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2. Lumped-parameter models of the pulmonary vasculature during the progression of pulmonary arterial hypertension.

Author

Gerringer, Jesse W, Wagner, Julie C, Vélez-Rendón, Daniela, and Valdez-Jasso, Daniela

Subjects
Pulmonary Artery, Animals, Rats, Rats, Sprague-Dawley, Hypertension, Pulmonary, Monocrotaline, Models, Cardiovascular, Male, Hemodynamics, Impedance, Windkessel models, mathematical modeling, monocrotaline, parameter estimation, pulmonary arterial hypertension, Physiology, Clinical Sciences, Medical Physiology
Abstract

A longitudinal study of monocrotaline-induced pulmonary arterial hypertension (PAH) was carried out in Sprague-Dawley rats to investigate the changes in impedance (comprising resistance and compliance) produced by elevated blood pressure. Using invasively measured blood flow as an input, blood pressure was predicted using 3- and 4-element Windkessel (3WK, 4WK) type lumped-parameter models. Resistance, compliance, and inductance model parameters were obtained for the five different treatment groups via least-squares errors. The treated animals reached levels of hypertension, where blood pressure increased two folds from control to chronic stage of PAH (mean pressure went from 24 ± 5 to 44 ± 6 mmHg, P

Published
2018

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