). The prevalence of TMD among the participants was 43.33% (n = 26), 26% (n = 16) were diagnosed with painful disorders, being myalgia the most prevalent diagnosis (21.67%; n = 13). About 16.67% (n = 10) of the participants presented disc displacement with reduction. All indicators of general health showed statistically significant difference such as psychological stress (p = 0.004), death wish (p = 0.006), distrust in performance (p < 0.001), sleep disturbance (p = 0.025), psychosomatic disorder (p < 0.001), and general health (p = 0.003). Quality of life was associated with the presence of painful disorder in the physical (p = 0.001), psychological (p = 0.003) and general (p = 0.015) dimensions. The state of anxiety (STAI-S) showed statistically significant difference (p = 0.042). In conclusion, painful muscle disorder was the most prevalent TMD subtype in dental students and several psychosocial factors are important indicators of TMD presence.

IntroductionThe One Health concept has proposed an integrated and unified approach aiming for health balance and enhancement by recognizing the interdependence of human, animal, and environmental health. The COVID-19 pandemic has pushed global One Health initiatives and policy improvement toward preventive measures for future pandemics, particularly of zoonotic origin. Such a scenario may be particularly relevant for South America, which is considered highly vulnerable due to its natural biodiversity superposed to socioeconomic and environmental issues, demanding effective methods and indicators for proper One Health strategies and goals that are aligned with macroregional contexts.MethodsAccordingly, the present study aimed to assess the One Health Index (OHI) in South American countries, along with potential interactions with socioeconomic indicators. The results obtained using clustering analysis and permutational multivariate analysis of variance (PERMANOVA) have revealed a positive association between the OHI and the Human Development Index (HDI) but not with gross domestic product (GDP).ResultsAlthough South American countries with political stability, robust investment in health, and progressive policies have shown a higher OHI, better environmental health is not associated with better human and animal health. In addition, although the Amazon biome— spanning 9 of the 12 South American countries—has positively impacted environmental health, this benefit contrasts with the rudimentary local human health systems, highlighting the complexity of One Health within the South American context. The lack of stronger indicators for animal health was also considered an important weak point for a true OHI assessment. Nonetheless, countries with more developed livestock have presented better animal health, which may not reflect an overall animal health indicator, as companion and wildlife animal health indicators were not available.DiscussionAlthough lower (within-country) scale analysis such as states and metropolitan areas may better shape internal differences, the study herein has clearly shown One Health inequalities and challenges among South American countries. Equally important, forests and other natural areas in developing countries, particularly the Amazon, should receive incentives to promote sustainable economic growth. This approach would help prevent sacrificing environmental health for the benefit of human and livestock animal health.

Climate change and biodiversity conservation are two of the most urgent challenges of the twenty-first century. Current global climate models indicate that climate-related events will continue to increase in frequency and intensity, leading to severe impacts on ecosystems, particularly plant diversity. Despite the 2015 Paris Agreement, efforts to limit global warming to 1.5 degrees Celsius and secure adequate climate financing remain unsatisfactory. In addition, the National Biodiversity Strategic Action Plans (NBSAPs), a core mechanism of the Convention on Biological Diversity (CBD), have faced issues in implementation at the national level. Many NBSAPs lack clear and measurable biodiversity targets, which limits their effectiveness. This review presents a comprehensive analysis of these urgent issues, highlighting the significant challenges and deficiencies in current climate and biodiversity conservation policies. It evaluates the effectiveness of the Kew conservation strategy as a model for protecting and conserving plant diversity. Furthermore, this review underscores the pivotal role of plant tissue culture (PTC) technology in achieving plant conservation targets within the post-2020 global biodiversity framework. This review strongly supports the post-2020 global biodiversity framework and the integration of PTC into global plant conservation strategies to meet the ambitious 30-by-30 targets. This review also advocates for the establishment of the Kew-Wide Mechanism (KWM) to bolster climate resilience, reduce anthropogenic impacts on plant diversity, revitalize global conservation efforts, and accelerate ecosystem restoration in the face of ongoing climate change. Proposed as a comprehensive approach to plant conservation, the KWM offers a strategic, innovative, and scalable solution as the global economy transitions toward decarbonization.

Abstract In the last decades, dengue has become one of the most widespread mosquito-borne arboviruses in the world, with an increasing incidence in tropical and temperate regions. The mosquito Aedes aegypti is the dengue primary vector and is more abundant in highly urbanized areas. Traditional vector control methods have showing limited efficacy in sustaining mosquito population at low levels to prevent dengue virus outbreaks. Considering disease transmission is not evenly distributed in the territory, one perspective to enhance vector control efficacy relies on identifying the areas that concentrate arbovirus transmission within an endemic city, i.e., the hotspots. Herein, we used a 13-month timescale during the SARS-Cov-2 pandemic and its forced reduction in human mobility and social isolation to investigate the spatiotemporal association between dengue transmission in children and entomological indexes based on adult Ae. aegypti trapping. Dengue cases and the indexes Trap Positive Index (TPI) and Adult Density Index (ADI) varied seasonally, as expected: more than 51% of cases were notified on the first 2 months of the study, and higher infestation was observed in warmer months. The Moran's Eigenvector Maps (MEM) and Generalized Linear Models (GLM) revealed a strong large-scale spatial structuring in the positive dengue cases, with an unexpected negative correlation between dengue transmission and ADI. Overall, the global model and the purely spatial model presented a better fit to data. Our results show high spatial structure and low correlation between entomological and epidemiological data in Foz do Iguaçu dengue transmission dynamics, suggesting the role of human mobility might be overestimated and that other factors not evaluated herein could be playing a significant role in governing dengue transmission.

IntroductionAlthough estimate models have been proposed to determine free-roaming (both stray and semi-domiciled) dog populations, to date, no study has focused on the three major border areas of Brazil. Therefore, the present study assessed the free-roaming dog population of Foz do Iguaçu, a major far-west Brazilian city located in a three-border area (Brazil, Argentina, and Paraguay), which is considered among the top five Brazilian tourist destinations.MethodsCapture-release sampling was performed in three phases with a 6-month interval and 10-day duration of each phase, totaling 18 months, between 2018 and 2019.ResultsA total of 1,273 dogs were estimated in the first [95% confidence interval (CI), 468–2,078 dogs], 904 in the second (95%CI, 452–1,355 dogs), and 1,564 in the third (95%CI, 521–2,607 dogs) capture phases in this area, suggesting a population density of 18.4 dogs/km2 (6.1–30.6 dogs/km2, 95% CI). Of all free-roaming dogs, 452/1,125 (40.2%) were stray with no confirmed ownership or household, whereas 672/1,125 (59.8%) had a known origin, among which 625/1,125 (55.6%) were semi-domiciled with ownership or a household, 36/1,125 (3.2%) were neighborhood dogs with maintainers, and 11/1,125 (1.0%) were owned by recycling material collectors and homeless individuals. The majority of the 1,125 dogs (862/1,125; 76.6%) had an ideal body condition score. The high outdoor access of owned dogs is likely caused by cultural behavior. However, because 533/1,125 (47.4%) of the free-roaming dogs presented with clinical abnormalities, irresponsible ownership may have negatively impacted dog health and welfare.DiscussionThis study was the first to establish the density of free-roaming dogs, the ratio of stray and semi-domiciled dogs, and their dynamics over time in Foz do Iguaçu. The findings may serve as a warning for the high level of dog outdoor access and irresponsible guardianship, which may negatively affect animal health and welfare, leading to diseases, accidents, trauma, and animal cruelty.

ABSTRACT Introduction: retransplantation is the only viable treatment for patients with irreversible graft loss. The objective of this study was to analyze the indications and outcomes of liver retransplantation in three medical centers. Methods: a total of 66 patients who underwent liver retransplantation from September 1991 to December 2021 were included in the study. A retrospective analysis was performed evaluating patients demographic, clinical, primary diagnosis, indications for and time interval to retransplantation, complications and patient survival. Results: from a total of 1293 primary liver transplants performed, 70 required one or more liver retransplant. The main indication for primary transplant was hepatitis C cirrhosis (21,2%). Hepatic artery thrombosis was the main cause of retransplantation (60,6%), with almost half (46,9%) of retransplants having occurred within 30 days from initial procedure. The average survival time after a repeat liver transplant, was 89,1 months, with confidence interval from 54 to 124,2. The 1-,5- and 10- year survival rate following liver retransplant were 48,4%, 38% and 30,1%, respectively. Male gender, primary non function as the cause for retransplant, prolonged operative time and higher MELD were associated with higher mortality. Conclusions: operative mortality and morbidity rates of liver retransplantation are higher than those of the first transplantation. Male gender, primary non function, prolonged operative time and higher MELD were associated with less favorable outcomes.

IntroductionLynch syndrome (LS) is an inherited cancer predisposition syndrome characterized by a high risk of colorectal and extracolonic tumors. Germline pathogenic variants (GPV) in the PMS2 gene are associated with

This article aims to promote reflections on the intertextual elements that dialogue thematically and influence the construction of the fictional project of the short story “Zaíta forgot to save the toys” by the author Conceição Evaristo, coming from the news genre. To do so, we use the analysis of the short story in dialogue with the theme evidenced in newspaper reports circumscribed to events caused by stray bullets. Through a qualitative approach and theoretical-analytical-comparative methodology, the objective is to propose a model of reading about the intertextual relationship between the news and the literary tale, considering their converging aspects (unit, means of origin) and divergent in which refers to the order, objectivity and language used in the way of portraying reality and discussing, through dialogue between textual genres the aspects that mobilized writing aimed at the childish universe and innocence in the violent context of the periphery.

Saffron (Crocus sativus L.) is a valuable geophyte plant and one of the most expensive spices in the world. Recently, the demand for saffron spice has increased in worldwide markets owing to its enormous application and value. However, the production of saffron is limited by the vegetative propagation technique and the limited number of high-quality corms planted. Furthermore, climatic changes, notably increasing temperatures, negatively influence saffron multiplication and growth. Thus, it is important to develop alternative cultivation and propagation techniques for saffron under a controlled environment, which could ensure an increase in saffron yield and avoid the negative impact of climatic changes. The present study aimed to develop an alternative method for vegetative propagation of Crocus sativus under controlled conditions. The effect of different cross-cuttings, including basal cuttings (BCs) and top-to-bottom cuttings (CTBs), was evaluated on shoot, leaf, flower, and daughter corm production. All the growth parameters examined were influenced by the cutting treatment applied. The results showed that the highest number of shoots formed was obtained by BCs and CTBs, with an average of 6.68 and 5.47 shoots per corm, respectively, compared to the control with an average of 2.70 shoots per corm. The cutting treatment positively affected the formation of daughter corms in which, the high mean number of corms recorded was obtained by the BC treatment. Meanwhile, the lower size of the daughter corms was obtained after the cross-cutting treatment. This is the first report that provides an alternative propagation for saffron using a controlled environment, which could help to improve the production of saffron.

EFFECT OF LIQUID SWINE WASTEWATER DOSES ON PHYSICAL, CHEMICAL AND ELECTROCHEMICAL ATTRIBUTES IN A CERRADO OXISOL. The addition of organic residues enhances soil and plant organic matter and nutrient content. To gauge the impact of varying liquid swine waste (LSW) levels on soil, we studied changes in a clayey Oxisol’s physical, chemical, and electrochemical traits from the Cerrado. LSW doses (0, 50, 150, 450, 600 m3 ha−1) were applied to the 0-0.20 m layer in a randomized design with three replicates. Post a 30-day incubation at 60% field capacity, the soil underwent mineralogical, physical (clay dispersed in water - CDW), chemical (sodium adsorption ratio - SAR, cation exchange capacity - CEC, base saturation - V%), and electrochemical (pH in H2O and KCl, ApH, point of zero charge - PZC, point of zero salt effect - PZSE, surface electric potential - iµo, and electrical conductivity - EC) analyses. The levels of exchangeable Ca, K, Mg, Na, and available P increased with increasing LSW doses. Increasing LSW doses in the soil led to an increase in EC, but soil salinization was not observed at the highest dose. With the application of LSW doses, there was a decrease in pH, ApH, PZSE, and an increase in CEC, PZC and ψo. Despite the increase in ψo, low clay dispersibility was observed.

Estudo, realizado como parte do curso de mestrado em Geografia na Universidade do Estado de Mato Grosso, com objetivo de analisar a fragilidade ambiental do córrego Lava-pés em Cáceres, Mato Grosso. A aplicação do Protocolo de Avaliação Rápida (PAR) em quatro segmentos do córrego foi conduzida com o acompanhamento do Professor Doutor Gustavo Roberto dos Santos Leandro. Registramos imagens para complementar a análise. Ao finalizar o PAR, consolidamos os dados e preenchemos a Escala de Qualidade Ambiental. A experiência evidenciou a falta de consciência ambiental, destacando as consequências negativas da negligência humana. O trabalho ressalta a necessidade urgente de ações responsáveis para preservar o meio ambiente. Os resultados obtidos são apresentados de forma acadêmica, reforçando a importância da conscientização e conservação ambiental.

IntroductionGloriosa superba L. is an endangered ornamental plant of significant medicinal, commercial, and cultural value. This study establishes an efficient protocol for rapid in vitro propagation of this plant species through callus-mediated organogenesis using non-dormant corm explants.MethodsPlant tissue culture techniques were employed to facilitate the in vitro regeneration process of Gloriosa superba L. This encompassed various stages, including the acquisition of plant material, surface sterilization, formulation of growth media, and the execution of callogenesis, shooting, rooting, and acclimatization experiments.Results and DiscussionInvestigation into the impact of plant growth regulators on callogenesis unveiled diverse callus morphologies, dependent on regulator type and concentration, with the NAA and KN combination emerging as the most effective for callus induction. Specifically, the callus induction medium supplemented with 1.5 mg L−1 NAA, 0.5 mg L−1 KN, and 10 mg L−1 casein hydrolysate (CH) achieved remarkable results, boasting an 81.25% callus induction rate and a substantial callus biomass fresh weight of 333 mg. Furthermore, the combination of BAP and NAA facilitated optimal shoot primordia induction and shooting in callus derived from non-dormant corm explants. The shoot induction medium, enriched with 2.0 mg L−1 BAP, 0.5 mg L−1 NAA, 5 mg L−1 CH, and 20% (v/v) coconut water (CW), resulted in an impressive 83.33% shoot primordia formation rate and an average of 6.86 shoot primordia per callus. For root induction, the medium supplemented with 1.0 mg L−1 IBA displayed a high root induction rate of 81.25% and robust rooting (+++). Successful acclimatization of in vitro plantlets in controlled environments and shade net houses culminated in thriving growth, and upon transplantation into a garden soil blend (garden soil : sand : vermiculite, 2:1:1, v/v), with direct sunlight exposure, the plantlets demonstrated commendable development and form, boasting a 69% survival rate at the seven-week mark. These findings offer a robust foundation for scalable and sustainable propagation strategies, ensuring the conservation and utilization of this valuable species.

ABSTRACT Background: Lactose tolerant test (LTT) is the most broadly used diagnostic test for lactose intolerance in Brazil, is an indirect, minimally invasive and a low-cost test that is widely available in primary care and useful in clinical practice. The C/T-13910 polymorphism in lactase persistence has been well characterized in Caucasian populations, but there are no studies evaluating the concordance between C/T-13910 polymorphism genotyping results and LTT results in Brazil, where the population is highly mixed. Objective: We aimed to evaluate agreement between presence of C/T-13910 polymorphism genotyping and malabsorption in LTT results. Methods: This is a retrospective analysis of a Brazilian population whose data were collected from a single laboratory database present in several Brazilian states. Results of individuals who underwent both genetic testing for lactose intolerance (C/T-13910 polymorphism genotyping) and an LTT from April 2016 until February 2019 were analysed to evaluate agreement between tests. Groups were classified according to age (

One Health (OH) is an integrative approach to human, animal, and environmental health and can be used as a comprehensive indicator for comparative purposes. Although an OH index has been proposed for comparing cities, states, and countries, to date, no practical study has compared countries using this approach. Accordingly, this study aimed to assess OH initiatives using a survey with a veterinary public health focus. The questionnaire contained 104 quantitative questions and was sent to representatives of governmental institutions of 32 countries in the Americas. After exclusion criteria were considered, a total of 35 questionnaires from 17 countries were analyzed, with country names remaining undisclosed during the statistical analyses to protect potentially sensitive information. Principal component analysis (PCA) of health parameters in Latin America and the Caribbean (LAC) as a function of country perception (self-vector) showed that food safety was ranked higher than public policies (p = 0.009), and that both (p = 0.003) were ranked higher than institutional routines related to zoonosis programs. National policies in accordance with international standards, regulations, recommendations, and guidelines was considered the standout topic for public policy, with higher-ranking topics including standard. Meanwhile, challenging topics included tools, preparedness, governance, and research. Food safety showed both strengths and challenges in the coordination of its activities with other sectors. Food safety communication was scored as a strength, while foodborne diseases prevention was ranked as a challenge. Institutional routines for zoonosis maintained both strong and challenging topics in the execution and implementation of attributions and daily routine. Thus, the survey showed that topics such as access to and compliance with international guidelines and intercountry integration were ranked higher than in-country articulation, particularly among food safety, zoonoses, and environmental institutions.

In 2018, an outbreak of human rabies caused by the hematophagous bat Desmodus rotundus hit the Brazilian Amazon Basin community of Melgaço, Brazil, resulting in the death of 10 people, 9 of them children. The incidence of rabies has been on the rise among populations in conditions of vulnerability in this ecosystem due to human expansion into sylvatic environments and limited access to public health services. To address this issue, in September 2019, a collaborative effort from national, local, and international institutions promoted and executed a pilot for pre-exposure prophylaxis of a population in high-risk areas for hematophagous bat-mediated rabies. This measure is usually only implemented in response to outbreaks. The pilot was conducted in Portel, in a nearby location to the previous outbreak, with the use of fluvial transportation, and 2987 individuals in 411 dwellings were successfully vaccinated. It established a methodology for pre-exposure prophylaxis for populations in conditions of vulnerability, identifying logistics and costs, as well as characterizing the target riverine population regarding risk factors associated with bites by hematophagous bats. This approach offers a proactive measure to prevent future outbreaks and provides valuable insights into how to address the issue of rabies in remote and difficult-to-reach areas.

Industry 5.0 (I5.0) represents a shift towards a human-centered industry and emphasizes the integration of human and machine capabilities. A highly compatible concept for enabling the I5.0 implementation is intelligent spaces (ISs), i.e., physical spaces equipped with a network of sensors, which obtains information about the place it observes, and a network of actuators, which enables changes in the environment through computing services. These spaces can sense, interpret, recognize user behavior, adapt to preferences, and provide natural interactions between humans and intelligent systems, using the IoT, AI, computer vision, data analytics, etc., to create dynamic and adaptive environments in real time. The integration of ISs and I5.0 has paved the way for the development of cognitive factories, which transform industrial environments into ISs. In this context, this article explores the convergence of IS and I5.0 concepts and aims to provide insights into the technical implementation challenges of cognitive factories. It discusses the development and implementation of a laboratory replica of a cognitive cell as an example of a segment of a cognitive factory. By analyzing the key points and challenges associated with cognitive cell implementation, this article contributes to the knowledge base surrounding the advanced manufacturing paradigm of I5.0.

One of the causes of the failure of dental implants is bone loss due to bacterial infiltration. To minimize this problem, biofilm adhesion on the abutments must be avoided to improve soft tissue sealing. The present work aimed the functionalization of titanium abutment surface with antimicrobials graphene oxide and copper oxide. The samples were divided into 4 groups: G1 (Cu2O coating); G2 (GO coating); G3 (GO + Cu2O coating) and G4 (no coating). They were characterized by Scanning Electron Microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, roughness, and wettability. Bacterial viability on the abutment surface was also investigated using a qualitative live/dead assay. After surface functionalization, all groups had adequate roughness values for soft tissue sealing, less than 0,4 μm. G1 samples had the lowest wettability (2.16 ± 6.23 mJ/m2). The surface of G2 samples had the largest number of dead bacteria (226.334 AU/42.38%). The roughness of G3 (0.094 ± 0.018 μm) had the most similarity to that of natural teeth (0.099 μm). G4 samples had the highest wettability (38.57 ± 10.51 mJ/m2) and allowed the greatest adherence of S. mutans strains (399.056 AU/32.10%).

Abstract The use of terpenoid compounds in different neural-related conditions is becoming useful for several illnesses. Another possible activity of these compounds is the reduction of nervous impairment. Cannabis sativa plants are known for their concentration of two important terpenoids, the delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD and THC have central peripheral activities already described and their usage in different brain diseases, such as Alzheimer's and multiple sclerosis. Aluminum (Al) is known as an important neurotoxic compound, the physiological action of Al is not known already, and in high concentrations can lead to intoxication and cause neurotoxicity. Here we evaluated the potential effect of two different doses of CBD- and THC-rich based oils against Al-induced toxicity, in the zebrafish model. We evaluated behavioral biomarkers of the novel tank test (NTT) and social preference test (SPT), and biochemical markers: the activity of the enzyme acetylcholinesterase (AChE) and the antioxidant enzymes—catalase, superoxide dismutase, and glutathione-S-transferase. CBD- and THC-based oils were able to increase the AChE activity helping the cholinergic nervous system actuate against Al toxicity which was reflected by the behavioral biomarkers changes. We concluded that the oils have a protective effect and might be used with proposals for neurological and antioxidant impairment avoidance caused by Al intoxications.

Estudos de precipitação máxima têm destaque em projetos de Engenharia, vistas as perdas que suas consequências podem gerar. Instalações prediais de água pluvial captam e conduzem a água incidente na edificação à rede de drenagem. A chuva de projeto é um parâmetro de dimensionamento da instalação predial, e para obtenção de sua intensidade a NBR 10844/1989 sugere uso de dados locais de chuva; quando não há dados, a norma indica a adoção de 150 mm/h para áreas de projeção horizontal menor que 100 m². Então, o estudo estimou valores locais de intensidade de chuva a partir da distribuição Generalizada de Valores Extremos (GEV) e Momentos-LH. Foram estudados 64 postos pluviométricos da região Oeste do Paraná e seus quantis com Tr de 1, 5 e 25 anos. A desagregação de chuvas foi aplicada para obter a intensidade da chuva de duração de 5 minutos. Verificou-se que para Tr de 1 ano os valores estão abaixo de 150 mm/h, enquanto, para os demais, a maioria é superior à referência. Por fim, os resultados foram espacializados em mapas gerados pela Krigagem Ordinária.

O texto em pauta procura delinear o cenário sociolinguístico da região sul da Bahia, que teria se caracterizado pelo multilinguismo, consequência da estagnação econômica da região, fato que teria gerado menos conflitos entre portugueses e índios, preservando os falantes das línguas locais. A alteração nesse quadro ocorreria a partir da década de 1820, com o crescimento da lavoura cacaueira, iniciada na região em 1746. Paralelamente a esse cenário, temos outro distinto: a fundação de três colônias suíço-alemãs, que teriam apresentado um contexto de transmissão linguística irregular do português L2 de alemães e suíços a africanos aloglotas escravizados. E, perpassando todo o texto, argumentamos que a compreensão dessas situações sociolinguísticas diferenciadas numa mesma região foi possível porque adotamos um olhar amplo que considerou as relações históricas transnacionais dentro das quais estava imerso o sul da Bahia, pois, sem isso, não seria possível compreender como se deu o desencadear dessas situações sociolinguísticas.

We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that we named Tietê mammarenavirus. Our results suggest that bats are an underrecognized arenavirus reservoir.

The present work focuses on a case study applying a maintenance management system model based on the degree of maturity in a thermoplastic industry. The system must support the decisions of the organization and promote progress in the company's continuous improvement system. The study was based on the answers to a questionnaire submitted to the maintenance, production, and process engineering sectors. The internal perception was compared with external perception in order to perform an analysis of the field of view of the three sectors on the current position of the maintenance sector in relation to the maintenance maturity model used for this analysis. From the application of the model, it was possible to develop a strategic action plan based on lean practices, so that the maintenance areas advance towards the higher levels of the maturity scale, aiming to reach and maintain performance levels recognized as excellence.

Despite biological invasions being widely recognised as an important driver of environmental change, lack of consensus regarding the definition of invasive alien species (IAS) and vagueness around the demonstration of their impacts limits knowledge and research in this field. In this study, a scientometric approach was used to analyse academic documents published between 2002 and 2021 in three databases with reference to invasive alien plants in Brazil. Despite the growing body of scientific literature in the area, only 10% of the publications provided some definition of invasive species. Of the 398 publications analysed, 23.6% found some type of damage caused by the invader and, of these, only 5% addressed economic or social damage. Only 17% of the publications proposed a method for controlling and/or mitigating biological invasions. The absence of clear terminology and the lack of focus on impacts limits understanding of IAS of plants in Brazil. Based on the present findings, future studies on IAS of plants should move towards a consensus on the definition of biological invasion, as well as understand the impact caused by these species. In addition, it is recommended that further scientometric studies should guide future efforts to support objective measures for management and decision-making.

As interações sociais e espaciais manifestadas no espaço podem ser vistas como heranças de tempos rápidos e lentos. Nesse sentido, a constituição da centralidade da cidade de Ceres implementada no território goiano a partir da institucionalização da Colônia Agrícola Nacional de Goiás, ganhou destaque regional. Com o avanço e a diversificação do setor terciário da economia, a cidade projetou-se como um polo regional na oferta de serviços relacionados aos setor de saúde, desempenhando funções importantes no território goiano, tornando-se, simultaneamente, centro e centralidade por meio da inserção de objetos técnicos e equipamentos urbanos que possibilitaram a constituição de uma rede urbana mais integrada e capaz de proporcionar um movimento centrípeto dos munícipios do entorno em busca dos serviços ofertados. Nessa perspectiva, é importante analisar o sistema urbano e o grau de polarização que este sistema exerce no território, pois a região é uma forma de ver o espaço em diferentes perspectivas. Destarte, pretende-se com base em referenciais teóricos e pesquisa empírica, tecer considerações acerca da centralidade, polarização e desenvolvimento regional exercido pela cidade de Ceres e compreender a interdependência e importância funcional estabelecida entre os municípios que recorrem aos serviços de saúde ofertados na cidade.

Introduction: The term female genital surgery encompasses several techniques to improve the female vulvar area, both aesthetically and functionally. Feelings of emotional distress are common in women who seek such surgeries, significantly impacting their self-esteem, sexuality, hygiene and vulvar functionality. The objective is to To evaluate the interest of women assisted in a Women Care Center in intimate surgery. Methods: Observational study carried out at the Women Care Center (CAM) in Rio do Sul-SC. For data collection, a semi-structured questionnaire developed by the authors was used. Data were processed and grouped in Microsoft Excel, and descriptive data analysis was performed using the Statistical Package for Social Sciences (SPSS) program. Results: The findings indicated a great general interest in performing intimate aesthetic surgeries. Of the 100 women interviewed, 32 were interested in performing some intimate aesthetic surgery. Conclusion: Due to the importance given to intimate cosmetics in physical, psychosocial, sexual and everyday interference, with a major impact on the quality of life of these people, adequate resources must be allocated to a greater supply of such procedures in the Unified Health System for the population of Brazil.

Introdução: O termo cirurgia genital feminina engloba várias técnicas com o objetivo de melhorar a área vulvar feminina estética e funcionalmente. Sentimentos de sofrimento emocional são comuns nas mulheres que buscam tais cirurgias, impactando significativamente em sua autoestima, sexualidade, higiene e funcionalidade vulvar. O objetivo é avaliar Avaliar o interesse das mulheres assistidas em um Centro de Atenção à Mulher em cirurgias íntimas. Métodos: Estudo observacional transversal ocorrido no Centro de Atenção à Mulher (CAM) de Rio do Sul-SC. Para coleta dos dados, foi utilizado um questionário semiestruturado elaborado pelos autores. Os dados foram tratados e agrupados no programa Microsoft Excel e realizadas as análises descritivas dos dados utilizando o programa Statistical Package for the Social Sciences (SPSS). Resultados: Os achados indicaram que houve um grande interesse geral na realização de cirurgias de estética íntima. Das 100 mulheres entrevistadas, 32 apresentavam interesse em realizar algum tipo de cirurgia de estética íntima. Conclusão: Devido à importância dada à estética íntima na interferência física, psicossocial, sexual e cotidiana, com importante impacto na qualidade de vida dessas pessoas, é imperativo que recursos adequados sejam alocados para maior fornecimento de tais procedimentos no Sistema Único de Saúde para a população do Brasil.

Abstract Substances from the Cannabis sativa species, especially cannabidiol (CBD) and Delta-9-tetrahydrocannabinol (Δ9-THC), have attracted medical attention in recent years. The actions of these two main cannabinoids modulate the cholinergic nervous system (CholNS) involving development, synaptic plasticity, and response to endogenous and environmental damage, as a characteristic of many neurodegenerative diseases. The dynamics of these diseases are mediated by specific neurotransmitters, such as the GABAergic nervous system (GNS) and the CholNS. The nematode Caenorhabditis elegans is an important experimental model, which has different neurotransmitter systems that coordinate its behavior and has a transgene strain that encodes the human β-amyloid 1–42 peptide in body wall muscle, one of the main proteins involved in Alzheimer´s disease. Therefore, the objective of this study was to evaluate the protective potential of terpenoids found in C. sativa in the GNS and CholNS of C. elegans. The effect of two C. sativa oils with variations in CBD and THC concentrations on acetylcholinesterase (AChE) activity, lipid peroxidation, and behavior of C. elegans was evaluated. C. sativa oils were efficient in increasing pharyngeal pumping rate and reducing defecation cycle, AChE activity, and ROS levels in N2 strains. In the muscle:Abeta1-42 strain, mainly when using CBD oil, worm movement, body bends, and pharyngeal pumping were increased, with a reduced AChE activity. Consequently, greater investments in scientific research are needed, in addition to breaking the taboo on the use of the C. sativa plant as an alternative for medicinal use, especially in neurodegenerative diseases, which have already shown positive initial results.

The increased demand for food worldwide, the reduced land availability for livestock production, the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more efficient. To tackle this problem, we propose the use of computational support to help researchers compare data on feed efficiency, therefore improving economic and environmental gains. As a solution, we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency indices. The proposed architecture, called FeedEfficiencyService, classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference engines. The results obtained from a case study with researchers from the Brazilian Agricultural Research Corporation – Dairy Cattle (EMBRAPA) demonstrate that this architecture is a supporting tool in their daily work routine. The researchers highlighted the importance of the proposed architecture as it allows analyzing animal data, comparing experiments, having reliable data analyses, and standardizing and organizing data from experiments. The novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related experiments. We store such data, relationships, and analyses of results in an integrated repository. This solution ensures unified access to the processing history and data from diverse experiments, including those conducted at external research centers.

Tendo como premissa a importância da otimização da cadeia de valor e introdução do pensamento enxuto nas empresas, este trabalho foca em responder a seguinte questão de pesquisa: seria possível identificar possíveis pontos de melhorias até mesmo numa empresa cafeeira que já utiliza como sistema de produção o Make to Order (MTO), por meio da aplicação da ferramenta MFV? Para isso adotou-se como objetivo geral a aplicação da ferramenta de mapeamento do fluxo de valor (MFV) caracterizando o Takt Time como parâmetro de performance numa empresa do setor cafeeiro, e em específico, buscou-se identificar as principais métricas pela ferramenta Takt Time com o fim de avaliar sua relevância no planejamento da produção. Como metodologia, esta pesquisa caracteriza-se como exploratória-quantitativa e se baseia em duas vertentes, na primeira, a revisão de literatura e na segunda, a aplicação de estudo de caso numa empresa que adota como estratégia o sistema de fabricação Make to Order (MTO). Como resultado, por meio da análise do MFV atual e do takt time, foi possível desenvolver um Novo MFV que se traduziu em ganhos efetivos para empresa e no aumento de eficiência de sua linha de produção, com redução do tempo de ciclo médio em 15%

Owing to sustainable characteristics, natural lignocellulosic fibers (FNLs) and graphene nanoplatelets (GNP)-reinforced composites are currently seeing applications in a wide range of industrial fields. Thus, in the present work, the mechanical, and flexural properties of high-density polyethylene (HDPE) reinforced with 0, 0.10, 0.25, and 0.50 wt.% of GNP combined with 50 vol.% of Juta fabric were investigated. In particular, the Juta/HDPE/0.25%GNP composite outperformed the strength of those described in the literature, even some with higher GNP. Enhancements of 38% were observed for the composite’s flexural modulus as compared to the GNP-free Juta/HDPE composite. Regarding the tensile properties, the ductility of the Juta/HDPE/0.25%GNP was increased by 112% when compared to the Juta/HDPE. Moreover, the toughness of the Juta/HDPE/0.25%GNP was 161% superior to the Juta/HDPE composite. SEM analysis of the fracture surfaces showed that, as GNP concentration rises, the fracture mechanisms change from shear band to a complex mixture of fibrillation, tearing, and crazing. Consequently, the results reveal the novel Juta/HDPE/0.25%GNP nanocomposite as a promising material for engineering applications.

Although Toxoplasma gondii exposure has been reported in indigenous populations worldwide, a One Health approach has not been applied to date. This study concurrently assessed T. gondii exposure in indigenous populations, and their dogs, environment, and indigenous or non-indigenous healthcare professionals (HPs). Human and dog serum samples from 9 indigenous communities in Brazil were assessed by indirect immunofluorescence antibody test for anti-T. gondii antibodies. Soil samples (30 per community) were processed with PCR to amplify T. gondii DNA. Associated risk factors and seroprevalence were analyzed using logistic regression models. Human seropositivity and type of water source were assessed by generalized linear mixed model (GLMM) with binomial error distribution, and game meat consumption with chi-squared test. Overall, 225/463 (49%) indigenous persons were seropositive for anti-T. gondii antibodies. Of all the HPs, 67/168 (40%) were positive, and included 54/147 (37%) positive non-indigenous HPs. Indigenous persons more likely to be seropositive compared with non-indigenous HPs (OR: 1.63; 95% CI: 1.11–2.39). A total of 97/253 (38%) dogs were seropositive and highly associated with seropositive owners (p

It is already known that light quality and intensity have major influences on the growth, etiolation, germination, and morphology of many plant species, but there is limited information about the effect of wavelength and light intensity on nutrient absorption by plants. Therefore, this study was established to evaluate the plant growth, stomata formation, chlorophyll index, and absorption of macro- and micronutrients by common bean plants under six light treatments. The experimental design was completely randomized and consisted of six treatments: strong blue (blue LED at high light intensity); weak blue (blue LED at low light intensity); strong red (red LED at high light intensity); weak red (red LED at low light intensity; pink (combined red + blue LED), and white (combined red + white led). The stomatal density (stomata mm−2); the SPAD index; plant height (cm); root length (cm); plant dry weight (g); root dry weight (g); and the concentrations of N, S, K, Mg, Ca, B, Zn, Mn, and Fe on leaf analysis were influenced by all treatments. We found that plant photomorphogenesis is controlled not only by the wavelength, but also by the light intensity. Etiolation was observed in bean plants under blue light at low intensity, but when the same wavelength had more intensity, the etiolation did not happen, and the plant height was the same as plants under multichromatic lights (pink and white light). The smallest plants showed the largest roots, some of the highest chlorophyll contents, and some of the highest stomatal densities, and consequently, the highest dry weight, under white LED, showing that the multichromatic light at high intensity resulted in better conditions for the plants in carbon fixation. The effect of blue light on plant morphology is intensity-dependent. Plants under multichromatic light tend to have lower concentrations of N, K, Mg, and Cu in their leaves, but the final amount of these nutrients absorbed is higher because of the higher dry weight of these plants. Plants under blue light at high intensity tended to have lower concentrations of N, Cu, B, and Zn when compared to the same wavelength at low intensity, and their dry weight was not different from plants grown under pink light. New studies are needed to understand how and on what occasions intense blue light can replace red light in plant physiology.

Mine tailings have been disposed of in a slurry form in tailings dams for many years. However, recent disasters involving conventional disposal in dams reinforced the need for alternative structures to store these materials safely. One alternative is dry stacking of tailings. In these structures, tailings are filtered to low moisture content and then compacted in layers. Due to material compaction, dry stacks tend to be stable and are usually built with elevated heights to use the available area better. So, it becomes essential to understand the mechanical behavior of tailings subjected to high pressures, especially concerning the possibility of grain breakage. In this context, the present research focuses on studying the geotechnical behavior of iron ore tailings from different stages of ore beneficiation plants in Quadrilátero Ferrífero, Brazil, when subjected to high pressures both in compression and in shear paths. The results demonstrate that the inclusion of fines can change the geotechnical performance of the dry stack tailings considering the same compaction energy (greater strength, stiffness, and lower permeability) both in drained and undrained conditions. No breakage could be identified for the stress level studied (6 MPa).

CERN, as many large organizations, heavily relies on a variety of communication means for different use-cases and teams. The large amount of notifications received every day leads to adverse consequences. For the users receiving them, it is challenging to control and keep track of where, how and when some information was received. At the same time for those sending and maintaining the tools that deliver notifications, it is difficult to choose which targets to adopt (email, messaging system and platforms, electronic devices, etc.). The CERN Notifications system aims at consolidating communication by providing a central place where notifications are created, maintained and distributed. CERN Notifications allows not only optimising the flow for the multiple people and teams which are responsible for sending, but also empowers the target users by respecting their preferences: how, where and when they receive their notifications. This paper describes the design and architecture of the CERN Notifications system and its components, how it was designed with a flexible and highly modular architecture which allows adding further device targets with little effort. Furthermore, it presents implementation details and the decisions behind those. And last but not least it describes the features that empower users to choose how to consume information sent to them.

GitLab has been in operation at CERN since 2012. It is a selfservice code hosting application based on Git that provides collaboration and code review features, becoming one of the key infrastructures at CERN. It is extensively utilised at CERN, with more than 17 000 active users, hosting more than 120 000 projects and triggering more than 5 000 jobs per hour. During the initial stages, a custom-made solution was deployed. However, with the exponential increase of projects, workflows, and continuous integrations, the GitLab infrastructure became hard and complex to scale and maintain. The recent migration, which involved adopting a new supported Cloud Hybrid infrastructure, has enabled CERN to align its GitLab infrastructure with industry standards and best practices. This has resulted in a significantly more robust and high-performing infrastructure, leading to notable benefits throughout the entire deployment process. This paper will address how this deployment process, on the road to success, has presented a series of challenges and pitfalls that have been faced during this complex migration process.

CERN hosts more than 1200 websites essential for the mission of the Organization, both for internal and external collaboration and communication, as well as public outreach. The complexity and scale of CERN’s online presence is very diverse with some websites, like home.cern, accommodating more than one million unique visitors in a day. However, regardless of their diversity, all websites are created using the Drupal content management system (CMS), and are self-hosted directly in the CERN Data Center on a dedicated infrastructure that runs on Kubernetes. Workflows like provisioning, deleting, cloning, upgrading, and similar are fully automated and managed by a customized Kubernetes controller. By leveraging the custom controller, the infrastructure has proven highly reliant with minimal, manual intervention necessary. In order to further automate deployments and improve governance, a customized version of Drupal called the CERN Drupal Distribution is implemented. Supported by end-to-end integration tests and automated browser simulation, this setup enables the propagation of security and feature updates seamlessly to all websites without any downtime. This paper outlines the architecture which allows building, testing, and distributing updates to a large number of websites without any downtime. Furthermore, it presents experiences and learnings from managing such a service at CERN with limited resources.

Carole Bandiera,1– 3 Jérôme Pasquier,3 Isabella Locatelli,3 Anne Niquille,2,3 Grégoire Wuerzner,4 Jennifer Dotta-Celio,3 Anna Hachfeld,5 Gilles Wandeler,5 Anna Dorothea Wagner,6 Chantal Csajka,1,2,7 Anne Zanchi,4,8 Matthias Cavassini,9 Marie P Schneider1,2 1School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; 2Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Geneva, Switzerland; 3Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland; 4Service of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 5Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland; 6Service of Oncology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 7Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 8Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 9Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, SwitzerlandCorrespondence: Marie P Schneider, School of Pharmaceutical Sciences, University of Geneva, Rue Michel Servet 1, Geneva, 1211, Switzerland, Tel + 41 22 379 53 16, Email Marie.Schneider@unige.chBackground: During the 2020 COVID-19 lockdown, patients included in the Interprofessional Medication Adherence Program (IMAP) in Switzerland continued to use electronic monitors (EMs) that registered daily drug-dose intake. We aimed to understand to what extent patients’ medication implementation (ie, the extent to which the patient took the prescribed medicine), measured with EMs, was impacted by the lockdown.Methods: Patients participating in the IMAP were diagnosed with diabetic kidney disease (DKD), solid cancer, human immunodeficiency virus (HIV) and miscellaneous long-term diseases (MLTD). Patient implementation was defined through a proxy: if all patient EMs were opened at least once daily, implementation was considered active (=1), and no implementation was considered (=0) otherwise. Implementation before (from December 2019 to March 2020), during (March to June 2020) and after (June to September 2020) the lockdown was compared. Subanalyses were performed according to the patients’ diseases. Subanalyses were performed in patients who used at least one EM in 2018– 2019 during the same periods (defined as winter, spring and summer). The logistic regression models used to estimate medication implementation according to the period were fitted using generalized estimating equations.Results: In 2020, patient implementation (n = 118) did not differ significantly before versus during (OR = 0.98, 95% CI: 0.84– 1.15, p = 0.789) and before versus after (OR = 0.91, 95% CI: 0.79– 1.06, p = 0.217) the lockdown. These findings remained stable when separately analyzing the implementation of patients with HIV (n = 61), DKD (n = 25) or MLTD (n = 22). Too few patients with cancer were included (n = 10) to interpret the results. In 2019, the implementation of 61/118 (51.7%) patients was significantly lower during summertime versus wintertime (OR = 0.73, 95% CI: 0.60– 0.89, p = 0.002).Conclusion: Medication implementation remained steady before, during and after the lockdown in 2020. The IMAP before, during and after the lockdown may have supported the adherence of most patients, by ensuring continuity of care during periods of routine disturbances.Keywords: SARS-CoV-2, COVID-19, medication adherence, patient compliance, implementation adherence, electronic adherence monitoring, interprofessional adherence intervention

Abstract Introduction mass contamination by the new coronavirus caused enough damage for the pandemic to extend indefinitely Objective the objective of this study was to analyze the emotional factors acquired by students from a dentistry course during the COVID-19 pandemic period and the influences related to the resumption of face-to-face activities. Material and method it is an observational, cross-sectional and analytical research conducted at a public university in the state of Pará, Brazil. A research questionnaire, prepared by the authors and validated by the ethics committee of the Federal University of Pará, was applied to the academic community for a period of three months (November 2020 to January 2021). The analysis was performed using the Excel program, Kappa statistics and the Chi-squared test, whose results were presented as frequency and percentage. Result a total of 188 dental students participated in the research. The findings proved to be in accordance with the hypothesis generated by the researchers, about 19.2% had emotional crises and 3.7% increase in the lockdown period. As for the expectations for care services, there was an increase in the oppressive state of psychic crises (anxiety, stress, anger, fear), considered influential in the cognition of behavioral traits during post-pandemic care. Conclusion the study identified that the emotional changes acquired in the pandemic outbreak had a negative impact on student performance; however, depressive symptoms were expressed in graduating students.

Introdução: A retenção dentária é uma anomalia em que o dente não entra em erupção na arcada dentária com base em aspectos clínicos e radiográficos. Um terceiro molar pode ter uma variedade de posições e níveis de retenção, o que pode resultar em uma gama de patologias associadas; são as mais comuns: cáries; reabsorção radicular do dente adjacente; perda óssea alveolar e aumento do espaço pericoronário. Objetivo: Avaliar radiograficamente a prevalência de patologias nos terceiros molares retidos, em uma subpopulação da região Norte do Brasil. Método: Foram avaliadas 1.192 radiografias panorâmicas digitais de pacientes atendidos em um curso de Odontologia da região Norte do Brasil. A faixa etária foi de 18 a 76 anos e os achados radiográficos observados foram: carie, reabsorção radícula, perda óssea alveolar e aumento do espaço pericoronário maior que 4 mm. Resultados: A prevalência de patologias associadas foi de 67,5%. A perda óssea alveolar do dente adjacente de mais de 5 mm teve a maior frequência da patologia, 507 (50,3%), a reabsorção radicular do dente adjacente, 222 (22,0%), cárie, 157 (15,6%) e aumento do espaço pericoronário, 121 (12,0%). Conclusão: A detecção precoce de patologias associadas ao terceiro molar retido é essencial para a realização de um tratamento eficaz. O estudo apresentou prevalência de patologias em terceiros molares inferiores retidos de 67,5%. A patologia mais comum foi a perda óssea alveolar, seguida por reabsorção radicular do dente adjacente, imagem sugestiva de cárie e aumento do espaço pericoronário.

Introdução: Náuseas e vômitos induzidos por quimioterapia (NVIQ) são importantes efeitos colaterais dos tratamentos antineoplásicos. Algumas plantas medicinais vêm sendo estudadas no manejo desses efeitos, como o gengibre (Zingiber officinale). Objetivo: Realizar uma revisão acerca do uso via oral do gengibre no manejo de NVIQ em pacientes com câncer. Método: Revisão integrativa da literatura realizada na base de dados MEDLINE, em setembro de 2022, adotando a combinação das palavras-chave “Zingiber officinale” e “Cancer”. Foram também aplicados filtros na seleção para incluir ensaios clínicos aleatórios publicados entre 2012 e 2022. Resultados: Ao todo, foram analisados nove estudos. O gengibre apresenta potencial de reduzir NVIQ em pacientes com câncer, refletindo positivamente na qualidade de vida e na melhora do apetite e da fadiga. Os estudos não observaram efeitos adversos da administração do gengibre. Conclusão: O uso por via oral do gengibre demonstra ser uma estratégia segura para o manejo de NVIQ em pacientes com câncer, na dose de 1 g/dia do gengibre em pó, podendo ser utilizado como terapia complementar juntamente com regimes antieméticos padrões.

Arbovirus epidemiology lacks efficient and timely surveillance systems with accurate outbreak alert signals. We devised a citywide integrated surveillance system combining entomologic, epidemiologic, and entomo-virologic data gathered during 2017–2020 in Foz do Iguaçu, Brazil. We installed 3,476 adult mosquito traps across the city and inspected traps every 2 months. We compared 5 entomologic indices: traditional house and Breteau indices for larval surveys and trap positivity, adult density, and mosquitoes per inhabitant indices for adult trapping. We screened for dengue, Zika, and chikungunya viruses in live adult Aedes aegypti mosquitoes collected from traps. Indices based on adult mosquito sampling had higher outbreak predictive values than larval indices, and we were able to build choropleth maps of infestation levels

O objetivo desta revisão sistemática é identificar os estudos científicos sobre os atletas deficientes visuais de futebol de cinco. As bases de dados eletrônicas Scielo, Web of Science, Scopus, Pubmed e Google Scholar foram utilizadas para identificar estudos relacionados ao futebol para pessoas com deficiência visual. As publicações se concentraram em 10 periódicos, sendo três estudos publicados em periódicos nacionais e sete estudos estão em periódicos internacionais, além disso, percebe-se que cinco estudos são da área da cineantropometria, enquanto quatro estudos são da área do treinamento desportivo e apenas um estudo é da área da cinesiologia e biomecânica. Conclui-se que, apesar de ser uma modalidade muito praticada existem poucas evidências na literatura acerca do futebol de cinco para deficientes visuais.