383 results on '"Wagner, Bridget K."'
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2. Predicting compound activity from phenotypic profiles and chemical structures
3. An expanded universe of cancer targets.
4. Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
5. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules
6. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
7. Chemical Approaches for Beta-cell Biology
8. SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
9. Small-molecule discovery in the pancreatic beta cell
10. Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines
11. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes
12. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
13. Nuisance compounds in cellular assays
14. An expanded universe of cancer targets
15. Identifying type 2 diabetes risk genes by β-cell CRISPR screening
16. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9
17. Introduction to Chemical Probes
18. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme
19. Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome
20. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes
21. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
22. Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
23. KD025 Is a Casein Kinase 2 Inhibitor That Protects Against Glucolipotoxicity in β-Cells.
24. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
25. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
26. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes
27. High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function
28. Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery
29. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
30. Automated Structure–Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles
31. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses
32. Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
33. A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening
34. Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
35. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells
36. A Human Islet Cell Culture System for High-Throughput Screening
37. Reference compounds for characterizing cellular injury in high-content cellular morphology assays
38. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections
39. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
40. Small-molecule inducers of insulin expression in pancreatic α-cells
41. Gene Expression-Based Screening Identifies Microtubule Inhibitors as Inducers of PGC-1α and Oxidative Phosphorylation
42. Chemical strategies to understand and manipulate host-pathogen interactions
43. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
44. Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling
45. Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension
46. Small-molecule inducers of insulin expression in pancreatic [alpha]-cells
47. Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics
48. From type 1 diabetes biology to therapy: The Human Islet Research Network
49. Phenotypic approaches to small-molecule discovery in chemical biology
50. Chemical Genomics: Probing Protein Function Using Small Molecules
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