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4. Response to the letter: “Predictive factors for transition to conversion therapy in HCC using atezolizumab plus bevacizumab”

Author

Kikuchi, Tatsuya, primary, Takeuchi, Yasuto, additional, Nouso, Kazuhiro, additional, Kariyama, Kazuya, additional, Kuwaki, Kenji, additional, Toshimori, Junichi, additional, Iwado, Shota, additional, Moriya, Akio, additional, Hagihara, Hiroaki, additional, Takabatake, Hiroyuki, additional, Tada, Toshifumi, additional, Yasunaka, Tetsuya, additional, Sakata, Masahiro, additional, Sue, Masahiko, additional, Miyake, Nozomi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Otsuka, Motoyuki, additional

Published
2024
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5. Predictive factors for transition to conversion therapy in hepatocellular carcinoma using atezolizumab plus bevacizumab

Author

Kikuchi, Tatsuya, primary, Takeuchi, Yasuto, additional, Nouso, Kazuhiro, additional, Kariyama, Kazuya, additional, Kuwaki, Kenji, additional, Toshimori, Junichi, additional, Iwado, Shota, additional, Moriya, Akio, additional, Hagihara, Hiroaki, additional, Takabatake, Hiroyuki, additional, Tada, Toshifumi, additional, Yasunaka, Tetsuya, additional, Sakata, Masahiro, additional, Sue, Masahiko, additional, Miyake, Nozomi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Otsuka, Motoyuki, additional

Published
2024
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7. The prediction of early progressive disease in patients with hepatocellular carcinoma receiving atezolizumab plus bevacizumab

Author

Takeuchi, Yasuto, primary, Nouso, Kazuhiro, additional, Fujioka, Shin‐ichi, additional, Kariyama, Kazuya, additional, Kobashi, Haruhiko, additional, Uematsu, Shuji, additional, Moriya, Akio, additional, Hagihara, Hiroaki, additional, Takabatake, Hiroyuki, additional, Nakamura, Shinichiro, additional, Yabushita, Kazuhisa, additional, Kikuchi, Tatsuya, additional, Oyama, Atsushi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, and Takaki, Akinobu, additional

Published
2023
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12. History of Transcatheter Arterial Chemoembolization Predicts the Efficacy of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

Author

Onishi, Hideki, Nouso, Kazuhiro, Takaki, Akinobu, Oyama, Atsushi, Adachi, Takuya, Wada, Nozomu, Takeuchi, Yasuto, Shiraha, Hidenori, and Okada, Hiroyuki

Subjects
refractory, Carcinoma, Hepatocellular, Treatment Outcome, Hepatic Artery, Liver Neoplasms, Antineoplastic Combined Chemotherapy Protocols, hepatic arterial infusion chemotherapy, Humans, hepatocellular carcinoma, Cisplatin, Chemoembolization, Therapeutic, transcatheter arterial chemoembolization, Retrospective Studies
Abstract

This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC.

Published
2022

13. A subclinical high tricuspid regurgitation pressure gradient independent of the mean pulmonary artery pressure is a risk factor for the survival after living donor liver transplantation

Author

Saragai, Yosuke, Takaki, Akinobu, Umeda, Yuzo, Matsusaki, Takashi, Yasunaka, Tetsuya, Oyama, Atsushi, Kaku, Ryuji, Nakamura, Kazufumi, Yoshida, Ryuichi, Nobuoka, Daisuke, Kuise, Takashi, Takagi, Kosei, Adachi, Takuya, Wada, Nozomu, Takeuchi, Yasuto, Koike, Kazuko, Ikeda, Fusao, Onishi, Hideki, Shiraha, Hidenori, Nakamura, Shinichiro, Morimatsu, Hiroshi, Ito, Hiroshi, Fujiwara, Toshiyoshi, Yagi, Takahito, and Okada, Hiroyuki

Published
2018
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14. Study Protocol for a Trial: A Single-Arm, Open-Labeled Study Evaluating Transcatheter Arterial Embolization Plus Everolimus Combination Therapy for Patients With Liver Metastasis of Gastroenteropancreatic Neuroendocrine Tumors

Author

Takeuchi, Yasuto, Kato, Hironari, Horiguchi, Shigeru, Oyama, Atsushi, Adachi, Takuya, Wada, Nozomu, Onishi, Hideki, Shiraha, Hidenori, Takaki, Akinobu, Takeuchi, Yasuto, Kato, Hironari, Horiguchi, Shigeru, Oyama, Atsushi, Adachi, Takuya, Wada, Nozomu, Onishi, Hideki, Shiraha, Hidenori, and Takaki, Akinobu

Abstract

Background: The number of patients with non-functional neuroendocrine tumors (NETs) has increased recently, and the rate of liver metastasis of NETs is about 20% in patients at the first diagnosis. Transcatheter arterial embolization (TAE) and everolimus are therapies with reported efficacy, but few reports have described their combined treatment. We therefore aim to evaluate the efficacy and safety of combination therapy with everolimus and TAE in patients with liver metastasis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in a prospective study. Methods: We design a single-arm, open-label, prospective study to evaluate the efficacy and safety of combination therapy with everolimus and TAE in patients with liver metastases of GEP-NETs. The study started in June 2021 at Okayama University Hospital and is expected to enroll 18 patients over a 2-year period. Discussion: This study is a prospective study investigating a new treatment method for a rare disease called GEP-NETs. We may obtain useful information that contributes to the treatment guidelines in this study. However, NET is a rare disease, and although the number of cases is statistically established, it may not be possible to accurately assess causality.

Published
2022

15. Promising therapeutic efficacy of a novel reduced expression in immortalized cells/dickkopf‐3 expressing adenoviral vector for hepatocellular carcinoma

Author

Sawahara, Hiroaki, Shiraha, Hidenori, Uchida, Daisuke, Kato, Hironari, Kato, Ryo, Oyama, Atsushi, Nagahara, Teruya, Iwamuro, Masaya, Horiguchi, Shigeru, Tsutsumi, Koichiro, Mandai, Mari, Mimura, Tetsushige, Wada, Nozomu, Takeuchi, Yasuto, Kuwaki, Kenji, Onishi, Hideki, Nakamura, Shinichiro, Watanabe, Masami, Sakaguchi, Masakiyo, Takaki, Akinobu, Nouso, Kazuhiro, Yagi, Takahito, Nasu, Yasutomo, Kumon, Hiromi, and Okada, Hiroyuki

Published
2017
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17. Efficacy of hepatic arterial infusion chemotherapy in combination with irradiation for advanced hepatocellular carcinoma with portal vein invasion

Author

Onishi, Hideki, Nouso, Kazuhiro, Nakamura, Shinichiro, Katsui, Kuniaki, Wada, Nozomu, Morimoto, Yuki, Miyahara, Koji, Takeuchi, Yasuto, Kuwaki, Kenji, Yasunaka, Tetsuya, Miyake, Yasuhiro, Shiraha, Hidenori, Takaki, Akinobu, Kobayashi, Yoshiyuki, Sakaguchi, Kohsaku, Kanazawa, Susumu, and Yamamoto, Kazuhide

Published
2015
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20. Study Protocol for a Trial: A Single-Arm, Open-Labeled Study Evaluating Transcatheter Arterial Embolization Plus Everolimus Combination Therapy for Patients With Liver Metastasis of Gastroenteropancreatic Neuroendocrine Tumors

Author

Takeuchi, Yasuto, primary, Kato, Hironari, additional, Horiguchi, Shigeru, additional, Oyama, Atsushi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, and Takaki, Akinobu, additional

Published
2022
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24. Use of non-invasive serum glycan markers to distinguish non-alcoholic steatohepatitis from simple steatosis

Author

Yamasaki, Yasushi, Nouso, Kazuhiro, Miyahara, Koji, Wada, Nozomu, Dohi, Chihiro, Morimoto, Yuki, Kinugasa, Hideaki, Takeuchi, Yasuto, Yasunaka, Tetsuya, Kuwaki, Kenji, Onishi, Hideki, Ikeda, Fusao, Miyake, Yasuhiro, Nakamura, Shinichiro, Shiraha, Hidenori, Takaki, Akinobu, Iwasaki, Yoshiaki, Amano, Maho, Nishimura, Shin-Ichiro, and Yamamoto, Kazuhide

Published
2015
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25. Lethal biliary congestive acute hepatitis E without acute liver failure: A case report

Author

Yamauchi, Nao, primary, Yasunaka, Tetsuya, additional, Takaki, Akinobu, additional, Hinami, Yoshimune, additional, Kinomura, Masaru, additional, Kawahara, Akina, additional, Adachi, Takuya, additional, Oyama, Atsushi, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, and Okada, Hiroyuki, additional

Published
2021
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26. Management of Cirrhotic Ascites under the Add-on Administration of Tolvaptan

Author

Adachi, Takuya, Takeuchi, Yasuto, Takaki, Akinobu, Oyama, Atsushi, Wada, Nozomu, Onishi, Hideki, Shiraha, Hidenori, Okada, Hiroyuki, Adachi, Takuya, Takeuchi, Yasuto, Takaki, Akinobu, Oyama, Atsushi, Wada, Nozomu, Onishi, Hideki, Shiraha, Hidenori, and Okada, Hiroyuki

Abstract

Tolvaptan is a recently available diuretic that blocks arginine vasopressin receptor 2 in the renal collecting duct. Its diuretic mechanism involves selective water reabsorption by affecting the water reabsorption receptor aquaporin 2. Given that liver cirrhosis patients exhibit hyponatremia due to their pseudo-aldosteronism and usage of natriuretic agents, a sodium maintaining agent, such as tolvaptan, is physiologically preferable. However, large scale studies indicating the patients for whom this would be effective and describing management under its use have been insufficient. The appropriate management of cirrhosis patients treated with tolvaptan should be investigated. In the present review, we collected articles investigating the effectiveness of tolvaptan and factors associated with survival and summarized their management reports. Earlier administration of tolvaptan before increasing the doses of natriuretic agents is recommended because this may preserve effective arterial blood volume.

Published
2021

30. Abnormal fucosylation of alpha‐fetoprotein in patients with nonalcoholic steatohepatitis

Author

Nouso, Kazuhiro, primary, Furubayashi, Yoshie, additional, Kariyama, Kazuya, additional, Wakuta, Akiko, additional, Miyake, Nozomi, additional, Inoue, Kanae, additional, Nagai, Yuta, additional, Murakami, Shiho, additional, Adachi, Takuya, additional, Oyama, Atsushi, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Sakata, Masahiro, additional, Yasunaka, Tetsuya, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Shiota, Shohei, additional, Yasuda, Satoshi, additional, Toyoda, Hidenori, additional, Kawanaka, Miwa, additional, Kumada, Takashi, additional, and Okada, Hiroyuki, additional

Published
2021
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32. High expression of a vascular stricture‐related marker is predictive of an early response to tolvaptan, and a low fractional excretion of sodium is predictive of a poor long‐term survival after tolvaptan administration for liver cirrhosis

Author

Adachi, Takuya, primary, Takaki, Akinobu, additional, Sato, Shuichi, additional, Tobita, Hiroshi, additional, Kobashi, Haruhiko, additional, Kinomura, Masaru, additional, Nakatsuka, Atsuko, additional, Oyama, Atsushi, additional, Wada, Nozomu, additional, Sakata, Masahiro, additional, Takeuchi, Yasuto, additional, Yasunaka, Tetsuya, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, and Okada, Hiroyuki, additional

Published
2020
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34. Prediction of the prognosis of advanced hepatocellular carcinoma by TERT promoter mutations in circulating tumor DNA

Author

Hirai, Mami, primary, Kinugasa, Hideaki, additional, Nouso, Kazuhiro, additional, Yamamoto, Shumpei, additional, Terasawa, Hiroyuki, additional, Onishi, Yuma, additional, Oyama, Atsushi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Sakata, Masahiro, additional, Yasunaka, Tetsuya, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2020
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36. Human Telomerase Reverse Transcriptase Gene Promoter Mutation in Serum of Patients with Hepatocellular Carcinoma

Author

Ako, Soichiro, primary, Nouso, Kazuhiro, additional, Kinugasa, Hideaki, additional, Matsushita, Hiroshi, additional, Terasawa, Hiroyuki, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Mandai, Mari, additional, Onishi, Hideki, additional, Ikeda, Fusao, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Fujioka, Shinichi, additional, Mimura, Tetsushige, additional, and Okada, Hiroyuki, additional

Published
2020
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37. The Early Decline of α-Fetoprotein and Des-γ-Carboxy Prothrombin Predicts the Response of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

Author

Yamamoto, Shumpei, primary, Onishi, Hideki, additional, Takaki, Akinobu, additional, Oyama, Atsushi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Sakata, Masahiro, additional, Yasunaka, Tetsuya, additional, Shiraha, Hidenori, additional, and Okada, Hiroyuki, additional

Published
2020
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39. A Phase I/Ib trial of Ad-REIC in liver cancer: study protocol

Author

Oyama, Astushi, primary, Shiraha, Hidenori, additional, Uchida, Daisuke, additional, Iwamuro, Masaya, additional, Kato, Hironari, additional, Takaki, Akinobu, additional, Ikeda, Fusao, additional, Onishi, Hideki, additional, Yasunaka, Tetsuya, additional, Takeuchi, Yasuto, additional, Wada, Nozomu, additional, Iwasaki, Yoshiaki, additional, Sakata, Masahiro, additional, Okada, Hiroyuki, additional, and Kumon, Hiromi, additional

Published
2019
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40. Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B

Author

Makita, Takashi, primary, Kanzaki, Hirotaka, additional, Onishi, Hideki, additional, Ikeda, Ailee, additional, Takaki, Akinobu, additional, Wada, Nozomu, additional, Takeuchi, Yasuto, additional, Yasunaka, Tetsuya, additional, Ikeda, Fusao, additional, Shiraha, Hidenori, additional, Tanaka, Yuta, additional, Nishihara, Shigeki, additional, Murakawa, Kiminaka, additional, Kitamura, Yoshihisa, additional, Okada, Hiroyuki, additional, and Sendo, Toshiaki, additional

Published
2019
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41. Prediction of the prognosis of advanced hepatocellular carcinoma by TERT promoter mutations in circulating tumor DNA.

Author

Hirai, Mami, Kinugasa, Hideaki, Nouso, Kazuhiro, Yamamoto, Shumpei, Terasawa, Hiroyuki, Onishi, Yuma, Oyama, Atsushi, Adachi, Takuya, Wada, Nozomu, Sakata, Masahiro, Yasunaka, Tetsuya, Onishi, Hideki, Shiraha, Hidenori, Takaki, Akinobu, and Okada, Hiroyuki

Subjects
CIRCULATING tumor DNA, TELOMERASE reverse transcriptase, HEPATOCELLULAR carcinoma, PROGNOSIS, AGROBACTERIUM tumefaciens, CHEMOEMBOLIZATION
Abstract

Background andAim: Human telomerase reverse transcriptase (TERT) promoter mutations were the most prevalent mutations in patients with hepatocellular carcinoma (HCC). We tried to detect the mutations with plasma circulating tumor DNA (ctDNA) in patients with advanced HCC and elucidated their clinical utility. Methods: Circulating tumor DNA in plasma was extracted from 130 patients with advanced HCC who were treated with systemic chemotherapy (n = 86) or transcatheter arterial chemoembolization (n = 44), and TERT promoter mutations were examined with digital droplet polymerase chain reaction. The correlations between these mutations and the clinical outcome of patients were analyzed. Results: Of the 130 patients examined, 71 patients (54.6%) were positive for TERT promoter mutations in ctDNA, of which 64 patients were −124bp G > A and 10 were −146bp G > A. The presence of TERT promoter mutations was correlated with large intrahepatic tumor size (P = 0.05) and high des‐gamma carboxyprothrombin (P = 0.005). Overall survival of the patients with the mutations was significantly shorter than those without them (P < 0.001), and the patients with high (≥ 1%) fractional abundance of the mutant alleles showed shorter survival than those with low (< 1%) fractional abundance. Multivariate analysis revealed that TERT promoter mutation (hazard ratio [HR]: 1.94; 95% confidence interval [CI], 1.18–3.24; P < 0.01), systemic chemotherapy (HR: 2.38; 95% CI, 1.29–4.57; P < 0.01), and vascular invasion (HR: 2.16; 95% CI, 1.22–3.76; P < 0.01) were significant factors for poor overall survival. Conclusions: TERT promoter mutations in ctDNA were associated with short survival and could be a valuable biomarker for predicting the prognosis of patients with advanced HCC. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Simple screening method for the diagnosis of nonB-nonC hepatocellular carcinoma

Author

Nouso, Kazuhiro, primary, Furubayashi, Yoshie, additional, Shiota, Shohei, additional, Wakuta, Akiko, additional, Oonishi, Ayano, additional, Kariyama, Kazuya, additional, Takeuchi, Yasuto, additional, Wada, Nozomu, additional, Onishi, Hideki, additional, Adachi, Takuya, additional, Oyama, Atsushi, additional, Dohi, Chihiro, additional, Yasunaka, Tetsuya, additional, Yasunaka, Yuki, additional, Ikeda, Fusao, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2018
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43. An activity survey of hepatitis medical care coordinators in Okayama Prefecture, Japan

Author

Namba, Shihoko, primary, Ikeda, Fusao, additional, Akiyama, Fumio, additional, Ishihara, Mitsumasa, additional, Shimomura, Yasuyuki, additional, Yamasaki, Noriko, additional, Inuyama, Naomi, additional, Koyama, Michihiro, additional, Kamegawa, Katsunori, additional, Okubo, Shinnosuke, additional, Hasegawa, Yuko, additional, Iwai, Kenji, additional, Sanki, Akiko, additional, Miura, Rumi, additional, Yano, Kanae, additional, Fujii, Yosuke, additional, Ohyama, Atsushi, additional, Adachi, Takuya, additional, Wada, Nozomu, additional, Yasunaka, Yuki, additional, Yasunaka, Tetsuya, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, Yamanoi, Hisami, additional, and Okada, Hiroyuki, additional

Published
2018
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44. The Serum Oxidative/Anti-oxidative Stress Balance Becomes Dysregulated in Patients with Non-alcoholic Steatohepatitis Associated with Hepatocellular Carcinoma

Author

Shimomura, Yasuyuki, Takaki, Akinobu, Wada, Nozomu, Yasunaka, Tetsuya, Ikeda, Fusao, Maruyama, Takayuki, Tamaki, Naofumi, Uchida, Daisuke, Onishi, Hideki, Kuwaki, Kenji, Nakamura, Shinichiro, Nouso, Kazuhiro, Miyake, Yasuhiro, Koike, Kazuko, Tomofuji, Takaaki, Morita, Manabu, Yamamoto, Kazuhide, Okada, Hiroyuki, Shimomura, Yasuyuki, Takaki, Akinobu, Wada, Nozomu, Yasunaka, Tetsuya, Ikeda, Fusao, Maruyama, Takayuki, Tamaki, Naofumi, Uchida, Daisuke, Onishi, Hideki, Kuwaki, Kenji, Nakamura, Shinichiro, Nouso, Kazuhiro, Miyake, Yasuhiro, Koike, Kazuko, Tomofuji, Takaaki, Morita, Manabu, Yamamoto, Kazuhide, and Okada, Hiroyuki

Abstract

Objective Oxidative stress is associated with the progression of chronic liver disease. Non-alcoholic fatty liver disease (NAFLD) is also an oxidative stress-related disease. However, the oxidative/anti-oxidative balance has not been fully characterized in NAFLD. The objective of the present study was to investigate the balance between oxidative stress and the anti-oxidative activity in NAFLD, including non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC). Patients We recruited 69 patients with histologically proven NAFLD without HCC (NAFLD; n=58), and with NASH-related HCC (NASH-HCC; n=11). The 58 NAFLD patients included patients with non-alcoholic fatty liver (NAFL; n=14) and NASH (n=44). Methods The serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY) were determined and then used to calculate the oxidative index. The correlations among such factors as ROM, OXY, oxidative index, and clinical characteristics were investigated. Results In NAFLD, ROM positively correlated with the body mass index (BMI), hemoglobin A1c (HbA1c), C-reactive protein (CRP), and the histological grade or inflammatory scores, while only high HbA1c and CRP levels were significant factors that correlated with a higher ROM according to a multivariate analysis. OXY positively correlated with the platelet counts, albumin, and creatinine levels, while negatively correlating with age. However, it improved after treatment intervention. The oxidative index positively correlated with BMI, CRP, and HbA1c. The NASH-HCC patients exhibited a lower OXY than the NASH patients, probably due to the effects of aging. Conclusion Oxidative stress correlated with the levels of NASH activity markers, while the anti-oxidative function was preserved in younger patients as well as in patients with a well-preserved liver function. The NASH-HCC patients tended to be older and exhibited a diminished anti-oxidative function.

Published
2017

45. Subclinical Pulmonary Hypertension is a Strong Risk of Post Living Donor Liver Transplantation Survival for Liver Cirrhosis

Author

Saragai, Yosuke, primary, Takaki, Akinobu, additional, Umeda, Yuzo, additional, Yasunaka, Tetsuya, additional, Kaku, Ryuji, additional, Nakamura, Kazufumi, additional, Yagi, Takahito, additional, Shinoura, Susumu, additional, Yoshida, Ryuichi, additional, Nobuoka, Daisuke, additional, Adachi, Takuya, additional, Shimomura, Yasuyuki, additional, Wada, Nozomu, additional, Kuwaki, Kenji, additional, Ikeda, Fusao, additional, Onishi, Hideki, additional, Shiraha, Hidenori, additional, Nakamura, Shinichiro, additional, Ito, Hiroshi, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2017
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47. A sofosbuvir-based direct-acting antiviral treatment regimen exhibits a strong protective effect against post-liver transplantation chronic hepatitis C recurrence

Author

Oyama, Atsushi, primary, Takaki, Akinobu, additional, Yasunaka, Tetsuya, additional, Adachi, Takuya, additional, Ikeda, Fusao, additional, Wada, Nozomu, additional, Takeuchi, Yasuhito, additional, Onishi, Hideki, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takagi, Kosei, additional, Kuise, Takashi, additional, Nobuoka, Daisuke, additional, Yoshida, Ryuichi, additional, Umeda, Yuzo, additional, Yoshida, Mari, additional, Arimori, Chisato, additional, Yagi, Takahito, additional, and Okada, Hiroyuki, additional

Published
2017
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48. The Serum Oxidative/Anti-oxidative Stress Balance Becomes Dysregulated in Patients with Non-alcoholic Steatohepatitis Associated with Hepatocellular Carcinoma

Author

Shimomura, Yasuyuki, primary, Takaki, Akinobu, additional, Wada, Nozomu, additional, Yasunaka, Tetsuya, additional, Ikeda, Fusao, additional, Maruyama, Takayuki, additional, Tamaki, Naofumi, additional, Uchida, Daisuke, additional, Onishi, Hideki, additional, Kuwaki, Kenji, additional, Nakamura, Shinichiro, additional, Nouso, Kazuhiro, additional, Miyake, Yasuhiro, additional, Koike, Kazuko, additional, Tomofuji, Takaaki, additional, Morita, Manabu, additional, Yamamoto, Kazuhide, additional, and Okada, Hiroyuki, additional

Published
2017
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49. Sufficient management of alert system of positive test results for HBV and HCV infection in electronic medical chart for facilitating hepatological consultation

Author

Shimomura, Yasuyuki, primary, Fujii, Yousuke, additional, Ikeda, Fusao, additional, Yasunaka, Tetsuya, additional, Yamasaki, Noriko, additional, Kasahara, Ikuko, additional, Inuyama, Naomi, additional, Koyama, Michihiro, additional, Namba, Shihoko, additional, Takeuchi, Yasuto, additional, Wada, Nozomu, additional, Kuwaki, Takeshi, additional, Onishi, Hideki, additional, Nakamura, Shinichiro, additional, Shiraha, Hidenori, additional, Takaki, Akinobu, additional, and Okada, Hiroyuki, additional

Published
2017
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