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4. Porocarcinoma with orbital metastasis, a case report with review of literature.

Author

Yong, Wei Wei Dayna, Gungab, Alexander Gerard Nino L., Tan Ze Lin, Gideon, Lee Boniao, Emmanuel, Zhang Ting, Trisha, Choi Ci-En, Ellie, Wong Soon Boon, Justin, and Sundar, Gangadhara

Subjects
NEEDLE biopsy, CANCER cells, CLINICAL deterioration, CELL morphology
Abstract

We present a patient who presented with an orbital mass lesion which was a metastatic lesion from a porocarcinoma of the scalp with progressive deterioration of the patient. A 78-year-old male presented with functional decline and a rapidly growing scalp lesion of 3 months duration. In addition to the scalp lesion, Computed Tomography showed an incidental finding of a left lateral orbital wall tumour. Fine-needle aspiration of the two lesions revealed malignant cells with similar morphologies. Punch biopsy of the scalp lesion showed histological features suggestive of a porocarcinoma. Patient underwent palliative radiotherapy and immunotherapy and subsequently succumbed to the disease. [ABSTRACT FROM AUTHOR] more...

Published
2024
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5. Erythema annulare centrifugum in a case of indolent lymphoma: a case report.

Author

He, Chen, Wong, Soon Boon Justin, and Choi, Ellie

Subjects
*FLUORESCENCE in situ hybridization, *BLOOD cell count, *SKIN diseases, *CHRONIC obstructive pulmonary disease, *CHRONIC lymphocytic leukemia
Abstract

The article discusses a case of Erythema annulare centrifugum (EAC) in a 72-year-old man with indolent lymphoma. The patient presented with annular erythematous plaques on his legs and back, along with weight loss. Despite declining bone marrow evaluation and chemotherapy, the patient's skin lesions improved with topical treatment and traditional medicine. The article explores the association between EAC and malignancies, highlighting the challenges in managing paraneoplastic skin features. [Extracted from the article] more...

Published
2025
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10. Corrigendum to “Chemotherapy response score (CRS) as a surrogate marker for homologous recombination deficiency (HRD) based on loss of heterozygosity (LOH) in high grade serous ovarian cancer (HGSOC) (165)” [Gynecologic Oncology Volume 166, Supplement 1, August 2022, Page S98]

Author

Wijaya, Silvana, primary, Loh, Jerold, additional, Lim, Diana, additional, Wong, Soon Boon Justin, additional, Low, Jeffrey, additional, Ng, Joseph, additional, Tong, Pearl, additional, Ilancheran, Arunachalam, additional, Lim, Yi Wan, additional, Lim, Siew Eng, additional, Ngoi, Natalie, additional, and Tan, David, additional more...

Published
2023
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12. Chemotherapy response score (CRS) as a surrogate marker for homologous recombination deficiency (HRD) based on loss of heterozygosity (LOH) in high grade serous ovarian cancer (HGSOC) (165)

Author

Wijaya, Silvana, primary, Loh, Jerold, additional, Lim, Diana, additional, Wong, Soon Boon Justin, additional, Low, Jeffrey, additional, Ng, Joseph, additional, Tong, Pearl, additional, Ilancheran, Arunachalam, additional, Lim, Yi Wan, additional, Lim, Siew Eng, additional, Wijaya, Silvana, additional, and Tan, David, additional more...

Published
2022
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13. All-in-focus fine needle aspiration biopsy imaging based on Fourier ptychographic microscopy

Author

Liang, Mingshu, Bernadt, Cory, Wong, Soon Boon Justin, Choi, Changsoon, Cote, Richard, and Yang, Changhuei

Subjects
Health Informatics, Computer Science Applications, Pathology and Forensic Medicine
Abstract

Context: Cytology is the study of whole cells in diagnostic pathology. Unlike standard histologic thinly sliced specimens, cytologic preparations consist of preparations of whole cells where cells commonly cluster and aggregate. As such, cytology preparations are generally much thicker than histologic slides, resulting in large patches of defocus when examined under the microscope. A diagnostic aggregate of cells often cannot be viewed in focus together, requiring pathologists to continually manipulate the focal plane, complicating the task of accurately assessing the entire cellular aggregate and thus in making a diagnosis. Further, it is extremely difficult to acquire useful uniformly in-focus digital images of cytology preparations for applications such as remote diagnostic evaluations and artificial intelligence models. The predominant current method to address this issue is to acquire digital images at multiple focal planes of the entire slide, which demands long scanning time, complex and expensive scanning systems, and huge storage capacity. Aims: Here we report a unique imaging method that can acquire cytologic images efficiently and computationally render all-in-focus digital images that are highly compact. Methods and material: This method applies a metric-based digital refocusing to microscopy data collected with a Fourier ptychographic microscope (FPM). The digitally refocused patches of images are then synthesized into an all-in-focus image. Results: We report all-in-focus FPM results of thyroid fine needle aspiration (FNA) cytology samples, demonstrating our method’s ability to overcome the height variance of 30 μm caused by cell aggregation, and rendering images at high resolution (corresponds to a standard microscope with objective NA of 0.75) and that are all-in-focus. Conclusions: This technology is applicable to standard microscopes, and we believe can have an impact on diagnostic accuracy as well as ease and speed of diagnosing challenging specimens. While we focus on cytology slides here, we anticipate this technology’s advantages will translate well for histology applications. This technique also addresses the issue of remote rapid evaluation of cytology preparations. Finally, we believe that by resolving the focus heterogeneity issues in standard digital images, this technique is a critical advance for applying machine learning to cytology specimens. more...

Published
2021

20. Idiopathic Granulomatous Mastitis and Erythema nodosum – A Unifying Pathophysiology?

Author

Choi, Ellie CE, Wong, Soon Boon Justin, and Ho, Sue‐Ann JE

Subjects
*ERYTHEMA nodosum, *MASTITIS, *PATHOLOGICAL physiology, *JOINT pain, *COUGH, *MULTINUCLEATED giant cells
Abstract

Few have reported concurrence of idiopathic granulomatous mastitis and erythema nodosum, both of which have an unclear aetiology. A week after developing the breast lumps, she developed painful indurated bumps on the shins and calves (Figure 1a), with fever, cough and arthralgia. This is supported by the observation that both conditions affect females of childbearing age, and reports of idiopathic granulomatous mastitis occurring in lactating females.17,18 However, a recent paper observed that only 1 of 32 females with idiopathic granulomatous mastitis had a history of breastfeeding,19 although a counter argument notes that pseudo-lactational breast changes can occur in women who are not lactating. [Extracted from the article] more...

Published
2021
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23. Type I IFNs and IL-18 Regulate the Antiviral Response of Primary Human γδ T Cells against Dendritic Cells Infected with Dengue Virus

Author

Tsai, Chen-Yu, primary, Liong, Ka Hang, additional, Gunalan, Matilda Gertrude, additional, Li, Na, additional, Lim, Daniel Say Liang, additional, Fisher, Dale A., additional, MacAry, Paul A., additional, Leo, Yee Sin, additional, Wong, Siew-Cheng, additional, Puan, Kia Joo, additional, and Wong, Soon Boon Justin, additional more...

Published
2015
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24. The Combination of Type I IFN, TNF-α, and Cell Surface Receptor Engagement with Dendritic Cells Enables NK Cells To Overcome Immune Evasion by Dengue Virus

Author

Lim, Daniel Say Liang, primary, Yawata, Nobuyo, additional, Selva, Kevin John, additional, Li, Na, additional, Tsai, Chen Yu, additional, Yeong, Lai Han, additional, Liong, Ka Hang, additional, Ooi, Eng Eong, additional, Chong, Mun Keat, additional, Ng, Mah Lee, additional, Leo, Yee Sin, additional, Yawata, Makoto, additional, and Wong, Soon Boon Justin, additional more...

Published
2014
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