30 results on '"Wada, Fumito"'
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2. Prodrug‐Type Phosphotriester Oligonucleotides with Linear Disulfide Promoieties Responsive to Reducing Environment
3. Development of APOC3 antisense oligonucleotide for broader dyslipidemia
4. Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility
5. Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides
6. Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides
7. Abstract 18674: Development of Antisense Drug Targeting PCSK9
8. Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides
9. Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides
10. Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides
11. Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma
12. Effect of modular conjugation strategy forN-acetylgalactosamine-targeted antisense oligonucleotides
13. Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA
14. Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides.
15. Preclinical Pharmacology and Safety Studies of GalNAc-conjugated Antisense Oligonucleotides Targeting Human PCSK9
16. Cholesterol–GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides
17. Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes
18. Efficacy and safety of antisense drug targeting PCSK9 in non human primates
19. Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivatives
20. Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency
21. Development of Antisense Drugs for Dyslipidemia
22. Effect of an N-substituent in sulfonamide-bridged nucleic acid (SuNA) on hybridization ability and duplex structure
23. Ca2+enrichment in culture medium potentiates effect of oligonucleotides
24. Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo
25. Evaluation of Multiple-Turnover Capability of Locked Nucleic Acid Antisense Oligonucleotides in Cell-Free RNase H-Mediated Antisense Reaction and in Mice
26. Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors
27. Superior Silencing by 2',4'-BNANC-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors.
28. Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility.
29. Triazole- and Tetrazole-Bridged Nucleic Acids: Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro and in Vivo Antisense Potency.
30. Ca2+ enrichment in culture medium potentiates effect of oligonucleotides.
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