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Objective To analyze and construct systolic blood pressure (SBP) fluctuation trajectory in a community population with hypertension and to analyze the factors influencing different trajectories. Methods This is a community-based retrospective cohort study. A latent class trajectory model was used to identify and construct longitudinal trajectories of blood pressure change. Multinomial logistic regression analysis was performed to identify the associated factors of blood pressure trajectories by adjusting for different confounders. Potential confounding factors were identified using a directed acyclic graph based on a priori knowledge. Results A total of 793 patients with hypertension were enrolled in the analysis. They were divided into 3 groups by LCTM-fitted systolic blood pressure trajectories, namely stable low-level group (n=561, 70.74%), declining group (n=170, 21.44%) and rising group (n=62, 7.82%). Significant differences were observed among the 3 trajectories groups in terms of age, frequency of exercise, ways of follow-up, salt intake, compliance behavior, and referral (P

Objective To investigate the results of ambulatory electrocardiographic (ECG) monitoring in a community-based homebound elderly population and to explore the applicability of wearable long-range ambulatory ECG monitor for them. Methods Elderly volunteers were recruited in Shuangbei Community, Shapingba District, Chongqing, from November 2021 to June 2023. A single-lead wearable ambulatory ECG recorder was applied to them to obtain ECG for 7 consecutive days. The adverse reactions, acceptability, monitoring duration, and arrhythmia detection rate during the wearing were described and recorded. Serious arrhythmic events included frequent atrial premature, atrial flutter, atrial fibrillation (AF), frequent ventricular premature, and RR intervals ≥5 s. Results There were 416 individuals enrolled, with a mean age of 71.2±6.6 years, and a male percentage of 36.1% (150 men). Finally, 384 (92.3%) participants completed the wearing of the ECG monitor for 7 d, with an average time of 159.2±29.4 h. There were 179 participants (48.5%) reporting no discomfort during wearing, and 175 ones (47.4%) feeling itchy at the wearing site. The monitoring results showed that the common arrhythmias were atrial premature contractions (97.1%), premature ventricular contractions (93.3%), atrial tachycardia (84.6%), bradycardia (46.6%), frequent atrial premature contractions (15.1%), ventricular tachycardia (13.2%), and long RR interval (11.8%). Among them, 29.1% of the participants experienced serious arrhythmic events, and the detection rate of certain serious arrhythmic events was comparatively higher in the individuals ≥70 years of age and those with history of previous cardiac disease. Conclusion The detection rate of common arrhythmias is quite high in the community-based homebound elderly population. A 7-day long-range ambulatory ECG monitoring may be appropriate.

Objective To investigate the effect of mmu_circ_0005019 on regulating Kcnn3 expression, small conductance calcium-activated potassium current (IK,Ca) which is generated by the small conductance calcium-activated potassium (SK) channel that is partly coded by Kcnn3, and action potential duration (APD). Methods We transfected pcDNA3.1-mmu_circ_0005019 expressing vectors and 2 independent small interfering RNAs into HL-1 cells to establish gain- and loss-of-expression cell models, respectively. The transfected cells were divided into overexpression group(n=3), empty vector group(n=3), interference 1 group(n=3), interference 2 group(n=3), and blank control group(n=3). RT-qPCR and Western blotting were used to determine the expression of Kcnn3. Whole-cell patch clamp technology was performed to record the IK, Ca and APD. The effects of mmu_circ_0005019 on Kcnn3 expression, IK, Ca and APD were observed. Results Gain- and loss-of-expression cell models were established successfully. The expression of Kcnn3 and IK,Ca current density significantly increased, and the APD was shortened in overexpression group compared with empty vector group(P < 0.05). The expression of Kcnn3 and IK,Ca current density were significantly decreased, and the APD was prolonged in interference groups compared with blank control group(P < 0.05). Conclusion Mmu_circ_0005019 promotes the expression of Kcnn3 and its coding channel protein, which regulates IK,Ca and APD in mouse cardiomyocytes, and may play a promoting role in the occurrence of atrial fibrillation.

Chronic diseases inclding diabetes have been important public health problems worldwide. Starch intake is one of the main causes of postprandial blood glucose elevation. Recent studies have demonstrated that polyphenols can slow down the rate of starch digestion. Brown rice is rich in phenolics, and its nutritional health benefits are widely recognized around the world as an essential source of whole grains. The unique functional groups of phenolic substances in brown rice, such as phenolic hydroxyl, have a certain inhibitory effect on digestive enzymes. Changes in the structure of starch during processing also decrease the effect of digestive enzymes on it. This not only affects the digestion rate and digestibility of starch in an effective way, but also improves food quality. This paper reviews several aspects of phenolics in brown rice and their antioxidant activities, the process of starch digestion, the effects of brown rice polyphenols on starch digestive properties and their mechanisms of action. The aim of this review is to elucidate the scientific basis of whole grain brown rice polyphenols to retard starch digestion, and provide theoretical references for the development of whole grain brown rice-based and starch-based foods which are beneficial for populations of chronic disease, obesity, overweight, elderly, etc.

ObjectiveThis paper discusses the development and design of food formulations for special medical purposes to provide a reference for product development and design， registration management， and the clinical use of such products.MethodsWe summarized and analyzed the formulations of formula food for special medical purposes， determined the important aspects of formula development and design， and identified key points for evaluating registration applications.ResultsThe formulation design of formula food for special medical purposes should be based on standards and regulations. The most important thing is to think the formula design as a whole， clinical use shuold be the leading of the formulation design， and attention should be paid to the registration dossiers.ConclusionFormulation design is the most important aspect in the research and development of formula foods for special medical purposes. Attention should be paid to the scientific， rational， and clinical applications of these foods. The administrative department should improve its standards and regulations to ensure they are widely used in clinical practice.

Whole grains have gained great attention due to their important roles in nutrition and health. Fresh brown rice noodles, which have been considered as a nutritious and healthy whole grain staple food, are more prone to be spoiling, aging, hardening and easy broken with high cooking loss rate. The factors affecting the quality of fresh brown rice noodles were systematically described, and the changes in water content, pH value, cooking quality, water migration, texture and microstructure of fresh brown rice noodles during storage were also summarized. The mechanism of quality deterioration of fresh brown rice noodles was elaborated and analyzed. Furthermore, the latest research progress (from the year 2016 to 2023) on the quality control technology of fresh brown rice noodles was reviewed, including the selection of raw materials for brown rice, the addition of exogenous additives, the whole grain grinding of brown rice, and the backfilling method of rice bran for preparing brown rice noodles. This review could provide the references for the quality control and improvement of fresh brown rice noodles.

Water-soluble dietary fiber was extracted from ten kinds of cereal bran, such as rice fragrance rice bran, long grain fragrant rice bran, indica rice bran, millet rice bran, wheat bran thick bran, wheat bran thin bran, oat bran, sweet buckwheat skin powder, tartary buckwheat skin powder, millet skin powder. The physicochemical characteristics, functional characteristics and molecular structure of these SDF samples were studied. SDF from tartary buckwheat skin powder had the strongest water holding capacity. SDF from millet skin powder had the strongest oil holding capacity. SDF from wheat bran thin bran showeds the strongest water expansion. SDF from rice fragrance rice bran, long grain fragrant rice bran, millet rice bran and sweet buckwheat skin powder did not have water absorption expansion ability. The glucose binding abilities of ten kinds of SDF were between 56.95~432.83 mg/g. The cholesterol adsorption capacity of SDF from Grain bran was significantly different in the range of 0.41~66.21 mol/g. The antioxidant ability of ABTS and DPPH for SDF from wheat bran was the highest, and the antioxidant ability of hydroxyl for SDF of millet rice bran was the highest. The total antioxidant capacity of the ten kinds of SDF was significantly varied with the range of 2.00~5.59 μmol/g. SEM results showed some uneven surface with granular and smooth with porous structure, and Fourier infrared absorption spectrum results show different weak peaks. In conclusion, there were obvious differences in the molecular structure, physical and functional properties of SDF from different sources, and SDF with different structural and functional properties can be selected according to the specific utilizations.

Background: To explore the association of polymorphisms of apoptosis-linked genes caspase3 (CASP3), integrin a subunit 1 (ITGA1), glutathione sulfur transferase M1 (GSTM1) with susceptibility to gastric cardia carcinoma (GCC). Methods: From February 2016 to March 2018, selection of 113 GCC patients was as the gastric cancer (GC), and selection of 75 patients without gastric disease was as the control. Detection of CASP3, ITGA1 and GSTM1 gene polymorphisms in patients' peripheral blood was to analyze their association with GC. Division of the GC was into the good prognosis and the unpleasing prognosis in the light of the survival of patients after surgery of 3 years, and the predictable value of gene polymorphisms of CASP3, ITGA1 and GSTM1 in GCC patients was analyzed. Results: CASP3 gene rs12108497 locus, ITGA1 gene rs1862610 locus and GSTM1 genotype of the GC and the control were in accord with Hardy-Weinberg equilibrium (P > 0.05); The detection rate of CASP3 gene rs12108497 locus TC/CC type, ITGA1's gene rs1862610 locus AC/AA type and GSTM1 blank type in the GC was elevated vs. the control (P < 0.05); Logistic regression analysis manifested smoking, anxiety, helicobacter pylori infection, family history of gastrointestinal tumor, combination with chronic gastric disease, CASP3 gene and GSTM1 gene polymorphism were risk factors for GC (P < 0.05); Stratification was in the light of individual smoking status, discovering that the detection rates of CASP3 gene rs12108497 locus TC/CC type, ITGA1 gene RS1862610 locus AC/AA type and GSTM1 blank type in the smoking were crucially augmented vs. the smoking (P < 0.05); The detection rates of CASP3 gene rs12108497 locus TC/CC type, ITGA1 gene rs1862610 locus AC/AA type and GSTM1 blank type in the death were augmented vs. the survival (P < 0.05); Combined detection of CASP3, ITGA1 and GSTM1 gene polymorphisms was provided with predictive value for GCC's prognosis (P < 0.05). Conclusions: CASP3 and GSTM1 genes are susceptibility genes for GCC, which might be associated with the occurrence of GCC in smoking patients, and the joint detection of multiple genes is provided with predictive value for patients' prognosis.

At present, there is no rail transit in China that can directly connect the main urban areas and satellite cities without passengers transferring halfway. In addition to the problem of passenger transfer, the construction of transfer stations presents a challenge to an already land-scarce city. In order to solve this problem, this paper introduces the status quo of rapid light rail technology in China and other countries, compares and analyzes the technical characteristics of rapid LRV, and finally puts forward suggestions on the selection of China’s rapid LRV scheme in the future.

In order to meet the public’s demand for higher and higher comfort level of low-floor trams, this paper analyzes the influence on comfort level from four aspects: equivalent conicity, hinge arrangement position, suspension parameters and track geometry quality. The results show that track geometry quality plays a decisive role in influencing the comfort of low-floor trams, and the power spectral density of track irregularity has a greater impact on the comfort of vehicles than the standard deviation and peak value. Finally, it is suggested that main line maintenance should be shifted from the current management of standard deviation and peak value to track power spectral density curve management. At the same time, it is suggested that vehicle manufacturer should study the track geometry quality more deeply.

Scanned reactive-ion-beam etching method was proposed to transfer two-dimensional mask patterns into quartz substrate, which would produce a larger-size and polarization-independent two-dimensional grating. This method was realized by moving grating substrate in a unidimensional scanning manner and adjusting ion beam density in the vertical scanning direction. Graphite plates between the ion beam source and the substrate were used to correct the beam density. The original Gaussian ion beam density was changed to a uniform distribution to establish a knife-edge shape around the vertical scanning direction. Therefore, a large-area pattern with consistent depth and duty cycle would be engraved into a quartz substrate. A two-dimensional, 1200 groves/mm grating with an 85-mm × 85-mm area was fabricated under scanned reactive-ion-beam etching method and exhibited a 0.197λ (λ = 632.8 nm) diffraction wave front. At 780 nm, the efficiency nonuniformity was less than 9%, and the average diffraction efficiencies of transverse-magnetic and transverse-electric polarized light were 57.2 and 58.0%, respectively. The large-size two-dimensional grating with uniform diffraction efficiency and polarization independence enabled grating displacement measurement with high resolution, long measurement range, multiple degrees of freedom, and potential miniaturization.

Objective To explore the quality of life and its influencing factors in patients with atrial fibrillation (AF). Methods The Chinese Atrial Fibrillation Effect on Quality-of-Life(AFEQT) questionnaire was used to investigate the quality of life in AF patients who had been treated in the Department of Cardiovascular Diseases of 2 tertiary Class A hospitals from June 2016 to March 2021. Multivariate logistic regression model was used to analyze the factors related to the quality of life in the patients. Results A total of 321 AF patients were investigated. The median of total score for quality of life was 79.86 (interquartile range: 70.25, 89.81) in the AF patients. Multivariate logistic regression analysis on different dimensions of quality of life found that smoking history, elevated thrombin time (TT), total protein and D-dimer levels were risk factors in the symptom dimension, while a history of thyroid dysfunction was a protective factor; risk factors in the daily activity dimension included advanced age (≥65 years), hypertension history, stroke history, history of warfarin use, and prolonged TT, while alcohol consumption may be protective factors; the patients with history of hypertension, warfarin and statin use, and elevated monocyte (MONO) count and prolonged prothrombin time (PT) had significantly lower scores in the dimension of treatment of worried, while an activated partial thromboplastin time ratio (APTT-ratio) was a protective factor in the treatment of the worry score; prolonged TT was a risk factor for decreased treatment satisfaction scores; a history of novel oral anticoagulants (NOACs) and elevated APTT-ratio were protective factors for decreased treatment satisfaction scores; risk factors for decreased overall quality of life scores included advanced age (≥75 years), history of stroke, warfarin and statin use, and D-dimer level, while alcohol consumption and higher neutrophil count were protective factors. Conclusion Advanced age (≥65 years), smoking history, warfarin and statin history, hypertension, stroke history, elevated MONO, TP, TT, PT, and D-dimer level affect quality of life in AF patients in different dimensions.

The defatted rice bran was modified by extrusion cooking, and the effects of extrusion cooking on enhancement of soluble dietary fiber (SDF) and structural properties of dietary fiber in rice bran were studied. Taking SDF content as an index, the optimum extrusion conditions of rice bran were determined by single factor experiment as follows: water content of 35%, extrusion temperature of 160 ℃, and screw speed of 250 r/min. After extrusion cooking treatment, the SDF content of rice bran increased from 4.34% to 14.34%. The microstructure of SDF from extruded rice bran was expanded loosely, the water holding capacity and expansion capacity of SDF significantly increased, while the oil holding capacity of SDF significantly decreased. The infrared spectrum of SDF did not produce a new absorption peak, the peak position moved to the long wavenumber direction, and the absorption intensity decreased. The position of crystal diffraction peak of SDF did not change significantly, and the relative crystallinity decreased. The microstructure of insoluble dietary fiber (IDF) from extruded rice bran was broken, the expansibility of IDF significantly increased, the oil-holding capacity of IDF significantly decreased, and the water-holding capacity had no obvious changes. The results of infrared spectra and crystallization properties both showed that cellulose and hemicellulose still existed in IDF from rice bran after extrusion cooking, but the structure of IDF was destroyed and the relative crystallinity of IDF decreased. The results showed that extrusion cooking treatment could change the structure properties of rice bran dietary fiber, providing a theoretical basis for the development and application of dietary fiber products.

In order to explore the quality changes of instant brown rice porridge rice during storage, gas chromatographic ion mobility spectrometry (GC-IMS) and dynamic principal component analysis (PCA) were used to study the changes of the composition and content of characteristic volatile organic compounds during the storage of instant brown rice porridge rice, the difference of volatile organic compounds (VOCs) between samples was evaluated by the flavor information fingerprint. The results showed that GC-IMS combined technology can quickly and qualitatively identify the monomers and dimers of volatile substances of instant brown rice porridge rice in different storage environments and storage times, and a total of 59 VOCs have been identified. The VOCs of fresh instant brown rice porridge rice mainly include aldehydes, ketones and esters, with relative contents of 24.44%, 20.40% and 43.59% respectively. When stored at room temperature, the relative contents of alcohols, aldehydes, pyrazines and furans in instant brown rice porridge increased, while the contents of ketones and esters decreased with the extension of storage time. Vacuum condition had little effect on flavor quality of instant brown rice porridge. In high humidity environment, with the extension of storage time, organic acids were gradually produced, aldehydes and alcohols increased greatly, ketones and esters decreased, and volatile substances changed significantly with the increase of storage temperature.

Objective To investigate the correlation between ADAP2 gene and immune infiltration in tumor microenvironment in lung squamous cell carcinoma (LUSC), and to explore the prognostic values of ADAP2 in patients with LUSC. Methods The clinical information of patients with LUSC as well as the data of ADAP2 mRNA levels in cancer tissues were downloaded from The Cancer Genome Atlas (TCGA) database. The association between ADAP2 gene and prognosis of patients was subsequently analyzed using Kaplan-Meier survival curve and Cox risk model analyses. xCell database was adopted to analyze the correlation of ADAP2 expression with immune infiltration in tumor microenvironment. Immunofluorescence double-staining test was employed to observe the co-localization of ADAP2 protein and CD163 (a specific biomarker of M2 macrophage). Results Multivariate Cox analysis showed that the expression of ADAP2 was an independent prognostic factor for LUSC patients, and its high expression was closely associated with the poor prognosis of patients (HR=1.533, 95%CI: 1.139~2.064, P=0.005). xCell analysis indicated that ADAP2 gene was positively correlated with both the tumor microenvironment score (r=0.609, 95%CI: 0.550~0.661, P < 0.001), and the immune infiltration score (r=0.596, 95%CI: 0.536~0.650, P < 0.001), and the expression of ADAP2 also showed a high positive association with mononuclear phagocyte system (macrophage, macrophage M1, macrophage M2 and monocyte) in LUSC (r=0.737, 0.718, 0.603 and 0.631, respectively, P < 0.001). Moreover, ADAP2 presented co-localization with CD163 and was mainly expressed in the cell membrane. Conclusion ADAP2 can act as a potential biomarker for predicting prognosis and evaluating the efficacy of immunotherapy in LUSC.

Objective To investigate the effect of hydroxysafflor yellow A (HSYA) on the migration and invasion in Huh7 cells, and to explore whether HSYA affects the epithelial-mesenchymal transition (EMT) of liver cancer in vitro and in vivo. Methods Human Huh7 cells were cultured in and divided into control group, 80 and 160 μmol/L HSYA experimental groups and treated for 24 h respectively. Wound healing and Transwell assay were used to evaluate the migration and invasion of HCC cells. Western blot analysis was used to detect the expression of vimentin and E-cadherin. To establish a model of Huh7 nude mice with subcutaneous xenograft, the morphology of transplanted tumor and liver tissues in nude mice were observed under microscopy with H/E staining. The expression of TGF-β1, vimentin and E-cadherin in tumor tissues was detected by immuno-histochemistry. Results Compared with the control group, cell migration and invasion of HSYA experimental group were significantly decreased, E-cadherin expression was increased, and vimentin expression was decreased(P＜0.05). Compared with the transplantation group, there was no tumor cell metastasis and tumor cell necrosis been found in the HSYA experimental group (2.25 mg/kg), expression of E-cadherin was increased and expression of vimentin as well as TGF-β1 was decreased(P＜0.05). Conclusions HSYA inhibits migration and invasion of HCC cells through inhibiting the occurrence of EMT.

Autophagy is a protective mechanism for eukaryotes to maintain homeostasis. Meanwhile, it plays an important role in maintaining the survival and energy metabolism of tumor cells, and also have some impacts on the therapeutic effect of liver cancer through different mechanisms, for example autophagy maintains liver cells homeostasis, causes drug resistance of liver cancer cells. The autophagy inhibitors or natural extracts play a role of resistance to liver cancer through autophagy pathways. It is a great significance to study the regulation mechanisms of autophagy in the prevention and treatment of hepatocellular carcinoma.

China is one the of the major production country of paddy rice, while during the processing of paddy rice, there is usually a high portion of nutrients loss and rice bran by-products are produced.γ-oryzanol is a mixture of bioactive compounds in the unsaponifiable part of rice bran layer. Research has been focusing on it in recent years due to its outstanding physiological functions. This paper reviews the effects of rice raw materials, precision of rice processing, rice processing methods on the content of γ-oryzanol and the research progress on the extraction of γ-oryzanol from rice bran. We suggest to stress the importance of the data collection of γ-oryzanol content of rice, advocate moderate processing of rice, develop brown rice products by extrusion, advance germination and fermentation techniques, and strengthen the separation of active components from rice bran. This is in line with the major development strategies of grain saving and waste reduction, which helps build a healthy China and support high quality development of China.

Objective To investigate the quality of life in patients with atrial fibrillation (AF) and to analyze its correlation with peripheral blood inflammatory factors. Methods A total of 258 patients with new-onset non-valvular AF who were admitted to the Department of Cardiology of the First Affiliated Hospital of Army Medical University from December 2013 to July 2015 were enrolled consecutively. The peripheral blood inflammatory factors, including C-reactive protein (CRP), albumin (ALB) and D-dimer, and platele to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) were detected and calculated at admission. Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire was adopted to assess the quality of life of these patients. Spearman correlation and partial correlation were used to analyze the correlation between peripheral blood inflammatory factors and quality of life. Results The correlation between the overall quality of life score and baseline variables such as age, gender, educational level, smoking, drinking, taking statins, history of hypertension or diabetes was statistically significant among the 230 patients who completed the questionaire about quality of life (P < 0.05). Spearman correlation analysis showed that D-dimer was negatively correlated with symptom scores (P < 0.05), and D-dimer and NLR were negatively while LMR positively correlated with daily activity scores and overall scores (P < 0.05). After adjustiment of confounders, the partial correlation analysis represented a negative correlation between D-dimer and daily activity scores in the patients (r=-0.136, P=0.044). Conclusion Elevated D-dimer level suggests lower ability to perform daily activities in AF patients, and may affect their quality of life.

To provide data references for the improvement of red bean pulp storage,transportation and quality stability,the changes of freeze-thaw stability and rheological properties of red bean pulp were analyzed through repeated freeze-thaw tests in this paper.The results showed that the structure system of the red bean pulp suffered serious damage after one freeze-thaw cycle (-18 ℃ storaged 7 days) ,the stability coefficient significantly declined,the syneresis rate,clarify index and grain size showed significant increasing trend,these indicators had no significant changes after repeated freeze-thaw cycles,but the loss angle tangent (tanδ) showed a trend of gradual increase,indicating that the repeated freeze-thaw cycles would lead to fewer polymers and lower degree of polymerization in red bean pulp.The freeze-thaw cycle had a correlation to the elastic modulus (G′) of red bean pulp,but had little influence on the viscosity modulus (G″).

To simplify the production process，cooked mashed potato instead of water were used to make potato wheat noodles.Cooked mashed potato content with 81.11% moisture were added to 65 g to 85 g to 200 g of wheat flour.Influence of potato content on the quality of noodles was discussed.The results showed that with the increase of mashed potato content，the cooking yield and cooking loss of potato wheat noodles increased，L* value decreased，a* value and b* value increased，and color quality decreased.The fracture distance of potato wheat noodles increased first and then decreased，and the fracture strength，firmness and shear work all showed a decreasing trend

Objective To investigate the expression profile of long non-coding RNA (lncRNA) OSER1-AS1 in non-small-cell lung cancer (NSCLC) cell lines and its effect on the biological behaviors in these cells. Methods The expression level of OSER1-AS1 in 25 pairs of lung cancer tissues and adjacent normal tissues was detected by real-time quantitative PCR (qRT-PCR). Survival analysis was conducted by online analysis at Kaplan-Meier plotter website. The overexpression vector of OSER1-AS1 was constructed in plasmid pcDNA3.1 and then transfected into H1299 and SPCA1 cells. The effects of overexpression of OSER1-AS1 on proliferation, migration, invasion and apoptosis of lung cancer cell lines were detected by cell counting kit-8 (CCK-8) assay, Transwell assay and flow cytometry, respectively. Results The expression of OSER1-AS1 was significantly lower in lung cancer tissues than paracancerous normal tissue (P < 0.01). Kaplan-Meier survival analysis showed that low expression of lncRNA OSER1-AS1 in NSCLC was significantly associated with poor prognosis. After transfection of overexpression vector in the H1299 and SPCA1 cells, the expression of OSER1-AS1 was remarkably enhanced (P < 0.01). The overexpression of OSER1-AS1 resulted in the inhibition of proliferation, migration and invasion (P < 0.01) and the improvement of apoptosis (P < 0.05) of H1299 and SPCA1 cells. Conclusion lncRNA OSER1-AS1 may inhibit the proliferation, migration and invasion (P < 0.01), promote the apoptosis (P < 0.05) of NSCLC cells, and play a role of tumor-suppressor in oncogenesis and development of the cancer.

Rice is the largest staple food species in China, which is closely related to national health.For a long time, it is common to over-process rice which caused serious nutrition loss since pursuit of taste and appearance quality.Because rice bran is rich in nutrients, the milling degree of rice has a significant impact on the nutritional value of rice.Milling process and milling degree will also affect flour properties, and cooking and sensory quality of cooked rice.The effects of milling degree on nutrient content, flour properties,cooking and sensory quality of rice were summerized in order to provide references for the proper processing and milling of rice.

In recent years, along with the development of Chinese economy, buckwheat dried noodles, with health promotion effects，have developed rapidly. From 2017 to May 2019, the product quantity of buckwheat dried noodles had increased seven times from 321 to more than 2 300. Because of lacking of relevant standard, all noodles containing buckwheat flour called buckwheat noodles if only with content of buckwheat flour from 0.5% to 100%. Such behavior disturbed the market order. In order to guide and regulate the buckwheat noodles market, some enterprises marked buckwheat type and quantity on the product label. Based on the analysis of the status of dried noodles in China，and combined the analysis of buckwheat noodles standard in Japan, the development direction of Chinese buckwheat dried noodle standard were discussed.

In view of unstable problem existed in fault diagnosis result for rolling bearing of shearer based on K-means clustering algorithm, a new fault diagnosis method of rolling bearing of shearer based on TDKM-RBF neural network was proposed. The method adopts Tree Distribution algorithm to determine initial clustering center of the K-means clustering algorithm, so as to eliminate volatility of K-means clustering results. The method uses K-means algorithm to determine the parameters of the RBF neural network, then the trained neural network was used for fault diagnosis. The simulation results show that the method has quick clustering process,higher steability, and obviously improves accuracy of fault diagnosis for rolling bearing of shearer.

Surface electromyography (sEMG), as a key technology of non-invasive muscle computer interface, is an important method of human-computer interaction. We proposed a CNN-IndRNN (Convolutional Neural Network-Independent Recurrent Neural Network) hybrid algorithm to analyse sEMG signals and classify hand gestures. Ninapro’s dataset of 10 volunteers was used to develop the model, and by using only one time-domain feature (root mean square of sEMG), an average accuracy of 87.43% on 18 gestures is achieved. The proposed algorithm obtains a state-of-the-art classification performance with a significantly reduced model. In order to verify the robustness of the CNN-IndRNN model, a compact real¬time recognition system was constructed. The system was based on open-source hardware (OpenBCI) and a custom Python-based software. Results show that the 10-subject rock-paper-scissors gesture recognition accuracy reaches 99.1%.

In view of problem of low computation efficiency and poor generality of existing evaluation method of coal mine power grid, an improved BFS-the minimal path evaluation method was proposed. The method uses the breadth-first search method to quickly solve division optimization model of distribution network island, and then adopts the minimal path evaluation method to evaluate reliability of power supply according to the operation scope of island. The experimental results show that the method improves evaluation speed of weak links of power grid, and evaluation results are safe, reliable, accurate and effective.