Search

Your search keyword '"WILLEMS, Emily"' showing total 10 results
Start Over Author "WILLEMS, Emily"
10 results on '"WILLEMS, Emily"'

3. Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Author

Rombaut, Ben, primary, Schepers, Melissa, additional, Tiane, Assia, additional, Mussen, Femke, additional, Koole, Lisa, additional, Kessels, Sofie, additional, Trippaers, Chloë, additional, Jacobs, Ruben, additional, Wouters, Kristiaan, additional, Willems, Emily, additional, Veggel, Lieve van, additional, Koulousakis, Philippos, additional, Deluyker, Dorien, additional, Bito, Virginie, additional, Prickaerts, Jos, additional, Wens, Inez, additional, Brône, Bert, additional, van den Hove, Daniel L. A., additional, and Vanmierlo, Tim, additional

Published
2024
Full Text
View/download PDF

4. Beta‐amyloid interacts with and activates the long‐form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability

Author

Sin, Yuan Yan, primary, Cameron, Ryan T., additional, Schepers, Melissa, additional, MacLeod, Ruth, additional, Wright, Tom A., additional, Paes, Dean, additional, van den Hove, Daniel, additional, Willems, Emily, additional, Vanmierlo, Tim, additional, Prickaerts, Jos, additional, Blair, Connor M., additional, and Baillie, George S., additional

Published
2024
Full Text
View/download PDF

7. Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-beta pathology

Author

PAES, Dean, SCHEPERS, Melissa, WILLEMS, Emily, ROMBAUT, Ben, TIANE, Assia, Solomina, Yevgeniya, Tibbo, Amy, Blair, Connor, Kyurkchieva, Elka, Baillie, George S., Ricciarelli, Roberta, Brullo, Chiara, Fedele, Ernesto, Bruno, Olga, van den Hove, Daniel, VANMIERLO, Tim, Prickaerts, Jos, PAES, Dean, SCHEPERS, Melissa, WILLEMS, Emily, ROMBAUT, Ben, TIANE, Assia, Solomina, Yevgeniya, Tibbo, Amy, Blair, Connor, Kyurkchieva, Elka, Baillie, George S., Ricciarelli, Roberta, Brullo, Chiara, Fedele, Ernesto, Bruno, Olga, van den Hove, Daniel, VANMIERLO, Tim, and Prickaerts, Jos

Subjects
PS1, CRISPR, Phosphodiesterase 4D, Alzheimer's disease, Cas9, APP
Abstract

Inhibition of phosphodiesterase 4D (PDE4D) enzymes has been investigated as therapeutic strategy to treat memory problems in Alzheimer's disease (AD). Although PDE4D inhibitors are effective in enhancing memory processes in rodents and humans, severe side effects may hamper their clinical use. PDE4D enzymes comprise different isoforms, which, when targeted specifically, can increase treatment efficacy and safety. The function of PDE4D isoforms in AD and in molecular memory processes per se has remained unresolved. Here, we report the upregulation of specific PDE4D isoforms in transgenic AD mice and hippocampal neurons exposed to amyloid-beta. Furthermore, by means of pharmacological inhibition and CRISPR-Cas9 knockdown, we show that the long-form PDE4D3, -D5, -D7, and -D9 isoforms regulate neuronal plasticity and convey resilience against amyloid-beta in vitro. These results indicate that isoform-specific, next to non-selective, PDE4D inhibition is efficient in promoting neuroplasticity in an AD context. Therapeutic effects of non-selective PDE4D inhibitors are likely achieved through actions on long isoforms. Future research should identify which long PDE4D isoforms should be specifically targeted in vivo to both improve treatment efficacy and reduce side effects. This work was supported by Alzheimer Nederland [Grant WE.03–2016-07]. TV and JP have a proprietary interest in selective PDE4D inhibitors for the treatment of demyelinating disorders and neurodegenerative disorders. JP has a proprietary interest in the PDE4 inhibitor rofumilast for the treatment of cognitive impairment as well as PDE4D inhibitors for the treatment of Alzheimer’s disease. OB, CB, EF, RR, and JP have a proprietary interest in GEBR32a compound.

Published
2023

9. Detection of pathogenic Leptospira spp. in herpetofauna in Central Appalachia

Author

Verma, Ashutosh, primary, Brandt, LaRoy, additional, Runser, Samantha, additional, Gruszynski, Karen, additional, Gallatin, Kenneth, additional, Morgan, Joey, additional, Barnhart, Hanna, additional, Duke, Conner, additional, Brovarney, Scott, additional, Geer, Allison, additional, Willems, Emily, additional, Strobel, Raeshelle, additional, Bryant, Christian, additional, Pawlowski, Emma, additional, and Thaker, Ashana, additional

Published
2022
Full Text
View/download PDF

10. Middle School Students, Teachers, and Parents Contracting for Success.

Author

Willems, Arnold L., McConnell, Rodney, and Willems, Emily M.

Abstract

Educational contracts define the parameters of teacher obligations to students, parents, and other stakeholders freeing teachers to design and implement instruction rather than trying to fulfill roles (counselor, social worker, parent) best filled by other stakeholders. Describes analogous contracts used in the business world and provides examples of prototype contracts for middle school students. (PEN)

Published
1997

Catalog

Books, media, physical & digital resources
See catalog results