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1. A regionally based precision medicine implementation initiative in North Africa:The PerMediNA consortium

Author

Hamdi, Yosr, primary, Boujemaa, Maroua, additional, Ben Aissa-Haj, Jihenne, additional, Radouani, Fouzia, additional, Khyatti, Meriem, additional, Mighri, Najah, additional, Hannachi, Mariem, additional, Ghedira, Kais, additional, Souiai, Oussema, additional, Hkimi, Chaima, additional, Kammoun, Mohamed Selim, additional, Mejri, Nesrine, additional, Bouaziz, Hanen, additional, Beloufa, Mohamed Amine, additional, Charoute, Hicham, additional, Barakat, Abdelhamid, additional, Najjar, Imène, additional, Taniguchi, Hiroaki, additional, Pietrosemoli, Natalia, additional, benider, Abdellatif, additional, El-hamouchi, Adil, additional, Sonia, AIT YOUNES, additional, Kahla, Alia Ben, additional, Abdelmalik, AMIMER, additional, Zine, AMIR, additional, Jaballah, Amira, additional, Louiza, Amira, additional, GIHBID, Amina, additional, Achouak, BACHIR, additional, Djihad, BELABDI, additional, Said, BELHADEF, additional, Rafika, BELNOUI, additional, Ayed, Belarbi, additional, Nadia, Benchakroune, additional, Nadia, Benchakroun, additional, Meriem, BENINAL, additional, Radja, BENKALI, additional, Asma, BENSIHAMDI, additional, Hichem, BENYOUCEF, additional, Thouraya, BENDIMRED, additional, Nadir, Bensouf, additional, Rafika, BENNOUI, additional, Yosra, Berrazegua, additional, Latefa, Biskri, additional, Saida, BOUAOUNI, additional, Meriem, BOUANIKA, additional, Abderezzak, Bouamra, additional, Hanen, Bouaziz, additional, Zohra, Boudinar Fatma, additional, Sabrina, Bouhara, additional, Nadir, Boussouf, additional, Saber, Boutayeb, additional, Adda, BOUNEDJAR, additional, Omar, Chabati, additional, Cherine, Charfeddine, additional, Dalia, Chilla, additional, Mehemmai, Chiraz, additional, Bouabid, Cyrine, additional, Souad, Dahnane, additional, Soraya, DIAB, additional, Adlane, Dib Hocine, additional, Wider, Dorra, additional, Fawzi, DERRAR, additional, Amina, ELKEBOUB, additional, Hicham, EL ATTAR, additional, Elmostafa, EL FAHIME, additional, Djazia, ELHADEF, additional, Fehri, Emna, additional, Hakkou, Farid, additional, Hadjam, Farida, additional, Mamboisse, Fanny, additional, Widad, GAIS, additional, Merzak, GHARNAOUT, additional, Nidhal, Guessoum Amir, additional, Farida, HADJAM, additional, SAHRAOUI, HADJ, additional, Rachdi, Haifa, additional, Yaiche, Hamza, additional, Leila, HANNACHI, additional, Mahfouf, Hassan, additional, Bouguerra, Hend, additional, Attar, Hicham El, additional, Hassine, Hichem Ben, additional, Filali, Houda, additional, Harmak, Houda, additional, Kanaane, Houda, additional, Benamri, Ichrak, additional, Alami, Imane El, additional, Reda, KASSA, additional, Bendahhou, Karima, additional, Errafii, Khaoula, additional, Bairi, Khalid El, additional, Wafaa, Khaali, additional, Mehdi, KARKOURI, additional, Maria, Kabbage, additional, Wafa, Kammoun, additional, Houda, Kanaane, additional, Reda, Kassa, additional, Narimane, LAOUAR, additional, Biskri, Latefa, additional, Amira, Louiza, additional, Marie, Louise, additional, Chevalier, Charion, additional, Nabila, MALOUM, additional, Monot, Marc, additional, Saadi, Mariem, additional, Campone, Mario, additional, Mrad, Mehdi, additional, KARKOURI, MEHDI, additional, Mohamed, MELIZI, additional, Saadi, Meriem, additional, CHAHER, Meriem, additional, Ardhaoui, Monia, additional, TALEB, Mourad, additional, Jmiaa, Nadia Ben, additional, Benchakroun, Nadia, additional, Hadhri, Najet, additional, SALHI, Nawel, additional, Taoufiq, Nezha, additional, Jandoubi, Nouha, additional, Wahiba, OUAHIOUNE, additional, Salima, OULDSLIMANE, additional, BELNOUI, Rafika, additional, Louiza, Rahman Amira, additional, Benkhalifa, Rym, additional, Boutaib, Saber, additional, Boutayeb, Saber, additional, Menif, Samia, additional, OULDSLIMANE, Salima, additional, Valcke, Samuel, additional, Assia, SLIMANI, additional, Nasr, Sonia Ben, additional, Maatoug, Sonia, additional, Younes, Sonia Ait, additional, BENCHEHIDA, Souad, additional, BEKOUACI, Souad, additional, Sahraoui, Souha, additional, Hassiba, Tali Maamar, additional, Soraya, Talha, additional, Mourad, TALEB, additional, Fella, TERKMANI, additional, Soraya, TALHA, additional, Wassila, TOUISI, additional, Kammoun, Wafa, additional, OUAHIOUNE, Wahiba, additional, Berrazegua, Yosra, additional, Amel, ZEMMOUR, additional, Sarah, ZEROUAL, additional, AMIR, Zine Charif, additional, Zouafi, Zineb, additional, Dellagi, Koussay, additional, Abdelhak, Sonia, additional, Boubaker, Mohamed Samir, additional, Chica, Claudia, additional, and Rouleau, Etienne, additional

Published
2024
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2. A regionally based precision medicine implementation initiative in North Africa:The PerMediNA consortium

Author

benider, Abdellatif, El-hamouchi, Adil, Sonia, AIT YOUNES, Kahla, Alia Ben, Abdelmalik, AMIMER, Zine, AMIR, charif, Jaballah, Amira, Louiza, Amira, GIHBID, Amina, Achouak, BACHIR, Djihad, BELABDI, Said, BELHADEF, Rafika, BELNOUI, Ayed, Belarbi, Nadia, Benchakroune, Nadia, Benchakroun, Meriem, BENINAL, Radja, BENKALI, Asma, BENSIHAMDI, Hichem, BENYOUCEF, Thouraya, BENDIMRED, Nadir, Bensouf, Rafika, BENNOUI, Yosra, Berrazegua, Latefa, Biskri, Saida, BOUAOUNI, Meriem, BOUANIKA, Abderezzak, Bouamra, Hanen, Bouaziz, Zohra, Boudinar Fatma, Sabrina, Bouhara, Nadir, Boussouf, Saber, Boutayeb, Adda, BOUNEDJAR, Omar, Chabati, Cherine, Charfeddine, Dalia, Chilla, Mehemmai, Chiraz, Bouabid, Cyrine, Souad, Dahnane, Soraya, DIAB, Adlane, Dib Hocine, Wider, Dorra, Fawzi, DERRAR, Amina, ELKEBOUB, Hicham, EL ATTAR, Elmostafa, EL FAHIME, Djazia, ELHADEF, Fehri, Emna, Hakkou, Farid, Hadjam, Farida, Mamboisse, Fanny, Widad, GAIS, Merzak, GHARNAOUT, Nidhal, Guessoum Amir, Farida, HADJAM, SAHRAOUI, HADJ, Rachdi, Haifa, Yaiche, Hamza, Leila, HANNACHI, Mahfouf, Hassan, Bouguerra, Hend, Attar, Hicham El, Hassine, Hichem Ben, Filali, Houda, Harmak, Houda, Kanaane, Houda, Benamri, Ichrak, Alami, Imane El, Reda, KASSA, Bendahhou, Karima, Errafii, Khaoula, Bairi, Khalid El, Wafaa, Khaali, Mehdi, KARKOURI, Maria, Kabbage, Wafa, Kammoun, Houda, Kanaane, Reda, Kassa, Narimane, LAOUAR, Biskri, Latefa, Amira, Louiza, Marie, Louise, Chevalier, Charion, Nabila, MALOUM, Monot, Marc, Saadi, Mariem, Campone, Mario, Mrad, Mehdi, KARKOURI, MEHDI, Mohamed, MELIZI, Saadi, Meriem, CHAHER, Meriem, Ardhaoui, Monia, TALEB, Mourad, Jmiaa, Nadia Ben, Benchakroun, Nadia, Hadhri, Najet, SALHI, Nawel, Taoufiq, Nezha, Jandoubi, Nouha, Wahiba, OUAHIOUNE, Salima, OULDSLIMANE, BELNOUI, Rafika, Louiza, Rahman Amira, Benkhalifa, Rym, Boutaib, Saber, Boutayeb, Saber, Menif, Samia, OULDSLIMANE, Salima, Valcke, Samuel, Assia, SLIMANI, Nasr, Sonia Ben, Maatoug, Sonia, Younes, Sonia Ait, BENCHEHIDA, Souad, BEKOUACI, Souad, Sahraoui, Souha, Hassiba, Tali Maamar, Soraya, Talha, Mourad, TALEB, Fella, TERKMANI, Soraya, TALHA, Wassila, TOUISI, Kammoun, Wafa, OUAHIOUNE, Wahiba, Berrazegua, Yosra, Amel, ZEMMOUR, Sarah, ZEROUAL, AMIR, Zine Charif, Zouafi, Zineb, Hamdi, Yosr, Boujemaa, Maroua, Ben Aissa-Haj, Jihenne, Radouani, Fouzia, Khyatti, Meriem, Mighri, Najah, Hannachi, Mariem, Ghedira, Kais, Souiai, Oussema, Hkimi, Chaima, Kammoun, Mohamed Selim, Mejri, Nesrine, Bouaziz, Hanen, Beloufa, Mohamed Amine, Charoute, Hicham, Barakat, Abdelhamid, Najjar, Imène, Taniguchi, Hiroaki, Pietrosemoli, Natalia, Dellagi, Koussay, Abdelhak, Sonia, Boubaker, Mohamed Samir, Chica, Claudia, and Rouleau, Etienne

Published
2024
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3. Prognostic value of Epstein-Barr virus DNA load in nasopharyngeal carcinoma: a meta-analysis

Author

Imane EL Alami, Amina Gihbid, Hicham Charoute, Wafaa Khaali, Selma Mohamed Brahim, Nezha Tawfiq, Rachida Cadi, Khalid Belghmi, Mohammed El Mzibri, and Meriem Khyatti

Subjects
Epstein-Barr Virus Infections, Herpesvirus 4, Human, Nasopharyngeal Carcinoma, Epstein-Barr virus, nasopharyngeal carcinoma, Epstein Barr Virus DNA load, prognostic, DNA, Viral, Humans, Nasopharyngeal Neoplasms, General Medicine, Prognosis, Disease-Free Survival
Abstract

The present meta-analysis was conducted to evaluate the prognostic value of pre and post-Epstein Barr Virus (EBV) DNA load testing and to assess the clinical benefit of using this molecular approach in the prognosis for a better nasopharyngeal carcinoma (NPC) management. Relevant studies were searched in different database until May 2020. Patient´s outcomes overall survival (OS), disease free survival (DFS), progression-free survival (PFS), distant-metastasis-free survival (DMFS), and local-regional-failure-free survival (LRFS), hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from selected studies. The association of pre and post-EBV DNA load and survival outcomes was assessed using review manager and the pooled HRs with 95% CIs were calculated. Twenty-six eligible studies were included in this meta-analysis, with a total of 9966 patients. Pooled HRs showed that EBV DNA levels before and after treatment are significantly associated with survival outcomes, with HR (95% CI) of 2.09 [1.74, 2.51] for OS, 1.77 [1.19, 2.62] for DFS, 2.53 [2.18, 2.92] for DMFS, 1.78 [1.45, 2.19] for LRFS and 2.17 [1.91, 2.47] for PFS in pre-EBV DNA, and an HR (95%) of 4.52 [2.44, 8.36], 4.08 [2.38, 6.99], 5.59 [ 3.58, 8.71] and 8.88 [5.29, 14.90] for OS, DFS and PFS and DMFS in post-EBV DNA, respectively. High pre and post-EBV DNA levels were significantly associated with poor NPC patient´s survival outcomes; which clearly confirm the high interest to introduce viral EBV DNA load as a prognostic biomarker for NPC management.

Published
2022

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