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1. A genomic mutational constraint map using variation in 76,156 human genomes

Author

Chen, Siwei, Francioli, Laurent C., Goodrich, Julia K., Collins, Ryan L., Kanai, Masahiro, Wang, Qingbo, Alföldi, Jessica, Watts, Nicholas A., Vittal, Christopher, Gauthier, Laura D., Poterba, Timothy, Wilson, Michael W., Tarasova, Yekaterina, Phu, William, Grant, Riley, Yohannes, Mary T., Koenig, Zan, Farjoun, Yossi, Banks, Eric, Donnelly, Stacey, Gabriel, Stacey, Gupta, Namrata, Ferriera, Steven, Tolonen, Charlotte, Novod, Sam, Bergelson, Louis, Roazen, David, Ruano-Rubio, Valentin, Covarrubias, Miguel, Llanwarne, Christopher, Petrillo, Nikelle, Wade, Gordon, Jeandet, Thibault, Munshi, Ruchi, Tibbetts, Kathleen, O’Donnell-Luria, Anne, Solomonson, Matthew, Seed, Cotton, Martin, Alicia R., Talkowski, Michael E., Rehm, Heidi L., Daly, Mark J., Tiao, Grace, Neale, Benjamin M., MacArthur, Daniel G., and Karczewski, Konrad J.

Published
2024
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2. Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

Author

Chen, Siwei, Francioli, Laurent C., Goodrich, Julia K., Collins, Ryan L., Kanai, Masahiro, Wang, Qingbo, Alföldi, Jessica, Watts, Nicholas A., Vittal, Christopher, Gauthier, Laura D., Poterba, Timothy, Wilson, Michael W., Tarasova, Yekaterina, Phu, William, Grant, Riley, Yohannes, Mary T., Koenig, Zan, Farjoun, Yossi, Banks, Eric, Donnelly, Stacey, Gabriel, Stacey, Gupta, Namrata, Ferriera, Steven, Tolonen, Charlotte, Novod, Sam, Bergelson, Louis, Roazen, David, Ruano-Rubio, Valentin, Covarrubias, Miguel, Llanwarne, Christopher, Petrillo, Nikelle, Wade, Gordon, Jeandet, Thibault, Munshi, Ruchi, Tibbetts, Kathleen, O’Donnell-Luria, Anne, Solomonson, Matthew, Seed, Cotton, Martin, Alicia R., Talkowski, Michael E., Rehm, Heidi L., Daly, Mark J., Tiao, Grace, Neale, Benjamin M., MacArthur, Daniel G., and Karczewski, Konrad J.

Published
2024
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3. The mutational constraint spectrum quantified from variation in 141,456 humans

Author

Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., and MacArthur, Daniel G.

Published
2020
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4. Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humanS

Author

Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Aguilar Salinas, Carlos A., Ahmad, Tariq, Albert, Christine M., Ardissino, Diego, Atzmon, Gil, Barnard, John, Beaugerie, Laurent, Benjamin, Emelia J., Boehnke, Michael, Bonnycastle, Lori L., Bottinger, Erwin P., Bowden, Donald W., Bown, Matthew J., Chambers, John C., Chan, Juliana C., Chasman, Daniel, Cho, Judy, Chung, Mina K., Cohen, Bruce, Correa, Adolfo, Dabelea, Dana, Daly, Mark J., Darbar, Dawood, Duggirala, Ravindranath, Dupuis, Josée, Ellinor, Patrick T., Elosua, Roberto, Erdmann, Jeanette, Esko, Tõnu, Färkkilä, Martti, Florez, Jose, Franke, Andre, Getz, Gad, Glaser, Benjamin, Glatt, Stephen J., Goldstein, David, Gonzalez, Clicerio, Groop, Leif, Haiman, Christopher, Hanis, Craig, Harms, Matthew, Hiltunen, Mikko, Holi, Matti M., Hultman, Christina M., Kallela, Mikko, Kaprio, Jaakko, Kathiresan, Sekar, Kim, Bong Jo, Kim, Young Jin, Kirov, George, Kooner, Jaspal, Koskinen, Seppo, Krumholz, Harlan M., Kugathasan, Subra, Kwak, Soo Heon, Laakso, Markku, Lehtimäki, Terho, Loos, Ruth J.F., Lubitz, Steven A., Ma, Ronald C.W., MacArthur, Daniel G., Marrugat, Jaume, Mattila, Kari M., McCarthy, Mark I., McGovern, Dermot, McPherson, Ruth, Meigs, James B., Melander, Olle, Metspalu, Andres, Neale, Benjamin M., Nilsson, Peter M., O’Donovan, Michael C., Ongur, Dost, Orozco, Lorena, Palotie, Aarno, Park, Kyong Soo, Pato, Carlos, Pulver, Ann E., Rahman, Nazneen, Remes, Anne M., Rioux, John D., Ripatti, Samuli, Roden, Dan M., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Scharf, Jeremiah, Schunkert, Heribert, Shoemaker, Moore B., Sklar, Pamela, Soininen, Hilkka, Sokol, Harry, Spector, Tim, Sullivan, Patrick F., Suvisaari, Jaana, Tai, E. Shyong, Teo, Yik Ying, Tiinamaija, Tuomi, Tsuang, Ming, Turner, Dan, Tusie-Luna, Teresa, Vartiainen, Erkki, Vawter, Marquis P., Watkins, Hugh, Weersma, Rinse K., Wessman, Maija, and Xavier, Ramnik J.

Subjects
Multidisciplinary, Science & Technology, General Science & Technology, Spectrum (functional analysis), Rare variants, Biology, Constraint (information theory), Multidisciplinary Sciences, Variation (linguistics), Genome Aggregation Database Consortium, Science & Technology - Other Topics, Author Correction, Medical genomics, Algorithm
Abstract

In this Article, author Marquis P. Vawter was missing from the Genome Aggregation Database Consortium list. They are associated with the affiliation: ‘Department of Psychiatry & Human Behavior, University of California Irvine, Irvine, CA, USA’, and contributed to the generation of the primary data incorporated into the gnomAD resource. In addition, in the legend to Fig. 1, ‘ten’ should have been ‘seven’ in the sentence: “a, Uniform manifold approximation and projection (UMAP)46,47 plot depicting the ancestral diversity of all individuals in gnomAD, using seven principal components.” The original Article has been corrected online.

Published
2021

6. Characterising the loss-of-function impact of 5’ untranslated region variants in whole genome sequence data from 15,708 individuals

Author

Whiffin, Nicola, Karczewski, Konrad J, Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J, Evans, D Gareth, Roberts, Angharad M, Quaife, Nicholas M, Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O’Donnell-Luria, Anne H, Francioli, Laurent C, Armean, Irina M., Banks, Eric, Bergelson, Louis, Cibulskis, Kristian, Collins, Ryan L, Connolly, Kristen M., Covarrubias, Miguel, Cummings, Beryl, Daly, Mark J., Donnelly, Stacey, Farjoun, Yossi, Ferriera, Steven, Francioli, Laurent, Gabriel, Stacey, Gauthier, Laura D., Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Karczewski, Konrad J., Laricchia, Kristen M., Llanwarne, Christopher, Minikel, Eric V., Munshi, Ruchi, Neale, Benjamin M, Novod, Sam, O’Donnell-Luria, Anne H., Petrillo, Nikelle, Poterba, Timothy, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Samocha, Kaitlin E., Schleicher, Molly, Seed, Cotton, Solomonson, Matthew, Soto, Jose, Tiao, Grace, Tibbetts, Kathleen, Tolonen, Charlotte, Vittal, Christopher, Wade, Gordon, Wang, Arcturus, Wang, Qingbo, Ware, James S, Watts, Nicholas A, Weisburd, Ben, Salinas, Carlos A Aguilar, Ahmad, Tariq, Albert, Christine M., Ardissino, Diego, Atzmon, Gil, Barnard, John, Beaugerie, Laurent, Benjamin, Emelia J., Boehnke, Michael, Bonnycastle, Lori L., Bottinger, Erwin P., Bowden, Donald W, Bown, Matthew J, Chambers, John C, Chan, Juliana C., Chasman, Daniel, Cho, Judy, Chung, Mina K., Cohen, Bruce, Correa, Adolfo, Dabelea, Dana, Darbar, Dawood, Duggirala, Ravindranath, Dupuis, Josée, Ellinor, Patrick T., Elosua, Roberto, Erdmann, Jeanette, Esko, Tõnu, Färkkilä, Martti, Florez, Jose, Franke, Andre, Getz, Gad, Glaser, Benjamin, Glatt, Stephen J., Goldstein, David, Gonzalez, Clicerio, Groop, Leif, Haiman, Christopher, Hanis, Craig, Harms, Matthew, Hiltunen, Mikko, Holi, Matti M., Hultman, Christina M., Kallela, Mikko, Kaprio, Jaakko, Kathiresan, Sekar, Kim, Bong-Jo, Kim, Young Jin, Kirov, George, Kooner, Jaspal, Koskinen, Seppo, Krumholz, Harlan M., Kugathasan, Subra, Kwak, Soo Heon, Laakso, Markku, Lehtimäki, Terho, Loos, Ruth J.F., Lubitz, Steven A., Ma, Ronald C.W., MacArthur, Daniel G., Marrugat, Jaume, Mattila, Kari M., McCarroll, Steven, McCarthy, Mark I, McGovern, Dermot, McPherson, Ruth, Meigs, James B., Melander, Olle, Metspalu, Andres, Nilsson, Peter M, O’Donovan, Michael C, Ongur, Dost, Orozco, Lorena, Owen, Michael J, Palmer, Colin N.A., Palotie, Aarno, Park, Kyong Soo, Pato, Carlos, Pulver, Ann E., Rahman, Nazneen, Remes, Anne M., Rioux, John D., Ripatti, Samuli, Roden, Dan M., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Scharf, Jeremiah, Schunkert, Heribert, Shoemaker, Moore B., Sklar, Pamela, Soininen, Hilkka, Soko, Harry, Spector, Tim, Sullivan, Patrick F., Suvisaari, Jaana, Tai, E Shyong, Teo, Yik Ying, Tiinamaija, Tuomi, Tsuang, Ming, Turner, Dan, Tusie-Luna, Teresa, Vartiainen, Erkki, Watkins, Hugh, Weersma, Rinse K, Wessman, Maija, Wilson, James G., Xavier, Ramnik J., Cook, Stuart A, Barton, Paul J R, and MacArthur, Daniel G

Subjects
0303 health sciences, education.field_of_study, Five prime untranslated region, Population, Computational biology, Biology, Genome, DNA sequencing, Frameshift mutation, 03 medical and health sciences, Negative selection, 0302 clinical medicine, Coding region, education, Gene, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract

Upstream open reading frames (uORFs) are important tissue-specific cis-regulators of protein translation. Although isolated case reports have shown that variants that create or disrupt uORFs can cause disease, genetic sequencing approaches typically focus on protein-coding regions and ignore these variants. Here, we describe a systematic genome-wide study of variants that create and disrupt human uORFs, and explore their role in human disease using 15,708 whole genome sequences collected by the Genome Aggregation Database (gnomAD) project. We show that 14,897 variants that create new start codons upstream of the canonical coding sequence (CDS), and 2,406 variants disrupting the stop site of existing uORFs, are under strong negative selection. Furthermore, variants creating uORFs that overlap the CDS show signals of selection equivalent to coding loss-of-function variants, and uORF-perturbing variants are under strong selection when arising upstream of known disease genes and genes intolerant to loss-of-function variants. Finally, we identify specific genes where perturbation of uORFs is likely to represent an important disease mechanism, and report a novel uORF frameshift variant upstream of NF2 in families with neurofibromatosis. Our results highlight uORF-perturbing variants as an important and under-recognised functional class that can contribute to penetrant human disease, and demonstrate the power of large-scale population sequencing data to study the deleteriousness of specific classes of non-coding variants.

Published
2019
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7. Variation across 141,456 human exomes and genomes reveals the spectrum of loss-of-function intolerance across human protein-coding genes

Author

Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., and MacArthur, Daniel G.

Abstract

Summary Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes critical for an organism’s function will be depleted for such variants in natural populations, while non-essential genes will tolerate their accumulation. However, predicted loss-of-function (pLoF) variants are enriched for annotation errors, and tend to be found at extremely low frequencies, so their analysis requires careful variant annotation and very large sample sizes. Here, we describe the aggregation of 125,748 exomes and 15,708 genomes from human sequencing studies into the Genome Aggregation Database (gnomAD). We identify 443,769 high-confidence pLoF variants in this cohort after filtering for sequencing and annotation artifacts. Using an improved model of human mutation, we classify human protein-coding genes along a spectrum representing intolerance to inactivation, validate this classification using data from model organisms and engineered human cells, and show that it can be used to improve gene discovery power for both common and rare diseases.

Published
2019
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8. Catman 2.0

Author

Wade, Gordon

Subjects
Online shopping -- Growth -- Forecasts and trends, Software industry -- Product introduction, Online shopping, Company growth, Market trend/market analysis, Business, Food and beverage industries, Retail industry
Abstract

Byline: Gordon Wade Introducing a new iteration of the business process, for a new century. Category management, one of the most successful business processes developed in the 20[sup.th] century, is [...]

Published
2016

9. Lower Extremity Limb Salvage: Lessons Learned From 14 Years at War

Author

Wade Gordon, James Blair, Sarah N. Pierrie, Emmanuel D. Eisenstein, Joseph R. Hsu, and Johnny G. Owens

Subjects
030222 orthopedics, medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, Limb salvage, MEDLINE, 030208 emergency & critical care medicine, General Medicine, humanities, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Amputation, Extremity injury, medicine, Orthopedics and Sports Medicine, Surgery, business
Abstract

American survivability during the current conflicts in Iraq and Afghanistan continues to improve, though the rate of extremity injury remains quite high. The decision to proceed with amputation versus limb salvage remains controversial. Exposure to combat wound with severe high-energy lower extremity trauma during the previous 14 years at war has incited important advances in limb salvage technique and rehabilitation.

Published
2016

10. Great Expectations

Author

Wade, Gordon

Subjects
Business, Food and beverage industries, Retail industry
Abstract

Byline: Gordon Wade Have these five things on your checklist for vendors. More money, right? Wrong. Your vendors have more to offer than cash, which, after all, is constrained not [...]

Published
2012

11. New Tools Help Optimize C-store Design

Author

Wade, Gordon

Subjects
Store design, Convenience stores, Food services, Business, Retail industry
Abstract

Byline: Gordon Wade For as long as I can remember, convenience store operators have fantasized about the perfect layout for the convenience store - one that would both optimize the [...]

Published
2012

12. The Coming Squeeze

Author

Wade, Gordon

Subjects
Business, Food and beverage industries, Retail industry
Abstract

Byline: Gordon Wade We are about to experience yet another spasm of center store space reductions as part of a new total-store space optimization tsunami. Virtually every category is going [...]

Published
2012

17. Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

Author

Gudmundsson, Sanna, Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., and MacArthur, Daniel G.

Published
2021
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18. Neuron-Microdevice Connections

Author

Regehr, Wade Gordon, Regehr, Wade Gordon, Regehr, Wade Gordon, and Regehr, Wade Gordon

Abstract

A new method for long-term recording and stimulation applicable to cultured neurons has been developed. Silicon-based microelectrodes have been fabricated using integrated-circuit technology and micromachining. The chronic connection is made by positioning the electrode tip into contact with the cell body, and gluing the device to the bottom of the culture dish. These "diving-board electrodes" consist of an insulated lead exposed only at the tip sealed to the cell body of a cultured neuron. A two-way electrical connection to Helisoma B19 neurons has been established for up to four days. Preliminary experiments with cultured superior cervical ganglion neurons indicate diving-board electrodes can be used with cultured neurons larger than 20 µm in diameter. In a related technique Helisoma neurons grown on special dish containing a multielectrode array were found to seal to the dish electrodes, establishing similar long-term connections. This capability will make it possible to conduct experiments with either diving-board electrodes or dishes that cannot be performed using conventional techniques.

Published
1988

21. READERS SAY.

Author

Silber, Brent, Koonce, Calvin S., James, Michael C., Houtkin, Harvey, Landers, Ann, Wade, Gordon, Ford, Gerald R., Pradt, Louis, Eisman, Regina, and Knapp, Robert L.

Subjects
LETTERS to the editor, SECURITIES trading, DATA processing in stock exchanges
Abstract

Presents several letters to the editor. Comment on the article "Fun and Games on Nasdaq," published in the August 16, 1993 issue of the journal "Forbes"; Information on Koonce Securities Inc. which executes customer orders in the Nasdaq market; Focus on the article "The Naked Truth," published in the August 16, 1993 issue of the journal.

Published
1993

24. From the loving earth

Author

Wade, Gordon S.

Subjects
From The Loving Earth (Book) -- Book reviews, Books
Published
1977

25. The complete urban farmer

Author

Wade, Gordon S.

Subjects
The Complete Urban Farmer (Book) -- Book reviews, Books
Published
1977

26. Tapping Into the Voice of the Shopper.

Author

WADE, GORDON

Subjects
CATEGORY management, CONSUMERS, CONSUMER behavior, MARKETING, MARKETING management
Abstract

The article discusses the benefits brought by shoppers' insights in category management. While shoppers present a lot of opportunity in terms of understanding their consumer behavior, the author believes the problem lies with marketers as they lack the necessary tool and process needed to capture data, deploy it across a firm and leverage it in the aisles. The three biggest problems in marketing is presented, which includes scattered data and lack of comprehensive shared shopper perspective.

Published
2013

28. Vegetables from Small Gardens/How To Grow, Preserve & Store All the Food You Need (Book).

Author

Wade, Gordon S.

Subjects
VEGETABLES From Small Gardens (Book), HOW to Grow, Preserve & Store All the Food You Need (Book), LARKCOM, Joy, RICE, Eddy
Abstract

Reviews the books 'Vegetables From Small Gardens: A Guide to Intensive Cultivation,' by Joy Larkcom, and 'How to Grow, Preserve and Store All the Food You Need,' by Eddy Rice.

Published
1977

30. Meltdown (Book).

Author

Wade, Gordon S.

Subjects
SCIENCE fiction, FICTION
Abstract

Reviews the book 'Meltdown,' by Ray Kytle.

Published
1976

31. Then and Now.

Author

Wade, Gordon

Subjects
NON-alcoholic beverages, CONSUMER package goods, EFFICIENT consumer response, CARBONATED beverages, ENERGY drinks
Abstract

In the article, the author discusses how carbonated soft drinks (CSD) category have changed since 20 years as of June 2014. He discusses a monograph on efficient item assortment, published by the consumer packaged goods (CPG) industry efficient consumer response (ECR) committee, 20 years ago. He says that today CSD category has been transferred into the liquid refreshment beverage (LRB) category which includes sparkling waters, enhanced waters, and energy drinks.

Published
2014

32. CatMan at 20: Looking to the Future.

Author

Wade, Gordon

Subjects
CATEGORY management, MARKETING management, PRODUCT management, RETAIL industry, CONSUMERS
Abstract

The article offers information on the category management approach which is said to be the principal language with which retailers and manufacturers communicate. It is said that this approach lets retailers and manufacturers meet the needs of their common shopper more effectively, however, in coherent response to the changes occurring since 2010, an upgraded version of the approach is needed.

Published
2015

34. Pruning Simplified (Book).

Author

Wade, Gordon S.

Subjects
PRUNING, NONFICTION
Abstract

Reviews the book 'Pruning Simplified: A Complete Guide to Pruning Trees, Shrubs, Bushes, Hedges, Vines, Flowers, Garden Plants, Houseplants and Bonsai,' by Lewis Hill.

Published
1979

35. The Alpha Raid (Book).

Author

Wade, Gordon S.

Subjects
RAIDS (Military science), FICTION
Abstract

Reviews the book 'The Alpha Raid,' by Alan Scholefield.

Published
1977

36. The Salad Green Gardener (Book Review).

Author

Wade, Gordon S.

Subjects
SALAD greens, NONFICTION, PLANTING
Abstract

Reviews the book 'The Salad Green Gardener,' by Barbara Chipman Moment.

Published
1977

37. Perfect Package.

Author

Wade, Gordon and St. Vrain, Kent

Subjects
PHARMACEUTICAL industry, PACKAGING, CONTAINERS, BRAND loyalty, CONSUMER behavior
Abstract

Focuses on the packaging practices and technologies in the pharmaceutical industry. Effect of the package design to patience compliance; Ability of packaging to solidify patient loyalty to the brand; Benefit of the blister-packaging format. INSET: Get Automated.

Published
2005

38. Seeking a Model of Success.

Author

Wade, Gordon

Subjects
CONVENIENCE stores, BUSINESS success, MARKET share, MERCHANDISING, RETAIL industry
Abstract

The article focuses on various issues which convenience store proprietors in the U.S. need to consider for building success models. According to the author, proprietors should consider the elasticity of product prices, market share of stores having high single serve margins, and merchandising alternatives available to them.

Published
2014

39. Mastering Category Management.

Author

WADE, GORDON

Subjects
CATEGORY management, CONSUMER package goods, RETAIL industry, ONLINE shopping, BRAND loyalty
Abstract

The article focuses on the importance of category management which is the primary platform from which consumer package goods (CPG) brand owners interact with retailers. Like consumer research or brand strategy development, category management is a fundamental discipline. There are several trends that threaten to overwhelm category management. Those trends include the increasing power of the retailer in the CPG ecosystem and the online shopping of former brand loyalists.

Published
2013

40. Shopper Fact or Insight?

Author

Wade, Gordon

Subjects
RETAIL industry, MARKET segmentation, CONVENIENCE stores, MARKETING, CONSUMERS
Abstract

The article discusses how retailers and marketers can determine and take advantage of shopper insight in order to address the product-related challenges. It emphasizes the need for retailers to know their profile mix by knowing what segment a shopper belongs. It cites a scenario which demonstrates how insight can be used to solve a problem at convenient stores in the beer cooler.

Published
2012

41. MARKETERS, UNLOCK THE POSSIBILITIES WITHIN DATA.

Author

Wade, Gordon

Subjects
*MARKETING research, *RESEARCH methodology evaluation, *CONSUMER attitude research, *CONSUMER behavior research, *COMPUTER software, *RESEARCH
Abstract

The author offers opinions on marketing research. Analysis of data on consumer attitudes and behavior generated though their Internet activity is seen as what will be by far the most important element in such research in the foreseeable future. Computer software which automates the analysis of that information and which can accurately forecast future consumer behavior is described.

Published
2009

42. WHY NETWORKS BEST SILOS IN THE NEW ENVIRONMENT.

Author

Wade, Gordon

Subjects
*MARKETING, *MARKETING science, *INDUSTRIAL management, *CONSUMERS
Abstract

The article discusses how to organize a marketing department. In the author's view a network structure is key, in which the nodes represent functional capabilities and the entire apparatus is built around the customer. Marketing departments will vary according to differences in a firm's customers, and no template exists for the perfect department.

Published
2009

43. CRISIS IN MARKETING BRINGS UNPRECEDENTED OPPORTUNITY.

Author

Wade, Gordon

Subjects
*MARKETING, *BRAND equity, *CUSTOMER loyalty, *CONSUMER behavior, *INTERNET, *CRISES
Abstract

The article discusses the field of marketing, which is said to be in crisis. Examples of problems include the decline of brand equity and customer loyalty. These are said to be largely due to the radical impact of the internet on the processing of information by consumers. Recommendations for reinventing marketing procedures to deal with these changes effectively are provided.

Published
2009

45. Enchanted Pilgrimage (Book).

Author

Wade, Gordon S.

Subjects
*SCIENCE fiction
Abstract

Reviews the book 'Enchanted Pilgrimage,' by Clifford D. Simak.

Published
1975

48. Beyond Control (Book Review).

Author

Wade, Gordon S.

Subjects
*PHYSICIANS, *FICTION
Abstract

Reviews the book 'Beyond Control,' by George Leonard.

Published
1975

49. Caution! Inflammable! (Book Review).

Author

Wade, Gordon S.

Subjects
*SCIENCE fiction, *FICTION
Abstract

Reviews the book 'Caution! Inflammable!,' by Thomas N. Scortia.

Published
1975

50. The Lion's Paw (Book Review).

Author

Wade, Gordon S.

Subjects
*HUNTERS in literature, *FICTION
Abstract

Reviews the book 'The Lion's Paw,' by D.R. Sherman.

Published
1975

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